Abstract:
PURPOSE:To evaluate the efficacy of topical mitomycin-C (MMC) for treatment of postoperative residual conjunctival squamous cell carcinoma (SCC). DESIGN:Retrospective noncomparative case series. PARTICIPANTS:Five patients, two males and three females, with conjunctival and histologically proven incompletely excised conjunctival SCC. METHODS:Patients were treated with topical MMC. Two to three courses of topical MMC, 0.02% or 0.04%, were applied four times daily for 14 days per course. One month after the final treatment, the scar area with surrounding normal conjunctiva was excised, and histologic evaluation was done. MAIN OUTCOME MEASURES:No evidence of malignant cells in excised tissues. RESULTS:Histologic evaluation of the five specimens showed no malignant cells. Conjunctival scarring with inflammatory response was observed. No regrowth was reported during the follow-up period of 18 to 37 months. The complications of MMC use included mild to moderate conjunctival hyperemia in three patients. All signs and symptoms were resolved after discontinuation of the treatment. CONCLUSIONS:Application of topical MMC is an efficient treatment for residual conjunctival SCC. Longer follow-up is required to confirm these findings.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Frucht-Pery J,Rozenman Y,Pe'er Jdoi
10.1016/s0161-6420(01)00967-8subject
Has Abstractpub_date
2002-03-01 00:00:00pages
548-52issue
3eissn
0161-6420issn
1549-4713pii
S0161-6420(01)00967-8journal_volume
109pub_type
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