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Synthesis and anti-inflammatory activity of indole glucosinolates.

Abstract：

:The nitronate and nitrovinyl methods to synthesize indole glucosinolates (GLs) have been investigated. The results were applied to generally the most prevalent natural indole glucosinolates to synthesize 4-methoxyglucobrassicin (MGB) and neo-glucobrassicin (NGB) in moderate overall yield for the first time. The anti-inflammatory activity of the synthetic indole GLs was determined by inhibition of TNF-α secretion in LPS-stimulated THP-1 cells. The data showed that glucobrassicin (GB) exhibited higher activity than other synthetic indolyl GLs.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Vo QV,Trenerry C,Rochfort S,Wadeson J,Leyton C,Hughes AB

doi

10.1016/j.bmc.2013.12.003

subject

Has Abstract

pub_date

2014-01-15 00:00:00

pages

856-64

issue

2

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(13)00997-8

journal_volume

22

pub_type

杂志文章

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