Expression of three zebrafish Six4 genes in the cranial sensory placodes and the developing somites.

abstract：:ADAMs are multidomain cell surface proteins that function in receptor-ligand processing, cell adhesion and fusion, and signaling. SpADAM, a single copy sea urchin ADAM gene with a 3072 bp open reading frame, is expressed during embryonic and larval development. The deduced SpADAM protein is 1023 amino acids long and i...

journal_title：Mechanisms of development

authors： Rise M,Burke RD

更新日期：2002-09-01 00:00:00

abstract：:To analyse the possible roles of Drosophila tumour suppressor genes, 1(2)gl and 1(2)gd, in differentiation programmes of imaginal cells, we investigated their interactions with two segment polarity genes, viz., cubitus interruptus Dominant (ci-D) and engrailed (en), by examining their patterns of expression in tumouro...

journal_title：Mechanisms of development

authors： Mukherjee A,Lakhotia SC,Roy JK

更新日期：1995-06-01 00:00:00

abstract：:Myogenic regulatory factors (MRFs) are known to have essential roles in both the establishment and differentiation of the skeletal muscle cell lineage. MyoD is expressed early in the Xenopus mesoderm where it is present and active several hours before the activation of muscle differentiation genes. Previous studies in...

journal_title：Mechanisms of development

authors： McQueen C,Pownall ME

更新日期：2017-08-01 00:00:00

abstract：:Mammalian embryos develop in coordination with extraembryonic tissues, which support embryonic development by implanting embryos into the uterus, supplying nutrition, providing a confined niche, and also providing patterning signals to embryos. Here, we show that in mouse embryos, the expansion of the amniotic cavity ...

journal_title：Mechanisms of development

authors： Imuta Y,Koyama H,Shi D,Eiraku M,Fujimori T,Sasaki H

更新日期：2014-05-01 00:00:00

abstract：:Transforming growth factor beta 2 (TGF-beta2) plays a critical role in growth, differentiation and cell death, but its function in the developing cerebellum is still uncertain. In this study we analyzed the effects of TGF-beta2 on ex vivo developing cerebellar slice cultures. Proliferation of granule cell precursors p...

journal_title：Mechanisms of development

authors： Elvers M,Pfeiffer J,Kaltschmidt C,Kaltschmidt B

更新日期：2005-04-01 00:00:00

abstract：:Transcription of the human interphotoreceptor retinoid binding protein (IRBP) gene is strictly tissue specific, being restricted to retinal photoreceptors and pinealocytes. We have previously demonstrated that a sequence named A element, in the IRBP promoter is essential for IRBP gene transcription in vivo. Here we de...

journal_title：Mechanisms of development

authors： Bobola N,Briata P,Ilengo C,Rosatto N,Craft C,Corte G,Ravazzolo R

更新日期：1999-04-01 00:00:00

abstract：:The growth and patterning of Drosophila wing and notum primordia depend on their subdivision into progressively smaller domains by secreted signals that emanate from localized sources termed organizers. While the mechanisms that organize the wing primordium have been studied extensively, those that organize the notum ...

journal_title：Mechanisms of development

authors： Del Signore SJ,Hayashi T,Hatini V

更新日期：2012-07-01 00:00:00

abstract：:We present a complete staging table of normal development for the lungless salamander, Hemidactylium scutatum (Caudata: Plethodontidae). Terrestrial egg clutches from naturally ovipositing females were collected and maintained at 15 °C in the laboratory. Observations, photographs, and time-lapse movies of embryos were...

journal_title：Mechanisms of development

authors： Hurney CA,Babcock SK,Shook DR,Pelletier TM,Turner SD,Maturo J,Cogbill S,Snow MC,Kinch K

更新日期：2015-05-01 00:00:00

abstract：:We have made a null mutation in the mouse activin beta B gene by deleting the portion of the gene encoding the proteolytic cleavage site and the majority of the coding region for the mature processed protein. Mice homozygous for this mutation complete embryogenesis and are completely viable. Approximately 40% of the h...

journal_title：Mechanisms of development

authors： Schrewe H,Gendron-Maguire M,Harbison ML,Gridley T

更新日期：1994-07-01 00:00:00

abstract：:The segmentation of vertebrate embryos depends on a complex genetic network that generates highly dynamic gene expression. Many of the elements of the network have been identified, but their interaction and their influence on segmentation remain poorly understood. A few mathematical models have been proposed to explai...

journal_title：Mechanisms of development

authors： Cinquin O

更新日期：2007-08-01 00:00:00

abstract：:The Bar homeobox genes play an essential role during nervous system and eye development in Drosophila. We isolated a medaka Bar gene closely related to the Drosophila and mammalian Bar genes. In the medaka embryo, OlBar is expressed from gastrula stages onwards, in a region demarcating the presumptive prosencephalic-m...

journal_title：Mechanisms of development

authors： Poggi L,Carl M,Vignali R,Barsacchi G,Wittbrodt J

更新日期：2002-06-01 00:00:00

abstract：:To investigate the origin and nature of the signals responsible for specification of the dermatomal lineage, excised axial organs in 2-day-old chick embryos were replaced by grafts of the dorsal neural tube, or the ventral neural tube plus the notochord, or aggregates of cells engineered to produce Sonic hedgehog (Shh...

journal_title：Mechanisms of development

authors： Olivera-Martinez I,Thélu J,Teillet MA,Dhouailly D

更新日期：2001-02-01 00:00:00

abstract：:We have cloned a chick homologue of Drosophila dachshund (dac), termed Dach1. Dach1 is the orthologue of mouse and human Dac/Dach (hereafter referred to as Dach1). We show that chick Dach1 is expressed in a variety of sites during embryonic development, including the eye and ear. Previous work has demonstrated the exi...

journal_title：Mechanisms of development

authors： Heanue TA,Davis RJ,Rowitch DH,Kispert A,McMahon AP,Mardon G,Tabin CJ

更新日期：2002-02-01 00:00:00

abstract：:The spatial and temporal expression of seven Drosophila protein tyrosine phosphatase genes during oogenesis was examined by whole mount in-situ hybridization of antisense RNA probes to ovaries. Our observations indicate diverse expression patterns consistent with multiple roles for protein tyrosine phosphatases in the...

journal_title：Mechanisms of development

authors： Fitzpatrick KA,Gorski SM,Ursuliak Z,Price JV

更新日期：1995-10-01 00:00:00

abstract：:CD44, the major cell-surface receptor for hyaluronate, is expressed on many cell types to mediate different functions including cell activation, homing and adhesion. The early pattern of CD44 expression was determined in the avian embryo by using a specific monoclonal antibody in whole-mount and tissue sections. CD44 ...

journal_title：Mechanisms of development

authors： Corbel C,Lehmann A,Davison F

更新日期：2000-08-01 00:00:00

abstract：:The normal embryogenesis of marine animals is typically confined to a species-specific range of temperatures. Within that temperature range development results in a consistent, or canalized, phenotype, whereas above and below the range abnormal phenotypes are produced. This study reveals a high temperature threshold, ...

journal_title：Mechanisms of development

authors： Irvine SQ,McNulty KB,Siler EM,Jacobson RE

更新日期：2019-06-01 00:00:00

abstract：:We describe the structural organization of a gene, termed XFDL 141/156, that is transiently activated during early Xenopus development. XFDL 141/156 is first transcribed at the midblastula transition (MBT) and during early gastrulation events. A roughly 200 nucleotide fragment immediately 5' to the transcription start...

journal_title：Mechanisms of development

authors： Bellefroid E,Bourguignon C,Bouwmeester T,Rausch O,Blumberg B,Pieler T

更新日期：1997-04-01 00:00:00

abstract：:The gastrointestinal tract is subdivided into regions with different roles in digestion and absorption. How this patterning is established is unknown. We now report that the pancreatic-duodenal homeobox 1 gene (pdx1) is also expressed in cells of the distal stomach. Positive cells include subpopulations of the three m...

journal_title：Mechanisms of development

authors： Larsson LI,Madsen OD,Serup P,Jonsson J,Edlund H

更新日期：1996-12-01 00:00:00

abstract：:The homeobox gene superfamily is highly conserved during evolution. These genes act as transcription factors during several important developmental processes through their 60 amino acid homeodomains that recognize and bind to the regulatory region of their target genes. We isolated a novel homeobox gene designated Tex...

journal_title：Mechanisms of development

authors： Lai YL,Li H,Chiang HS,Hsieh-Li HM

更新日期：2002-05-01 00:00:00

abstract：:Smad5, together with Smad1 and Smad8, have been implicated as downstream signal mediators for several bone morphogenetic proteins (BMPs). Recent studies have shown that primordial germ cells (PGCs) are absent or greatly reduced in Bmp4 or Bmp8b mutant mice. To define the role of Smad5 in PGC development, we examined P...

journal_title：Mechanisms of development

authors： Chang H,Matzuk MM

更新日期：2001-06-01 00:00:00

abstract：:In mammals, the Ror-family receptor tyrosine kinases consist of two structurally related proteins, Ror1 and Ror2, characterized by the extracellular Frizzled-like cysteine-rich domain and membrane proximal kringle domains. As an attempt to gain insights into their roles in mouse development, expression patterns of Ror...

journal_title：Mechanisms of development

authors： Matsuda T,Nomi M,Ikeya M,Kani S,Oishi I,Terashima T,Takada S,Minami Y

更新日期：2001-07-01 00:00:00

abstract：:Drosophila Spitz is a homolog of transforming growth factor alpha (TGF-alpha) and is an activating ligand for the EGF receptor (Egfr). It has been shown that Star is required for Spitz activity. Here we show that Star is quantitatively limiting for Spitz production during eye development. We also show that Star and Sp...

journal_title：Mechanisms of development

authors： Hsiung F,Griffis ER,Pickup A,Powers MA,Moses K

更新日期：2001-09-01 00:00:00

abstract：:T-box genes constitute a conserved multi-gene family with important roles in many developmental processes. In this report, we describe the cloning and expression analysis of a novel mouse T-box gene, Tbx20. Expression is prominent in the extraembryonic mesoderm, in the developing heart, the eye anlage and motor neuron...

journal_title：Mechanisms of development

authors： Kraus F,Haenig B,Kispert A

更新日期：2001-01-01 00:00:00

abstract：:Drosophila melanogaster possesses a single gene, Dm myb, that is closely related to the vertebrate family of Myb genes, which encode transcription factors involved in regulatory decisions affecting cell proliferation, differentiation and apoptosis. In proliferating cells, the Dm myb gene product, DMyb, promotes both S...

journal_title：Mechanisms of development

authors： Fung SM,Ramsay G,Katzen AL

更新日期：2003-06-01 00:00:00

abstract：:The development of skeletal muscle in vertebrate embryos is controlled by a transcriptional cascade involving the four myogenic regulatory factors. In the somites of the mouse embryo the order of expression is thought to be Myf5, Myogenin, Mrf4 and MyoD. We have re-examined the expression pattern of Mrf4 and show that...

journal_title：Mechanisms of development

authors： Summerbell D,Halai C,Rigby PW

更新日期：2002-09-01 00:00:00

abstract：:We isolated and characterized embryonic lethal mutations in piragua (prg). The prg locus encodes a protein with an amino terminus Zinc Finger-Associated-Domain (ZAD) and nine C2H2 zinc fingers (ZF). prg mRNA and protein expression during embryogenesis is dynamic with widespread maternal contribution, and subsequent ex...

journal_title：Mechanisms of development

authors： Nazario-Yepiz NO,Riesgo-Escovar JR

更新日期：2017-04-01 00:00:00

abstract：:NK-2 class homeobox genes are candidate patterning and lineage regulators in diverse organisms. We report here the embryonic expression pattern of murine member, Nkx2-6. In keeping with its vertebrate relatives, Nkx2-6 was transcribed in ventrolateral embryonic structures. Expression was first detected at E8.0 in endo...

journal_title：Mechanisms of development

authors： Biben C,Hatzistavrou T,Harvey RP

更新日期：1998-04-01 00:00:00

abstract：:In many animals, germline progenitors are kept undifferentiated to give rise to germline stem cells (GSCs), enabling continuous production of gametes throughout animal life. In the Drosophila ovary, GSCs arise from a subset of primordial germ cells (PGCs) that stay undifferentiated even after gametogenesis has started...

journal_title：Mechanisms of development

authors： Matsuoka S,Hiromi Y,Asaoka M

更新日期：2013-04-01 00:00:00

abstract：:Although the molecular mechanisms directing anteroposterior patterning of the Drosophila embryo (long-germband mode) are well understood, how these mechanisms were evolved from an ancestral mode of insect embryogenesis remains largely unknown. In order to gain insight into mechanisms of evolution in insect embryogenes...

journal_title：Mechanisms of development

authors： Shinmyo Y,Mito T,Matsushita T,Sarashina I,Miyawaki K,Ohuchi H,Noji S

更新日期：2005-02-01 00:00:00

abstract：:Imitation Switch (ISWI) is a member of the SWI2/SNF2 superfamily of ATP-dependent chromatin remodelers, which regulate transcription and maintain chromatin structure by mobilizing nucleosomes using the energy of ATP. Four distinct ISWI complexes have been identified in Xenopus oocytes. The developmental role of Xenopu...

journal_title：Mechanisms of development

authors： Dirscherl SS,Henry JJ,Krebs JE

更新日期：2005-11-01 00:00:00