Behavioral consequences in rats from chronic exposure to 10 PPM halothane during early development.

Abstract:

:Albino rats were chronically exposed for 40 hours a week to 10 ppm halothane in air during early development (conception to day 60), adult life (day 60 to day 135), or both. An unexposed group served as a control. Rats exposed during early development made 30 percent more errors than rats unexposed during this period when tested on a shock-motivated visual-discrimination task, or a food-motivated spatial-discrimination task. However, the relative rate of learning was the same for all groups. Exposure during early development also lowered the jump and flinch thresholds to electric footshock as compared to animals not so treated.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Quimby KL,Katz J,Bowman RE

doi

10.1213/00000539-197509000-00017

subject

Has Abstract

pub_date

1975-09-01 00:00:00

pages

628-3

issue

5

eissn

0003-2999

issn

1526-7598

journal_volume

54

pub_type

杂志文章
  • Comparison of Thrombelastography-Derived Fibrinogen Values at Rewarming and Following Cardiopulmonary Bypass in Cardiac Surgery Patients.

    abstract:BACKGROUND:The inflated costs and documented deleterious effects of excess perioperative transfusion have led to the investigation of targeted coagulation factor replacement strategies. One particular coagulation factor of interest is factor I (fibrinogen). Hypofibrinogenemia is typically tested for using time-consumin...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章

    doi:10.1213/ANE.0000000000001465

    authors: Fabbro M 2nd,Gutsche JT,Miano TA,Augoustides JG,Patel PA

    更新日期:2016-09-01 00:00:00

  • Postoperative ventilatory failure in an obese, myopathic woman with periodic somnolence: A case report.

    abstract::An obese woman with periodic sommolence developed postoperative ventilatory problems following an uncomplicated cholecystectomy. A severe myopathic process involving the respiratory muscles was found at necropsy. A brother, who died a week later, had myotonic dystrophy. ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-197507000-00026

    authors: Tsueda K,Shibutani K,Lefkowitz M

    更新日期:1975-07-01 00:00:00

  • Vasoconstrictors in spinal anesthesia with tetracaine--a comparison of epinephrine and phenylephrine.

    abstract::A randomized double-blind study was conducted in 50 orthopedic patients to determine the effect of epinephrine and phenylephrine on the anesthetic properties of intrathecally administered tetracaine. Two doses of each vasoconstrictor agent were studied: 0.2 mg of epinephrine, 0.3 mg of epinephrine, 1 mg of phenylephri...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Concepcion M,Maddi R,Francis D,Rocco AG,Murray E,Covino BG

    更新日期:1984-02-01 00:00:00

  • Residual halothane: Patient and personnel exposure.

    abstract::In addition to offering further data on the exposure of surgical and recovery-room personnel to low levels of halothane in room air, the authors demonstrate the presence of halothane levels in the blood of some surgical patients managed by other inhalation agents from machines previously used for halothane. The author...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-197507000-00010

    authors: Nicholson JA,Sada T,Aldrete JA

    更新日期:1975-07-01 00:00:00

  • Effects of Electrical Transcutaneous Vagus Nerve Stimulation on the Perceived Intensity of Repetitive Painful Heat Stimuli: A Blinded Placebo- and Sham-Controlled Randomized Crossover Investigation.

    abstract:BACKGROUND:Transcutaneous vagus nerve stimulation (TVNS) is a promising treatment for acute and chronic pain. However, experimental studies yielded controversial results. We examined if TVNS reduces the perceived intensity of repetitive painful heat stimulation and temporal summation of pain (TSP) in healthy volunteers...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/ANE.0000000000002820

    authors: Janner H,Klausenitz C,Gürtler N,Hahnenkamp K,Usichenko TI

    更新日期:2018-06-01 00:00:00

  • Selective spinal anesthesia: a comparison of hyperbaric bupivacaine 4 mg versus 6 mg for outpatient knee arthroscopy.

    abstract:IMPLICATIONS:A low-dose (4 mg), low-volume (0.8 mL), low-flow (2 min) technique with hyperbaric bupivacaine toward the dependent side oriented injection and maintenance of the lateral decubitus position for 10 min produced selective spinal anesthesia with rapid recession of motor block and early discharge home. ...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-200112000-00005

    authors: Valanne JV,Korhonen AM,Jokela RM,Ravaska P,Korttila KK

    更新日期:2001-12-01 00:00:00

  • Small-dose ketamine reduces the pain of propofol injection.

    abstract:BACKGROUND:I.v. injection of propofol during anesthetic induction induces pain. Ketamine has been shown to reduce injection pain. In this study, we established the optimal dose of ketamine to prevent the pain of injection with propofol. METHODS:Two hundred forty patients presenting for elective surgery were randomly a...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/01.ane.0000243334.83816.53

    authors: Koo SW,Cho SJ,Kim YK,Ham KD,Hwang JH

    更新日期:2006-12-01 00:00:00

  • Prolonged intrathecal fentanyl analgesia via 32-gauge catheters after thoracotomy.

    abstract::We hypothesized that intrathecal fentanyl infusion would provide excellent analgesia, require lower doses than necessary for the epidural or intravenous route of administration, and reduce the incidence and/or severity of side effects. Accordingly, we studied 12 patients during 48 h after thoracotomy (three pneumonect...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-199311000-00011

    authors: Guinard JP,Chiolero R,Mavrocordatos P,Carpenter RL

    更新日期:1993-11-01 00:00:00

  • Ilioinguinal iliohypogastric nerve blocks--before or after cesarean delivery under spinal anesthesia?

    abstract::Preoperative local anesthetic blockade of somatosensory pathways involved with skin incision and other noxious perioperative stimuli may "preempt" or attenuate the postoperative pain response. Since the Pfannenstiel incision lies within the L1 dermatome, bilateral ilioinguinal, iliohypogastric nerve blocks (IINBs) sho...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-199601000-00003

    authors: Huffnagle HJ,Norris MC,Leighton BL,Arkoosh VA

    更新日期:1996-01-01 00:00:00

  • Closed-Loop Delivery Systems Versus Manually Controlled Administration of Total IV Anesthesia: A Meta-analysis of Randomized Clinical Trials.

    abstract::Bispectral Index Scale (BIS)-guided closed-loop delivery of anesthetics has been extensively studied. We performed a meta-analysis of all the randomized clinical trials comparing efficacy and performance between BIS-guided closed-loop delivery and manually controlled administration of total IV anesthesia. Scopus, PubM...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,meta分析,评审

    doi:10.1213/ANE.0000000000001394

    authors: Pasin L,Nardelli P,Pintaudi M,Greco M,Zambon M,Cabrini L,Zangrillo A

    更新日期:2017-02-01 00:00:00

  • Cerebral Small Vessel, But Not Large Vessel Disease, Is Associated With Impaired Cerebral Autoregulation During Cardiopulmonary Bypass: A Retrospective Cohort Study.

    abstract:BACKGROUND:Impaired cerebral blood flow (CBF) autoregulation during cardiopulmonary bypass (CPB) is associated with stroke and other adverse outcomes. Large and small arterial stenosis is prevalent in patients undergoing cardiac surgery. We hypothesize that large and/or small vessel cerebral arterial disease is associa...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/ANE.0000000000003384

    authors: Nomura Y,Faegle R,Hori D,Al-Qamari A,Nemeth AJ,Gottesman R,Yenokyan G,Brown C,Hogue CW

    更新日期:2018-12-01 00:00:00

  • Emergency tracheal intubation: complications associated with repeated laryngoscopic attempts.

    abstract::Repeated conventional tracheal intubation attempts may contribute to patient morbidity. Critically-ill patients (n = 2833) suffering from cardiovascular, pulmonary, metabolic, neurologic, or trauma-related deterioration were entered into an emergency intubation quality improvement database. This practice analysis was ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ANE.0000122825.04923.15

    authors: Mort TC

    更新日期:2004-08-01 00:00:00

  • A clinical profile of a cohort of patients referred to an anesthesiology-based pediatric chronic pain medicine program.

    abstract:BACKGROUND:Pediatric chronic pain is very common and results in significant health care costs. Pediatric chronic pain is both an individual and a public health concern. The primary objective of this study was to generate a descriptive clinical profile of the patients referred to an anesthesiology-based pediatric chroni...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ane.0b013e3181609483

    authors: Vetter TR

    更新日期:2008-03-01 00:00:00

  • Sevoflurane, but not propofol, significantly prolongs the Q-T interval.

    abstract:UNLABELLED:Prolongation of the Q-T interval may be associated with polymorphic ventricular tachycardia known as torsade de pointes, syncope and sudden death. Existing data show that isoflurane prolongs the Q-T interval, whereas halothane shortens it. The aim of this study was to determine whether sevoflurane or propofo...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-200001000-00006

    authors: Kleinsasser A,Kuenszberg E,Loeckinger A,Keller C,Hoermann C,Lindner KH,Puehringer F

    更新日期:2000-01-01 00:00:00

  • The Cognitive Science of Learning: Concepts and Strategies for the Educator and Learner.

    abstract::Education is the fundamental process used to develop and maintain the professional skills of physicians. Medical students, residents, and fellows are expected to learn considerable amounts of information as they progress toward board certification. Established practitioners must continue to learn in an effort to remai...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审

    doi:10.1213/ANE.0000000000000890

    authors: Weidman J,Baker K

    更新日期:2015-12-01 00:00:00

  • The effects of tidal volume and respiratory rate on oxygenation and respiratory mechanics during laparoscopy in morbidly obese patients.

    abstract:UNLABELLED:Morbidly obese (MO) patients undergoing laparoscopy have lower PaO(2) compared with normal-weight (NW) patients. We hypothesized that increases in tidal volume (V(T)) or respiratory rate (RR) would improve oxygenation. All measurements were performed at: 1) baseline: V(T) 600-700 mL and 10 breaths/min, 2) do...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章

    doi:10.1213/01.ane.0000067409.33495.1f

    authors: Sprung J,Whalley DG,Falcone T,Wilks W,Navratil JE,Bourke DL

    更新日期:2003-07-01 00:00:00

  • Alpha-2 adrenoceptor activity affects propofol-induced sleep time.

    abstract:UNLABELLED:alpha(2) Adrenoceptor activity is involved in the mechanism of anesthesia. Clonidine, a alpha(2) adrenoceptor agonist, and yohimbine, a alpha(2) adrenoceptor antagonist, increase and decrease barbiturate-induced sleep times. In this study, we examined the effects of these drugs on propofol-induced sleep time...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200205000-00028

    authors: Kushikata T,Hirota K,Yoshida H,Kubota T,Ishihara H,Matsuki A

    更新日期:2002-05-01 00:00:00

  • Prior epidural lidocaine alters the pharmacokinetics and drug effects of extended-release epidural morphine (DepoDur®) after cesarean delivery.

    abstract:BACKGROUND:A potential physicochemical interaction between epidural local anesthetics and extended-release epidural morphine (EREM) could negate the sustained release. In this study, we sought to determine the pharmacokinetic and drug effects of prior epidural lidocaine administration on EREM. METHODS:Thirty healthy w...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/ANE.0b013e318222f59c

    authors: Atkinson Ralls L,Drover DR,Clavijo CF,Carvalho B

    更新日期:2011-08-01 00:00:00

  • The effect of graded hypothermia (36 degrees C-32 degrees C) on hemostasis in anesthetized patients without surgical trauma.

    abstract:UNLABELLED:The isolated effects of hypothermia on hemostasis have not been investigated in healthy humans. We cooled 16 anesthetized patients scheduled for elective intracranial surgery to 32 degrees C body core temperature and assessed prothrombin time (PT), activated partial thromboplastin time, thrombelastogram (TEG...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章

    doi:10.1213/01.ane.0000062520.65192.c9

    authors: Kettner SC,Sitzwohl C,Zimpfer M,Kozek SA,Holzer A,Spiss CK,Illievich UM

    更新日期:2003-06-01 00:00:00

  • Symmetry aortic connector devices and acute renal injury: a comparison of renal dysfunction after three different aortocoronary bypass surgery techniques.

    abstract::Although the pathogenesis of acute renal injury after cardiac surgery is multifactorial, atherosclerosis of the ascending aorta and embolic burden are strong independent predictors. Use of the Symmetry aortic connector device (ACD) for proximal anastomosis of coronary grafts may reduce ascending aortic atheroembolism....

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000189054.17725.73

    authors: Fischer SS,Phillips-Bute B,Swaminathan M,Milano C,Stafford-Smith M

    更新日期:2006-01-01 00:00:00

  • Validating the Physiologic Model HumMod as a Substitute for Clinical Trials Involving Acute Normovolemic Hemodilution.

    abstract:BACKGROUND:Blood conservation strategies and transfusion guidelines remain a heavily debated clinical topic. Previous investigational trials have shown that acute isovolemic hemodilution does not limit adequate oxygen delivery; however, a true critical hemoglobin level has never been investigated or defined due to safe...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000002430

    authors: Sims CR 3rd,Delima LR,Calimaran A,Hester R,Pruett WA

    更新日期:2018-01-01 00:00:00

  • Fentanyl and alfentanil plasma protein binding in preterm and term neonates.

    abstract::The effects of gestational age (GA) and plasma protein concentrations on the plasma protein binding of fentanyl and alfentanil were studied in preterm and term neonates. Binding experiments were performed using split-cell equilibrium dialysis. Fentanyl and alfentanil concentrations were measured using specific radioim...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199702000-00013

    authors: Wilson AS,Stiller RL,Davis PJ,Fedel G,Chakravorti S,Israel BA,McGowan FX Jr

    更新日期:1997-02-01 00:00:00

  • Sameridine is safe and effective for spinal anesthesia: a comparative dose-ranging study with lidocaine for inguinal hernia repair.

    abstract:UNLABELLED:Sameridine is a new compound with local anesthetic and analgesic properties when injected intrathecally. We studied the anesthetic and analgesic efficacy of three doses of isobaric sameridine (15, 20, and 23 mg) compared with 100 mg of hyperbaric lidocaine for spinal anesthesia in 140 healthy male patients u...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1097/00000539-199904000-00025

    authors: Mulroy MF,Greengrass R,Ganapathy S,Chan V,Heierson A

    更新日期:1999-04-01 00:00:00

  • A Comparison of Photoplethysmography Versus Esophageal Doppler for the Assessment of Cardiac Index During Major Noncardiac Surgery.

    abstract:BACKGROUND:In this prospective observational study, we compared changes in cardiac index (CI) during fluid challenge using photoplethysmography (PPG; Nexfin™) (CIPPG) versus esophageal Doppler (ED) (CIED) in major noncardiac surgery patients. METHODS:Measurements were obtained when the attending anesthesiologist decid...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000001113

    authors: Blanié A,Soued M,Benhamou D,Mazoit JX,Duranteau J

    更新日期:2016-02-01 00:00:00

  • Case report: intraoperative management of extreme hemodilution in a patient with a severed axillary artery.

    abstract::We present a case of extreme hemodilution in which appropriately crossmatched blood was not available. A 53-year-old man was admitted to our hospital because of hemorrhagic shock due to multiple stab wounds. His blood type was B, Rh negative, and his intravascular fluid volume was maintained with balanced salt solutio...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0b013e3181e668b8

    authors: Dai J,Tu W,Yang Z,Lin R

    更新日期:2010-11-01 00:00:00

  • The association of maternal race and ethnicity and the risk of postpartum hemorrhage.

    abstract:BACKGROUND:There are profound racial and ethnic disparities in obstetric outcomes in the United States, but little is known about disparities in risk of postpartum hemorrhage (PPH). We explored the association of race and ethnicity on the risk of PPH due to uterine atony with sequential adjustment for possible mediatin...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0b013e3182691e62

    authors: Bryant A,Mhyre JM,Leffert LR,Hoban RA,Yakoob MY,Bateman BT

    更新日期:2012-11-01 00:00:00

  • Differential changes of alveolar gas concentrations during anesthetic induction of a patient with an absent right pulmonary artery.

    abstract::A 38-yr-old man with congenital right pulmonary artery agenesis, whose right lung was perfused with collateral systemic arterial blood, presented for right pneumonectomy. Because of a likely difference in gas exchange between the two lungs, we sampled end-tidal gases from each lung individually, as well as from the co...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000226089.53300.7a

    authors: Jiang Y,Wain JC,Chang AW,Zapol WM,Xie Z

    更新日期:2006-08-01 00:00:00

  • Lung recruitment and positive end-expiratory pressure have different effects on CO2 elimination in healthy and sick lungs.

    abstract:BACKGROUND:We studied the effects that the lung recruitment maneuver (RM) and positive end-expiratory pressure (PEEP) have on the elimination of CO(2) per breath (Vtco(2,br)). METHODS:In 7 healthy and 7 lung-lavaged pigs at constant ventilation, PEEP was increased from 0 to 18 cm H(2)O and then decreased to 0 in steps...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0b013e3181f0c2da

    authors: Tusman G,Bohm SH,Suarez-Sipmann F,Scandurra A,Hedenstierna G

    更新日期:2010-10-01 00:00:00

  • The additive pulmonary vasodilatory effects of inhaled prostacyclin and inhaled milrinone in postcardiac surgical patients with pulmonary hypertension.

    abstract:UNLABELLED:Selective pulmonary vasodilation is an advantageous therapeutic strategy for cardiac surgical patients with increased pulmonary vascular resistance (PVR) and right ventricular failure. We hypothesized that milrinone, an adenosine-3',5'-cyclic monophosphate (cAMP)-selective phosphodiesterase enzyme (PDE) inhi...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章

    doi:10.1097/00000539-200112000-00018

    authors: Haraldsson s A,Kieler-Jensen N,Ricksten SE

    更新日期:2001-12-01 00:00:00

  • The effect of isoflurane or spinal anesthesia on indocyanine green disappearance rate in the elderly.

    abstract::This study was designed to measure the disappearance rate of indocyanine green (ICG) as an indicator of hepatic blood flow in elderly patients undergoing internal fixation of fractured neck of femur. All patients were aged 60-90 yr and were randomized to receive either spinal (n = 10) or isoflurane (n = 10) anesthesia...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1213/00000539-199404000-00016

    authors: Darling JR,Murray JM,Hainsworth AM,Trinick TR

    更新日期:1994-04-01 00:00:00