Abstract:
:Over the last three decades, a handful of photochemical mechanisms have been applied to a large number of nanoscale assemblies that encapsulate a payload to afford spatio-temporal and remote control over activity of the encapsulated payload. Many of these systems are designed with an eye towards biomedical applications, as spatio-temporal and remote control of bioactivity would advance research and clinical practice. This review covers five underlying photochemical mechanisms that govern the activity of the majority of photoresponsive nanocarriers: 1. photo driven isomerization and oxidation, 2. surface plasmon absorption and photothermal effects, 3. photo driven hydrophobicity changes, 4. photo driven polymer backbone fragmentation and 5. photo driven de-crosslinking. The ways in which these mechanisms have been incorporated into nanocarriers and how they affect release are detailed, as well as the advantages and disadvantages of each system.
journal_name
Adv Drug Deliv Revjournal_title
Advanced drug delivery reviewsauthors
Fomina N,Sankaranarayanan J,Almutairi Adoi
10.1016/j.addr.2012.02.006subject
Has Abstractpub_date
2012-08-01 00:00:00pages
1005-20issue
11eissn
0169-409Xissn
1872-8294pii
S0169-409X(12)00029-4journal_volume
64pub_type
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