Abstract:
PURPOSE:The role of sentinel lymph node biopsy (SLNB) in breast cancer patients who undergo neoadjuvant chemotherapy (NAC) remains controversial. This study aims to investigate if axillary lymph node dissection (ALND) could be safely omitted after a negative SLNB in cN1/2 patients who become cN0 after NAC. METHODS:We retrospectively assessed T1-4, cN1/2 patients who were submitted to NAC between 2010 and 2016. T1-T3 patients who achieved complete axillary clinical response underwent SLNB. Those whose SLNs were negative were not subjected to additional ALND. The oncological outcomes of the patients were analyzed. RESULTS:Fifty-nine T1-T3 patients (45.0%) achieved a complete axillary response (cN0), and were selected to undergo SLNB. SLNs were detected in 55 of them (93.2%). Seventeen of those patients (30.9%) had SLN metastases detected and subsequently underwent ALND. In contrast, 38 patients (69.1%) had no nodal metastases detected and were managed without complementary ALND. After a mean follow-up of 55.8 months, only one patient (2.6%) submitted to SLNB without a complementary ALND had axillary recurrence as compared with three patients (3.2%) in the ALND group (p = 0.71). Distant recurrence occurred more frequently among patients submitted to ALND (92.1%) than among those only submitted to SLNB (7.9%) (p < 0.0006). Overall survival and disease-free survival were significantly better in patients who were not submitted to ALND. CONCLUSION:SLNB could be successfully used in guiding a more selective axillary approach in cN+ patients that became cN0 after NAC. Omitting ALND in CN0 patients with negative SLNs did not seem to compromise disease control and oncological outcomes.
journal_name
Breast Cancer Res Treatjournal_title
Breast cancer research and treatmentauthors
Damin AP,Zancan M,Melo MP,Biazus JVdoi
10.1007/s10549-020-06011-8subject
Has Abstractpub_date
2020-11-09 00:00:00eissn
0167-6806issn
1573-7217pii
10.1007/s10549-020-06011-8pub_type
杂志文章abstract::The DNA repair pathway is known to play a role in the etiology of breast cancer. A number of studies have demonstrated that common germline variants in genes involved in the DNA repair pathway influence breast cancer risk. To assess whether alterations in DNA repair genes contribute to breast cancer, we genotyped 12 s...
journal_title:Breast cancer research and treatment
pub_type: 杂志文章
doi:10.1007/s10549-008-0084-4
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journal_title:Breast cancer research and treatment
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journal_title:Breast cancer research and treatment
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1007/BF00689679
更新日期:1994-01-01 00:00:00
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journal_title:Breast cancer research and treatment
pub_type: 杂志文章
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journal_title:Breast cancer research and treatment
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journal_title:Breast cancer research and treatment
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journal_title:Breast cancer research and treatment
pub_type: 杂志文章
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journal_title:Breast cancer research and treatment
pub_type: 杂志文章
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journal_title:Breast cancer research and treatment
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journal_title:Breast cancer research and treatment
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pub_type: 杂志文章
doi:10.1007/s10549-017-4502-3
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journal_title:Breast cancer research and treatment
pub_type: 杂志文章
doi:10.1007/BF00666212
更新日期:1994-01-01 00:00:00
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journal_title:Breast cancer research and treatment
pub_type: 临床试验,杂志文章
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更新日期:2012-12-01 00:00:00
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journal_title:Breast cancer research and treatment
pub_type: 杂志文章
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更新日期:2014-09-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2011-02-01 00:00:00
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journal_title:Breast cancer research and treatment
pub_type: 杂志文章
doi:10.1023/a:1006081127924
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journal_title:Breast cancer research and treatment
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2021-01-03 00:00:00
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journal_title:Breast cancer research and treatment
pub_type: 杂志文章
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更新日期:2005-01-01 00:00:00
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journal_title:Breast cancer research and treatment
pub_type: 杂志文章,meta分析
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更新日期:2016-11-01 00:00:00
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journal_title:Breast cancer research and treatment
pub_type: 杂志文章
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更新日期:2019-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-11-01 00:00:00
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journal_title:Breast cancer research and treatment
pub_type: 杂志文章
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journal_title:Breast cancer research and treatment
pub_type: 杂志文章
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更新日期:2017-01-01 00:00:00
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journal_title:Breast cancer research and treatment
pub_type: 杂志文章,评审
doi:10.1023/a:1025455130476
更新日期:2003-01-01 00:00:00