Adeno-associated virus-mediated expression of recombinant CBD-HepII polypeptide of human fibronectin inhibits metastasis of breast cancer.

abstract：BACKGROUND:To investigate the correlation among some of the commonly used clinical, pathological factors and newer biological indicators, and to identify the independent predictors of distant metastasis at presentation in patients with breast cancer. METHODS:The pathological specimens from 73 patients with breast canc...

journal_title：Breast cancer research and treatment

authors： Bozcuk H,Uslu G,Peştereli E,Samur M,Ozdoğan M,Karaveli S,Sargin F,Savaş B

更新日期：2001-08-01 00:00:00

abstract：:The effect of estradiol (E2) on the [3H]-acetylation of nuclear histones was studied in the MCF-7 human mammary cancer cell line in culture. Cells (approximately 10(8) were incubated with 8 x 10(-6) M [3H]-acetate in the absence (control) or in the presence of estradiol (10(-5)-10(-8) M). After 20 min incubation, the ...

journal_title：Breast cancer research and treatment

authors： Pasqualini JR,Mercat P,Giambiagi N

更新日期：1989-10-01 00:00:00

abstract：:Two human cancer cell lines (MA 2 and MA 3) were established from pleural effusions of infiltrating ductal carcinomas of the breast. The lines were maintained in continuous monolayer culture with doubling times of 70 (MA 2) and 78 (MA 3) hr for more than two years and possessed extensively rearranged abnormal karyo-ty...

journal_title：Breast cancer research and treatment

authors： Zoli W,Roncuzzi L,Zini N,Lenzi L,Gruppioni R,Barzanti F,Sensi A,Amadori D,Gasperi-Campani A

更新日期：1997-04-01 00:00:00

abstract：:To evaluate differences in use of sentinel lymph node biopsy (SLNB) by age and race in Medicare recipients with early-stage breast cancer, we examined Surveillance, Epidemiology and End Results-Medicare linked data for women undergoing breast conserving surgery for stage I or II breast cancer, including axillary stagi...

journal_title：Breast cancer research and treatment

authors： Reeder-Hayes KE,Bainbridge J,Meyer AM,Amos KD,Weiner BJ,Godley PA,Carpenter WR

更新日期：2011-08-01 00:00:00

abstract：:Prognosis of early beast cancer is heterogeneous. Today, no histoclinical or biological factor predictive for clinical outcome after adjuvant anthracycline-based chemotherapy (CT) has been validated and introduced in routine use. Using DNA microarrays, we searched for a gene expression signature associated with metast...

journal_title：Breast cancer research and treatment

authors： Bertucci F,Borie N,Roche H,Bachelot T,Le Doussal JM,Macgrogan G,Debono S,Martinec A,Treilleux I,Finetti P,Esterni B,Extra JM,Geneve J,Hermitte F,Chabannon C,Jacquemier J,Martin AL,Longy M,Maraninchi D,Fert V,Birnb

更新日期：2011-06-01 00:00:00

abstract：PURPOSE:Mitochondrial unfolding protein are abundant in breast cancer cells, but the mechanism by which breast cancer cells resist apoptosis is still not fully elucidated. In this study, we explored the role of mitochondrial unfolded protein response (mtUPR)-related proteins in four types of breast cancer tissues. MET...

journal_title：Breast cancer research and treatment

authors： Chen FM,Huang LJ,Ou-Yang F,Kan JY,Kao LC,Hou MF

更新日期：2020-08-01 00:00:00

abstract：:Identification of novel targets for the treatment of basal-like breast cancer is essential for improved outcomes in patients with this disease. This study investigates the association of MMP7 expression and MMP7 promoter methylation with subtype and outcome in breast cancer patient cohorts. Immunohistochemical analysi...

journal_title：Breast cancer research and treatment

authors： Sizemore ST,Sizemore GM,Booth CN,Thompson CL,Silverman P,Bebek G,Abdul-Karim FW,Avril S,Keri RA

更新日期：2014-07-01 00:00:00

abstract：PURPOSE:Breast density (BD), an important risk factor for breast cancer, can change over time in some women, but the underlying mechanism is unclear. Very little is known about the impact of surgical weight loss on BD. Our hypothesis is that weight loss after bariatric surgery is associated with a significant and favor...

journal_title：Breast cancer research and treatment

authors： Williams AD,So A,Synnestvedt M,Tewksbury CM,Kontos D,Hsiehm MK,Pantalone L,Conant EF,Schnall M,Dumon K,Williams N,Tchou J

更新日期：2017-10-01 00:00:00

abstract：:This analysis was conducted to determine whether comorbid medical conditions predict additional breast cancer events and all-cause mortality in women with a history of early stage breast cancer. Women (n = 2,542) participating in a randomized diet trial completed a self-administered questionnaire regarding whether the...

journal_title：Breast cancer research and treatment

authors： Patterson RE,Flatt SW,Saquib N,Rock CL,Caan BJ,Parker BA,Laughlin GA,Erickson K,Thomson CA,Bardwell WA,Hajek RA,Pierce JP

更新日期：2010-08-01 00:00:00

abstract：:In previous studies, we observed that regulation of expression of CD200, both on cells of a transplantable breast cancer, EMT6, and of the host, as well as of the receptor, CD200R in host mice, regulated local tumor growth and metastasis in immunocompetent animals. This in turn led to an improved ability to document i...

journal_title：Breast cancer research and treatment

authors： Gorczynski RM,Chen Z,Khatri I,Podnos A,Yu K

更新日期：2013-11-01 00:00:00

abstract：OBJECTIVES:To determine any changes in usage of axillary dissection over time from 1983 to 1993, and to characterize those patients who do not receive axillary node dissection. METHODS:A total of 129,946 female patients receiving cancer-directed surgery for early stage breast cancer, who were identified from the SEER ...

journal_title：Breast cancer research and treatment

authors： Du X,Freeman JL,Goodwin JS

更新日期：1999-01-01 00:00:00

abstract：:E6-associated protein (E6-AP) is a dual function protein. It acts as an E3 ubiquitin-protein ligase enzyme and coactivator of steroid hormone receptors such as estrogen (ERα) and progesterone (PR) receptors. It promotes the degradation of ERα and PR through the ubiquitin-proteasome pathway. Furthermore, it has been sh...

journal_title：Breast cancer research and treatment

authors： Ramamoorthy S,Tufail R,Hokayem JE,Jorda M,Zhao W,Reis Z,Nawaz Z

更新日期：2012-02-01 00:00:00

abstract：:The mechanism by which transforming growth factor-alpha (TGF-alpha) stimulates breast cancer cell proliferation is largely unknown. Furthermore, its potential role as an autocrine effector of estradiol-17 beta (E2)-stimulated growth of hormone-dependent mammary tumors remains controversial. Transient changes in phosph...

journal_title：Breast cancer research and treatment

authors： Etindi RN,Manni A,Martel J

更新日期：1992-01-01 00:00:00

abstract：:25-Hydroxy-3-oxoolean-12-en-28-oic acid (Amooranin-AMR) is a triterpene acid isolated from the stem bark of a tropical tree (Amoora rohituka) grown wild in India. A herbal preparation used for the treatment of cancer by the Ayurvedic system of medicine contains the stem bark of Amoora rohituka as one of the ingredient...

journal_title：Breast cancer research and treatment

authors： Rabi T,Wang L,Banerjee S

更新日期：2007-01-01 00:00:00

abstract：:The effect of 17-beta-estradiol (E2) on the induction of osteolytic lesions by estrogen receptor (ER)-negative breast cancer cells was investigated in 4-week-old female nude mice. Exposure to exogenous E2 was found to increase osteolytic areas on radiographs up to 5.3 times in mice inoculated intracardially with MDA-2...

journal_title：Breast cancer research and treatment

authors： Winding B,Misander H,Høegh-Andersen P,Brünner N,Foged NT

更新日期：2003-03-01 00:00:00

abstract：:We have compared the effects of the progestin R5020 and the antiprogestin RU486 on the growth of the MCF-7 and T47D breast cancer cell lines. Differences between the two compounds were demonstrated in several parameters. 1. Estradiol was required for the efficient inhibition of cell growth of both lines by R5020 but n...

journal_title：Breast cancer research and treatment

authors： Gill PG,Vignon F,Bardon S,Derocq D,Rochefort H

更新日期：1987-10-01 00:00:00

abstract：:Experimental evidence provides strong support for anti-carcinogenic effects of calcium and vitamin D with respect to breast cancer. Observational epidemiologic data also provide some support for inverse associations with risk. We tested the effect of calcium plus vitamin D supplementation on risk of benign proliferati...

journal_title：Breast cancer research and treatment

authors： Rohan TE,Negassa A,Chlebowski RT,Ceria-Ulep CD,Cochrane BB,Lane DS,Ginsberg M,Wassertheil-Smoller S,Page DL

更新日期：2009-07-01 00:00:00

abstract：:To investigate the prognostic value of tumor markers, cancer antigen 15-3 (CA 15-3) and carcinoembryonic antigen (CEA) levels at diagnosis of systemic recurrence. After primary treatments of locoregional breast cancers, serum CA 15-3 and/or CEA concentrations were regularly measured, and systemic recurrences were iden...

journal_title：Breast cancer research and treatment

authors： Lee JS,Park S,Park JM,Cho JH,Kim SI,Park BW

更新日期：2013-10-01 00:00:00

abstract：:Transforming growth factor-beta (TGFB) is a potent inhibitor of normal epithelial cell proliferation, and may be one of the regulatory factors that are perturbed during tumor development. While many tumor cell lines no longer respond to the inhibitory effects of TGFB due to a reduction or absence of the type II recept...

journal_title：Breast cancer research and treatment

authors： Barlow J,Yandell D,Weaver D,Casey T,Plaut K

更新日期：2003-05-01 00:00:00

abstract：PURPOSE:Radiotherapy (RT) constitutes an important part of breast cancer treatment. However, triple negative breast cancers (TNBC) exhibit remarkable resistance to most therapies, including RT. Developing new ways to radiosensitize TNBC cells could result in improved patient outcomes. The M2 isoform of pyruvate kinase ...

journal_title：Breast cancer research and treatment

authors： Zhang L,Bailleul J,Yazal T,Dong K,Sung D,Dao A,Gosa L,Nathanson D,Bhat K,Duhachek-Muggy S,Alli C,Dratver MB,Pajonk F,Vlashi E

更新日期：2019-11-01 00:00:00

abstract：:Estrogenic steroids, such as estradiol, are known to play a crucial role in the development and growth of hormone-dependent breast cancer. Steroid sulfatase (STS) inhibitors that can prevent the biosynthesis of these steroids via the sulfatase pathway offer therapeutic potential. We show here the in vivo profile, incl...

journal_title：Breast cancer research and treatment

authors： Foster PA,Chander SK,Parsons MF,Newman SP,Woo LW,Potter BV,Reed MJ,Purohit A

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:The Z0011 trial initiated a paradigm shift in the axillary treatment of breast cancer patients with a positive sentinel lymph node biopsy (SLNB), disregarding patients with a positive ultrasound-guided lymph node biopsy (UGLNB). We examined whether relevant differences exist between these patients to determi...

journal_title：Breast cancer research and treatment

authors： Verheuvel NC,Voogd AC,Tjan-Heijnen VCG,Siesling S,Roumen RMH

更新日期：2017-10-01 00:00:00

abstract：PURPOSE:Evidence suggests that premenopausal obesity decreases and postmenopausal obesity increases breast cancer risk. Because it is not well known whether this is subtype dependent, we studied the association between body mass index (BMI) and age at breast cancer diagnosis, or the probability of being diagnosed with ...

journal_title：Breast cancer research and treatment

authors： Brouckaert O,Van Asten K,Laenen A,Soubry A,Smeets A,Nevelstreen I,Vergote I,Wildiers H,Paridaens R,Van Limbergen E,Weltens C,Moerman P,Floris G,Neven P,Multidisciplinary breast centre Leuven.

更新日期：2018-02-01 00:00:00

abstract：:Macroautophagy (autophagy), a process for lysosomal degradation of organelles and long-lived proteins, has been linked to various pathologies including cancer and to the cellular response to anticancer therapies. In the human estrogen receptor positive MCF7 breast adenocarcinoma cell line, treatment with the endocrine...

journal_title：Breast cancer research and treatment

authors： Qadir MA,Kwok B,Dragowska WH,To KH,Le D,Bally MB,Gorski SM

更新日期：2008-12-01 00:00:00

abstract：:Psoriasin (S100A7) is a calcium-binding protein that has shown to be highly expressed in high-grade ductal carcinoma in situ (DCIS) and a subset of invasive breast cancers. However, its role in invasion and metastasis is not very well known. In this study, we have shown that S100A7 differentially regulates epidermal g...

journal_title：Breast cancer research and treatment

authors： Sneh A,Deol YS,Ganju A,Shilo K,Rosol TJ,Nasser MW,Ganju RK

更新日期：2013-04-01 00:00:00

abstract：:The potential advantage of using quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) methodology to detect metastasis in sentinel lymph nodes (SLNs) of breast cancer (BC) patients was evaluated in this prospective study. We measured the expression of relevant gene transcripts in SLNs using an innova...

journal_title：Breast cancer research and treatment

authors： Wallwiener CW,Wallwiener M,Kurth RR,Röhm C,Neubauer H,Banys MJ,Staebler A,Schönfisch B,Meuer SC,Giese T,Fehm TN

更新日期：2011-12-01 00:00:00

abstract：PURPOSE:A number of studies have tested the hypothesis that breast cancer patients with low-activity CYP2D6 genotypes achieve inferior benefit from tamoxifen treatment, putatively due to lack of metabolic activation to endoxifen. Studies have provided conflicting data, and meta-analyses suggest a small but significant ...

journal_title：Breast cancer research and treatment

authors： Hertz DL,Kidwell KM,Hilsenbeck SG,Oesterreich S,Osborne CK,Philips S,Chenault C,Hartmaier RJ,Skaar TC,Sikora MJ,Rae JM

更新日期：2017-11-01 00:00:00

abstract：:A major goal of cancer chemotherapy is the identification of cytotoxic compounds that are highly selective for cancer cells. We describe here one such compound - a novel iron chelator, desferri-exochelin 772SM. This desferri-exochelin has unique chemical and pharmacological properties, including extremely high iron bi...

journal_title：Breast cancer research and treatment

authors： Pahl PM,Horwitz MA,Horwitz KB,Horwitz LD

更新日期：2001-09-01 00:00:00

abstract：INTRODUCTION:The incidence of breast cancer varies among women living in the Southwestern part of the US. We evaluate how body size influences breast cancer risk among these women. METHODS:Cases (n = 2,325) diagnosed with breast cancer between October 1, 1999 and May 2004 residing in Arizona, Colorado, New Mexico, or ...

journal_title：Breast cancer research and treatment

authors： Slattery ML,Sweeney C,Edwards S,Herrick J,Baumgartner K,Wolff R,Murtaugh M,Baumgartner R,Giuliano A,Byers T

更新日期：2007-03-01 00:00:00

abstract：:To evaluate the prognostic relevance of Ki-67 and topoisomerase IIalpha expression in relation to tumor stage, grade, and hormone receptor content, 942 ductal infiltrating carcinomas of the breast were examined by means of the monoclonal antibodies Ki-S11 (Ki-67) and Ki-S4 (topoisomerase IIalpha). pS2, c-erbB2, and p5...

journal_title：Breast cancer research and treatment

authors： Rudolph P,MacGrogan G,Bonichon F,Frahm SO,de Mascarel I,Trojani M,Durand M,Avril A,Coindre JM,Parwaresch R

更新日期：1999-05-01 00:00:00