FOXM1 transcriptionally regulates expression of integrin β1 in triple-negative breast cancer.

abstract：BACKGROUND:Adjuvant therapy decisions may be partly based on the results of a multigene quantitative reverse transcription-polymerase chain reaction (RT-PCR)-based assay: the 21-gene recurrence score (RS) test of resection specimens. When necessary, core needle biopsy (CNB) may be considered as a surrogate. Here, we ev...

journal_title：Breast cancer research and treatment

authors： Qi P,Yang Y,Bai QM,Xue T,Ren M,Yao QL,Yang WT,Zhou XY

更新日期：2021-01-13 00:00:00

abstract：:There remains a high unmet need for effective treatments for metastatic breast cancer. In recent years there have been many advances in the understanding of biological basis of cancer. Several cellular pathways have been identified that play crucial roles in causing or maintaining the cancer phenotype. Many new agents...

journal_title：Breast cancer research and treatment

authors： Roy V,Perez EA

更新日期：2009-07-01 00:00:00

abstract：:Mitogenic and growth inhibitory signals influence the activity of a family of cyclin dependent kinases (cdks). p27 is an important cdk inhibitor, acting in G1 to inhibit cyclin-cdks. As negative growth regulators, the cdk inhibitors may function as tumor suppressors. While the p16 gene plays a tumor suppressor role in...

journal_title：Breast cancer research and treatment

authors： Cariou S,Catzavelos C,Slingerland JM

更新日期：1998-01-01 00:00:00

abstract：:There are suggestions in the literature that common variants in the XPD gene may be associated with an altered risk of melanoma and breast cancer. To establish if the XPD common variants Asp312Asn and Lys751Gln are associated with an increased melanoma or breast cancer risk we performed an association study based on g...

journal_title：Breast cancer research and treatment

authors： Debniak T,Scott RJ,Huzarski T,Byrski T,Masojć B,van de Wetering T,Serrano-Fernandez P,Górski B,Cybulski C,Gronwald J,Debniak B,Maleszka R,Kładny J,Bieniek A,Nagay L,Haus O,Grzybowska E,Wandzel P,Niepsuj S,Narod SA,

更新日期：2006-07-01 00:00:00

abstract：:Germline mutations in the BRCA1/2 genes account for the majority of hereditary breast ovarian cancer (HBOC). Identification of causal mutations may have significant impact on clinical management of such families. Despite high mutation detection rate, many HBOC cases remain without identified cause. These cases warrant...

journal_title：Breast cancer research and treatment

authors： Konecny M,Milly M,Zavodna K,Weismanova E,Gregorova J,Mlkva I,Ilencikova D,Kausitz J,Bartosova Z

更新日期：2011-02-01 00:00:00

abstract：:In order to assess the impact of modern combination chemotherapy on overall survival of metastatic breast cancer patients, we retrospectively analysed survival data of those patients who presented with breast cancer and developed metastases at our clinic from 1971-78 inclusive. Our results indicate a trend towards imp...

journal_title：Breast cancer research and treatment

authors： Paterson AH,Szafran O,Cornish F,Lees AW,Hanson J

更新日期：1981-01-01 00:00:00

abstract：PURPOSE:Aberrant DNA methylation occurs frequently in breast carcinogenesis. Tools for translational epigenetic studies of breast cancer involving formalin-fixed paraffin-embedded (FFPE) human tissues have now been developed. Few studies have measured genome-wide methylation in DNA derived from paraffin-embedded tumour...

journal_title：Breast cancer research and treatment

authors： Wong EM,Joo JE,McLean CA,Baglietto L,English DR,Severi G,Wu HC,Terry MB,Hopper JL,Milne RL,Giles GG,Southey MC

更新日期：2016-11-01 00:00:00

abstract：:Estrogen receptor protein is known to be an important prognostic factor for patients with breast cancer. The presence of estrogen receptor correlates with response to endocrine therapy in patients with metastatic disease and is associated with prolonged disease-free and overall survival in patients with primary diseas...

journal_title：Breast cancer research and treatment

authors： Clark GM,McGuire WL

更新日期：1983-01-01 00:00:00

abstract：PURPOSE:Mobile mammography can improve access to screening mammography in rural areas and underserved populations. We evaluated the frequency of incomplete reports in mobile mammography screening and the relationships between prior mammograms and recall rates. METHODS:The frequency of incomplete mammogram reports, the...

journal_title：Breast cancer research and treatment

authors： Roubidoux MA,Shih-Pei Wu P,Nolte ELR,Begay JA,Joe AI

更新日期：2018-10-01 00:00:00

abstract：PURPOSE:Radial scar's stellate appearance may mimic carcinoma mammographically and histologically. Management of radial scar (RS) found on breast core needle biopsies (CNB) ranges from excision to clinical observation due to the variation in reported upgrades to malignancy at surgical excision. We examined the upgrade ...

journal_title：Breast cancer research and treatment

authors： Chou WYY,Veis DJ,Aft R

更新日期：2018-07-01 00:00:00

abstract：PURPOSE:Breast cancer brain metastases (BCBM) are becoming an increasingly common diagnosis due to improved systemic control and more routine surveillance imaging. Treatment continues to require a multidisciplinary approach managing systemic and intracranial disease burden. Although, improvements have been made in the ...

journal_title：Breast cancer research and treatment

authors： Mills MN,Figura NB,Arrington JA,Yu HM,Etame AB,Vogelbaum MA,Soliman H,Czerniecki BJ,Forsyth PA,Han HS,Ahmed KA

更新日期：2020-04-01 00:00:00

abstract：:This retrospective study investigates the correlation of intra-individual HER2 status between primary breast cancers and corresponding recurrences in a population derived cohort. The REMARK criteria were used as reference. In 151 breast cancer patients, primary tumors were analyzed for HER2 status on histopathology se...

journal_title：Breast cancer research and treatment

authors： Wilking U,Karlsson E,Skoog L,Hatschek T,Lidbrink E,Elmberger G,Johansson H,Lindström L,Bergh J

更新日期：2011-01-01 00:00:00

abstract：:Uncontrolled proliferation is one of the hallmarks of breast cancer. We have previously identified the human Ecd protein (human ortholog of Drosophila Ecdysoneless, hereafter called Ecd) as a novel promoter of mammalian cell cycle progression, a function related to its ability to remove the repressive effects of Rb-fa...

journal_title：Breast cancer research and treatment

authors： Zhao X,Mirza S,Alshareeda A,Zhang Y,Gurumurthy CB,Bele A,Kim JH,Mohibi S,Goswami M,Lele SM,West W,Qiu F,Ellis IO,Rakha EA,Green AR,Band H,Band V

更新日期：2012-07-01 00:00:00

abstract：:The aim of this study was to evaluate the effectiveness of an additional, individualized, multi-component complementary medicine treatment offered to breast cancer patients at the Merano Hospital (South Tyrol) on health-related quality of life compared to patients receiving usual care only. A randomized pragmatic tria...

journal_title：Breast cancer research and treatment

authors： Witt CM,Außerer O,Baier S,Heidegger H,Icke K,Mayr O,Mitterer M,Roll S,Spizzo G,Scherer A,Thuile C,Wieser A,Schützler L

更新日期：2015-01-01 00:00:00

abstract：:The association of smoking with outcomes following breast cancer prognosis is not well understood. In a cohort study called Life After Cancer Epidemiology (LACE), 2,265 women diagnosed with breast cancer were followed for a median of 12 years. We used multivariable proportional-hazards models to determine whether smok...

journal_title：Breast cancer research and treatment

authors： Braithwaite D,Izano M,Moore DH,Kwan ML,Tammemagi MC,Hiatt RA,Kerlikowske K,Kroenke CH,Sweeney C,Habel L,Castillo A,Weltzien E,Caan B

更新日期：2012-11-01 00:00:00

abstract：:Photodynamic therapy (PDT) is a minimally invasive, FDA-approved therapy for treatment of endobronchial and esophageal cancers that are accessible to light. Inflammatory breast cancer (IBC) is an aggressive and highly metastatic form of breast cancer that spreads to dermal lymphatics, a site that would be accessible t...

journal_title：Breast cancer research and treatment

authors： Aggarwal N,Santiago AM,Kessel D,Sloane BF

更新日期：2015-11-01 00:00:00

abstract：:Preclinical and epidemiologic evidence supports a possible role for beta-adrenergic blocking drugs (beta-blockers), and angiotensin-converting enzyme inhibitors (ACEIs) in promoting survival after breast cancer. However, these drugs are often used concurrently with aspirin, and there is a growing body of evidence indi...

journal_title：Breast cancer research and treatment

authors： Holmes MD,Hankinson SE,Feskanich D,Chen WY

更新日期：2013-06-01 00:00:00

abstract：:Estrogen has an important role in stimulating the growth of breast carcinomas. Inhibition of estrogen production is therefore a logical treatment strategy. A number of selective inhibitors have been developed against aromatase, a cytochrome P-450 enzyme which catalyzes the rate limiting step in the biosynthesis of est...

journal_title：Breast cancer research and treatment

authors： Brodie AM,Santen RJ

更新日期：1994-01-01 00:00:00

abstract：:Identifying risk factors for lymphedema in patients treated for breast cancer has become increasingly important, given the current lack of standardization surrounding diagnosis and treatment. Reports on the association of body mass index (BMI) and weight change with lymphedema risk are conflicting. We sought to examin...

journal_title：Breast cancer research and treatment

authors： Jammallo LS,Miller CL,Singer M,Horick NK,Skolny MN,Specht MC,O'Toole J,Taghian AG

更新日期：2013-11-01 00:00:00

abstract：:ALIQUOT (Anastrozole vs. Letrozole, an Investigation of Quality Of Life and Tolerability) was a prospective, open-label, randomized pharmacodynamic study designed to assess the effects of aromatase inhibitors (AIs) on bone turnover in healthy postmenopausal women with estrogen receptor-positive breast cancer. Ninety-f...

journal_title：Breast cancer research and treatment

authors： McCaig FM,Renshaw L,Williams L,Young O,Murray J,Macaskill EJ,McHugh M,Hannon R,Dixon JM

更新日期：2010-02-01 00:00:00

abstract：PURPOSE:Androgen receptor (AR) and AR signaling pathways are thought to play a role in breast cancer (BC) and are potentially related to treatment responses and outcomes. Ankyrin 3 (ANK3) is associated with AR stability in cancer cells. In the present study, we investigated the clinicopathological utility of ANK3 expre...

journal_title：Breast cancer research and treatment

authors： Kurozumi S,Joseph C,Raafat S,Sonbul S,Kariri Y,Alsaeed S,Pigera M,Alsaleem M,Nolan CC,Johnston SJ,Aleskandarany MA,Ogden A,Fujii T,Shirabe K,Martin SG,Alshankyty I,Mongan NP,Ellis IO,Green AR,Rakha EA

更新日期：2019-07-01 00:00:00

abstract：:Cytochrome P450s are enzymes which catalyze Phase-I metabolism reactions; cytochrome P450 1A1 (CYP1A1) is a member of the CYP1 family and participates in the metabolism of a vast number of xenobiotics, as well as endogenous substrates. Four single nucleotide polymorphisms in CYP1A1 have been studied concerning their p...

journal_title：Breast cancer research and treatment

authors： Sergentanis TN,Economopoulos KP

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Estimating an individual woman's absolute risk for breast cancer is essential for decision making about screening and preventive recommendations. Although the current standard, the Gail model, is well calibrated in populations, it performs poorly for individuals. Mammographic breast density (BD) may improve ...

journal_title：Breast cancer research and treatment

authors： Tice JA,Cummings SR,Ziv E,Kerlikowske K

更新日期：2005-11-01 00:00:00

abstract：:Tamoxifen has been used for the treatment of breast cancer since the 1970s, but is considered a carcinogen because it has been linked to liver cancer in rats and an increased risk of endometrial cancer in patients. In rats, DNA adducts appear to be responsible for carcinogenesis, but their contribution to carcinogenes...

journal_title：Breast cancer research and treatment

authors： Hellmann-Blumberg U,Taras TL,Wurz GT,DeGregorio MW

更新日期：2000-03-01 00:00:00

abstract：:The effect of obesity and fat distribution on survival of breast cancer patients was studied prospectively in 241 women with a natural menopause who participated in a breast cancer screening project, the DOM-project in Utrecht, The Netherlands. Mean follow-up time was 9.1 years and endpoint of interest was death from ...

journal_title：Breast cancer research and treatment

authors： den Tonkelaar I,de Waard F,Seidell JC,Fracheboud J

更新日期：1995-05-01 00:00:00

abstract：:We aimed to compare the clinicopathological features, treatment strategies and clinical outcomes of breast sarcomas (BS) and malignant phyllodes tumours (MPT), and determine their prognostic factors. Cases of BS and MPT diagnosed at the Department of Pathology, Singapore General Hospital from January 1991 to December ...

journal_title：Breast cancer research and treatment

authors： Lim SZ,Selvarajan S,Thike AA,Nasir ND,Tan BK,Ong KW,Tan PH

更新日期：2016-09-01 00:00:00

abstract：PURPOSE:This study aimed to examine the prevalence and trends of breast cancer-related risk factors and characteristics in premenopausal underweight Korean women according to birth year cohort. METHODS:Socioeconomic and breast cancer-related risk factors were investigated in 13,415 premenopausal women using nationwide...

journal_title：Breast cancer research and treatment

authors： Kim JH,Yoon KH,Hur H,Park S,Kim JY,Park HS,Kim SI,Cho YU,Park BW

更新日期：2019-04-01 00:00:00

abstract：:Angiogenesis is important for the growth and spread of malignant tumors, and anti-angiogenesis treatment is currently being evaluated for breast cancer and other tumors. Although microvessel density is the most commonly used tissue-based marker of tumor associated angiogenesis, it has significant limitations and has n...

journal_title：Breast cancer research and treatment

authors： Arnes JB,Stefansson IM,Straume O,Baak JP,Lønning PE,Foulkes WD,Akslen LA

更新日期：2012-06-01 00:00:00

abstract：:In view of the essential role of transforming growth factorβ1 (TGFB1) on both inhibiting the development of early benign breast tumors as well as promoting tumor invasion, the association of TGFB1 L10P polymorphism and breast cancer risk has been widely reported, but results of previous studies were somewhat contradic...

journal_title：Breast cancer research and treatment

authors： Ma X,Chen C,Xiong H,Li Y

更新日期：2010-11-01 00:00:00

abstract：:The purpose of this article is to comprehensively summarize the associations between carotenoids and breast cancer and quantitatively estimate their dose-response relationships. We searched PubMed, Embase, and Cochrane databases (from January 1982 to 1 May 2011) and the references of the relevant articles in English w...

journal_title：Breast cancer research and treatment

authors： Hu F,Wang Yi B,Zhang W,Liang J,Lin C,Li D,Wang F,Pang D,Zhao Y

更新日期：2012-01-01 00:00:00