Abstract:
:Psoriasis occurs with at least undiminished frequency in HIV-infected individuals. The behavior of psoriasis in HIV disease is of interest, in terms of pathogenesis and therapy because of the background of profound immunodysregulation. It is paradoxical that, while drugs that target T lymphocytes are effective in psoriasis, the condition should be exacerbated by HIV infection. The etiopathogenesis of psoriasis is unknown, but genetic and environmental factors are thought to be involved. There are controversial issues regarding the immunological basis of psoriasis and the role of CD4+ versus CD8+ T lymphocytes. Current opinion favors an autoimmune basis for psoriasis although the precipitating activating signal(s) within psoriatic plaques remains unknown. Candidate skin autoantigens that have cross-reactive determinants with bacterial antigens include keratins. The immunodysregulation resulting from HIV infection may trigger psoriasis in those genetically predisposed by the Cw*0602 allele. Because CD8 T cells recognize antigen in the context of class I molecules, the identification of a human leucocyte antigen (HLA) class I association in HIV-associated psoriasis strengthens the argument for an important role for CD8+ T lymphocytes in the immunopathogenesis of psoriasis. HLA-Cw*0602 could act as a cross-reactive target for cytotoxic T lymphocytes (CTLs) responding to processed peptides from microorganisms.
journal_name
AIDS Patient Care STDSjournal_title
AIDS patient care and STDsauthors
Mallon E,Bunker CBdoi
10.1089/108729100317696subject
Has Abstractpub_date
2000-05-01 00:00:00pages
239-46issue
5eissn
1087-2914issn
1557-7449journal_volume
14pub_type
杂志文章,评审abstract::Nationally representative data from the 2007 National Health Interview Survey (NHIS) were used to compare HIV testing prevalence among US adults with mental illness (schizophrenia spectrum disorder, bipolar disorder, depression, and/or anxiety) to those without, providing an update of prior work using 1999 and 2002 NH...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
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journal_title:AIDS patient care and STDs
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/108729100413202
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章,评审
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2014.0279
更新日期:2015-01-01 00:00:00
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章,评审
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章,评审
doi:10.1089/apc.2007.0136
更新日期:2008-06-01 00:00:00
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2008.0241
更新日期:2009-08-01 00:00:00
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journal_title:AIDS patient care and STDs
pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2012-01-01 00:00:00
abstract::To successfully implement the Seek, Test, and Treat (STT) strategy to curb the HIV epidemic, the criminal justice system must be a key partner. Increasing HIV testing and treatment among incarcerated persons has the potential to decrease HIV transmission in the broader community, but whether it is feasible to consider...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
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更新日期:2005-07-01 00:00:00
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/108729100438854
更新日期:2000-09-01 00:00:00
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章,随机对照试验
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更新日期:2018-07-01 00:00:00
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2008.0149
更新日期:2009-06-01 00:00:00
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2006.20.760
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journal_title:AIDS patient care and STDs
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章,随机对照试验
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journal_title:AIDS patient care and STDs
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2011.0025
更新日期:2011-07-01 00:00:00
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章,评审
doi:10.1089/108729103322277402
更新日期:2003-08-01 00:00:00
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
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journal_title:AIDS patient care and STDs
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2018.0035
更新日期:2018-05-01 00:00:00
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章,评审
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