Abstract：
:In a long-term study of 1270 patients with at least one of the findings, open-angle glaucoma, disc haemorrhages or retinal vein occlusions, disc haemorrhages were witnessed in approximately 20% of the cases with open-angle glaucoma, and were a precursor of glaucomatous disc changes and associated visual field defects. Disc haemorrhages also preceded a rising intraocular pressure (IOP) in the destructive process among open-angle glaucoma cases. Similar glaucomatous development appears among cases independent of IOP or detection of exfoliation syndrome. Retinal vein occlusions and disc haemorrhages behave similarly with respect to glaucoma. The large number of transgressions is an argument against dividing glaucoma into different types. These findings support a vascular genesis to open-angle glaucoma, presented in earlier epidemiological studies.
journal_name
Prog Retin Eye Resjournal_title
Progress in retinal and eye researchauthors
Sonnsjö B,Dokmo Y,Krakau Tdoi
10.1016/s1350-9462(01)00019-2subject
Has Abstractpub_date
2002-01-01 00:00:00pages
35-56issue
1eissn
1350-9462issn
1873-1635pii
S1350946201000192journal_volume
21pub_type
杂志文章,评审abstract：:Cell replacement therapy is a promising treatment for irreversible retinal cell death in diverse diseases, such as age-related macular degeneration (AMD), Stargardt's disease, retinitis pigmentosa (RP) and glaucoma. These diseases are all characterized by the degeneration of one or two retinal cell types that cannot r...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/j.preteyeres.2018.11.003
更新日期：2019-03-01 00:00:00
abstract：:The refractive power of a lens is determined largely by its surface curvatures and the refractive index of its medium. These properties can also be used to control the sharpness of focus and hence the image quality. One of the most effective ways of doing this is with a gradient index. Eye lenses of all species, thus ...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章
doi：10.1016/j.preteyeres.2012.03.001
更新日期：2012-07-01 00:00:00
abstract：:Understanding of corneal wound healing plays an important role, not only in management of corneal infections, but especially in refractive surgery. A better control of wound healing mechanisms might improve the results of such resculpturing techniques and help to avoid complications arising from these procedures. Whil...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/s1350-9462(02)00064-2
更新日期：2003-05-01 00:00:00
abstract：:Renin-Angiotensin System is classically recognized for its role in the control of systemic blood pressure. However, the retina is recognized to have all the components necessary for angiotensin II formation, suggestive of a role for Angiotensin II in the retina that is independent of the systemic circulation. The most...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章
doi：10.1016/j.preteyeres.2010.03.003
更新日期：2010-07-01 00:00:00
abstract：:Compression of the optic chiasm causes an optic neuropathy that may be associated with reversible visual loss often immediately following surgical decompression. While the precise pathogenesis of retinal ganglion cell impairment and eventual death remains poorly understood, a number of putative mechanisms may play a r...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/j.preteyeres.2019.06.001
更新日期：2019-11-01 00:00:00
abstract：:Autophagy is a catabolic pathway that promotes the degradation and recycling of cellular components. Proteins, lipids, and even whole organelles are engulfed in autophagosomes and delivered to the lysosome for elimination. In response to stress, autophagy mediates the degradation of cell components, which are recycled...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/j.preteyeres.2016.08.001
更新日期：2016-11-01 00:00:00
abstract：:The thickness of tear film has been investigated under both invasive and non-invasive methods. While invasive methods are largely historical, more recent noninvasive methods are generally based on optical approaches that provide accurate, precise, and rapid measures. Optical microscopy, interferometry, and optical coh...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/j.preteyeres.2017.02.002
更新日期：2017-05-01 00:00:00
abstract：:The role of alpha-crystallin as a molecular chaperone may explain how the lens stays transparent for so long. Alpha-crystallin prevents the aggregation of other lens crystallins and proteins that have become unfolded by "trapping" the protein in a high molecular weight complex. It also protects enzyme activities. The ...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/s1350-9462(98)00030-5
更新日期：1999-07-01 00:00:00
abstract：:Axonal degeneration is an active, highly controlled process that contributes to beneficial processes, such as developmental pruning, but also to neurodegeneration. In glaucoma, ocular hypertension leads to vision loss by killing the output neurons of the retina, the retinal ganglion cells (RGCs). Multiple processes ha...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/j.preteyeres.2019.07.002
更新日期：2019-11-01 00:00:00
abstract：:Uveitis is a group of diseases characterized by intraocular inflammation, of which some are driven by autoinflammatory or autoimmune responses, such as Vogt-Koyanagi-Harada disease, Behçet's disease, uveitis associated with spondyloarthritis, ocular sarcoidosis, sympathetic ophthalmia and birdshot chorioretinopathy. T...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/j.preteyeres.2020.100866
更新日期：2021-01-01 00:00:00
abstract：:Diabetes mellitus (DM) is a major health problem with devastating effects on ocular health in both industrialized and developing countries. The control of hyperglycemia is critical to minimizing the impact of DM on ocular tissues because inadequate glycemic control leads to ocular tissue changes that range from a temp...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/j.preteyeres.2016.04.006
更新日期：2016-09-01 00:00:00
abstract：:Uveitis is a major cause of blindness, with the visual loss that occurs being due primarily to retinal tissue damage. The tissue damage is mediated mainly by phagocytic inflammatory cells, such as macrophages, by the release of various proteolytic enzymes, arachidonic acid metabolites, cytokines and free radicals. The...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/s1350-9462(99)00003-8
更新日期：2000-01-01 00:00:00
abstract：:Vision is the most important sense for humans and it is irreversibly impaired by axonal damage of retinal ganglion cells (RGCs) in the optic nerve due to the lack of axonal regeneration. The failure of regeneration is partially attributable to factors located in the inhibitory environment of the forming glial scar and...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/j.preteyeres.2012.06.005
更新日期：2012-11-01 00:00:00
abstract：:In a typical fish eye, the crystalline lens is the only refractive element. It is spherical in shape and has high refractive power. Most fish species have elaborate color vision and spectral sensitivity may range from the near-infrared to the near-ultraviolet. Longitudinal chromatic aberration exceeds depth of focus a...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/j.preteyeres.2012.12.001
更新日期：2013-05-01 00:00:00
abstract：:Neuroprotection is an emerging challenge in ophthalmology due to the particularly exposed location of retinal neurons and to the steadily increasing rate of intraocular surgical and pharmacological treatments applied to various eye diseases. Within few decades neuroprotection has developed from strongly contested appr...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/j.preteyeres.2014.06.004
更新日期：2014-09-01 00:00:00
abstract：:Autoimmune diseases usually follow a relapsing-remitting or a chronic progressive course. To understand the underlying immunopathogenesis we investigated experimental Lewis rat models displaying both disease types, which were only dependent on the autoantigen peptide used for immunization. Retinal S-Antigen-peptide PD...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/j.preteyeres.2018.02.003
更新日期：2018-07-01 00:00:00
abstract：:Optimal retinal neuronal cell function requires an appropriate, tightly regulated environment, provided by cellular barriers, which separate functional compartments, maintain their homeostasis, and control metabolic substrate transport. Correctly regulated hemodynamics and delivery of oxygen and metabolic substrates, ...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/j.preteyeres.2008.02.002
更新日期：2008-05-01 00:00:00
abstract：:Bacterial endophthalmitis is a sight threatening infection of the interior structures of the eye. Incidence in the US has increased in recent years, which appears to be related to procedures being performed on an aging population. The advent of outpatient intravitreal therapy for management of age-related macular dege...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/j.preteyeres.2012.03.004
更新日期：2012-07-01 00:00:00
abstract：:The retinal pigment epithelium (RPE) maintains retinal function as the metabolic gatekeeper between photoreceptors (PRs) and the choriocapillaries. The RPE and Bruch's membrane (BM) suffer cumulative damage over lifetime, which is thought to induce age-related macular degeneration (AMD) in susceptible individuals. Unl...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/j.preteyeres.2007.02.002
更新日期：2007-09-01 00:00:00
abstract：:Ocular hypertension in glaucoma develops due to age-related cellular dysfunction in the conventional outflow tract, resulting in increased resistance to aqueous humor outflow. Two cell types, trabecular meshwork (TM) and Schlemm's canal (SC) endothelia, interact in the juxtacanalicular tissue (JCT) region of the conve...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/j.preteyeres.2014.08.002
更新日期：2015-01-01 00:00:00
abstract：:Purines (in particular, ATP and adenosine) act as neuro- and gliotransmitters in the sensory retina where they are involved in bidirectional neuron-glia signaling. This review summarizes the present knowledge about the expression and functional importance of P1 (adenosine) and P2 (nucleotide) receptors in Müller glial...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/j.preteyeres.2011.06.001
更新日期：2011-09-01 00:00:00
abstract：:The ability of the human lens to accommodate is mediated by the ciliary muscle and zonule; the manifest optical power changes depend on the shape and material properties of the lens. The latter are difficult to measure with accuracy and, given the dynamic aspects of accommodation and the ageing of cells and tissues, t...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/j.preteyeres.2018.11.004
更新日期：2019-07-01 00:00:00
abstract：:The tear film, lacrimal glands, corneal and conjunctival epithelia and Meibomian glands work together as a lacrimal functional unit (LFU) to preserve the integrity and function of the ocular surface. The integrity of this unit is necessary for the health and normal function of the eye and visual system. Nervous connec...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/j.preteyeres.2012.02.003
更新日期：2012-05-01 00:00:00
abstract：:Age-related macular degeneration (AMD) is a common cause of irreversible visual loss and the disease burden is rising world-wide as the population ages. Both environmental and genetic factors contribute to the development of this disease. Among environmental factors, smoking, obesity and dietary factors including anti...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/j.preteyeres.2013.12.004
更新日期：2014-05-01 00:00:00
abstract：:The generation of expression and subtractive libraries from the ocular ciliary body and cultured ciliary epithelial cells has been instrumental in the cloning, identification and characterization of many genes which, overall reflect a representative profile of transcripts expressed in ciliary nonpigmented, ciliary pig...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/s1350-9462(98)00026-3
更新日期：1999-05-01 00:00:00
abstract：:Transforming growth factor-β-induced protein (TGFBIp), an extracellular matrix protein, is the second most abundant protein in the corneal stroma. In this review, we summarize the current knowledge concerning the expression, molecular structure, binding partners, and functions of human TGFBIp. To date, 74 mutations in...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/j.preteyeres.2020.100843
更新日期：2020-07-01 00:00:00
abstract：:Retinoblastoma is lethal by metastasis if left untreated, so the primary goal of therapy is to preserve life, with ocular survival, visual preservation and quality of life as secondary aims. Historically, enucleation was the first successful therapeutic approach to decrease mortality, followed over 100 years ago by th...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/j.preteyeres.2019.05.005
更新日期：2019-11-01 00:00:00
abstract：:Although the tear film has been extensively studied as it exists in the open eye state, until recently very little was known as to what happens to the tear film on eye closure. Recent studies have shown that eye closure results in a profound change in the composition, origins, turnover and physiological functions of t...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/s1350-9462(00)00006-9
更新日期：2000-11-01 00:00:00
abstract：:Disturbances in the retinal vascular supply are involved in the pathophysiology of the most frequent diseases causing visual impairment and blindness in the Western World. These diseases are diagnosed by noting how morphological lesions in the retina vary in shape, size, location and dynamics, and subsequently conclud...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/j.preteyeres.2013.07.002
更新日期：2013-09-01 00:00:00
abstract：:Leber congenital amaurosis (LCA) is the most severe retinal dystrophy causing blindness or severe visual impairment before the age of 1 year. Linkage analysis, homozygosity mapping and candidate gene analysis facilitated the identification of 14 genes mutated in patients with LCA and juvenile retinal degeneration, whi...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/j.preteyeres.2008.05.003
更新日期：2008-07-01 00:00:00
