Lavage and nipple aspiration of breast ductal fluids: a source of biomarkers for environmental mutagenesis.

abstract：:Synthetic dyes are released in wastewater from textile manufacturing plants, and many of these dyes are genotoxic. In the present study, the mutagenicity of azo, anthraquinone, and triphenyl methane dyes was investigated before and after successive biodegradation with activated sludge and the ligninolytic fungus, Irpe...

journal_title：Environmental and molecular mutagenesis

authors： Malachová K,Pavlícková Z,Novotný C,Svobodová K,Lednická D,Musílková E

更新日期：2006-08-01 00:00:00

abstract：:Genomes of all living organisms are constantly threatened by endogenous and exogenous agents that challenge the chemical integrity of DNA. Most bacteria have evolved a coordinated response to DNA damage. In Escherichia coli, this inducible system is termed the SOS response. The SOS global regulatory network consists o...

journal_title：Environmental and molecular mutagenesis

authors： Maslowska KH,Makiela-Dzbenska K,Fijalkowska IJ

更新日期：2019-05-01 00:00:00

abstract：:The mitochondrial genome is essential for producing ATP (adenosine 5'-triphosphate) via oxidative phosphorylation. The gradual decline of mitochondrial function with age has long been postulated as a factor in aging. More recently, a variety of diseases have been related to molecular defects in human mitochondrial DNA...

journal_title：Environmental and molecular mutagenesis

authors： Grossman LI

更新日期：1995-01-01 00:00:00

abstract：:A data base consisting of 61 heterocyclic amines formed during food preparation and their des-amino analogs were subjected to structure-activity analysis using the CASE method, a structural activity relational expert system. The program identified the major structural determinants associated with mutagenic activity or...

journal_title：Environmental and molecular mutagenesis

authors： Zhang YP,Klopman G,Rosenkranz HS

更新日期：1993-01-01 00:00:00

abstract：:Gravid Swiss Webster dams were injected via tail vein with a single (1.1, 2.2, or 3.3 mmol/kg) dose of ethyl carbamate (urethane) on days 13-17 of pregnancy. Relative sister chromatid exchange (SCE) responses in maternal bone marrow vs. individual fetal liver cells were assessed. In addition, in order to evaluate the ...

journal_title：Environmental and molecular mutagenesis

authors： Neeper-Bradley TL,Conner MK

更新日期：1989-01-01 00:00:00

abstract：:Methyl 3,4-diphenyl-5-hydroxylamino-2-furoate (N-OH-MDPF) (I), methyl 3,4-diphenyl-5-acetoxyamino-2-furoate (N-OAc-MDPF) (II), methyl 3,4-diphenyl-N-hydroxy-5-acetylamino-2-furoate (N-OH-MDPAF) (III), and methyl 3,4-diphenyl-N-acetoxy-5-acetylamino-2-furoate (N-OAc-MDPAF) (IV) were synthesized and tested for mutagenic...

journal_title：Environmental and molecular mutagenesis

authors： Swaminathan S,Hatcher JF,Yamamoto K,Tanaka A,Ichikawa M,Bryan GT

更新日期：1991-01-01 00:00:00

abstract：:The mutational spectrum for 28 X-ray induced mutations and 2 spontaneous mutations, previously determined by genetic and cytogenetic methods, consisted of 20 multilocus deficiencies (19 induced and 1 spontaneous) and 10 intragenic mutations (9 induced and 1 spontaneous). One of the X-ray induced intragenic mutations w...

journal_title：Environmental and molecular mutagenesis

authors： Mahmoud J,Fossett NG,Arbour-Reily P,McDaniel M,Tucker A,Chang SH,Lee WR

更新日期：1991-01-01 00:00:00

abstract：:Molybdenum is an essential element in plants and animals as a cofactor for enzymes. Molybdenum trioxide is used in metallurgical processes, in cosmetics as a pigment, and in contact lens solution, yet limited information is available on molybdenum genotoxicity. In the present study the micronucleus (MN) assay in human...

journal_title：Environmental and molecular mutagenesis

authors： Titenko-Holland N,Shao J,Zhang L,Xi L,Ngo H,Shang N,Smith MT

更新日期：1998-01-01 00:00:00

abstract：:AQ-13 ([N1-(7-chloro-quinolin-4yl)-3-(N3,N3-diethylamino)propylamine] dihydrochloride trihydrate) is an aminoquinoline antimalarial drug that is effective against chloroquine-resistant strains of Plasmodium falciparum. It is structurally similar to the widely used chloroquine diphosphate (CQ). We evaluated these drugs...

journal_title：Environmental and molecular mutagenesis

authors： Riccio ES,Lee PS,Winegar RA,Krogstad DJ,De D,Mirsalis JC

更新日期：2001-01-01 00:00:00

abstract：:Eleven mutagenic heterocyclic amines, 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]-indole (Trp-P-1), 3-amino-1-methyl-5H-pyrido[4,3]indole (Trp-P-2), 2-amino-6-methyl-dipyrido[1,2-a:3',2'-d]imidazole (Glu-P-1), 2-aminodipyrido[1,2-a:3',2'-d]imidazole (Glu-P-2), 2-amino-9H-pyrido[2,3-b]indole (A alpha C), 2-amino-3-methyl-9H-...

journal_title：Environmental and molecular mutagenesis

authors： Yoshimi N,Sugie S,Iwata H,Mori H,Williams GM

更新日期：1988-01-01 00:00:00

abstract：:Several genotoxicity endpoints have been evaluated to define nonlinear dose-responses for SN 1 and SN 2 alkylating genotoxicants. Dose-response studies acknowledging the process of multistage tumorigenesis are important; however, data pertaining nonlinearity are not yet available. In this communication, the role of DN...

journal_title：Environmental and molecular mutagenesis

authors： Becker K,Thomas AD,Kaina B

更新日期：2014-03-01 00:00:00

abstract：:Previous population-based studies have identified subject characteristics that, when combined, can account for approximately 20% of the observed interindividual variation in baseline SCE rates. In the present investigation, a classic twin study design was used to address the issue of the relevance of genetic factors t...

journal_title：Environmental and molecular mutagenesis

authors： Hirsch BA,Sentz KK,McGue M

更新日期：1992-01-01 00:00:00

abstract：:The accessibility of reactive metabolites to test cells is critical for a genotoxic response. However, sulfo-conjugates formed outside may not readily enter cells, and some metabolites formed by cytochromes P450 (CYPs) may not endure transport. This topic was addressed in the present study, using V79 cells engineered ...

journal_title：Environmental and molecular mutagenesis

authors： Zhu N,Hu K,Li Z,Chen Y,Liu Y

更新日期：2020-02-01 00:00:00

abstract：:The hydroxyl radical scavengers thiourea, ethanol, and dimethyl sulfoxide significantly reduced the killing of Escherichia coli elicited by low concentrations of H2O2 (resulting in mode 1 killing) when treatments with the oxidant and the scavengers were performed in a complete growth medium (K medium) but not in M9 sa...

journal_title：Environmental and molecular mutagenesis

authors： Brandi G,Salvaggio L,Cattabeni F,Cantoni O

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Recently, high concentrations of arsenic have been documented in ground waters of Southern Assam, India. Indiscriminate smokeless tobacco consumption is a common practice in this region. Correlation between nutritional status and arsenic and smokeless tobacco-induced health effects has not been taken up in h...

journal_title：Environmental and molecular mutagenesis

authors： Das S,Langthasa P,Barhoi D,Upadhaya P,Giri S

更新日期：2018-06-01 00:00:00

abstract：:Experiments are described which elucidate some of the technical problems associated with the direct sequencing of polymerase chain reaction (PCR) amplified DNA. Sequencing primer purity, labeling methodology, and template preparation were explored. Conditions are presented for the routine sequencing of single- and dou...

journal_title：Environmental and molecular mutagenesis

authors： Zimmerman LJ,Fuscoe JC

更新日期：1991-01-01 00:00:00

abstract：:Tandem-base mutations (TBM) are associated with ultraviolet light and other mutagens. Herein, we report an age- and tissue-specific difference in the frequency of spontaneous TBM in Big Blue transgenic mice. A total of 390 mutants from liver and adipose tissue contained 17 and 4 TBM, respectively, while no TBM were de...

journal_title：Environmental and molecular mutagenesis

authors： Buettner VL,Hill KA,Halangoda A,Sommer SS

更新日期：1999-01-01 00:00:00

abstract：:Bhawalpur is a major cotton-growing area in Pakistan. Cotton picking in Pakistan is carried out by females and as a result of the intensive use of pesticides during the growing season these females are exposed to pesticide residues in the picking season. In the present study, peripheral blood was obtained from 69 cott...

journal_title：Environmental and molecular mutagenesis

authors： Ali T,Bhalli JA,Rana SM,Khan QM

更新日期：2008-06-01 00:00:00

abstract：:DAS (diallyl sulfide), DADS (diallyl disulfide), and DATS (diallyl trisulfide) are major oil-soluble allyl sulfides (OAS) that represent major garlic constituents. The anticarcinogenic and antimutagenic effects of these substances have been extensively studied during the last decades. Previous reports suggest that ind...

journal_title：Environmental and molecular mutagenesis

authors： Wu XJ,Hu Y,Lamy E,Mersch-Sundermann V

更新日期：2009-04-01 00:00:00

abstract：:To evaluate whether blood-based genotoxicity endpoints can provide temporal and dose-response data within the low-dose carcinogenic range that could contribute to carcinogenic mode of action (MoA) assessments, we evaluated the sensitivity of flow cytometry-based micronucleus and Pig-a gene mutation assays at and below...

journal_title：Environmental and molecular mutagenesis

authors： Dertinger SD,Phonethepswath S,Avlasevich SL,Torous DK,Mereness J,Cottom J,Bemis JC,Macgregor JT

更新日期：2014-05-01 00:00:00

abstract：:Micronuclei were assessed among the bone marrow PCEs of mice 28 hr after exposures to 1 to 8 Gy of X-rays and at 6-hr intervals from 12-60 hr after exposures to 2 or 6 Gy. At 28 hr, the frequency of micronuclei declined as the exposure level increased from 1 to 8 Gy. The peak proportion of micronucleated PCEs appeared...

journal_title：Environmental and molecular mutagenesis

authors： McFee AF,Cook SB,Abbott MG

更新日期：1994-01-01 00:00:00

abstract：:Benzene is an important industrial chemical and widespread environmental pollutant known to induce leukemia and other blood disorders. To be carcinogenic, benzene must be metabolized to produce toxic metabolites. To investigate whether single nucleotide polymorphisms (SNPs) in the metabolic enzyme genes are associated...

journal_title：Environmental and molecular mutagenesis

authors： Xing C,Chen Q,Li G,Zhang L,Zheng M,Zou Z,Hou L,Wang QF,Liu X,Guo X

更新日期：2013-07-01 00:00:00

abstract：:Antioxidant vitamins are able to deactivate highly bioactive molecules, such as free radicals, that are generated during cellular biochemical processes. Doxorubicin (DXR) is a cancer chemotherapeutic agent that generates free radicals as a byproduct. In the present study, the Drosophila melanogaster somatic wing spot ...

journal_title：Environmental and molecular mutagenesis

authors： Costa WF,Nepomuceno JC

更新日期：2006-01-01 00:00:00

abstract：:In this study we compared the ability of extractable organic material from particulate and semivolatile fractions of gasoline emission to induce mutations in bacteria and form adducts with calf thymus (CT) DNA with corresponding data obtained from diesel exhaust. Exhaust particles from gasoline-powered passenger cars ...

journal_title：Environmental and molecular mutagenesis

authors： Pohjola SK,Lappi M,Honkanen M,Savela K

更新日期：2003-01-01 00:00:00

abstract：:The potential of 1,3-dichloropropene (1,3-DCP) to induce dominant lethal mutations in the germ cells of male CD rats following inhalation exposure was investigated. Groups of 11-week-old males (30 animals/group) were exposed to 1,3-DCP vapors by inhalation at targeted concentrations of 0 (negative control), 10, 60, an...

journal_title：Environmental and molecular mutagenesis

authors： Gollapudi BB,Cieszlak FS,Day SJ,Carney EW

更新日期：1998-01-01 00:00:00

abstract：:The endogenous X-linked PIG-A gene is involved in the synthesis of glycosyl phosphatidyl inositol (GPI) anchors that tether specific protein markers to the exterior of mammalian cell cytoplasmic membranes. Earlier studies in rodent models indicate that Pig-a mutant red blood cells (RBCs) can be induced in animals trea...

journal_title：Environmental and molecular mutagenesis

authors： Dobrovolsky VN,Elespuru RK,Bigger CA,Robison TW,Heflich RH

更新日期：2011-12-01 00:00:00

abstract：:The aim of this research was to study the gaseous and particulate emissions of genotoxic substances during cooking with two types of methane stoves (a new one and an old one). The particulates were sampled both with a cascade impactor air sampler and an impinger with ice trap and analyzed by two bacterial mutagenicity...

journal_title：Environmental and molecular mutagenesis

authors： Monarca S,Zanardini A,Feretti D,Falistocco E,Antonelli P,Resola S,Moretti M,Villarini M,Nardi G

更新日期：1998-01-01 00:00:00

abstract：:A mutagenesis moonshot addressing the influence of the environment on our genetic wellbeing was launched just 2 months before astronauts landed on the moon. Its impetus included the discovery that X-rays (Muller HJ. [1927]: Science 64:84-87) and chemicals (Auerbach and Robson. [1946]: Nature 157:302) were germ-cell mu...

journal_title：Environmental and molecular mutagenesis

authors： DeMarini DM

更新日期：2020-01-01 00:00:00

abstract：:Riddelliine (RID) is a pyrrolizidine alkaloid found in plants of the genera Crotalaria, Amsinckia, and Senecio in the United States. RID has been extensively studied in a wide variety of in vitro short-term genotoxicity tests and has yielded positive responses in most test systems; however, there are fewer data availa...

journal_title：Environmental and molecular mutagenesis

authors： Mirsalis JC,Steinmetz KL,Blazak WF,Spalding JW

更新日期：1993-01-01 00:00:00

abstract：:Exposure to emissions from laser printers during the printing process is commonplace worldwide, both in the home and workplace environment. In the present study, cytotoxic and genotoxic effects of the emission from five low to medium-throughput laser printers were investigated with respect to the release of ozone (O(3...

journal_title：Environmental and molecular mutagenesis

authors： Tang T,Gminski R,Könczöl M,Modest C,Armbruster B,Mersch-Sundermann V

更新日期：2012-03-01 00:00:00