Phenotypic and functional characteristics of tumour-derived microvascular endothelial cells.

abstract：:The colon carcinoma cell line HT-29 was used to explore the potential of interleukin-4 (IL-4) and tumor necrosis factor alpha (TNF-alpha) to modify integrin expression and adhesive functions of tumor cells in vitro and to examine corresponding metastatic effects in vivo. Preincubation of HT-29 cells with 100 U/ml of I...

journal_title：Clinical & experimental metastasis

authors： Herzberg F,Schöning M,Schirner M,Topp M,Thiel E,Kreuser ED

更新日期：1996-03-01 00:00:00

abstract：:Sentinel lymph node (SLN) identification with preoperative image guidance may improve pathological staging of prostate cancer by identifying nodes outside the standard template of dissection. Four anesthetized male dogs received an intra-prostatic injection of Ga-68-labeled tilmanocept. Every 20 min the pelvic lymph n...

journal_title：Clinical & experimental metastasis

authors： Stroup SP,Kane CJ,Farchshchi-Heydari S,James CM,Davis CH,Wallace AM,Hoh CK,Vera DR

更新日期：2012-10-01 00:00:00

abstract：:A previous study from our laboratory suggested that prostate cancer metastasis to bone may be mediated, in part, by preferential adhesion to human bone marrow endothelial (HBME) cells. Tumor cell adhesion to endothelial cells may be modulated by the effect of cytokines on cell adhesion molecules (CAMs). Tumor necrosis...

journal_title：Clinical & experimental metastasis

authors： Cooper CR,Bhatia JK,Muenchen HJ,McLean L,Hayasaka S,Taylor J,Poncza PJ,Pienta KJ

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Metastasis to bone from endometrial adenocarcinoma is rare, when metastasises it usually locates in axial skeleton. Metastasis to extremities is extremely rare. Additionally the detection of the bone metastasis as a presenting feature is uncommon. In the present study we report the 10th cases of bone metasta...

journal_title：Clinical & experimental metastasis

authors： Kaya A,Olmezoglu A,Eren CS,Bayol U,Altay T,Karapinar L,Ozturk H,Oztekin D,Guvenli Y,Karadogan I

更新日期：2007-01-01 00:00:00

abstract：:The abilities of tumor cells to extravasate from the blood vessel system and to migrate through the connective tissue are prerequisites in metastasis formation. Both processes are chiefly mediated by integrins, which mediate both cell-cell and cell-matrix interactions. We investigated the role of integrin subunits in ...

journal_title：Clinical & experimental metastasis

authors： Heyder C,Gloria-Maercker E,Hatzmann W,Niggemann B,Zänker KS,Dittmar T

更新日期：2005-01-01 00:00:00

abstract：:Tumour endothelial markers (TEMs) are a newly discovered family of endothelial markers associated with tumour specific angiogenesis. This study sought to examine the levels of expression for TEMs in human breast cancer. Breast cancer tissues (n = 120) together with normal background tissues (n = 33) were obtained afte...

journal_title：Clinical & experimental metastasis

authors： Davies G,Cunnick GH,Mansel RE,Mason MD,Jiang WG

更新日期：2004-01-01 00:00:00

abstract：:We have previously isolated a series of MCF-7 human breast cancer cell variants which no longer require estrogen-supplementation for tumor growth in nude mice (Clarke et al. Proc Natl Acad Sci USA 86: 3649-3653, 1989). We now report that these hormone-independent and hormone-responsive variants (MIII, MCF7/LCC1) can i...

journal_title：Clinical & experimental metastasis

authors： Thompson EW,Brünner N,Torri J,Johnson MD,Boulay V,Wright A,Lippman ME,Steeg PS,Clarke R

更新日期：1993-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide with increasing incidence. Despite curative surgical resection and advanced chemotherapy, its survival rate remains low. The presence of microvascular invasion and occult metastasis is one of the major causes for this poor outcome. MDM2 Binding...

journal_title：Clinical & experimental metastasis

authors： Bi Q,Ranjan A,Fan R,Agarwal N,Welch DR,Weinman SA,Ding J,Iwakuma T

更新日期：2015-04-01 00:00:00

abstract：:Intravenous infusions of perfluorochemical emulsions, combined with administration of inspired oxygen or carbogen have been found to improve tumor oxygenation and increase the response of solid tumors in animals to radiotherapy. Fluosol-DA 20 per cent, the only perfluorochemical emulsion currently approved for testing...

journal_title：Clinical & experimental metastasis

authors： Rockwell S,Irvin CG,Nierenburg M

更新日期：1986-01-01 00:00:00

abstract：:Cancer cells selected from a cultured murine fibrosarcoma by rapid migration through micropore membranes moved considerably faster through such membranes and invaded biological tissues much more efficiently than did the unselected parent cells. The present data show that populations of cells selected by unstimulated m...

journal_title：Clinical & experimental metastasis

authors： Grimstad IA

更新日期：1988-07-01 00:00:00

abstract：:In order to study the usefulness of treatment with vinblastine (VLB) in the prevention of cancer metastasis in squamous cell lung cancer, 50 patients with locoregional disease were randomized to receive either locoregional RT alone (group A) or a weekly intravenous bolus injection of VLB (6 mg/m2) concurrently with an...

journal_title：Clinical & experimental metastasis

authors： Schallier DC,De Neve WJ,De Greve JL,Van Belle SP,De Wasch GJ,Dotremont G,Storme GA

更新日期：1988-01-01 00:00:00

abstract：:A murine mammary carcinoma, which had a high potential for metastasis to the lungs, was established in culture, and from the parent line several clonally derived variants were isolated, showing different characteristics including metastatic potential. C1, a high metastatic clone, and C2, a low one, were selected for f...

journal_title：Clinical & experimental metastasis

authors： Lee AE,Rogers LA,Jeffery RE,Longcroft JM

更新日期：1988-11-01 00:00:00

abstract：:At least one-third of patients with epithelial ovarian cancer (OC) present ascites at diagnosis and almost all have ascites at recurrence. The presence of ascites, which acts as a dynamic reservoir of active molecules and cellular components, correlates with the OC peritoneal metastasis and is associated with poor pro...

journal_title：Clinical & experimental metastasis

authors： Carduner L,Leroy-Dudal J,Picot CR,Gallet O,Carreiras F,Kellouche S

更新日期：2014-08-01 00:00:00

abstract：:We aimed to define the clinicopathologic characteristics of breast cancer (BC) patients with brain metastasis (BM) and to investigate the effect of these parameters on survival. Seventy-nine patients diagnosed with BC and symptomatic BM between 1995 and 2011 were retrospectively evaluated. The relationship between cli...

journal_title：Clinical & experimental metastasis

authors： Tarhan MO,Demir L,Somali I,Yigit S,Erten C,Alacacioglu A,Ellidokuz H,Seseogullari O,Kucukzeybek Y,Can A,Dirican A,Bayoglu V,Akyol M

更新日期：2013-02-01 00:00:00

abstract：:Metastatic spinal cord compression (MSCC) is a frequent phenomenon in advanced tumor diseases with often severe neurological impairments. Affected patients are often treated by decompressive laminectomy. To assess the impact of this procedure on Karnofsky Performance Index (KPI) and Frankel Grade (FG) at discharge, a ...

journal_title：Clinical & experimental metastasis

authors： Younsi A,Riemann L,Scherer M,Unterberg A,Zweckberger K

更新日期：2020-04-01 00:00:00

abstract：:Although in the past little attention has been paid to the influence of osteosarcoma cells in osteoclast function, recent studies suggest a close relationship between osteosarcoma aggressiveness and osteoclastic activity. The present study addresses the paracrine effects of MG63 cells, a human osteosarcoma-derived cel...

journal_title：Clinical & experimental metastasis

authors： Costa-Rodrigues J,Teixeira CA,Fernandes MH

更新日期：2011-08-01 00:00:00

abstract：:Electrochemotherapy (ECT) is a novel treatment for recurrent or in-transit unresectable melanoma metastases based on the administration of anti-neoplastic drugs followed by cancer cell electroporation. Whether ECT can also induce anti-tumour immunity is unclear. We addressed this issue investigating the presence of de...

journal_title：Clinical & experimental metastasis

authors： Gerlini G,Sestini S,Di Gennaro P,Urso C,Pimpinelli N,Borgognoni L

更新日期：2013-01-01 00:00:00

abstract：:Smad interacting protein 1 (SIP1) is an epithelial-mesenchymal transition (EMT)-inducible gene that plays a key role in tumor progression in various cancers. This study seeks to clarify the clinical and biological significance of SIP1 expression, especially in intestinal type gastric cancer. We analyzed the mRNA level...

journal_title：Clinical & experimental metastasis

authors： Okugawa Y,Inoue Y,Tanaka K,Kawamura M,Saigusa S,Toiyama Y,Ohi M,Uchida K,Mohri Y,Kusunoki M

更新日期：2013-04-01 00:00:00

abstract：:Tumor metastasis often confers poor prognosis for cancer patients due to lack of comprehensive strategy in dealing with cells growing in different environment. Current anticancer therapies have incomplete effectiveness because they were designed assuming metastatic tumors behave similarly in different organs. We hypot...

journal_title：Clinical & experimental metastasis

authors： Alsaggar M,Yao Q,Cai H,Liu D

更新日期：2016-02-01 00:00:00

abstract：:Breast cancer dissemination can be monitored in patients by detecting circulating and/or disseminated tumor cells. However, bone marrow disseminated tumor cells (BM DTC) may undergo a dormancy during several years before growing (or not) into clinically detectable metastases. We therefore hypothesized that breast canc...

journal_title：Clinical & experimental metastasis

authors： Bidard FC,Vincent-Salomon A,Sigal-Zafrani B,Rodrigues M,Diéras V,Mignot L,Sastre-Garau X,Poupon MF,Pierga JY

更新日期：2008-01-01 00:00:00

abstract：:The mechanisms leading to rapid invasive growth of malignant gliomas are poorly understood. Expression of the hyaluronic acid (HA) receptor CD44 and adhesion to HA are involved in invasive properties. Our previous studies have shown that malignant glioma cells are able to adhere to extracellular HA. Here we investigat...

journal_title：Clinical & experimental metastasis

authors： Knüpfer MM,Poppenborg H,Hotfilder M,Kühnel K,Wolff JE,Domula M

更新日期：1999-02-01 00:00:00

abstract：:For more effective oncological management of disseminated colorectal cancer, therapies must be devised that target the different individual stages of metastasis development. Recent work showed that integrin subunits alpha2, alpha6 and beta4 are involved in the colorectal cancer cell extravasation process. By means of ...

journal_title：Clinical & experimental metastasis

authors： Robertson JH,Yang SY,Winslet MC,Seifalian AM

更新日期：2009-01-01 00:00:00

abstract：:Basement membrane forms widespread barriers to tumor invasion. It has been shown that tumor-secreted, basement membrane-degrading enzymes, namely metalloproteinases (MMPs) play an important role in tumor invasion and metastasis. In this study, we determined the enzymatic activity, content, and mRNA of both the 72 kDa ...

journal_title：Clinical & experimental metastasis

authors： Rao VH,Bridge JA,Neff JR,Schaefer GB,Buehler BA,Vishwanatha JK,Pollock RE,Nicolson GL,Yamamoto M,Gokaslam ZL

更新日期：1995-11-01 00:00:00

abstract：:Osteopontin (OPN) is a glycosylated, secreted phosphoprotein that functions both as a cell attachment and chemotactic factor. Elevated expression of OPN confers enhanced metastatic ability on transformed cells, suggesting that OPN may contribute to the malignant progression of tumors. Migration of mammary carcinoma ce...

journal_title：Clinical & experimental metastasis

authors： Khan SA,Cook AC,Kappil M,Günthert U,Chambers AF,Tuck AB,Denhardt DT

更新日期：2005-01-01 00:00:00

abstract：:We have previously reported that induction of MMP-2 activation by Concanavalin A (ConA) in MDA-MB-231 human breast cancer cells involves both transcriptional and post-transcriptional mechanisms, and that the continuous presence of ConA is required for MMP-2 activation (Yu et al. Cancer Res, 55, 3272-7, 1995). In an ef...

journal_title：Clinical & experimental metastasis

authors： Yu M,Sato H,Seiki M,Spiegel S,Thompson EW

更新日期：1998-02-01 00:00:00

abstract：:NIH3T3 cells transfected with an activated Ha-ras oncogene were treated with L-PHA, the leukoagglutinin from red kidney beans. Cell lines resistant to L-PHA-mediated cytotoxicity were isolated and found to contain reduced levels of L-PHA-binding oligosaccharides. The levels of N-acetylglucosaminyltransferase V, the en...

journal_title：Clinical & experimental metastasis

authors： Lu Y,Pelling JC,Chaney WG

更新日期：1994-01-01 00:00:00

abstract：:Type IV collagenases, matrix metalloproteinase (MMP) 2 and MMP9 are implicated in tumor invasion and metastasis. In patients with nasopharyngeal carcinoma (NPC), poor prognosis due to development of local and distant metastasis has been reported to be predicted by antibody titers against the Z protein which is an AP-1...

journal_title：Clinical & experimental metastasis

authors： Yoshizaki T,Sato H,Murono S,Pagano JS,Furukawa M

更新日期：1999-07-01 00:00:00

abstract：:Using alternative splicing reporters we have previously observed mesenchymal epithelial transitions in Dunning AT3 rat prostate tumors. We demonstrate here that the Dunning DT and AT3 cells, which express epithelial and mesenchymal markers, respectively, represent an excellent model to study epithelial transitions sin...

journal_title：Clinical & experimental metastasis

authors： Oltean S,Febbo PG,Garcia-Blanco MA

更新日期：2008-01-01 00:00:00

abstract：:The growth and metastatic behavior of three human tumor cell lines and a human colon carcinoma previously passaged in vivo were compared between nude mice and scid mice after xenotransplantation. The three human tumor lines included a bladder carcinoma (T24B), a melanoma (RPMI 7931) and a lacZ gene-transduced breast c...

journal_title：Clinical & experimental metastasis

authors： Xie X,Brünner N,Jensen G,Albrectsen J,Gotthardsen B,Rygaard J

更新日期：1992-05-01 00:00:00

abstract：:Experimental hepatic metastasis of colorectal tumors is frequently studied by local intrahepatic tumor cell implantation. However, although a variety of factors of the implantation procedure may markedly influence tumor growth characteristics, standards are not defined yet. Herein, we studied the effect of different m...

journal_title：Clinical & experimental metastasis

authors： Kollmar O,Schilling MK,Menger MD

更新日期：2004-01-01 00:00:00