Age-of-onset heterogeneity in hereditary breast cancer: minimal clues for diagnosis.

abstract：PURPOSE:PARP4 has been proposed as a candidate breast cancer susceptibility gene. However, its function and involvement in breast carcinogenesis is unclear. We sought to determine the variant frequency of PARP4 in BRCA-negative women referred for genetic testing from Singapore and to perform functional analyses of PARP...

journal_title：Breast cancer research and treatment

authors： Prawira A,Munusamy P,Yuan J,Chan CHT,Koh GL,Shuen TWH,Hu J,Yap YS,Tan MH,Ang P,Lee ASG

更新日期：2019-08-01 00:00:00

abstract：:Sentinel lymph node (SLN) biopsy is rapidly emerging as an alternative to axillary lymph node dissection (ALND) for many female breast cancer patients. In contrast, ALND remains the standard of care for male breast cancer patients with similar tumors. We evaluated the results of SLN biopsy in male breast cancer patien...

journal_title：Breast cancer research and treatment

authors： Albo D,Ames FC,Hunt KK,Ross MI,Singletary SE,Kuerer HM

更新日期：2003-01-01 00:00:00

abstract：:Fresh organically grown pomegranates (Punica granatum L.) of the Wonderful cultivar were processed into three components: fermented juice, aqueous pericarp extract and cold-pressed or supercritical CO2-extracted seed oil. Exposure to additional solvents yielded polyphenol-rich fractions ('polyphenols') from each of th...

journal_title：Breast cancer research and treatment

authors： Kim ND,Mehta R,Yu W,Neeman I,Livney T,Amichay A,Poirier D,Nicholls P,Kirby A,Jiang W,Mansel R,Ramachandran C,Rabi T,Kaplan B,Lansky E

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND:Telomerase is a ribonucleoprotein enzyme that synthesises telomeres in human germ cells, embryogenesis and in cancer, maintaining chromosomal length, stability and cellular immortality. The hTERT gene is the rate-limiting determinant of telomerase reactivation during immortalization and malignant transformat...

journal_title：Breast cancer research and treatment

authors： Salhab M,Jiang WG,Newbold RF,Mokbel K

更新日期：2008-05-01 00:00:00

abstract：PURPOSE:Platinum plays an important role in the treatment of triple-negative breast cancer (TNBC) in neoadjuvant and metastatic settings. However, its role in an adjuvant setting remains unclear. METHODS:In this non-inferior randomized phase 2 trial, we randomly assigned 308 chemotherapy-naive patients with histologic...

journal_title：Breast cancer research and treatment

authors： Du F,Wang W,Wang Y,Li M,Zhu A,Wang J,Cai R,Ma F,Fan Y,Li Q,Zhang P,Todorovic V,Yuan P,Xu B

更新日期：2020-07-01 00:00:00

abstract：:GB3 and GB5 are mouse monoclonal antibodies raised against human amnion. GB3 detects the epidermal basement membrane, and GB5 reacts with the junctional substances between the epithelial cells. These two antibodies were studied on breast tissues by indirect immunofluorescence. All (n = 8) of the normal mammary glandul...

journal_title：Breast cancer research and treatment

authors： Yeh CJ,Hsi BL,Ettore F

更新日期：1986-01-01 00:00:00

abstract：:In the context of neoadjuvant therapy (NT) for breast cancer patients, different targeted therapy approaches are currently evaluated in clinical trials. Serum markers could help to monitor and optimize such treatment strategies. We investigated human epidermal growth factor receptor 2 serum (sHER2) levels in 175 breas...

journal_title：Breast cancer research and treatment

authors： Witzel I,Loibl S,von Minckwitz G,Mundhenke C,Huober J,Hanusch C,Henschen S,Hauschild M,Lantzsch T,Tesch H,Latos K,Just M,Hilfrich J,Barinoff J,Eulenburg CZ,Roller M,Untch M,Müller V

更新日期：2010-09-01 00:00:00

abstract：:Estrogen plus progestin hormone therapy has been associated with increased breast proliferation, breast density, and breast cancer risk in postmenopausal women, beyond that seen with estrogen alone. The goal of this study was to evaluate progestogen effects on gene expression profiles in the breast contributing to thi...

journal_title：Breast cancer research and treatment

authors： Wood CE,Register TC,Cline JM

更新日期：2009-03-01 00:00:00

abstract：:Photodynamic therapy (PDT) is a minimally invasive, FDA-approved therapy for treatment of endobronchial and esophageal cancers that are accessible to light. Inflammatory breast cancer (IBC) is an aggressive and highly metastatic form of breast cancer that spreads to dermal lymphatics, a site that would be accessible t...

journal_title：Breast cancer research and treatment

authors： Aggarwal N,Santiago AM,Kessel D,Sloane BF

更新日期：2015-11-01 00:00:00

abstract：:We analyzed the p53 mutational status, mRNA and protein expression in 24 human breast carcinoma cell lines. Following measurement of their DNA content with flow cytometry, we ascertained the copy numbers of the centromere of chromosome 17 (cen17) and p53 with fluorescence in situ hybridization (FISH). A functional yea...

journal_title：Breast cancer research and treatment

authors： Concin N,Zeillinger C,Tong D,Stimpfl M,König M,Printz D,Stonek F,Schneeberger C,Hefler L,Kainz C,Leodolter S,Haas OA,Zeillinger R

更新日期：2003-05-01 00:00:00

abstract：:A risk prediction model is a statistical tool for estimating the probability that a currently healthy individual with specific risk factors will develop a condition in the future such as breast cancer. Reliably accurate prediction models can inform future disease burdens, health policies and individual decisions. Brea...

journal_title：Breast cancer research and treatment

authors： Meads C,Ahmed I,Riley RD

更新日期：2012-04-01 00:00:00

abstract：PURPOSE:Previous work found that lower BMI is associated with a pathologic complete response (pCR) following neoadjuvant chemotherapy for breast cancer. Relative dose intensity (RDI) of chemotherapy is an important marker of treatment tolerability. We hypothesized that patients with low BMI would have higher RDI than p...

journal_title：Breast cancer research and treatment

authors： Usiskin I,Li F,Irwin ML,Cartmel B,Sanft T

更新日期：2020-10-30 00:00:00

abstract：:The diagnosis and treatment of patients with breast cancer is beginning to be influenced by new ideas and discoveries emerging from the field of angiogenesis research. This field, pursued in the laboratory for more than 20 years, has in the past 5 years generated clinical applications. Some of these applications have ...

journal_title：Breast cancer research and treatment

authors： Folkman J

更新日期：1995-01-01 00:00:00

abstract：:The biology of breast cancer in Japan appears to be changing in that, while post-menopausal Japanese patients have a better prognosis than comparable British women, no differences in recurrence or survival rates can now be found in pre-menopausal patients. ...

journal_title：Breast cancer research and treatment

authors： Allen DS,Bulbrook RD,Chaudary MA,Hayward JL,Yoshida M,Miura S,Murai JT

更新日期：1991-05-01 00:00:00

abstract：PURPOSE:Evidence suggests that premenopausal obesity decreases and postmenopausal obesity increases breast cancer risk. Because it is not well known whether this is subtype dependent, we studied the association between body mass index (BMI) and age at breast cancer diagnosis, or the probability of being diagnosed with ...

journal_title：Breast cancer research and treatment

authors： Brouckaert O,Van Asten K,Laenen A,Soubry A,Smeets A,Nevelstreen I,Vergote I,Wildiers H,Paridaens R,Van Limbergen E,Weltens C,Moerman P,Floris G,Neven P,Multidisciplinary breast centre Leuven.

更新日期：2018-02-01 00:00:00

abstract：:Fibroblast growth factor receptor 2 (FGFR2) is a member of a receptor tyrosine kinase gene superfamily, involved in cell growth, invasiveness, motility, and angiogenesis, which has attracted considerable attention as a candidate gene for breast cancer (BC) since it was first identified through genome-wide association ...

journal_title：Breast cancer research and treatment

authors： Wang H,Yang Z,Zhang H

更新日期：2013-01-01 00:00:00

abstract：PURPOSE:Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer and associated with early metastasis, drug resistance, and poor patient survival. Fork head box M1 (FOXM1) is considered as an emerging molecular target due to its oncogenic role and high overexpression profile in 85% in TNBC. However, ...

journal_title：Breast cancer research and treatment

authors： Hamurcu Z,Kahraman N,Ashour A,Ozpolat B

更新日期：2017-06-01 00:00:00

abstract：:Addition of epirubicin to adjuvant chemotherapy can provide important benefits for patients with early breast cancer, but the optimal dose remains unclear. Further improvements can be achieved with dose-dense regimens, but densification of fluorouracil/epirubicin/cyclophosphamide (FEC) has proved difficult, with FEC(6...

journal_title：Breast cancer research and treatment

authors： Kahán Z,Spanik S,Wagnerova M,Skacel T,Planko B,Fitzthum E,Lindner E,Soldatenkova V,Zielinski CC,Brodowicz T

更新日期：2008-12-01 00:00:00

abstract：PURPOSE:The significance of HER-2/neu results obtained by immunohistochemical analyses (IHC) which are neither negative nor strongly positive is controversial. The incidence of fluorescence in situ hybridization (FISH) positivity in these tumors is small and the implication is that these borderline results represent la...

journal_title：Breast cancer research and treatment

authors： Killeen JL,Ortega-Lopez A,Shaha J,Shaha SH,Fu JB

更新日期：2006-07-01 00:00:00

abstract：PURPOSE:In our microarray analysis we observed that Seven-in-Absentia Homolog 2 (SIAH2) levels were low in estrogen receptor (ER) positive breast tumors of patients resistant to first-line tamoxifen therapy. The aim of this study was to evaluate SIAH2 for its (a) predictive/prognostic value, and (b) functional role in ...

journal_title：Breast cancer research and treatment

authors： Jansen MP,Ruigrok-Ritstier K,Dorssers LC,van Staveren IL,Look MP,Meijer-van Gelder ME,Sieuwerts AM,Helleman J,Sleijfer S,Klijn JG,Foekens JA,Berns EM

更新日期：2009-07-01 00:00:00

abstract：:We aimed to compare the clinicopathological features, treatment strategies and clinical outcomes of breast sarcomas (BS) and malignant phyllodes tumours (MPT), and determine their prognostic factors. Cases of BS and MPT diagnosed at the Department of Pathology, Singapore General Hospital from January 1991 to December ...

journal_title：Breast cancer research and treatment

authors： Lim SZ,Selvarajan S,Thike AA,Nasir ND,Tan BK,Ong KW,Tan PH

更新日期：2016-09-01 00:00:00

abstract：:The prognostic significance of estradiol (ER) and progesterone receptors (PgR) for survival from relapse has been studied in two groups of breast cancer patients: group 1, 35 patients in whom receptor levels were measured at the time of mastectomy; group II, 49 patients in whom receptor levels were measured at the tim...

journal_title：Breast cancer research and treatment

authors： Bonneterre J,Horner D,Peyrat JP,Vandewalle B,Cambier L,Demaille A

更新日期：1985-01-01 00:00:00

abstract：:The basal-like or basal phenotype (BP) class of breast cancers have recently attracted attention as a poor prognostic form of breast cancer. However, BP appears to encompass biologically and clinically heterogeneous tumours, resulting in a lack of consensus definition of BP. We analysed 48,000 gene transcripts in 132 ...

journal_title：Breast cancer research and treatment

authors： Zhang H,Rakha EA,Ball GR,Spiteri I,Aleskandarany M,Paish EC,Powe DG,Macmillan RD,Caldas C,Ellis IO,Green AR

更新日期：2010-05-01 00:00:00

abstract：:MicroRNAs play a role in breast cancer development and progression by post-transcriptional repression of the expression of important genes, such as the tumor suppressor gene phosphatase and tensin homolog (PTEN). The focus of the current study was to examine the diagnostic potential of circulating cell-free microRNAs ...

journal_title：Breast cancer research and treatment

authors： Schwarzenbach H,Milde-Langosch K,Steinbach B,Müller V,Pantel K

更新日期：2012-08-01 00:00:00

abstract：:A new method of measuring gene copy number in small samples of DNA was used to measure amplification of the erbB-2 gene and of chromosome 20q in breast cancer. This method, termed 'differentially competitive polymerase chain reaction' (DC-PCR) combines the advantages of two other techniques for measuring amplification...

journal_title：Breast cancer research and treatment

authors： Deng G,Yu M,Chen LC,Moore D,Kurisu W,Kallioniemi A,Waldman FM,Collins C,Smith HS

更新日期：1996-01-01 00:00:00

abstract：:This is the consensus statement regarding the clinical utility of DNA cytometry in breast cancer from the DNA Cytometry Consensus Conference held in Prout's Neck, Maine, USA, on October 1-4, 1992. Guidelines for clinical DNA cytometry generated at that meeting also appear in this issue of Breast Cancer Research and Tr...

journal_title：Breast cancer research and treatment

authors： Hedley DW,Clark GM,Cornelisse CJ,Killander D,Kute T,Merkel D

更新日期：1993-10-01 00:00:00

abstract：:Progesterone, through its nuclear receptors (PR), regulates the development and growth of breast cancers. PR also serve as markers of hormone dependence and prognosis in patients with this disease, and functional PR are required to mediate the antiproliferative effects of progestin therapies. We find that normal and m...

journal_title：Breast cancer research and treatment

authors： Richer JK,Lange CA,Wierman AM,Brooks KM,Tung L,Takimoto GS,Horwitz KB

更新日期：1998-04-01 00:00:00

abstract：PURPOSE:Breast cancer is the most common cancer and leading cause of cancer death in women. Body composition parameters, especially those related to muscle, have become a growing focus of cancer research. In this review, we summarize the literature on breast cancer and muscle parameters as well as combine their outcome...

journal_title：Breast cancer research and treatment

authors： Aleixo GFP,Williams GR,Nyrop KA,Muss HB,Shachar SS

更新日期：2019-10-01 00:00:00

abstract：PURPOSE:The role of sentinel lymph node biopsy (SLNB) in breast cancer patients who undergo neoadjuvant chemotherapy (NAC) remains controversial. This study aims to investigate if axillary lymph node dissection (ALND) could be safely omitted after a negative SLNB in cN1/2 patients who become cN0 after NAC. METHODS:We ...

journal_title：Breast cancer research and treatment

authors： Damin AP,Zancan M,Melo MP,Biazus JV

更新日期：2020-11-09 00:00:00

abstract：:The aim of this study is to evaluate the impact of CYP2D6 genotyping in predicting disease-free survival and toxicity in breast cancer patients treated with adjuvant tamoxifen. DNA from 91 patients was genotyped using the AmpliChip CYP450 GeneChip, Roche that facilitates the classification of individuals by testing 27...

journal_title：Breast cancer research and treatment

authors： Ramón y Cajal T,Altés A,Paré L,del Rio E,Alonso C,Barnadas A,Baiget M

更新日期：2010-01-01 00:00:00