Abstract：
PURPOSE:To determine the effect of intraoperative application of 5-fluorouracil (5-FU) on the long-term outcome of trabeculectomy in uveitis-related glaucoma. DESIGN:An open, prospective, noncomparative case study to evaluate the use of intraoperative application for 5 minutes of 25 mg/ml 5-FU in primary trabeculectomy for uveitis-related glaucoma. PARTICIPANTS:Fifty eyes of 43 consecutive patients were enrolled in the study. METHODS:Data were recorded prospectively on specifically designed forms at visits every 3 months after surgery. MAIN OUTCOME MEASURES:The intraocular pressure, need for additional medication, and the need for repeat surgery were the criteria that determined the outcome of surgery. RESULTS:No significant intraoperative, postoperative, or late complications of 5-FU administration were noted. Successful filtration was achieved in 82% of eyes at 1 and 2 years after surgery. The success rate was 67% at 5 years. Failure was significantly more common and occurred earlier in patients of black ethnic origin. No deleterious effect on control of uveitis in relation to surgical intervention was observed. CONCLUSIONS:Intraoperative application of 5-FU appears to be a long-term, safe, and effective adjunct to trabeculectomy in uveitis-related glaucoma.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Towler HM,McCluskey P,Shaer B,Lightman Sdoi
10.1016/s0161-6420(00)00351-1subject
Has Abstractpub_date
2000-10-01 00:00:00pages
1822-8issue
10eissn
0161-6420issn
1549-4713pii
S0161-6420(00)00351-1journal_volume
107pub_type
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