Influenza infection promotes macrophage traffic into arteries of mice that is prevented by D-4F, an apolipoprotein A-I mimetic peptide.

abstract：:Although a family history of ischemic heart disease is a well-accepted risk factor for cardiovascular disease, only three prospective studies--all in men--have examined the predictive strength of a positive family history after adjusting for other heart disease risk factors. The present analysis is based on a 9 year f...

journal_title：Circulation

authors： Barrett-Connor E,Khaw K

更新日期：1984-06-01 00:00:00

abstract：BACKGROUND:Chronic, complete AV block (CAVB) in the dog leads to ventricular hypertrophy, which has been described as an independent risk factor for arrhythmias. In this model, we examined (1) whether the short- and long-term electrical adaptations predispose to acquired torsade de pointes arrhythmias (TdP) and (2) the...

journal_title：Circulation

authors： Vos MA,de Groot SH,Verduyn SC,van der Zande J,Leunissen HD,Cleutjens JP,van Bilsen M,Daemen MJ,Schreuder JJ,Allessie MA,Wellens HJ

更新日期：1998-09-15 00:00:00

abstract：BACKGROUND:Degeneration of xenografts or homografts is a major cause for reoperation in young patients after pulmonary valve replacement. We present the early results of fresh decellularized pulmonary homografts (DPH) implantation compared with glutaraldehyde-fixed bovine jugular vein (BJV) and cryopreserved homografts...

journal_title：Circulation

authors： Cebotari S,Tudorache I,Ciubotaru A,Boethig D,Sarikouch S,Goerler A,Lichtenberg A,Cheptanaru E,Barnaciuc S,Cazacu A,Maliga O,Repin O,Maniuc L,Breymann T,Haverich A

更新日期：2011-09-13 00:00:00

abstract：:Resting left ventricular (LV) function was evaluated in 22 patients with permanent ventricular pacemakers. LV ejection fraction and volume indexes were determined by gated blood pool scintigraphy at ventricular pacing rates of 50-100 beats/min. In patients with a normal heart size, increases in pacing rates resulted i...

journal_title：Circulation

authors： Narahara KA,Blettel ML

更新日期：1983-02-01 00:00:00

abstract：BACKGROUND:Systemic delivery of bone marrow-derived mesenchymal stem cells (BM-MSCs) is an attractive approach for myocardial repair. We aimed to test this strategy in a rat model after myocardial infarction (MI). METHODS AND RESULTS:BM-MSCs were obtained from rat bone marrow, expanded in vitro to a purity of >50%, an...

journal_title：Circulation

authors： Barbash IM,Chouraqui P,Baron J,Feinberg MS,Etzion S,Tessone A,Miller L,Guetta E,Zipori D,Kedes LH,Kloner RA,Leor J

更新日期：2003-08-19 00:00:00

abstract：:Fifty-four Japanese patients with occlusive thromboaortopathy (OTAP), including four males, were classified according to evidence of complications attributed to OTAP at the time when the diagnosis was established: Group I, uncomplicated OTAP with or without the involvement of the pulmonary artery. Group II, mono-compl...

journal_title：Circulation

authors： Ishikawa K

更新日期：1978-01-01 00:00:00

abstract：:We assessed the reversibility of functional and morphological changes of arterialized vein segments by returning them to the venous circulation. Thirteen dogs underwent right carotid and femoral veno-arterial grafting. After 12 weeks, veno-arterial grafts were removed for contractility (norepinephrine [NE] and 5-hydro...

journal_title：Circulation

authors： Fann JI,Sokoloff MH,Sarris GE,Yun KL,Kosek JC,Miller DC

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND:Recent experimental data indicate that ultrasound-induced destruction of ultrasound contrast microbubbles can cause immediate rupture of the microvessels in which these microbubbles are located. METHODS AND RESULTS:To examine the functional and morphological significance of these findings in the heart, isol...

journal_title：Circulation

authors： Ay T,Havaux X,Van Camp G,Campanelli B,Gisellu G,Pasquet A,Denef JF,Melin JA,Vanoverschelde JL

更新日期：2001-07-24 00:00:00

abstract：BACKGROUND:Extracorporeal circulation with circuits coated with surface-bound heparin has allowed reduced levels of systemic heparinization. Clinical benefits have included reduced postoperative bleeding and less homologous blood usage. However, the effects on the hemostatic and fibrinolytic systems have remained in pa...

journal_title：Circulation

authors： Ovrum E,Brosstad F,Am Holen E,Tangen G,Abdelnoor M

更新日期：1995-11-01 00:00:00

abstract：:The ameliorative effect of antiplatelet therapy on atherogenesis of vein grafts was assessed in autologous cephalic veins grafted into femoral arteries of 16 normolipemic and 11 hyperlipemic stump-tailed macaque monkeys. Before grafting, one half of each vein was distended at high pressure (700 mm Hg) and the other ha...

journal_title：Circulation

authors： Bonchek LI,Boerboom LE,Olinger GN,Pepper JR,Munns J,Hutchinson L,Kissebah AH

更新日期：1982-08-01 00:00:00

abstract：BACKGROUND:Preconditioning the heart before an ischemic insult has been shown to protect against contractile dysfunction, arrhythmias, and infarction. Pharmacological studies have suggested that fibroblast growth factor-2 (FGF2) is involved in cardioprotection. However, because of the number of FGFs expressed in the he...

journal_title：Circulation

authors： House SL,Bolte C,Zhou M,Doetschman T,Klevitsky R,Newman G,Schultz Jel J

更新日期：2003-12-23 00:00:00

abstract：BACKGROUND:Chronic thromboembolic pulmonary hypertension (CTEPH) is a disorder characterized by pulmonary arterial hypertension as a consequence of organized thrombotic material in the central pulmonary arteries. Incomplete resolution of acute pulmonary emboli is believed to be pathogenically important; however, the me...

journal_title：Circulation

authors： Olman MA,Marsh JJ,Lang IM,Moser KM,Binder BR,Schleef RR

更新日期：1992-10-01 00:00:00

abstract：BACKGROUND:Emerging studies suggest that early administration of dual antiplatelet therapy may be better than monotherapy for prevention of early recurrent stroke and cardiovascular outcomes in acute ischemic stroke and transient ischemic attack (TIA). We performed a meta-analysis of randomized, controlled trials evalu...

journal_title：Circulation

authors： Wong KS,Wang Y,Leng X,Mao C,Tang J,Bath PM,Markus HS,Gorelick PB,Liu L,Lin W,Wang Y

更新日期：2013-10-08 00:00:00

abstract：BACKGROUND:Studies on apolipoprotein E (apoE) alleles have reported an increased risk of coronary heart disease in patients with the apoE4 allele. Given the risk factor and histological similarities between coronary and calcific valvular heart disease (aortic stenosis [AS] and mitral annular calcification [MAC]), we po...

journal_title：Circulation

authors： Novaro GM,Sachar R,Pearce GL,Sprecher DL,Griffin BP

更新日期：2003-10-14 00:00:00

abstract：BACKGROUND:The isthmus between the inferior vena cava and the tricuspid annulus has been shown to be involved in the reentry circuit of common atrial flutter. The effects of radio-frequency catheter ablation of this isthmus were examined in the canine model of atrial flutter due to reentry around the tricuspid annulus....

journal_title：Circulation

authors： Tabuchi T,Okumura K,Matsunaga T,Tsunoda R,Jougasaki M,Yasue H

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND:The pathophysiology of hypertension in the immediate postpartum period is unclear. METHODS AND RESULTS:We studied 988 consecutive women admitted to a tertiary medical center for cesarean section of a singleton pregnancy. The angiogenic factors soluble fms-like tyrosine kinase 1 and placental growth factor, ...

journal_title：Circulation

authors： Goel A,Maski MR,Bajracharya S,Wenger JB,Zhang D,Salahuddin S,Shahul SS,Thadhani R,Seely EW,Karumanchi SA,Rana S

更新日期：2015-11-03 00:00:00

abstract：BACKGROUND:Both a vascular endothelial cytochrome P450 (CYP450) product of arachidonic acid metabolism and the potassium ion (K(+)) have been identified as endothelium-derived hyperpolarizing factors (EDHFs) in animal vascular tissues. We studied the relative importance of EDHF, nitric oxide (NO), and prostacyclin (PGI...

journal_title：Circulation

authors： Coats P,Johnston F,MacDonald J,McMurray JJ,Hillier C

更新日期：2001-03-27 00:00:00

abstract：BACKGROUND:The signal transduction mechanism linking mitochondrial ATP synthesis with cytosolic ATP utilization in heart changes during postnatal development in vivo. This maturational process occurs in parallel with accumulation of mitochondrial adenine nucleotide translocator (ANT), which provides a possible site for...

journal_title：Circulation

authors： Portman MA,Xiao Y,Qian K,Tucker RL,Parish SM,Ning XH

更新日期：2000-09-12 00:00:00

abstract：BACKGROUND:The growing postnatal human heart maintains electromechanical function while undergoing substantial changes of cellular topology and myocardial architecture. The capacity for growth and remodeling of ventricular myocardium in adaptation to the hemodynamic changes of early infancy later declines. This decline...

journal_title：Circulation

authors： Peters NS,Severs NJ,Rothery SM,Lincoln C,Yacoub MH,Green CR

更新日期：1994-08-01 00:00:00

abstract：BACKGROUND:Sensitivity to apoptotic signals, the clearance rate of apoptosis, and the apoptotic ultrastructure have not been studied in cells of the in vivo adult heart. METHODS AND RESULTS:To minimize the systemic influence, soluble Fas ligand was injected directly into in vivo rat hearts and livers (as the control) ...

journal_title：Circulation

authors： Hayakawa K,Takemura G,Koda M,Kawase Y,Maruyama R,Li Y,Minatoguchi S,Fujiwara T,Fujiwara H

更新日期：2002-06-25 00:00:00

abstract：BACKGROUND:Phosphatidylserine-expressing microparticles circulate in blood with a short half-life of <10 minutes. We tested the role of an endothelium-derived phosphatidylserine-binding opsonin, developmental endothelial locus-1 (Del-1), in the uptake of platelet microparticles. METHODS AND RESULTS:Cultured human umbi...

journal_title：Circulation

authors： Dasgupta SK,Le A,Chavakis T,Rumbaut RE,Thiagarajan P

更新日期：2012-04-03 00:00:00

abstract：BACKGROUND:Long-term implantable left ventricular assist devices (LVADs) are increasingly used as a bridge to cardiac transplantation and may be used as long-term therapy for end-stage heart failure. After insertion of an LVAD, patients frequently become ambulatory. Sensors contained within these devices can measure th...

journal_title：Circulation

authors： Foray A,Williams D,Reemtsma K,Oz M,Mancini D

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:The implantable left ventricular assist device (LVAD) was designed to provide circulatory support as an alternative to heart transplantation or to continued medical therapy of end-stage heart failure. Initial experience with the implantable LVAD used as a bridge to heart transplantation provides a clinical o...

journal_title：Circulation

authors： McCarthy PM,James KB,Savage RM,Vargo R,Kendall K,Harasaki H,Hobbs RE,Pashkow FJ

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND:S100B, a 20-kDa, Ca2+-binding dimer, is a putative intrinsic negative regulator of myocardial hypertrophy expressed after myocardial infarction. S100B-overexpressing transgenic (TG) and S100B-knockout (KO) mice have been generated to assess the consequences of S100B expression and altered hypertrophy after i...

journal_title：Circulation

authors： Tsoporis JN,Marks A,Haddad A,Dawood F,Liu PP,Parker TG

更新日期：2005-02-08 00:00:00

abstract：BACKGROUND:Alterations in the balance of matrix metalloproteinases (MMPs) and their specific tissue inhibitors (TIMPs) are involved in left ventricular (LV) remodeling. Whether their expression is related to interstitial fibrosis or LV dysfunction in patients with chronic pressure overload-induced LV hypertrophy, howev...

journal_title：Circulation

authors： Heymans S,Schroen B,Vermeersch P,Milting H,Gao F,Kassner A,Gillijns H,Herijgers P,Flameng W,Carmeliet P,Van de Werf F,Pinto YM,Janssens S

更新日期：2005-08-23 00:00:00

abstract：BACKGROUND:In patients with neurogenic orthostatic hypotension (NOH), the availability of the sympathetic neurotransmitter norepinephrine (NE) in the synaptic cleft is insufficient to maintain blood pressure while in the standing posture. METHODS AND RESULTS:We determined the effect of oral administration of the synth...

journal_title：Circulation

authors： Kaufmann H,Saadia D,Voustianiouk A,Goldstein DS,Holmes C,Yahr MD,Nardin R,Freeman R

更新日期：2003-08-12 00:00:00

abstract：:Echocardiography was used to study left ventricular size and contraction in 128 patients with isolated aortic valve disease -45 patients with aortic stenosis, 25 with mixed aortic valve disease and 58 with aortic regurgitation. Left ventricular measurements included the end-diastolic internal dimension (LVIDd), mural ...

journal_title：Circulation

authors： McDonald IG

更新日期：1976-05-01 00:00:00

abstract：BACKGROUND:Mechanisms favoring the occurrence of paroxysmal atrial fibrillation (PAF) are complex and poorly defined. This study was designed to analyze dynamic changes in autonomic tone preceding the onset of PAF in a large group of patients. METHODS AND RESULTS:Holter tapes from 77 unselected consecutive patients (6...

journal_title：Circulation

authors： Bettoni M,Zimmermann M

更新日期：2002-06-11 00:00:00

abstract：BACKGROUND:Heart valve surgery has an associated in-hospital mortality rate of 4% to 8%. This study aims to develop a simple risk model to predict the risk of in-hospital mortality for patients undergoing heart valve surgery to provide information to patients and clinicians and to facilitate institutional comparisons. ...

journal_title：Circulation

authors： Ambler G,Omar RZ,Royston P,Kinsman R,Keogh BE,Taylor KM

更新日期：2005-07-12 00:00:00

abstract：:Ventricular septal defects are the most common congenital heart defect. They vary greatly in location, clinical presentation, associated lesions, and natural history. The present article describes the clinical aspects of ventricular septal defects and current management strategies. ...

journal_title：Circulation

authors： Minette MS,Sahn DJ

更新日期：2006-11-14 00:00:00