A maintained absolute lymphocyte count predicts the overall survival benefit from eribulin therapy, including eribulin re-administration, in HER2-negative advanced breast cancer patients: a single-institutional experience.

abstract：:CH50, a recombinant CBD-HepII polypeptide of human fibronectin, was shown to suppress tumor metastasis in murine hepatocarcinoma and melanoma models. However, the effect of CH50 on human cancer cells is still not clear. Here we evaluated the efficiency of CH50 delivered by recombinant adeno-associated virus (rAAV) vec...

journal_title：Breast cancer research and treatment

authors： He ZH,Lei Z,Zhen Y,Gong W,Huang B,Yuan Y,Zhang GM,Wang XJ,Feng ZH

更新日期：2014-01-01 00:00:00

abstract：PURPOSE:We used multiplex immunofluorescence (mIF) to determine whether mitotic rate represents an independent prognostic marker in triple-negative breast cancer (TNBC). Secondary aims were to confirm the prognostic significance of immune cells in TNBC, and to investigate the relationship between immune cells and proli...

journal_title：Breast cancer research and treatment

authors： Lai CPT,Yeong JPS,Tan AS,Ong CHC,Lee B,Lim JCT,Thike AA,Iqbal J,Dent RA,Lim EH,Tan PH

更新日期：2019-11-01 00:00:00

abstract：:Digital breast tomosynthesis (DBT) is emerging as the new standard of care for breast cancer screening based on improved cancer detection coupled with reductions in recall compared to screening with digital mammography (DM) alone. However, many prior studies lack follow-up data to assess false negatives examinations. ...

journal_title：Breast cancer research and treatment

authors： Conant EF,Beaber EF,Sprague BL,Herschorn SD,Weaver DL,Onega T,Tosteson AN,McCarthy AM,Poplack SP,Haas JS,Armstrong K,Schnall MD,Barlow WE

更新日期：2016-02-01 00:00:00

abstract：:Genetic testing enables women at risk for hereditary breast and/or ovarian cancer to find out whether they have inherited the gene mutation (BRCA1/BRCA2), and if so, to opt for frequent surveillance and/or prophylactic surgery (bilateral mastectomy and/or oophorectomy). Here, a follow-up is described for 63 healthy wo...

journal_title：Breast cancer research and treatment

authors： Lodder LN,Frets PG,Trijsburg RW,Meijers-Heijboer EJ,Klijn JG,Seynaeve C,van Geel AN,Tilanus MM,Bartels CC,Verhoog LC,Brekelmans CT,Burger CW,Niermeijer MF

更新日期：2002-05-01 00:00:00

abstract：PURPOSE:The objective of this study is to understand an impact of financial burden on the adjuvant hormonal therapy (AHT) adherence and persistence for insured women aged 18-64 with early breast cancer in Texas. METHODS:We conducted a retrospective cohort study using claims data for population insured by Blue Cross Bl...

journal_title：Breast cancer research and treatment

authors： Kim J,Rajan SS,Du XL,Franzini L,Giordano SH,Morgan RO

更新日期：2018-06-01 00:00:00

abstract：:The biology of breast cancer in Japan appears to be changing in that, while post-menopausal Japanese patients have a better prognosis than comparable British women, no differences in recurrence or survival rates can now be found in pre-menopausal patients. ...

journal_title：Breast cancer research and treatment

authors： Allen DS,Bulbrook RD,Chaudary MA,Hayward JL,Yoshida M,Miura S,Murai JT

更新日期：1991-05-01 00:00:00

abstract：:miRNAs regulate the expression of genes in both normal physiology and disease. While miRNAs have been demonstrated to play a pivotal role in aspects of cancer biology, these reports have generally focused on the regulation of single genes. Such single-gene approaches have significant limitations, relying on miRNA expr...

journal_title：Breast cancer research and treatment

authors： Pillai MM,Gillen AE,Yamamoto TM,Kline E,Brown J,Flory K,Hesselberth JR,Kabos P

更新日期：2014-07-01 00:00:00

abstract：INTRODUCTION:There has been a sharp rise in the rate of contralateral prophylactic mastectomy over the last decade, despite the low incidence of new primary cancers predicted for the contralateral breast. This study compares the postoperative complication rates between the diseased breast treated with mastectomy and th...

journal_title：Breast cancer research and treatment

authors： Nealon KP,Sobti N,Gadd M,Specht M,Liao EC

更新日期：2020-01-01 00:00:00

abstract：:Sialyl-Tn is a carbohydrate antigen overexpressed in several epithelial cancers including breast cancer, and usually associated with poor prognosis. Sialyl-Tn is synthesized by a CMP-Neu5Ac: GalNAc alpha2,6-sialyltransferase: ST6GalNAc I, which catalyzes the transfer of a sialic acid residue in alpha2,6-linkage to the...

journal_title：Breast cancer research and treatment

authors： Julien S,Lagadec C,Krzewinski-Recchi MA,Courtand G,Le Bourhis X,Delannoy P

更新日期：2005-03-01 00:00:00

abstract：OBJECTIVE:To measure the association between dietary fiber intake and eleven hormones and peptides in postmenopausal breast cancer survivors. METHODS:Intake of fiber from food and supplements was measured two to three years after breast cancer diagnosis in 493 postmenopausal women from three western states. Concurrent...

journal_title：Breast cancer research and treatment

authors： Wayne SJ,Neuhouser ML,Ulrich CM,Koprowski C,Baumgartner KB,Baumgartner RN,McTiernan A,Bernstein L,Ballard-Barbash R

更新日期：2008-11-01 00:00:00

abstract：PURPOSE:Nutritional factors during different periods in life impact breast cancer risk. Because benign breast disease (BBD) is a well-established risk factor for breast cancer, we investigated childhood nutrition from birth through age 14 year and subsequent BBD. METHODS:A prospective cohort study of 9031 females, 9-1...

journal_title：Breast cancer research and treatment

authors： Berkey CS,Tamimi RM,Willett WC,Rosner B,Hickey M,Toriola AT,Lindsay Frazier A,Colditz GA

更新日期：2019-09-01 00:00:00

abstract：:Hormone replacement therapy, which is a common menopausal treatment, is contraindicated in women with breast cancers due to concerns regarding the potential for breast cell proliferation. As such, there is a need for alternative methods for treating menopausal symptoms. To determine the influence of one such alternati...

journal_title：Breast cancer research and treatment

authors： Bodinet C,Freudenstein J

更新日期：2002-11-01 00:00:00

abstract：PURPOSE:The epithelial-mesenchymal transition (EMT) plays a key role in breast cancer progression and metastasis. Lipocalin 2 (LCN2) is involved in the regulation of EMT. The aim of this study was to investigate the clinicopathological significance of LCN2 expression in breast cancer. METHODS:The expression of LCN2 pr...

journal_title：Breast cancer research and treatment

authors： Kurozumi S,Alsaeed S,Orah N,Miligy IM,Joseph C,Aljohani A,Toss MS,Fujii T,Shirabe K,Green AR,Aleskandarany MA,Rakha EA

更新日期：2020-02-01 00:00:00

abstract：:We describe a method for the isolation of free DNA from ductal lavage (DL) and nipple aspirate fluid (NAF), and its evaluation for the presence of LOH at the BRCA1 and FHIT genes and for mitochondrial DNA (mtDNA) mutations at the D310 marker, to improve early detection of breast cancer. We evaluated 26 DL and six NAF ...

journal_title：Breast cancer research and treatment

authors： Isaacs C,Cavalli LR,Cohen Y,Pennanen M,Shankar LK,Freedman M,Singh B,Liu M,Gallagher A,Rone JD,Dickson RB,Sidransky D,Haddad BR

更新日期：2004-03-01 00:00:00

abstract：:In 141 postmenopausal node-positive patients with primary breast cancer, routine biochemical markers (alkaline phosphatase, gamma-glutamyl transpeptidase, carcinoembryonic antigen), and chest x-ray, in combination with history and clinical examination, have been performed at 3 monthly intervals for at least 2 years. S...

journal_title：Breast cancer research and treatment

authors： Mansi JL,Earl HM,Powles TJ,Coombes RC

更新日期：1988-07-01 00:00:00

abstract：BACKGROUND:High insulin levels have been associated with poor outcomes in breast cancer. Our goal was to investigate whether hyperinsulinemia was associated with insulin resistance in a cohort of newly diagnosed locoregional breast cancer patients and to examine associations of hyperinsulinemia with the broader insulin...

journal_title：Breast cancer research and treatment

authors： Goodwin PJ,Ennis M,Bahl M,Fantus IG,Pritchard KI,Trudeau ME,Koo J,Hood N

更新日期：2009-04-01 00:00:00

abstract：:Cell migration is essential in many diverse processes ranging from embryonic development to wound healing and immune response. Cancer cells have recently been shown to utilize chemoattraction mechanisms mediated by chemokines and their respective receptors, e.g., the CXCL12/CXCR4 pathway normally found in leukocytes. ...

journal_title：Breast cancer research and treatment

authors： Schmid BC,Rezniczek GA,Fabjani G,Yoneda T,Leodolter S,Zeillinger R

更新日期：2007-12-01 00:00:00

abstract：:Patients from hereditary breast cancer-prone (HBC) families provide one of the most powerful and potentially cost effective models for cancer prevention and control. Paradoxically, this opportunity is often missed in the clinical practice setting due, in part, to inattention to the family history and/or lack of knowle...

journal_title：Breast cancer research and treatment

authors： Lynch HT,Watson P,Conway TA,Lynch JF

更新日期：1990-02-01 00:00:00

abstract：:Although new chemotherapeutic drugs for metastatic breast cancer (MBC) have been approved over the past decade, it is unclear whether this has changed the overall outcome of patients. This study assessed the clinical and economic impacts of these drugs. We retrospectively studied MBC patients receiving chemotherapy in...

journal_title：Breast cancer research and treatment

authors： Galy G,Labidi-Galy SI,Perol D,Bachelot T,Ray-Coquard I,Tredan O,Biron P,Latour JF,Blay JY,Guastalla JP,Favier B

更新日期：2011-07-01 00:00:00

abstract：:Adiponectin is one of the most important adipocytokines secreted from adipose tissue. In addition to its effects on glucose and fatty acid metabolism, it has been reported that adiponectin has a direct growth-inhibitory effect on breast cancer cells. However, it still remains to be established how adiponectin affects ...

journal_title：Breast cancer research and treatment

authors： Nakayama S,Miyoshi Y,Ishihara H,Noguchi S

更新日期：2008-12-01 00:00:00

abstract：AIMS:Rapamycin and its analogues are currently being tested in clinical trials as novel-targeted anticancer agents. Pre-clinical studies that used breast cancer cell lines have suggested that p-Akt or p-S6K1 expressing tumors, as well as PTEN negative tumors, were sensitive to rapamycin. The aims of this study were to ...

journal_title：Breast cancer research and treatment

authors： Noh WC,Kim YH,Kim MS,Koh JS,Kim HA,Moon NM,Paik NS

更新日期：2008-08-01 00:00:00

abstract：:The diagnosis and treatment of patients with breast cancer is beginning to be influenced by new ideas and discoveries emerging from the field of angiogenesis research. This field, pursued in the laboratory for more than 20 years, has in the past 5 years generated clinical applications. Some of these applications have ...

journal_title：Breast cancer research and treatment

authors： Folkman J

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:At the present time, there is no consensus on the association between benign thyroid diseases and breast cancer (BC). Therefore, the aim of this study is to help shed some light on the association between hyperthyroidism, hypothyroidism, and thyroiditis and breast cancer risk. METHODS:Use of the Disease Ana...

journal_title：Breast cancer research and treatment

authors： Bach L,Kostev K,Schiffmann L,Kalder M

更新日期：2020-07-01 00:00:00

abstract：PURPOSE:APOBEC3B belongs to the family of DNA-editing enzymes. A copy number variant targeting the genomic APOBEC3A-APOBEC3B locus has a significant impact on breast cancer risk, but the relative contribution of APOBEC3B is uncertain. In this study, we investigate a loss-of-function mutation that selectively targets AP...

journal_title：Breast cancer research and treatment

authors： Radmanesh H,Spethmann T,Enßen J,Schürmann P,Bhuju S,Geffers R,Antonenkova N,Khusnutdinova E,Sadr-Nabavi A,Shandiz FH,Park-Simon TW,Hillemanns P,Christiansen H,Bogdanova N,Dörk T

更新日期：2017-02-01 00:00:00

abstract：:Tamoxifen is currently the adjuvant treatment of choice for postmenopausal women with hormone-sensitive breast cancer. However, in the treatment of postmenopausal women with advanced disease, the third-generation aromatase inhibitor anastrozole ('Arimidex') has been shown to be at least as effective as tamoxifen, and ...

journal_title：Breast cancer research and treatment

authors： Aapro MS,Forbes JF

更新日期：2003-01-01 00:00:00

abstract：:Complete remissions in patients with metastatic breast cancer using endocrine therapy or chemotherapy are infrequent. Breast tumors are known to be heterogeneous with respect to estrogen receptor status, and the low complete remission rate may be related to this biochemical heterogeneity. Based on laboratory experimen...

journal_title：Breast cancer research and treatment

authors： Allegra JC,Woodcock TM,Richman SP,Bland KI,Wittliff JL

更新日期：1982-01-01 00:00:00

abstract：:The Breast Imaging Reporting and Data System (BI-RADS) was introduced in 1993 to standardize the interpretation of mammograms. Though many studies have assessed the validity of the system, fewer have examined its reliability. Our objective is to identify predictors of reliability as measured by the kappa statistic. We...

journal_title：Breast cancer research and treatment

authors： Antonio AL,Crespi CM

更新日期：2010-04-01 00:00:00

abstract：:Mammosphere culture has been used widely for the enrichment of mammary epithelial stem cells and breast cancer stem cells (CSCs). Epithelial-to-mesenchymal transition (EMT) also induces stem cell features in normal and transformed mammary cells. We examined whether mammosphere culture conditions per se induced EMT in ...

journal_title：Breast cancer research and treatment

authors： Guttilla IK,Phoenix KN,Hong X,Tirnauer JS,Claffey KP,White BA

更新日期：2012-02-01 00:00:00

abstract：:Cancer-associated retinopathy (CAR) is a rare paraneoplastic syndrome usually associated with small-cell lung carcinoma and serum autoantibodies against recovering. We report the breast cancer woman with visual impairments and electrophysiological abnormalities characteristic of CAR. Her serum contained high-titer ant...

journal_title：Breast cancer research and treatment

authors： Ejma M,Misiuk-Hojło M,Gorczyca WA,Podemski R,Szymaniec S,Kuropatwa M,Rogozińska-Szczepka J,Bartnik W

更新日期：2008-07-01 00:00:00

abstract：:Whether wide excision with margins ≥1 cm is sufficient treatment for small low- or intermediate-grade ductal carcinoma in situ (DCIS) is unclear. This is an updated analysis of a phase II, single-arm, prospective trial testing this hypothesis. A total of 158 patients with low- or intermediate-grade DCIS who underwent ...

journal_title：Breast cancer research and treatment

authors： Wong JS,Chen YH,Gadd MA,Gelman R,Lester SC,Schnitt SJ,Sgroi DC,Silver BJ,Smith BL,Troyan SL,Harris JR

更新日期：2014-01-01 00:00:00