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Participation of the conjugated diene part for potent cytotoxicity of callystatin A, a spongean polyketide.

Abstract：

:5-epi, 10-epi, 8-Deethyl, and 10-demethyl analogues of callystatin A, a potent cytotoxic spongean polyketide, were synthesized to elucidate structure-requirement for cytotoxic potency. Inversion of the asymmetric center at C-10 in callystatin A minimally affected the activity, while lack of the 10-methyl group in callystatin A decreased cytotoxicity. In addition, the C-5 epimer and the 8-deethyl analogue of callystatin A showed weaker cytotoxicity.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Murakami N,Sugimoto M,Nakajima T,Kawanishi M,Tsutsui Y,Kobayashi M

doi

10.1016/s0968-0896(00)00199-1

subject

Has Abstract

pub_date

2000-11-01 00:00:00

pages

2651-61

issue

11

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(00)00199-1

journal_volume

8

pub_type

杂志文章

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