Abstract:
:Although many methods for assessing adherence have been developed, most are not feasible for busy clinical settings. Using patients from the Adherence and Efficacy of Protease inhibitor Therapy (ADEPT) study (1998-2000), we systematically evaluated the relationship between psychosocial, environmental, clinical, and other factors with adherence to create composite variables (CVs) that are efficient with high sensitivity for detecting nonadherence and great potential for busy clinics. Eligible patients were protease inhibitor naïve or started a regimen within 3 months from baseline. Of the 128 patients who responded to survey at baseline, weeks 8, 24, and/or 48, mean (standard deviation [SD]) age was 39.3 (8.2) years with 81% male. About half of the patients were Latino, followed by 28% African American and 14% Caucasian. Sixteen percent reported injection drug use, and 40% had male-male sex. Mean CD4 count was 184.8 cells/mm(3) with a range from 1 to 1130 cells/mm(3). Thirty-two variables had a significant association with adherence at one or two time points and 9 were significantly associated with adherence over time. Among these significant factors, 8 also had a relationship with a clearly monotonic trend, by which 219 CVs were formed. Among these CVs, 8 were significantly associated with adherence and had a relationship with monotonic trend. Compared to traditional self-reported adherence, CVs had much higher sensitivities (p < 0.001) for detecting nonadherence. We conclude that CVs consisting of a combination of psychological, behavior, and adherence questions may be reasonable substitutes for direct adherence questions, which are limited by problems with recall and social biases. Trust in physicians, having a child, history of substance use, CD4 count, and belief that antiretrovirals can help living longer or improve quality of life can efficiently predict nonadherence. Because these variables are readily obtainable in clinical settings, these selected questions may provide a clinically useful means of screening patients for antiretroviral medication nonadherence.
journal_name
AIDS Patient Care STDSjournal_title
AIDS patient care and STDsauthors
Liu H,Miller LG,Hays RD,Golin CE,Zhao H,Wenger NS,Kaplan AHdoi
10.1089/apc.2006.20.760subject
Has Abstractpub_date
2006-11-01 00:00:00pages
760-72issue
11eissn
1087-2914issn
1557-7449journal_volume
20pub_type
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/108729100413202
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2016.0226
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2007.9987
更新日期:2007-01-01 00:00:00
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2012.0435
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章,评审
doi:10.1089/108729100750018326
更新日期:2000-10-01 00:00:00
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2005.19.353
更新日期:2005-06-01 00:00:00
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/108729102761041074
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2005.19.135
更新日期:2005-03-01 00:00:00
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2011.0125
更新日期:2011-09-01 00:00:00
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2009.0242
更新日期:2010-01-01 00:00:00
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/108729103322395456
更新日期:2003-09-01 00:00:00
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/108729100317894
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2013.0321
更新日期:2014-05-01 00:00:00
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2014.0196
更新日期:2014-12-01 00:00:00
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.1996.10.77
更新日期:1996-04-01 00:00:00
abstract::Little is known about the accessibility and longevity of Internet references in medical and scientific journals. This is particularly problematic in the ever changing field of HIV/AIDS. We examined all issues of AIDS Patient Care and STDs between 2001 and 2004 to test the use and accessibility of Internet citations du...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章,评审
doi:10.1089/apc.2005.19.5
更新日期:2005-01-01 00:00:00
abstract::Superior mesenteric artery (SMA) syndrome is a unique type of small bowel obstruction resulting from the compression of the duodenum by the SMA. This is a case of SMA syndrome in a cachectic 6-year-old boy with AIDS who presented after a 2.3-kg weight loss in the preceding month. Unfamiliarity with this condition coup...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/108729100318073
更新日期:2000-01-01 00:00:00
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章,评审
doi:10.1089/10872910050206559
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2015.0333
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journal_title:AIDS patient care and STDs
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
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更新日期:1999-11-01 00:00:00
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2009.0240
更新日期:2010-07-01 00:00:00
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2008.0119
更新日期:2008-12-01 00:00:00
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journal_title:AIDS patient care and STDs
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doi:10.1089/10872910151133701
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abstract::Initial linkage to medical care is a critical step in the HIV care continuum leading to improved health outcomes, reduced morbidity and mortality, and decreased HIV transmission risk. We explored differences in perspectives on engagement in HIV care between people living with HIV who attended (Arrived) their initial m...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2018.0039
更新日期:2018-09-01 00:00:00
abstract::In an effort to understand issues affecting prenatal care access and utilization from the perspectives of human immunodeficiency virus (HIV)-infected women who receive inadequate prenatal care, we conducted three in-depth qualitative and quantitative interviews. From a thematic analysis of the narrative interviews, fo...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/108729100416623
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
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更新日期:2019-04-01 00:00:00
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
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journal_title:AIDS patient care and STDs
pub_type: 杂志文章
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更新日期:2017-07-01 00:00:00