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Metabolites of orally active NO-independent pyrazolopyridine stimulators of soluble guanylate cyclase.

Abstract：

:The pyrazolopyridine stimulators of soluble guanylate cyclase BAY 41-2272 and 41-8543 were oxidised in rats and dogs at their 5-pyrimidinyl-cyclopropyl and -morpholino residue. These metabolites activate the soluble guanylate cyclase, induce vasoelaxation and thereby may contribute to the in vivo activity of BAY 41-2272 and BAY 41-8543.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Straub A,Benet-Buckholz J,Fröde R,Kern A,Kohlsdorfer C,Schmitt P,Schwarz T,Siefert HM,Stasch JP

doi

10.1016/s0968-0896(02)00034-2

subject

Has Abstract

pub_date

2002-06-01 00:00:00

pages

1711-7

issue

6

eissn

0968-0896

issn

1464-3391

pii

S0968089602000342

journal_volume

10

pub_type

杂志文章

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