Relationship between estrogen receptors and risk factors of breast cancer in Japanese pre- and postmenopausal patients.

abstract：:Node-positive breast carcinoma is associated with a poor prognosis. Some patients benefit from adjuvant chemotherapy but new treatment modalities should still be developed in order to further increase the cure rate in this patient group. Prognostic factors are needed to define patients for such studies. Here, the prog...

journal_title：Breast cancer research and treatment

authors： Talvensaari-Mattila A,Pääkkö P,Turpeenniemi-Hujanen T

更新日期：1999-12-01 00:00:00

abstract：PURPOSE:The Ki67 proliferation index is a prognostic and predictive marker in breast cancer. Manual scoring is prone to inter- and intra-observer variability. The aims of this study were to clinically validate digital image analysis (DIA) of Ki67 using virtual dual staining (VDS) on whole tissue sections and to assess ...

journal_title：Breast cancer research and treatment

authors： Koopman T,Buikema HJ,Hollema H,de Bock GH,van der Vegt B

更新日期：2018-05-01 00:00:00

abstract：:Estrogen receptor (ER) alpha is a well-established independent prognostic factor in breast cancer whose presence determines the clinical implications of adjuvant endocrine therapy. A second receptor, ERb has been described, and a number of studies have examined its expression in breast tissue. However elucidation of t...

journal_title：Breast cancer research and treatment

authors： Carder PJ,Murphy CE,Dervan P,Kennedy M,McCann A,Saunders PT,Shaaban AM,Foster CS,Witton CJ,Bartlett JM,Walker RA,Speirs V

更新日期：2005-08-01 00:00:00

abstract：:The mitochondrial DNA (mtDNA) 4977-bp deletion (DeltamtDNA(4977) mutation) is one of the most frequently observed mtDNA mutations in human tissues and may play a role in carcinogenesis. Only a few studies have evaluated DeltamtDNA(4977) mutation in breast cancer tissue, and the findings have been inconsistent, which m...

journal_title：Breast cancer research and treatment

authors： Ye C,Shu XO,Wen W,Pierce L,Courtney R,Gao YT,Zheng W,Cai Q

更新日期：2008-04-01 00:00:00

abstract：:Although a wealth of research has focused on the influence of diet on breast cancer risk, the relationships between dietary factors and tumor characteristics of breast cancer, like estrogen receptor (ER) status, are not well characterized. In a case-case study, we evaluated self-reported dietary intake for five indivi...

journal_title：Breast cancer research and treatment

authors： Jakovljevic J,Touillaud MS,Bondy ML,Singletary SE,Pillow PC,Chang S

更新日期：2002-09-01 00:00:00

abstract：:CH50, a recombinant CBD-HepII polypeptide of human fibronectin, was shown to suppress tumor metastasis in murine hepatocarcinoma and melanoma models. However, the effect of CH50 on human cancer cells is still not clear. Here we evaluated the efficiency of CH50 delivered by recombinant adeno-associated virus (rAAV) vec...

journal_title：Breast cancer research and treatment

authors： He ZH,Lei Z,Zhen Y,Gong W,Huang B,Yuan Y,Zhang GM,Wang XJ,Feng ZH

更新日期：2014-01-01 00:00:00

abstract：:Seroma formation after axillary lymphadenectomy in women with breast cancer remains a problem despite many efforts to reduce surgery-related morbidity. In a prospective, randomised, open, parallel-group, controlled clinical trial we evaluated the effect of a fibrin-glue coated collagen patch (TachoComb H, Nycomed Phar...

journal_title：Breast cancer research and treatment

authors： Berger A,Tempfer C,Hartmann B,Kornprat P,Rossmann A,Neuwirth G,Tulusan A,Kubista E

更新日期：2001-05-01 00:00:00

abstract：:Obesity is associated with an increased risk of breast cancer (BC) and poorer outcome. We assessed the impact of body mass index (BMI) on pathological complete response (pCR), disease-free (DFS), and overall survival (OS), according to BC subtypes in patients with primary BC treated with neoadjuvant chemotherapy. 8,87...

journal_title：Breast cancer research and treatment

authors： Fontanella C,Lederer B,Gade S,Vanoppen M,Blohmer JU,Costa SD,Denkert C,Eidtmann H,Gerber B,Hanusch C,Hilfrich J,Huober J,Schneeweiss A,Paepke S,Jackisch C,Mehta K,Nekljudova V,Untch M,Neven P,von Minckwitz G,Loibl

更新日期：2015-02-01 00:00:00

abstract：:NF-E2-related factor 2 (Nrf2) is an important transcription factor involved in antioxidant response. Nrf2 binds antioxidant response elements (ARE) within promoters of genes encoding detoxification enzymes (e.g., NAD (P) H-quinone oxidoreductase 1 (NQO1)) leading to their transcriptional activation. Nrf2 function is r...

journal_title：Breast cancer research and treatment

authors： Yang M,Yao Y,Eades G,Zhang Y,Zhou Q

更新日期：2011-10-01 00:00:00

abstract：:IBEP-2, an established cell line recently derived from breast carcinoma, was characterized with regard to estrogen receptor (ER) expression, cell mitogenic response to estrogenic stimulation and sensitivity to antiestrogens. In addition, we examined ER modulation following binding of agonist and antagonists, and the E...

journal_title：Breast cancer research and treatment

authors： Journé F,Body JJ,Leclercq G,Nonclercq D,Laurent G

更新日期：2004-07-01 00:00:00

abstract：:Resveratrol is a natural polyphenolic compound and has been shown to exhibit cardio-protective as well as anti-neoplastic effects on various types of cancers. However, the exact mechanism of its anti-tumor effect is not clearly defined. Resveratrol has been shown to have strong hypolipidemic effect on normal adipocyte...

journal_title：Breast cancer research and treatment

authors： Pandey PR,Okuda H,Watabe M,Pai SK,Liu W,Kobayashi A,Xing F,Fukuda K,Hirota S,Sugai T,Wakabayashi G,Koeda K,Kashiwaba M,Suzuki K,Chiba T,Endo M,Fujioka T,Tanji S,Mo YY,Cao D,Wilber AC,Watabe K

更新日期：2011-11-01 00:00:00

abstract：:Obesity is a risk factor for the development of new cases of breast cancer and also affects survival in women who have already been diagnosed with breast cancer. Early studies of obesity and breast cancer survival have been summarised in two meta-analyses, but the latest of these only included studies that recruited w...

journal_title：Breast cancer research and treatment

authors： Protani M,Coory M,Martin JH

更新日期：2010-10-01 00:00:00

abstract：PURPOSE:To examine the association of plasma carotenoids, micronutrients in fruits, and vegetables, with risk of premalignant breast disease (PBD) in younger women. METHODS:Blood samples were collected at the Siteman Cancer Center between 2008 and 2012 from 3537 women aged 50 or younger with no history of cancer or PB...

journal_title：Breast cancer research and treatment

authors： Cohen K,Liu Y,Luo J,Appleton CM,Colditz GA

更新日期：2017-04-01 00:00:00

abstract：OBJECTIVE:To determine whether fruit, vegetable, and micronutrient intake 1 year prior to breast cancer diagnosis is associated with a reduction in the subsequent risk of all-cause or breast cancer-specific mortality. METHODS:Follow-up data from 1,235 invasive breast cancer cases age 25-98 years from the Long Island B...

journal_title：Breast cancer research and treatment

authors： Fink BN,Gaudet MM,Britton JA,Abrahamson PE,Teitelbaum SL,Jacobson J,Bell P,Thomas JA,Kabat GC,Neugut AI,Gammon MD

更新日期：2006-07-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFr) levels were analyzed in 140 primary breast cancer specimens by immunohistochemical assay (ICA), competitive binding assay (BA), or enzyme immunoassay (EIA). Thirty-nine of 118 specimens (33.1%) were scored as positive by ICA, 30 of 116 (25.9%; cut-off level 10 fmol/mg protein) b...

journal_title：Breast cancer research and treatment

authors： Iwase H,Kobayashi S,Itoh Y,Kuzushima T,Yamashita H,Iwata H,Naito A,Yamashita T,Itoh K,Masaoka A

更新日期：1993-12-01 00:00:00

abstract：PURPOSE:Previous work found that lower BMI is associated with a pathologic complete response (pCR) following neoadjuvant chemotherapy for breast cancer. Relative dose intensity (RDI) of chemotherapy is an important marker of treatment tolerability. We hypothesized that patients with low BMI would have higher RDI than p...

journal_title：Breast cancer research and treatment

authors： Usiskin I,Li F,Irwin ML,Cartmel B,Sanft T

更新日期：2020-10-30 00:00:00

abstract：:Breast Cancer 2 gene (BRCA2) mutation carriers have a 45% chance of developing breast cancer and a 11% risk of developing ovarian cancer by the age of 70. While hundreds of BRCA2-truncating mutations have been associated with an increased cancer risk in carriers, the contribution of unclassified variants (UCVs) to can...

journal_title：Breast cancer research and treatment

authors： Balia C,Galli A,Caligo MA

更新日期：2011-10-01 00:00:00

abstract：:HER2/neu overexpression leads to poorer prognosis and higher risk of disease reoccurrence in breast cancer patients. The causative factors responsible for increasing HER2/neu expression levels on mammary cells are not known. We investigated whether factors associated with inflammation or metastasis could induce HER2/n...

journal_title：Breast cancer research and treatment

authors： Fatunmbi M,Shelton J,Aronica SM

更新日期：2012-09-01 00:00:00

abstract：:The population-based Ontario Breast Screening Program (OBSP) provides two-yearly screening by both nurse examiner clinical breast examination (CBE) and two-view mammography to women aged 50 to 69. CBE alone accounts for about 5% of cancer detection. The purpose of this study was to determine whether CBE information af...

journal_title：Breast cancer research and treatment

authors： Knight JA,Libstug AR,Moravan V,Boyd NF

更新日期：1998-03-01 00:00:00

abstract：PURPOSE:Dysregulation of HER2 signaling pathway in breast cancer is well documented. Our bioinformatics analysis predicted hsa-miR-512-3p (miR-512-3p) as a bona fide regulator of HER2 as well as HER3, PIK3R2, and AKT1 genes. Then, we intended to examine the effect of miR-512-3p on the predicted target genes that are in...

journal_title：Breast cancer research and treatment

authors： Mohamadzade Z,Mahjoubi F,Soltani BM

更新日期：2021-01-01 00:00:00

abstract：:The biology of breast cancer in Japan appears to be changing in that, while post-menopausal Japanese patients have a better prognosis than comparable British women, no differences in recurrence or survival rates can now be found in pre-menopausal patients. ...

journal_title：Breast cancer research and treatment

authors： Allen DS,Bulbrook RD,Chaudary MA,Hayward JL,Yoshida M,Miura S,Murai JT

更新日期：1991-05-01 00:00:00

abstract：:A novel human mammary epithelial cell line, HME348, was established from benign breast tissue from a 44-year-old germ-line BRCA2 mutation carrier with a history of stage 1 breast cancer. Mutation analysis showed that the patient had a known 6872del4 BRCA2 heterozygous mutation. The human mammary epithelial cells passa...

journal_title：Breast cancer research and treatment

authors： Lewis CM,Herbert BS,Bu D,Halloway S,Beck A,Shadeo A,Zhang C,Ashfaq R,Shay JW,Euhus DM

更新日期：2006-09-01 00:00:00

abstract：:Breast tumor infiltrating lymphocytes (TIL) are enriched in tumor-specific cytotoxic T lymphocytes (CTL), and may represent a superior source of CTL compare to peripheral blood lymphocytes (PBL), for adoptive T cell immunotherapy of breast cancer. However, the immunocompetence of TIL and the possibility to consistentl...

journal_title：Breast cancer research and treatment

authors： Kass R,Bellone S,Palmieri M,Canè S,Bignotti E,Henry-Tillman R,Hutchins L,Cannon MJ,Klimberg S,Santin AD

更新日期：2003-08-01 00:00:00

abstract：PURPOSE:Triple-negative breast cancer (TNBC)/basal-like breast cancer (BLBC) is a highly aggressive form of breast cancer. We previously reported that a small molecule agonist ligand for the orphan nuclear receptor estrogen-related receptor beta (ERRβ or ESRRB) has growth inhibitory and anti-mitotic activity in TNBC ce...

journal_title：Breast cancer research and treatment

authors： Fernandez AI,Geng X,Chaldekas K,Harris B,Duttargi A,Berry VL,Berry DL,Mahajan A,Cavalli LR,Győrffy B,Tan M,Riggins RB

更新日期：2020-02-01 00:00:00

abstract：:Aromatase inhibitors (AIs) are used for treatment of estrogen receptor α (ER)-positive breast cancer; however, resistance is a major obstacle for optimal outcome. This preclinical study aimed at identifying potential new treatment targets in AI-resistant breast cancer cells. Parental MCF-7 breast cancer cells and four...

journal_title：Breast cancer research and treatment

authors： Hole S,Pedersen AM,Lykkesfeldt AE,Yde CW

更新日期：2015-02-01 00:00:00

abstract：:Targeting HER-2 over-expressing breast cancer cells with trastuzumab has resulted in significant improvements in both disease-free and overall survival rates. However, despite a favorable initial response, some cancer cells become resistant and develop into fatal metastatic disease. Here we report that we can specific...

journal_title：Breast cancer research and treatment

authors： Zhang KX,Kim C,Chow E,Chen IS,Jia W,Rennie PS

更新日期：2011-01-01 00:00:00

abstract：:A potential advantage of primary over adjuvant chemotherapy in breast cancer survival had been proposed on theoretical grounds. In 1994, early results of the S6-trial comparing primary chemotherapy vs. adjuvant chemotherapy for operable breast cancer in 390 premenopausal patients had shown significant improvement in s...

journal_title：Breast cancer research and treatment

authors： Broët P,Scholl SM,de la Rochefordière A,Fourquet A,Moreau T,De Rycke Y,Asselain B,Pouillart P

更新日期：1999-11-01 00:00:00

abstract：PURPOSE:Vitamin D (VD) metabolism regulates adipose tissue, lipogenesis inflammation, and tumor growth. CYP24A1 is the key enzyme for metabolic inactivation of active VD (1,25(OH)2D3). We examined whether common germline single nucleotide polymorphisms (SNPs) in the CYP24A1 gene could affect the association between adu...

journal_title：Breast cancer research and treatment

authors： Cao S,Wei F,Zhou J,Zhu Z,Li W,Wu M

更新日期：2020-01-01 00:00:00

abstract：:We have previously shown that the anti-proliferative effect of retinoic acid in human breast cancer cell line MCF-7 is dependent on HES-1 expression. Here we show that retinoic acid induces HES-1 expression via upregulation of transcription factor SOX9. By expressing a dominant negative form of SOX9, disrupting endoge...

journal_title：Breast cancer research and treatment

authors： Müller P,Crofts JD,Newman BS,Bridgewater LC,Lin CY,Gustafsson JA,Ström A

更新日期：2010-04-01 00:00:00

abstract：:Recent breast cancer treatment studies conducted in large urban settings have reported racial disparities in the appropriate use of adjuvant chemotherapy. This article presents the first focused evaluation of black-white differences in receipt and completion of chemotherapy for breast cancer in a primarily rural regio...

journal_title：Breast cancer research and treatment

authors： Lipscomb J,Gillespie TW,Goodman M,Richardson LC,Pollack LA,Ryerson AB,Ward KC

更新日期：2012-05-01 00:00:00