Survival of leukemic B cells promoted by engagement of the antigen receptor.

abstract：:Protective protein/cathepsin A (PPCA), a lysosomal carboxypeptidase, is deficient in the neurodegenerative lysosomal disorder galactosialidosis (GS). PPCA(-/-) mice display a disease course similar to that of severe human GS, resulting in nephropathy, ataxia, and premature death. Bone marrow transplantation (BMT) in m...

journal_title：Blood

authors： Leimig T,Mann L,Martin Mdel P,Bonten E,Persons D,Knowles J,Allay JA,Cunningham J,Nienhuis AW,Smeyne R,d'Azzo A

更新日期：2002-05-01 00:00:00

abstract：:The human immunodeficiency virus (HIV) causes impairment of the immune system in part by targeting CD4(+) T cells for infection and dysfunction. HIV envelope (Env) present on free virions and infected cells causes dysfunction of uninfected bystander CD4(+) T cells via interaction with both CD4 and coreceptors. Env is ...

journal_title：Blood

authors： Fernando K,Hu H,Ni H,Hoxie JA,Weissman D

更新日期：2007-03-15 00:00:00

abstract：:The inv(11)(p15q22) is a recurrent chromosomal abnormality associated with de novo and therapy-related myeloid malignancies. Here we report the molecular definition of this chromosomal aberration in four patients. Positional cloning showed the consistent rearrangement of the DDX10 gene on chromosome 11q22, which encod...

journal_title：Blood

authors： Arai Y,Hosoda F,Kobayashi H,Arai K,Hayashi Y,Kamada N,Kaneko Y,Ohki M

更新日期：1997-06-01 00:00:00

abstract：:The importance of glutamine (Gln) metabolism in multiple myeloma (MM) cells and its potential role as a therapeutic target are still unknown, although it has been reported that human myeloma cell lines (HMCLs) are highly sensitive to Gln depletion. In this study, we found that both HMCLs and primary bone marrow (BM) C...

journal_title：Blood

authors： Bolzoni M,Chiu M,Accardi F,Vescovini R,Airoldi I,Storti P,Todoerti K,Agnelli L,Missale G,Andreoli R,Bianchi MG,Allegri M,Barilli A,Nicolini F,Cavalli A,Costa F,Marchica V,Toscani D,Mancini C,Martella E,Dall'Asta V

更新日期：2016-08-04 00:00:00

abstract：:A 53-yr-old man sequentially developed aplastic anemia from phenytoin and carbamazepine. Both compounds undergo metabolism to potentially toxic arene oxide intermediates. We tested the hypothesis that the patient's adverse reactions were due to a defect in detoxification of such metabolites by challenging his peripher...

journal_title：Blood

authors： Gerson WT,Fine DG,Spielberg SP,Sensenbrenner LL

更新日期：1983-05-01 00:00:00

abstract：:Acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) are associated with disease-initiating stem cells that are not eliminated by conventional therapies. Novel therapeutic targets against preleukemic stem cells need to be identified for potentially curative strategies. We conducted parallel transcriptional...

journal_title：Blood

authors： Schinke C,Giricz O,Li W,Shastri A,Gordon S,Barreyro L,Bhagat T,Bhattacharyya S,Ramachandra N,Bartenstein M,Pellagatti A,Boultwood J,Wickrema A,Yu Y,Will B,Wei S,Steidl U,Verma A

更新日期：2015-05-14 00:00:00

abstract：:PAX5-JAK2 has recently been identified as a novel recurrent fusion gene in B-cell precursor acute lymphoblastic leukemia, but the function of the encoded chimeric protein has not yet been characterized in detail. Herein we show that the PAX5-JAK2 chimera, which consists of the DNA-binding paired domain of PAX5 and the...

journal_title：Blood

authors： Schinnerl D,Fortschegger K,Kauer M,Marchante JR,Kofler R,Den Boer ML,Strehl S

更新日期：2015-02-19 00:00:00

abstract：:Although the potential role of Pim2 as a cooperative oncogene has been well described in lymphoma, its role in leukemia has remained largely unexplored. Here we show that high expression of Pim2 is observed in patients with acute promyelocytic leukemia (APL). To further characterize the cooperative role of Pim2 with p...

journal_title：Blood

authors： Agrawal-Singh S,Koschmieder S,Gelsing S,Stocking C,Stehling M,Thiede C,Thoennissen NH,Köhler G,Valk PJ,Delwel R,Mills K,Bäumer N,Tickenbrock L,Hansen K,Berdel WE,Müller-Tidow C,Serve H

更新日期：2010-06-03 00:00:00

abstract：:The initial B-cell repertoire is generated by combinatorial immunoglobulin V(D)J gene segment rearrangements that occur in a preferential sequence. Because cellular proliferation occurs during the course of these rearrangement events, it has been proposed that intraclonal diversification occurs during this phase of B-...

journal_title：Blood

authors： Wang YH,Zhang Z,Burrows PD,Kubagawa H,Bridges SL Jr,Findley HW,Cooper MD

更新日期：2003-02-01 00:00:00

abstract：:Rituximab therapy is associated with a long in vivo persistence, yet little is known about the effect of circulating rituximab on B-cell non-Hodgkin lymphoma (B-NHL) targeting by the other available anti-CD20 monoclonal antibodies (MoAbs) (131)iodine-tositumomab and (90)yttrium-ibritumomab tiuxetan. Therefore we asses...

journal_title：Blood

authors： Gopal AK,Press OW,Wilbur SM,Maloney DG,Pagel JM

更新日期：2008-08-01 00:00:00

abstract：:The expression of early and mature B cell markers, surface beta 2-microglobulin (B2M) and cytoplasmic immunoglobulin (clg) by aneuploid tumor cells in bone marrow aspirates from 44 patients with multiple myeloma was evaluated by correlated DNA immunofluorescence flow cytometry. Myeloma tumor cells of almost 90% of the...

journal_title：Blood

authors： Epstein J,Barlogie B,Katzmann J,Alexanian R

更新日期：1988-04-01 00:00:00

abstract：:Red cell enzymes, 2,3-diphosphoglycerate (2,3-DPG) and adenosine triphosphate (ATP), were evaluated in a 23-mo-old boy with juvenile chronic myelocytic leukemia (JCML) at the onset of his illness and 6 mo later during the accelerated phase. The activities of the age-dependent red cell enzymes, hexokinase, aldolase, py...

journal_title：Blood

authors： Travis SF

更新日期：1983-09-01 00:00:00

abstract：:In this issue of Blood, den Exter et al highlight the importance of subsegmental pulmonary emboli. ...

journal_title：Blood

authors： Raskob GE

更新日期：2013-08-15 00:00:00

abstract：:Cytogenetic analysis of leukemic cells from 2,805 children with newly diagnosed acute lymphoblastic leukemia (ALL) identified 83 cases (3%) that had a stemline with at least one isochromosome. The i(9q) was present in 28 (1%), the i(17q) in 23 (0.8%), and the i(7q) in 23 (0.8%). Other isochromosomes--i(21q), i(6p), i(...

journal_title：Blood

authors： Pui CH,Carroll AJ,Raimondi SC,Schell MJ,Head DR,Shuster JJ,Crist WM,Borowitz MJ,Link MP,Behm FG

更新日期：1992-05-01 00:00:00

abstract：:Delivery of biologically active peptides into human polymorphonuclear neutrophils (PMNs) has implications for studying cellular functions and may be therapeutically relevant. The transcription factor nuclear factor-kappaB (NF-kappaB) regulates the expression of multiple genes controlling inflammation, proliferation, a...

journal_title：Blood

authors： Choi M,Rolle S,Wellner M,Cardoso MC,Scheidereit C,Luft FC,Kettritz R

更新日期：2003-09-15 00:00:00

abstract：:The pathogenesis of thrombotic thrombocytopenic purpura (TTP) is obscure. It is manifested classically by platelet thrombi and localized microvascular endothelial cell (EC) proliferation, in the absence of an inflammatory response. It is statistically associated with human retroviral disease, but pathological studies ...

journal_title：Blood

authors： Laurence J,Mitra D,Steiner M,Staiano-Coico L,Jaffe E

更新日期：1996-04-15 00:00:00

abstract：:Activation of human normal serum with tetanus/antitetanus immune complexes (TAT-IC) resulted in increased binding of 125I-labeled interleukin-1 beta (IL-1 beta) to serum factors, as opposed to untreated serum. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) followed by autoradiography showed label...

journal_title：Blood

authors： Borth W,Urbanski A,Prohaska R,Susanj M,Luger TA

更新日期：1990-06-15 00:00:00

abstract：:Acute graft-versus-host disease (aGVHD) remains a major complication of allogeneic hematopoietic stem cell transplant (alloHSCT), underscoring the need to further elucidate its mechanisms and develop novel treatments. Based on recent observations that microRNA-155 (miR-155) is up-regulated during T-cell activation, we...

journal_title：Blood

authors： Ranganathan P,Heaphy CE,Costinean S,Stauffer N,Na C,Hamadani M,Santhanam R,Mao C,Taylor PA,Sandhu S,He G,Shana'ah A,Nuovo GJ,Lagana A,Cascione L,Obad S,Broom O,Kauppinen S,Byrd JC,Caligiuri M,Perrotti D,Hadley G

更新日期：2012-05-17 00:00:00

abstract：:Spectrin Jendouba (alpha II/31) was found in a Tunisian family. In the heterozygous state, it is associated with asymptomatic elliptocytosis and a minimal defect in spectrin dimer self-association. On partial digestion of spectrin with trypsin, an abnormal cleavage appeared following Lys 788. Peptide and DNA sequencin...

journal_title：Blood

authors： Alloisio N,Wilmotte R,Morlé L,Baklouti F,Maréchal J,Ducluzeau MT,Denoroy L,Féo C,Forget BG,Kastally R

更新日期：1992-08-01 00:00:00

abstract：:T-cell homing to secondary lymphoid tissues generally depends on chemokine-induced firm adhesion in high endothelial venules (HEVs) and is primarily mediated through the CC chemokine receptor 7 (CCR7) on lymphocytes. The CCR7 ligand designated CCL21 is considered the most important trigger because it appears constitut...

journal_title：Blood

authors： Carlsen HS,Haraldsen G,Brandtzaeg P,Baekkevold ES

更新日期：2005-07-15 00:00:00

abstract：:Using urea-solubilized human fibrin monomer as an immunogen, we raised in mice a battery of monoclonal antibodies that reacted with the immunogen but not with urea-treated or native fibrinogen. Although they all failed to react with acid-solubilized fibrin monomer (acid-FM) alone, an antibody designated as IF-43 was f...

journal_title：Blood

authors： Soe G,Kohno I,Inuzuka K,Itoh Y,Matsuda M

更新日期：1996-09-15 00:00:00

abstract：:We investigated the effects of interleukin-4 (IL-4) on the survival of leukemic and normal B-cell progenitors cultured on bone marrow stroma. IL-4 (at 100 U/mL) was cytotoxic in 16 of 21 cases of B-lineage acute lymphoblastic leukemia, causing reductions in CD19+ cell numbers that ranged from 50% to greater than 99% (...

journal_title：Blood

authors： Manabe A,Coustan-Smith E,Kumagai M,Behm FG,Raimondi SC,Pui CH,Campana D

更新日期：1994-04-01 00:00:00

abstract：:In eighty-three patients with confirmed deep vein thrombosis, the fibrinolytic system was studied before and after a 10-minute venous occlusion. Blood was collected at least 3 months after the last acute episode, and PAI-1 antigen and activity, as well as tissue-type plasminogen activator (t-PA) antigen, urokinase-typ...

journal_title：Blood

authors： Nguyen G,Horellou MH,Kruithof EK,Conard J,Samama MM

更新日期：1988-08-01 00:00:00

abstract：:Endothelial progenitor cells are critically involved in essential biologic processes, such as vascular homeostasis, regeneration, and tumor angiogenesis. Endothelial colony-forming cells (ECFCs) are endothelial progenitor cells with robust proliferative potential. Their profound vessel-forming capacity makes them a pr...

journal_title：Blood

authors： Reinisch A,Hofmann NA,Obenauf AC,Kashofer K,Rohde E,Schallmoser K,Flicker K,Lanzer G,Linkesch W,Speicher MR,Strunk D

更新日期：2009-06-25 00:00:00

abstract：:Interleukin-3 (IL-3) has been shown to be a promising agent in the stimulation of bone marrow regeneration following myeloablative therapy. The biologic half-life of this agent is very short (5 to 15 minutes), which limits the effectiveness of low-dose therapy. Here we show that the biologic effects of low-dose IL-3 i...

journal_title：Blood

authors： Jones AT,Ziltener HJ

更新日期：1993-08-15 00:00:00

abstract：:We have amplified and sequenced the 5' flanking and the second intervening sequence (IVS-II) regions of both the G gamma- and A gamma-globin genes of the beta S chromosomes from sickle cell anemia (SS) patients with homozygosities for five different haplotypes. The sequencing data, compared with previously published s...

journal_title：Blood

authors： Lanclos KD,Oner C,Dimovski AJ,Gu YC,Huisman TH

更新日期：1991-06-01 00:00:00

abstract：:Two distinct classes of granulocyte progenitor cells present in normal mouse bone marrow are expressed sequentially in the vivo plasma clot diffusion chamber culture system. By several criteria, progenitor cells giving rise to granulocyte colonies on day 4 of culture (CFU-D4) are different from those giving rise to co...

journal_title：Blood

authors： Steinberg HN,Page PL,Robinson SH

更新日期：1982-04-01 00:00:00

abstract：:Administration of lymphodepletion chemotherapy followed by CD19-specific chimeric antigen receptor (CAR)-modified T cells is a remarkably effective approach to treating patients with relapsed and refractory CD19(+) B-cell malignancies. We treated 7 patients with B-cell acute lymphoblastic leukemia (B-ALL) harboring re...

journal_title：Blood

authors： Gardner R,Wu D,Cherian S,Fang M,Hanafi LA,Finney O,Smithers H,Jensen MC,Riddell SR,Maloney DG,Turtle CJ

更新日期：2016-05-19 00:00:00

abstract：:Hypomethylating agents (HMAs) improve survival in patients with higher-risk myelodysplastic syndromes (MDS) but are less well-studied in lower-risk disease. We compared the safety and efficacy of low-dose decitabine vs low-dose azacitidine in this group of patients. Adults with low- or intermediate 1-risk MDS or MDS/m...

journal_title：Blood

authors： Jabbour E,Short NJ,Montalban-Bravo G,Huang X,Bueso-Ramos C,Qiao W,Yang H,Zhao C,Kadia T,Borthakur G,Pemmaraju N,Sasaki K,Estrov Z,Cortes J,Ravandi F,Alvarado Y,Komrokji R,Sekeres MA,Steensma DP,DeZern A,Roboz G,

更新日期：2017-09-28 00:00:00

abstract：:The adhesion of leukocytes to platelets deposited at the site of vascular injury may represent an important mechanism by which leukocytes contribute to hemostasis and thrombosis. In this study, we examined whether, in comparison with their distribution in circulating blood, certain leukocyte types are enriched at site...

journal_title：Blood

authors： Kirchhofer D,Riederer MA,Baumgartner HR

更新日期：1997-02-15 00:00:00