Cyclodextrins in transdermal and rectal delivery.

abstract：:The great interest in mucosal vaccine delivery arises from the fact that mucosal surfaces represent the major site of entry for many pathogens. Among other mucosal sites, nasal delivery is especially attractive for immunization, as the nasal epithelium is characterized by relatively high permeability, low enzymatic ac...

journal_title：Advanced drug delivery reviews

authors： Csaba N,Garcia-Fuentes M,Alonso MJ

更新日期：2009-02-27 00:00:00

abstract：:Mesenchymal stem cells (MSC) are a promising tool for cell therapy, either through direct contribution to the repair of bone, tendon and cartilage or as an adjunct therapy through protein production and immune mediation. They are an attractive vehicle for cellular therapies due to a variety of cell intrinsic and envir...

journal_title：Advanced drug delivery reviews

authors： Meyerrose T,Olson S,Pontow S,Kalomoiris S,Jung Y,Annett G,Bauer G,Nolta JA

更新日期：2010-09-30 00:00:00

abstract：:Despite the wide use of antibiotics, bacterial infection is still one of the leading causes of hospitalization and mortality. The clinical failure of antibiotic therapy is linked with low bioavailability, poor penetration to bacterial infection sites, and the side effects of antibiotics, as well as the antibiotic resi...

journal_title：Advanced drug delivery reviews

authors： Xiong MH,Bao Y,Yang XZ,Zhu YH,Wang J

更新日期：2014-11-30 00:00:00

abstract：:Two-photon excitation imaging is the least invasive optical approach to study living tissues. We have established two-photon extracellular polar-tracer (TEP) imaging with which it is possible to visualize and quantify all exocytic events in the plane of focus within secretory tissues. This technology also enables esti...

journal_title：Advanced drug delivery reviews

authors： Kasai H,Kishimoto T,Nemoto T,Hatakeyama H,Liu TT,Takahashi N

更新日期：2006-09-15 00:00:00

abstract：:A great deal of interest has surrounded the activities of monoclonal antibodies (mAbs), and mAb-drug, toxin and radionuclide conjugates for the treatment of human cancers. In the last few years, a number of new mAb-based reagents have been clinically approved (Rituxan, Herceptin, and Panorex), and several others are n...

journal_title：Advanced drug delivery reviews

authors： Senter PD,Springer CJ

更新日期：2001-12-31 00:00:00

abstract：:Injury to the podocytes is the initiating cause of many renal diseases, leading to proteinuria with possible progression to end-stage renal disease. Podocytes are highly specialized cells, with an important role in maintaining the glomerular filtration barrier and producing growth factors for both mesangial cells and ...

journal_title：Advanced drug delivery reviews

authors： Leeuwis JW,Nguyen TQ,Dendooven A,Kok RJ,Goldschmeding R

更新日期：2010-11-30 00:00:00

abstract：:The incorporation of polymer-lipid conjugates, initially using PEG and subsequently other selected flexible, hydrophilic polymers, into lipid bilayers gives rise to sterically stabilized liposomes that exhibit reduced blood clearance and concomitant changes in tissue distribution largely because of reduced, but not el...

journal_title：Advanced drug delivery reviews

authors： Woodle MC

更新日期：1998-06-08 00:00:00

abstract：:This review presents a summary of the various types of cellular therapy used to treat spinal cord injury. The inhibitory environment and loss of axonal connections after spinal cord injury pose many obstacles to regenerating the lost tissue. Cellular therapy provides a means of restoring the cells lost to the injury a...

journal_title：Advanced drug delivery reviews

authors： Willerth SM,Sakiyama-Elbert SE

更新日期：2008-01-14 00:00:00

abstract：:In recent years, drug development costs have soared, primarily due to the failure of preclinical animal and cell culture models, which do not directly translate to human physiology. Organ-on-a-chip (OOC) is a burgeoning technology with the potential to revolutionize disease modeling, drug discovery, and toxicology res...

journal_title：Advanced drug delivery reviews

authors： Wnorowski A,Yang H,Wu JC

更新日期：2019-02-01 00:00:00

abstract：:Current treatment of human immunodeficiency virus type-1 (HIV-1) infection involves a combination of antiretroviral drugs (ARVs) that target different stages of the HIV-1 life cycle. This strategy is commonly referred to as highly active antiretroviral therapy (HAART) or combined antiretroviral therapy (cART). Membran...

journal_title：Advanced drug delivery reviews

authors： Alam C,Whyte-Allman SK,Omeragic A,Bendayan R

更新日期：2016-08-01 00:00:00

abstract：:This article reviews the studies on skin electroporation carried out in vivo in animals and emphasizes its potential therapeutic applications for transdermal and topical drug delivery. In agreement with in vitro studies, transport across skin due to high-voltage pulses in vivo was shown to increase by orders of magnit...

journal_title：Advanced drug delivery reviews

authors： Vanbever R,Préat V V

更新日期：1999-01-04 00:00:00

abstract：:Nucleic acids have gained a lot of interest for the treatment of ocular diseases. The first to enter in clinic has been Vitravene an antisense oligonucleotide for the treatment of cytomegalovirus (CMV) infection and more recently, research on aptamers have led to the marketing of anti-vascular endothelial growth facto...

journal_title：Advanced drug delivery reviews

authors： Fattal E,Bochot A

更新日期：2006-11-15 00:00:00

abstract：:Basic science advances in bone tissue engineering using osteoinductive protein therapy have already been translated to the use in patients with selected orthopedic problems. The story of the development of bone morphogenetic protein (BMP) osteoinductive therapy, from the discovery of this class of molecules in 1965 to...

journal_title：Advanced drug delivery reviews

authors： Nussenbaum B,Krebsbach PH

更新日期：2006-07-07 00:00:00

abstract：:Over the last three decades, a handful of photochemical mechanisms have been applied to a large number of nanoscale assemblies that encapsulate a payload to afford spatio-temporal and remote control over activity of the encapsulated payload. Many of these systems are designed with an eye towards biomedical application...

journal_title：Advanced drug delivery reviews

authors： Fomina N,Sankaranarayanan J,Almutairi A

更新日期：2012-08-01 00:00:00

abstract：:Infliximab (Remicade) is an antitumor necrosis factor (TNF) therapy effective in both induction and maintenance of remission in Crohn's disease. Identifying predictors of response or relapse to infliximab is important given the potential toxicities and cost of this therapy. Currently available data suggest that concur...

journal_title：Advanced drug delivery reviews

authors： Su C,Lichtenstein GR

更新日期：2005-01-06 00:00:00

abstract：:Thioredoxin 1 (Trx 1) is a redox-active small protein ubiquitously present in human body. It is one of the defensive proteins induced in response to various stress conditions. In addition to its anti-oxidative effect by dithiol-disulfide exchange in its active site, Trx 1 has anti-apoptotic and anti-inflammatory effec...

journal_title：Advanced drug delivery reviews

authors： Nakamura H,Hoshino Y,Okuyama H,Matsuo Y,Yodoi J

更新日期：2009-04-28 00:00:00

abstract：:Vaccines are one of the most powerful technologies supporting public health. The adaptive immune response induced by immunization arises following appropriate activation and differentiation of T and B cells in lymph nodes. Among many parameters impacting the resulting immune response, the presence of antigen and infla...

journal_title：Advanced drug delivery reviews

authors： Irvine DJ,Aung A,Silva M

更新日期：2020-01-01 00:00:00

abstract：:Topical delivery to the various regions of the skin and underlying tissues, transdermal drug delivery and dermal exposure to environmental chemicals are important areas of research. Mathematical models of epidermal and dermal transport, involving penetration of a solute through various layers of the skin, metabolism i...

journal_title：Advanced drug delivery reviews

authors： Anissimov YG,Jepps OG,Dancik Y,Roberts MS

更新日期：2013-02-01 00:00:00

abstract：:During the past few decades, the novel biotherapeutic agents such as peptides and proteins have been contributed to the treatment of several diseases. However, their oral absorption is significantly limited due to their poor delivery through the intestinal mucosa. Therefore, the feasible approaches are needed for impr...

journal_title：Advanced drug delivery reviews

authors： Khafagy el-S,Morishita M

更新日期：2012-05-01 00:00:00

abstract：:Carbon-based functional nanomaterials have attracted immense scientific interest from many disciplines and, due to their extraordinary properties, have offered tremendous potential in a diverse range of applications. Among the different carbon nanomaterials, graphene is one of the newest and is considered the most imp...

journal_title：Advanced drug delivery reviews

authors： Zhang B,Wei P,Zhou Z,Wei T

更新日期：2016-10-01 00:00:00

abstract：:Microdialysis can give simultaneous information on unbound drug concentration-time profiles in brain extracellular fluid (ECF) and blood, separating the information on blood-brain barrier (BBB) processes from confounding factors such as binding to brain tissue or proteins in blood. This makes microdialysis suitable fo...

journal_title：Advanced drug delivery reviews

authors： Hammarlund-Udenaes M

更新日期：2000-12-15 00:00:00

abstract：:Cell-penetrating peptides (CPPs) traverse the membrane of biological cells at low micromolar concentrations and are able to take various cargo molecules along with. Despite large differences in their chemical structure, CPPs share the structural similarity of a high cationic charge density. This property confers to th...

journal_title：Advanced drug delivery reviews

authors： Ziegler A

更新日期：2008-03-01 00:00:00

abstract：:This paper reviews key issues found to affect acceptability and preferences for vaginal products to prevent HIV infection or HIV and pregnancy. We focus on the interplay between the biological and physico-chemical aspects of formulation and the social and behavioral issues that may affect use. The need for an HIV prev...

journal_title：Advanced drug delivery reviews

authors： Woodsong C,Holt JD

更新日期：2015-09-15 00:00:00

abstract：:A pharmaceutical formulation is composed of several formulation factors and process variables. Several responses relating to the effectiveness, usefulness, stability, as well as safety must be optimized simultaneously. Consequently, expertise and experience are required to design acceptable pharmaceutical formulations...

journal_title：Advanced drug delivery reviews

authors： Takayama K,Fujikawa M,Obata Y,Morishita M

更新日期：2003-09-12 00:00:00

abstract：:Intravenous administration of low (milligram) doses of nanoparticulate materials in pigs can lead to acute cardiopulmonary, hemodynamic, hematological, biochemical and dermatological changes within minutes, mimicking the human infusion (or anaphylactoid) reactions to many state-of-the-art (nano)medicines and biologica...

journal_title：Advanced drug delivery reviews

authors： Szebeni J,Bedőcs P,Csukás D,Rosivall L,Bünger R,Urbanics R

更新日期：2012-12-01 00:00:00

abstract：:Recent pre-clinical and clinical studies have shown that stem cell-based therapies hold tremendous promise for the treatment of human disease. Mesenchymal stem cells (MSC) are emerging as promising anti-cancer agents which have an enormous potential to be utilized to treat a number of different cancer types. MSC have ...

journal_title：Advanced drug delivery reviews

authors： Shah K

更新日期：2012-06-01 00:00:00

abstract：:Regenerative medicine aims to create functional tissue replacements, typically through creating a controlled environment that promotes and directs the differentiation of stem or progenitor cells, either endogenous or transplanted. Scaffolds serve a central role in many strategies by providing the means to control the ...

journal_title：Advanced drug delivery reviews

authors： De Laporte L,Shea LD

更新日期：2007-05-30 00:00:00

abstract：:Hepatocellular carcinoma (HCC) remains one of the most lethal forms of cancer in the world. In this arena, utilities of microRNA (miRNA) as a sophisticated tool, in therapeutics and diagnostics, remains a prime focus among the leading researchers. It is well known that viral hepatitis, chronic alcoholism and metabolic...

journal_title：Advanced drug delivery reviews

authors： Yang N,Ekanem NR,Sakyi CA,Ray SD

更新日期：2015-01-01 00:00:00

abstract：:Synthetic micro/nanomotors are tiny devices than can be self-propelled or externally powered in the liquid phase by different types of energy source including but not limited to: catalytic, magnetic or acoustic. Showing a myriad of mechanical movements, building block materials, sizes, shapes and propulsion mechanisms...

journal_title：Advanced drug delivery reviews

authors： Chałupniak A,Morales-Narváez E,Merkoçi A

更新日期：2015-12-01 00:00:00

abstract：:Systemic drug delivery methods such as oral or parenteral administration of free drugs possess relatively low treatment efficiency and marked adverse side effects. The use of nanoparticles for drug delivery in most cases substantially enhances drug efficacy, improves pharmacokinetics and drug release and limits their ...

journal_title：Advanced drug delivery reviews

authors： Majumder J,Taratula O,Minko T

更新日期：2019-04-01 00:00:00