Identification of breast cancer-restricted antigens by antibody screening of SKBR3 cDNA library using a preselected patient's serum.

abstract：:The purpose of the present study was to characterize primitive epithelial progenitor populations present in adult normal human mammary tissue using a combination of flow cytometry and in vitro colony assay procedures. Three types of human breast epithelial cell (HBEC) progenitors were identified: luminal-restricted, m...

journal_title：Breast cancer research and treatment

authors： Stingl J,Eaves CJ,Zandieh I,Emerman JT

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:The genes mutated in the cancer-prone syndrome, xeroderma pigmentosum (XP genes), have been well studied both biochemically and mechanistically. These genes are important components of the DNA nucleotide excision repair (NER) pathway, which protects against environmentally-induced cancers. XP genes are also ...

journal_title：Breast cancer research and treatment

authors： Jorgensen TJ,Visvanathan K,Ruczinski I,Thuita L,Hoffman S,Helzlsouer KJ

更新日期：2007-01-01 00:00:00

abstract：:Mammographic density is a strong risk factor for breast cancer; however the mechanism that underlies this association is unclear. We hypothesized that measures of energy balance early in life and in adulthood may be associated with mammographic density. We conducted a cross-sectional analysis of 1,398 women in the Nur...

journal_title：Breast cancer research and treatment

authors： Samimi G,Colditz GA,Baer HJ,Tamimi RM

更新日期：2008-05-01 00:00:00

abstract：:We examined the role of Mcl-1 and Bcl-2 expression in the induction of apoptosis. through blocking protein tyrosine kinase (PTK), protein kinase C (PKC), phosphatidylinositol 3-kinase (P13-K) and mitogen-activated protein kinase (MAPK)/Erk kinase (MEK) signaling pathways by various kinase inhibitors in MCF-7 breast ca...

journal_title：Breast cancer research and treatment

authors： Hu Y,Dragowska WH,Wallis A,Duronio V,Mayer L

更新日期：2001-11-01 00:00:00

abstract：:Co-transfection studies indicate that HER2 (erbB-2) overexpression results in the phosphorylation and enhanced transcriptional activity of the androgen receptor (AR). This amplification of AR action is further enhanced by the expression of ARA70, a putative co-activator with a predilection for the AR. Because androgen...

journal_title：Breast cancer research and treatment

authors： Kollara A,Kahn HJ,Marks A,Brown TJ

更新日期：2001-06-01 00:00:00

abstract：PURPOSE:Discordance between HER2 expression in tumor tissue (tHER2) and HER2 status on circulating tumor cells (cHER2) has been reported. It remains largely underexplored whether patients with tHER2-/cHER2+ can benefit from anti-HER2 targeted therapies. METHODS:cHER2 status was determined in 105 advanced-stage patient...

journal_title：Breast cancer research and treatment

authors： Wang C,Mu Z,Ye Z,Zhang Z,Abu-Khalaf MM,Silver DP,Palazzo JP,Jagannathan G,Fellin FM,Bhattacharya S,Jaslow RJ,Tsangaris TN,Berger A,Neupane M,Cescon TP,Lopez A,Yao K,Chong W,Lu B,Myers RE,Hou L,Wei Q,Li B,Cri

更新日期：2020-06-01 00:00:00

abstract：:Although high mammographic density is a risk factor for postmenopausal breast cancer, its etiology remains unclear. We examined whether serum and dietary cholesterol, which increase breast cancer risk and are involved in endogenous estrogen formation, were associated with increased mammographic density. We conducted a...

journal_title：Breast cancer research and treatment

authors： Tamburrini AL,Woolcott CG,Boyd NF,Yaffe MJ,Terry T,Yasui Y,Jones CA,Patten SB,Courneya KS,Friedenreich CM

更新日期：2011-01-01 00:00:00

abstract：:We conducted gene-based analysis in 26 genes in the FGFR signaling pathway to identify genes carrying genetic variation affecting risk of breast cancer and the specific estrogen receptor (ER) subtypes. Tagging single-nucleotide polymorphisms (SNPs) for each gene were selected and genotyped on a customized Illumina Exo...

journal_title：Breast cancer research and treatment

authors： Ruiz-Narváez EA,Haddad SA,Lunetta KL,Yao S,Bensen JT,Sucheston-Campbell LE,Hong CC,Haiman CA,Olshan AF,Ambrosone CB,Palmer JR

更新日期：2016-01-01 00:00:00

abstract：:Partner and localizer of BRCA2 (PALB2), plays an important functional role in DNA damage repair. Recent studies indicate that germline mutations in PALB2 predispose individuals to a high risk of developing familial breast cancer. Therefore, comprehensive identification of PALB2 germline mutations is potentially import...

journal_title：Breast cancer research and treatment

authors： Downs B,Kim YC,Xiao F,Snyder C,Chen P,Fleissner EA,Becirovic D,Wen H,Sherman S,Cowan KH,Lynch HT,Wang SM

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:At the present time, there is no consensus on the association between benign thyroid diseases and breast cancer (BC). Therefore, the aim of this study is to help shed some light on the association between hyperthyroidism, hypothyroidism, and thyroiditis and breast cancer risk. METHODS:Use of the Disease Ana...

journal_title：Breast cancer research and treatment

authors： Bach L,Kostev K,Schiffmann L,Kalder M

更新日期：2020-07-01 00:00:00

abstract：:Transforming growth factor-beta (TGFB) is a potent inhibitor of normal epithelial cell proliferation, and may be one of the regulatory factors that are perturbed during tumor development. While many tumor cell lines no longer respond to the inhibitory effects of TGFB due to a reduction or absence of the type II recept...

journal_title：Breast cancer research and treatment

authors： Barlow J,Yandell D,Weaver D,Casey T,Plaut K

更新日期：2003-05-01 00:00:00

abstract：:The prognostic significance of estradiol (ER) and progesterone receptors (PgR) for survival from relapse has been studied in two groups of breast cancer patients: group 1, 35 patients in whom receptor levels were measured at the time of mastectomy; group II, 49 patients in whom receptor levels were measured at the tim...

journal_title：Breast cancer research and treatment

authors： Bonneterre J,Horner D,Peyrat JP,Vandewalle B,Cambier L,Demaille A

更新日期：1985-01-01 00:00:00

abstract：:A major goal of cancer chemotherapy is the identification of cytotoxic compounds that are highly selective for cancer cells. We describe here one such compound - a novel iron chelator, desferri-exochelin 772SM. This desferri-exochelin has unique chemical and pharmacological properties, including extremely high iron bi...

journal_title：Breast cancer research and treatment

authors： Pahl PM,Horwitz MA,Horwitz KB,Horwitz LD

更新日期：2001-09-01 00:00:00

abstract：:Obesity and metabolic syndrome are risk and prognostic factors for breast cancer (BC) and are associated with chronic inflammation. We investigated the association between distinct BC subtypes and markers of adiposity, dysmetabolisms, and inflammation. We analyzed 1779 patients with primary invasive BC treated at a si...

journal_title：Breast cancer research and treatment

authors： Agresti R,Meneghini E,Baili P,Minicozzi P,Turco A,Cavallo I,Funaro F,Amash H,Berrino F,Tagliabue E,Sant M

更新日期：2016-05-01 00:00:00

abstract：:Knowledge of the family history of cancer may significantly influence diagnosis and surgical management. Hereditary breast cancer (HBC) is common and accounts for approximately 9% of the total breast cancer burden. The pattern of HBC's natural history, including age of onset, increased incidence of bilaterality, integ...

journal_title：Breast cancer research and treatment

authors： Lynch HT,Conway T,Fitzgibbons R Jr,Schreiman J,Watson P,Marcus J,Fitzsimmons ML,Lynch JF

更新日期：1988-12-01 00:00:00

abstract：PURPOSE:To evaluate the patterns of failure, relapse-free survival and overall survival among African American breast cancer patients younger than 40 years. PATIENTS AND METHODS:We retrospectively reviewed the records of 124 African American breast cancer patients younger than 40 years who were registered with the How...

journal_title：Breast cancer research and treatment

authors： De Jesus MA,Fujita M,Kim KS,Goldson AL

更新日期：2003-03-01 00:00:00

abstract：:Epidemiological studies on the association between SULT1A1 codon 213 polymorphism and breast cancer risk are inconclusive. In order to derive a more precise estimation of the association, a meta-analysis was conducted in this article. Sixteen studies including 9,881 cases and 13,564 controls were collected for SULT1A1...

journal_title：Breast cancer research and treatment

authors： Sun Y,Zang Z,Xu X,Zhang Z,Zhong L,Zan W,Zhao Y,Sun L

更新日期：2011-01-01 00:00:00

abstract：:Axillary management in breast cancer is becoming increasingly conservative. This approach is based on the identification of low axillary burden on sentinel node biopsy (SNB). The modern practice of routine pre-operative axillary ultrasound has meant that patients are 'fast tracked' to axillary node clearance (ANC) in ...

journal_title：Breast cancer research and treatment

authors： Ahmed M,Jozsa F,Douek M

更新日期：2017-09-01 00:00:00

abstract：:Although a significant proportion of familial aggregation of breast cancer remains unexplained, many of the currently known breast cancer susceptibility genes, including BRCA1, BRCA2 and TP53, play a role in maintaining genome integrity by engaging in DNA repair. RAD51L1 is one of the five RAD51 paralogs involved in h...

journal_title：Breast cancer research and treatment

authors： Johnson J,Healey S,Khanna KK,kConFab.,Chenevix-Trench G

更新日期：2011-08-01 00:00:00

abstract：:The population-based Ontario Breast Screening Program (OBSP) provides two-yearly screening by both nurse examiner clinical breast examination (CBE) and two-view mammography to women aged 50 to 69. CBE alone accounts for about 5% of cancer detection. The purpose of this study was to determine whether CBE information af...

journal_title：Breast cancer research and treatment

authors： Knight JA,Libstug AR,Moravan V,Boyd NF

更新日期：1998-03-01 00:00:00

abstract：:The response to primary chemotherapy is an important prognostic factor in patients with non metastatic breast cancer. In this study we compared the assessment of response performed by clinical palpation to that performed by echography and mammography in 141 out of 157 consecutive breast cancer patients (T2-4, N0-1, M0...

journal_title：Breast cancer research and treatment

authors： Fiorentino C,Berruti A,Bottini A,Bodini M,Brizzi MP,Brunelli A,Marini U,Allevi G,Aguggini S,Tira A,Alquati P,Olivetti L,Dogliotti L

更新日期：2001-09-01 00:00:00

abstract：PURPOSE:Eribulin methylate (eribulin) improved the overall survival (OS) of HER2-negative advanced breast cancer (HER2-ABC) patients; however, the mechanism underlying the OS improvement has not been clarified. Several reports suggest that eribulin promotes antitumor immunity via tumor micro-environment conditioning. R...

journal_title：Breast cancer research and treatment

authors： Watanabe J,Saito M,Horimoto Y,Nakamoto S

更新日期：2020-05-01 00:00:00

abstract：PURPOSE:We investigated the associations of adolescent adiposity, changes in adiposity during adulthood, and attained adiposity with volumetric mammographic density measures. METHODS:We recruited 383 premenopausal women who had a routine screening mammogram at the Breast Health Center, Washington University in St. Lou...

journal_title：Breast cancer research and treatment

authors： Alimujiang A,Appleton C,Colditz GA,Toriola AT

更新日期：2017-11-01 00:00:00

abstract：:The relation between estrogen receptors (ER) in breast cancer and risk factors was studied in 456 Japanese patients. ER was shown to be positive in 55.3% (252/456) of patients. There was no difference in ER positivity between pre- and postmenopausal patients. In premenopausal patients, only the age at menarche and obe...

journal_title：Breast cancer research and treatment

authors： Nomura Y,Tashiro H,Hamada Y,Shigematsu T

更新日期：1984-01-01 00:00:00

abstract：PURPOSE:Cardiac dysfunction risk associated with intravenous trastuzumab (H IV) treatment may differ in real-world practice versus randomized trials. We investigated cardiac events in patients with HER2-positive early breast cancer (EBC) treated with H IV as adjuvant therapy in routine practice. METHODS:The observatio...

journal_title：Breast cancer research and treatment

authors： Lidbrink E,Chmielowska E,Otremba B,Bouhlel A,Lauer S,Liste Hermoso M,Nüesch E,Shing M,Misra V

更新日期：2019-02-01 00:00:00

abstract：:The site of several lectin receptors in human mammary tumors and stroma was studied with the electron microscope. The advantage of the ultrastructural over light microscopic study was that lectin receptors could be localized with precision on the different cell types of the tumor and stroma. Eighteen human mammary car...

journal_title：Breast cancer research and treatment

authors： Calafat J,Janssen H

更新日期：1984-01-01 00:00:00

abstract：:Mutations in breast cancer susceptibility genes, BRCA1 and BRCA2 account for more than 80% of hereditary breast and ovarian cancers. p53 tumor suppressor gene that controls cellular growth and differentiation is also known to be mutated in more than 50% of human cancers including breast cancer. We have carried out a s...

journal_title：Breast cancer research and treatment

authors： Hedau S,Jain N,Husain SA,Mandal AK,Ray G,Shahid M,Kant R,Gupta V,Shukla NK,Deo SS,Das BC

更新日期：2004-11-01 00:00:00

abstract：:Our previous study found cancer detection rates were equivalent for direct radiography compared to screen-film mammography, while rates for computed radiography were significantly lower. This study compares prognostic features of invasive breast cancers by type of mammography. Approved by the University of Toronto Res...

journal_title：Breast cancer research and treatment

authors： Prummel MV,Done SJ,Muradali D,Majpruz V,Brown P,Jiang H,Shumak RS,Yaffe MJ,Holloway CM,Chiarelli AM

更新日期：2014-09-01 00:00:00

abstract：PURPOSE:The Ki67 proliferation index is a prognostic and predictive marker in breast cancer. Manual scoring is prone to inter- and intra-observer variability. The aims of this study were to clinically validate digital image analysis (DIA) of Ki67 using virtual dual staining (VDS) on whole tissue sections and to assess ...

journal_title：Breast cancer research and treatment

authors： Koopman T,Buikema HJ,Hollema H,de Bock GH,van der Vegt B

更新日期：2018-05-01 00:00:00

abstract：:The pp32 gene family consists of at least three closely related members, pp32, pp32r1 and pp32r2. In spite of a high degree of identity at the nucleotide level, pp32 functionally behaves as a tumor suppressor where as pp32r1 and pp32r2 are pro-oncogenic. The purpose of this pilot study was to determine pp32-related ex...

journal_title：Breast cancer research and treatment

authors： Kadkol SS,El Naga GA,Brody JR,Bai J,Gusev Y,Dooley WC,Pasternack GR

更新日期：2001-07-01 00:00:00