Abstract:
:2-Hydroxypropane-1,3-bis(arsonic acid) after six successive reactions gives the arsinolipid 2-acyloxy-As, As'-bis[2,3-di(acyloxy)propyl]propane-1,3-diylbis(arsinic acid) in 20-40% overall yields. This arsinolipid is a non-isosteric analogue of the fully acylated cardiolipin. The R- and S-glycidol, used to create the backbone of the lipid, give the optically active RR and SS, respectively, arsinolipids, while the rac-glycidol produces a mixture of diastereomers (a racemic pair, RR and SS, and two meso forms with an RS configuration). Some properties of these arsinolipids are described, from which the most interesting are the facile hydrolysis of the middle acyl group and their tendency to absorb environmental water.
journal_name
Chem Phys Lipidsjournal_title
Chemistry and physics of lipidsauthors
Ioannou PVdoi
10.1016/s0009-3084(02)00009-9subject
Has Abstractpub_date
2002-08-01 00:00:00pages
7-18issue
1-2eissn
0009-3084issn
1873-2941pii
S0009308402000099journal_volume
117pub_type
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