Abstract：
:Chronic graft-versus-host disease (cGVHD) is a complex clinical entity with various target organs, including the salivary glands. Oral pilocarpine (Salagen(R)), 30 mg/day, can ameliorate cGVHD-induced xerostomia and improve the flow rate from the major salivary glands. The purpose here was to evaluate the effect of this drug at 30 mg/day on salivary biochemical and immunological composition in cGVHD patients. Significantly higher concentrations of salivary sodium (Na), magnesium (Mg), total protein, albumin, epidermal growth factor (EGF) and total IgG, accompanied by a concomitant increase in total IgA which did not reach significance, were observed in cGVHD patients in comparison with controls, in both resting and stimulated conditions (p < 0.05), while salivary potassium, calcium and phosphate were not altered. Two weeks of oral pilocarpine, at 30 mg/day, resulted in normalization of the altered salivary biochemical and immunological composition in the cGVHD patients. Oral pilocarpine was able to reduce and normalise the elevated Na, Mg, total protein, albumin, EGF, IgG and IgA concentrations in both resting and stimulated conditions. The ability of oral pilocarpine to normalise and reverse the salivary biochemical and immunological alterations induced by cGVHD parallels its known stimulatory effect on salivary flow rates. As the biochemical and immunological composition of saliva provides its protective antimicrobial characteristics, the ability of pilocarpine to abrogate cGVHD salivary gland abnormalities may be of clinical significance.
journal_name
Arch Oral Bioljournal_title
Archives of oral biologyauthors
Nagler RM,Nagler Adoi
10.1016/s0003-9969(01)00035-8subject
Has Abstractpub_date
2001-08-01 00:00:00pages
689-95issue
8eissn
0003-9969issn
1879-1506pii
S0003-9969(01)00035-8journal_volume
46pub_type
杂志文章abstract：OBJECTIVE:To identify the genetic risk markers of aggressive periodontitis (AgP), researchers focus on genetic components that regulate the immune response. Therefore the purpose of this study was to investigate genetic impact of monocyte chemoattractant protein (MCP)-1-2518A/G and CC chemokine receptor 2 (CCR2) -190G/...
journal_title：Archives of oral biology
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更新日期：2017-08-01 00:00:00
abstract：OBJECTIVE:To explore the gene mutation in an incontinentia pigmenti (IP) patient with syndromic tooth agenesis. METHODS:Long-range polymerase chain reaction (PCR) and Sanger sequencing were used to detect inhibitor of nuclear factor kappa-B kinase subunit gamma (IKBKG) mutation in the IP patient. We used the nuclear f...
journal_title：Archives of oral biology
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doi：10.1016/j.archoralbio.2019.03.013
更新日期：2019-05-01 00:00:00
abstract：:Although mechanisms underlying chronic muscle pain are poorly understood, one prevalent theory is that it is due, in part, to localized hypoxia. The purpose of this study was to evaluate this theory using non-invasive near-infra-red spectroscopy that monitors relative changes in intramuscular haemoglobin (Hb) concentr...
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doi：10.1016/0003-9969(96)00009-x
更新日期：1996-06-01 00:00:00
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journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/j.archoralbio.2011.04.016
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abstract：:Albumin and alpha 2-macroglobulin were analysed in gingival fluid collected by filter paper strips from 6 volunteers before, during and after 10 days of dental plaque accumulation. The two proteins were also determined in samples of venous blood at the beginning of abstention from tooth brushing and 10 days later. A n...
journal_title：Archives of oral biology
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doi：10.1016/0003-9969(90)90107-l
更新日期：1990-01-01 00:00:00
abstract：:Stem cells possess multipotent properties that allow them to differentiate into various cells, which may be potentially useful in tissue regeneration. Stem cell populations are reported to be present in various tissues of hematopoietic, neural and mesenchymal lineages, with the presence of stem cell populations in den...
journal_title：Archives of oral biology
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doi：10.1016/s0003-9969(03)00012-8
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journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/0003-9969(87)90022-7
更新日期：1987-01-01 00:00:00
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journal_title：Archives of oral biology
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更新日期：1994-07-01 00:00:00
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journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/j.archoralbio.2004.10.006
更新日期：2005-02-01 00:00:00
abstract：UNLABELLED:Tooth enamel is formed by ameloblasts, which are derived from the epithelial cells of the enamel organ. OBJECTIVE:The purpose of this study was to grow human ameloblast-like epithelial cells in culture. DESIGN:Human fetal tooth organs were isolated, and the cells were separated by digestion in collagenase/...
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pub_type： 杂志文章
doi：10.1016/j.archoralbio.2004.12.008
更新日期：2005-08-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.archoralbio.2011.10.017
更新日期：2012-05-01 00:00:00
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journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/j.archoralbio.2015.10.021
更新日期：2016-01-01 00:00:00
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journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/0003-9969(85)90116-5
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journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/0003-9969(93)90094-3
更新日期：1993-10-01 00:00:00
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journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/0003-9969(83)90066-3
更新日期：1983-01-01 00:00:00
abstract：:Apoptosis in regressive primary (deciduous) dental primordia was examined in the embryos of Suncus murinus, which is a monophyodont. The primary tooth germs of S. murinus are temporarily formed and disappear during the embryonic period before they are calcified. Most primary tooth germs reach the bell stage and degene...
journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/s0003-9969(01)00007-3
更新日期：2001-07-01 00:00:00
abstract：:Green tea is a leading beverage in the Far East for thousands of years; it is regarded for a long time as a health product. Green tea is important source of polyphenol antioxidants. Polyphenols including epigallocatechin 3 gallate (EGCG) constitute the most interesting components in green tea leaves. Green tea has the...
journal_title：Archives of oral biology
pub_type： 杂志文章,评审
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更新日期：2012-05-01 00:00:00
abstract：:The ability of cadmium (Cd) to induce the synthesis of metallothionein (MT) in the developing teeth of the rat was investigated. Rats were given daily intraperitoneal injections of cadmium chloride (1.5 mg Cd/kg) for 7 days. The induction of MT synthesis in incisor teeth after Cd treatment was investigated immunohisto...
journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/s0003-9969(98)00088-0
更新日期：1999-01-01 00:00:00
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journal_title：Archives of oral biology
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doi：10.1016/j.archoralbio.2014.05.014
更新日期：2014-10-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.archoralbio.2004.06.006
更新日期：2005-01-01 00:00:00
abstract：OBJECTIVE:Increasing attention has been given to the potential protective roles of specific antioxidant nutrients found in fruits and vegetables. However, there are relatively few reports on the cancer chemopreventive effects of lycopene or tomato carotenoids in animal models. Therefore, the chemopreventive efficacy of...
journal_title：Archives of oral biology
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doi：10.1016/j.archoralbio.2010.12.007
更新日期：2011-07-01 00:00:00
abstract：OBJECTIVE:To compare the effectiveness and acceptability of a newly developed pediatric sialometer as an alternative to the conventional spitting method. METHODS:A clinical study was carried out with healthy children (G1; n = 30) and oncological children (G2; n = 30). A newly developed pediatric sialometer was compare...
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pub_type： 杂志文章
doi：10.1016/j.archoralbio.2020.104847
更新日期：2020-10-01 00:00:00
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journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/0003-9969(86)90030-0
更新日期：1986-01-01 00:00:00
abstract：OBJECTIVE:Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is a birth defect for which several genes susceptibility genes been proposed. Consequently, it has been suggested that many of these genes belong to common inter-related pathways during craniofacial development gene-gene interaction. We evaluated th...
journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/j.archoralbio.2018.04.009
更新日期：2018-07-01 00:00:00
abstract：:Destrin, an actin-binding protein, is partly phosphorylated at Ser-2 (numbering on the matured form) in the resting rat parotid gland, and beta-adrenergic or cholinergic stimulation of this gland induces its dephosphorylation. In this study, we searched for the protein kinase involved in phosphorylation of destrin. We...
journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/s0003-9969(03)00129-8
更新日期：2003-09-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to analyse the antibacterial effects of Emdogain Gel or its constituents on the growth of the suspected periodontopathogen Porphyromonas gingivalis. STUDY DESIGN:The effects of the proteins of enamel matrix derivative (EMD), the commercial product Emdogain Gel or its vehicle propyle...
journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/j.archoralbio.2005.07.005
更新日期：2006-03-01 00:00:00
abstract：:A variable capacitance displacement transducer, previously employed for continuously monitoring movements of the rabbit mandibular incisor, was modified for use with the ferret mandibular canine. Comparing this tooth of limited growth with the tooth of continuous growth, similarities were seen in the reactions to extr...
journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/0003-9969(83)90177-2
更新日期：1983-01-01 00:00:00
abstract：OBJECTIVE:Biofilms are complex, multi-species bacterial communities that colonize the oral cavity in the form of plaque and are known to cause dental caries and periodontal disease. Present study demonstrated the potential of three selected medicinal plants against isolated and identified dental biofilm forming strains...
journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/j.archoralbio.2017.05.011
更新日期：2017-09-01 00:00:00
abstract：OBJECTIVES:This research investigates the ability of live and heat-killed (HK) Lactic Acid Bacteria (LAB) to interfere with Streptococcus mutans ATCC 25175 and Streptococcus oralis ATCC 9811 during biofilm formation. DESIGN:Eight Lactobacillus spp. and two oral colonizers, pathogenic Streptococcus mutans and resident ...
journal_title：Archives of oral biology
pub_type： 杂志文章
doi：10.1016/j.archoralbio.2017.02.004
更新日期：2017-06-01 00:00:00
