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Tyrosine as important contributor to the antioxidant capacity of seminal plasma.

Abstract：

:A novel post-addition method, based on the trapping of ABTS-radicals, is applied for studying the total antioxidant capacity of seminal plasma. A remarkable profile is observed, in which seminal plasma quenches radicals in a continuous, relatively slow fashion. Five putative antioxidants present in seminal plasma were studied using the same assay. Some of the compounds such as ascorbic acid, alpha-tocopherol and uric acid exert immediate, fast radical trapping, whereas hypotaurine and tyrosine give rise to the same slow radical trapping curve as seminal plasma. Due to this slow, continuous radical trapping, quantification of the total antioxidant capacity (expressed as trolox equivalent antioxidant capacity, TEAC) strongly depends on the chosen time point after onset of radical trapping. When determined during the slow antioxidant trapping phase, tyrosine has a powerful antioxidant capacity, which in combination with its relatively high plasma concentration makes it an important contributor to the total antioxidant capacity of seminal plasma.

journal_name

Chem Biol Interact

journal_title

Chemico-biological interactions

authors

van Overveld FW,Haenen GR,Rhemrev J,Vermeiden JP,Bast A

doi

10.1016/s0009-2797(00)00179-4

subject

Has Abstract

pub_date

2000-07-03 00:00:00

pages

151-61

issue

2

eissn

0009-2797

issn

1872-7786

pii

S0009-2797(00)00179-4

journal_volume

127

pub_type

杂志文章

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