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Oral microbial colonization in children with sickle cell anaemia under long-term prophylaxis with penicillin.

Abstract：

BACKGROUND AND OBJECTIVE:Sickle cell anaemia (SCA) is the most frequent haematological hereditary disease. Children with SCA are submitted to long-term prophylactic therapy with penicillin, but little is known about its impact on oral microflora. The aim of this study was to evaluate the oral microbial colonization of paediatric patients with SCA. DESIGN:Forty children (4-11yrs old) with SCA (genotype SS) under long-term prophylactic treatment with penicillin were included in the study. Age/gender-matched control group of healthy children was also included. Scores of dmft/DMFT (number of decayed (D), missing (M), or filled (F) teeth; dmft, for primary dentition; DMFT, for permanent dentition) were obtained and stimulated saliva was sampled. Salivary flow rate and buffering capacity were evaluated. Counts of microorganisms (mutans streptococci, lactobacilli and yeasts) were determined by plating method. Yeasts were identified by API 20C AUX and PCR. RESULTS:Mean dmft/DMFT values were similar in the studied groups (SCA 2.13/1.60 and control 2.38/1.3). Although no significant differences between cariogenic microorganism counts were observed, significantly higher yeasts oral levels were observed in SCA group. Controls showed lower salivary buffering capacity. Candida albicans was the most frequently isolated species in both groups. Candida famata, Candida parapsilosis and Candida tropicalis were also isolated from controls. Candida dubliniensis, Candida rugosa and Candida sphaerica were found only in SCA group. CONCLUSIONS:Based on the results, it could be concluded that paediatric patients with SCA showed significantly higher oral level of yeasts. Uncommon fungal species were found in SCA group. Similar caries prevalence and counts of lactobacilli and streptococci in relation to controls were observed.

journal_name

Arch Oral Biol

journal_title

Archives of oral biology

authors

de Matos BM,Ribeiro ZE,Balducci I,Figueiredo MS,Back-Brito GN,Mota AJ,Braga JA,Koga-Ito CY

doi

10.1016/j.archoralbio.2014.05.014

subject

Has Abstract

pub_date

2014-10-01 00:00:00

pages

1042-7

issue

eissn

0003-9969

issn

1879-1506

pii

S0003-9969(14)00116-2

journal_volume

pub_type

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Oral microbial colonization in children with sickle cell anaemia under long-term prophylaxis with penicillin.