Abstract：
:A large number of drugs are introduced every year, and new interactions between medications are increasingly reported. Consequently, it is no longer practical for physicians to rely on memory alone to avoid potential drug interactions. Multiple drug regimens carry the risk of adverse interactions. Precipitant drugs modify the object drug's absorption, distribution, metabolism, excretion or actual clinical effect. Nonsteroidal anti-inflammatory drugs, antibiotics and, in particular, rifampin are common precipitant drugs prescribed in primary care practice. Drugs with a narrow therapeutic range or low therapeutic index are more likely to be the objects for serious drug interactions. Object drugs in common use include warfarin, fluoroquinolones, antiepileptic drugs, oral contraceptives, cisapride and 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. Many other drugs, act as precipitants or objects, and a number of drugs act as both. Regularly updated manuals of drug interactions and CD-ROM-formatted programs are useful office references.
journal_name
Am Fam Physicianjournal_title
American family physicianauthors
Ament PW,Bertolino JG,Liszewski JLsubject
Has Abstractpub_date
2000-03-15 00:00:00pages
1745-54issue
6eissn
0002-838Xissn
1532-0650journal_volume
61pub_type
杂志文章,评审abstract：:Sudden cardiac death is a major public health problem, affecting 500,000 patients in the United States annually. An implantable cardioverter-defibrillator (ICD) can terminate malignant ventricular arrhythmias and has been shown to improve survival in high-risk populations. Although sudden cardiac death is a heterogene...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：2010-12-01 00:00:00
abstract：:Group B streptococcus (GBS) is a leading cause of morbidity and mortality among newborns. Universal screening for GBS among women at 35 to 37 weeks of gestation is more effective than administration of intrapartum antibiotics based on risk factors. Lower vaginal and rectal cultures for GBS are collected at 35 to 37 we...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：2005-03-01 00:00:00
abstract：:The female athlete triad is defined as the combination of disordered eating, amenorrhea and osteoporosis. This disorder often goes unrecognized. The consequences of lost bone mineral density can be devastating for the female athlete. Premature osteoporotic fractures can occur, and lost bone mineral density may never b...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：2000-06-01 00:00:00
abstract：:Endometrial biopsy is a safe and efficient method to evaluate the endometrium for a variety of indications, most commonly abnormal uterine bleeding and postmenopausal bleeding. Endometrial biopsy is highly specific for diagnosing atypical hyperplasia and endometrial cancer in postmenopausal women. Pregnancy is the onl...
journal_title：American family physician
pub_type： 杂志文章
doi：
更新日期：2020-05-01 00:00:00
abstract：:Testicular torsion is characterized by the sudden onset of testicular pain associated with abdominal pain, nausea and vomiting. Fever is unusual and urinalysis is often normal. Fever, pyuria, dysuria and urethral discharge are characteristic of epididymitis. Radionuclide scanning and Doppler ultrasound are helpful in ...
journal_title：American family physician
pub_type： 杂志文章
doi：
更新日期：1988-03-01 00:00:00
abstract：:Persons whose experienced or expressed gender differs from their sex assigned at birth may identify as transgender. Transgender and gender-diverse persons may have gender dysphoria (i.e., distress related to this incongruence) and often face substantial health care disparities and barriers to care. Gender identity is ...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：2018-12-01 00:00:00
abstract：:Serotonin syndrome is a potentially life-threatening complication of psychopharmacologic drug therapy. The syndrome is produced most often by the concurrent use of two or more drugs that increase brainstem serotonin activity and is often unrecognized because of the varied and nonspecific nature of its symptomatology. ...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：1995-10-01 00:00:00
abstract：:Tonsillectomy and adenoidectomy (T&A) is the most commonly performed surgical procedure in the U.S. Considerable controversy surrounds this operation because all previous studies have demonstrated experimental flaws that compromise the value of the findings. While an apparent immunologic deficit following T&A has been...
journal_title：American family physician
pub_type： 杂志文章
doi：
更新日期：1977-09-01 00:00:00
abstract：:Systemic lupus erythematosus, chronic cutaneous lupus erythematosus and subacute and acute cutaneous lupus erythematosus are associated with distinct cutaneous manifestations, and each disease has a particular clinical course and prognosis. Dermatomyositis, an immune-mediated disorder of unknown etiology that is often...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：1996-04-01 00:00:00
abstract：:Rheumatoid arthritis is a connective tissue disorder of unknown etiology that can involve any synovial-lined joint in the body. The most frequently involved joints are the small joints of the hands and feet, the wrists, knees and elbows, and the glenohumeral and acromioclavicular joints. The radiographic hallmarks of ...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：1995-10-01 00:00:00
abstract：:A biopsychosocial theory and approach to drug-seeking behavior suggests new questions for the family physician to ask his patient when psychotropic drugs are being considered. The theory and rational guidelines for prescribing allow the physician to make more appropriate decisions when faced with difficult situations....
journal_title：American family physician
pub_type： 杂志文章
doi：
更新日期：1979-01-01 00:00:00
abstract：:The process of identifying and evaluating the common causes of vaginal bleeding during pregnancy changes as the pregnancy progresses to term. The most common identifiable causes of vaginal bleeding during early pregnancy include spontaneous abortion and ectopic pregnancy. Pelvic ultrasound and quantitative beta-human ...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：1995-02-15 00:00:00
abstract：:Alzheimer disease is the most common form of dementia, affecting nearly one-half [corrected] of Americans older than 85 years. It is characterized by progressive memory loss and cognitive decline. Amyloid plaque accumulation, neurofibrillary tau tangles, and depletion of acetylcholine are among the pathologic manifest...
journal_title：American family physician
pub_type： 杂志文章
doi：
更新日期：2011-06-15 00:00:00
abstract：:Appendicitis is one of the most common causes of acute abdominal pain in adults and children, with a lifetime risk of 8.6% in males and 6.7% in females. It is the most common nonobstetric surgical emergency during pregnancy. Findings from the history, physical examination, and laboratory studies aid in the diagnosis o...
journal_title：American family physician
pub_type： 杂志文章
doi：
更新日期：2018-07-01 00:00:00
abstract：:Tension-type headache typically causes pain that radiates in a band-like fashion bilaterally from the forehead to the occiput. Pain often radiates to the neck muscles and is described as tightness, pressure, or dull ache. Migraine-type features (unilateral, throbbing pain, nausea, photophobia) are not present All pati...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：2002-09-01 00:00:00
abstract：:Eating disorders are potentially life-threatening conditions characterized by disordered eating and weight-control behaviors that impair physical health and psychosocial functioning. Early intervention may decrease the risk of long-term pathology and disability. Clinicians should interpret disordered eating and body i...
journal_title：American family physician
pub_type： 杂志文章
doi：
更新日期：2021-01-01 00:00:00
abstract：:Kawasaki disease is an acute vasculitis of childhood that predominantly affects the coronary arteries. The etiology of Kawasaki disease remains unknown, although an infectious agent is strongly suspected based on clinical and epidemiologic features. A genetic predisposition is also likely, based on varying incidences ...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：2006-10-01 00:00:00
abstract：:Strenuous exercise may cause menstrual abnormalities, including amenorrhea. The hypoestrogenemia that accompanies amenorrhea has been associated with a low bone mineral content and an increased incidence of stress fractures. With the resumption of menses, which usually occurs soon after female athletes decrease the in...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：1989-02-01 00:00:00
abstract：:Health care-associated infections cause approximately 75,000 deaths annually, in addition to increasing morbidity and costs. Over the past decade, a downward trend in health care-associated infections has occurred nationwide. Basic prevention measures include administrative support, educating health care personnel, an...
journal_title：American family physician
pub_type： 杂志文章
doi：
更新日期：2014-09-15 00:00:00
abstract：:Persons with mental retardation sometimes exhibit behaviors that are difficult to control. Use of neuroleptic medications may be limited by side effects or ineffectiveness. Beta blockers such as propranolol and metoprolol have been shown to decrease aggressive and impulsive behaviors in some patients with mental retar...
journal_title：American family physician
pub_type： 指南,杂志文章,评审
doi：
更新日期：1990-12-01 00:00:00
abstract：:Problems resulting from cold exposure can be successfully treated when a coordinated emergency medical transport system and appropriate equipment are available, as well as medical personnel knowledgeable in the management of frostbite and hypothermia. Clinical suspicion of these disorders is essential. Profoundly hypo...
journal_title：American family physician
pub_type： 杂志文章
doi：
更新日期：1982-01-01 00:00:00
abstract：:Osteopetrosis is a hereditary disorder in which pathologic alteration of osteoclast resorption of bone results in thickening of cortical and lamellar bone. Before bone marrow transplantation, the infantile recessive form was uniformly fatal within the first two decades of life as a result of invasion of the marrow spa...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：1993-01-01 00:00:00
abstract：:Flexible sigmoidoscopy is a procedure that is commonly used by primary care physicians for the evaluation of rectal disorders and for colorectal screening. Retroflexion of the endoscope improves views of the anorectum and rectal vault, which increases the diagnostic yield of sigmoidoscopy. We report three cases of rec...
journal_title：American family physician
pub_type： 杂志文章
doi：
更新日期：1995-05-15 00:00:00
abstract：:Benign pulmonary neoplasms are relatively uncommon. The symptoms vary, depending on the location of the tumor. Specific diagnosis can be a time-consuming process and requires an orderly plan. Polytomography or computed tomographic scan, bronchoscopy, percutaneous biopsy or thoracotomy may be required. Tissue diagnosis...
journal_title：American family physician
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：:Childhood bullying has potentially serious implications for bullies and their targets. Bullying involves a pattern of repeated aggression, a deliberate intent to harm or disturb a victim despite the victim's apparent distress, and a real or perceived imbalance of power. Bullying can lead to serious academic, social, e...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：2004-11-01 00:00:00
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journal_title：American family physician
pub_type： 杂志文章
doi：
更新日期：2003-06-01 00:00:00
abstract：:Myasthenia gravis is a disorder that most commonly affects young adults but occasionally appears in the elderly. Muscle weakness and easy fatigability, particularly of the ocular muscles, are characteristic. Diagnosis is confirmed by electromyography and the edrophonium (Tensilon) test. The pathology results from inab...
journal_title：American family physician
pub_type： 杂志文章
doi：
更新日期：1978-06-01 00:00:00
abstract：:Gout is a disease resulting from the deposition of urate crystals caused by the overproduction or underexcretion of uric acid. The disease is often, but not always, associated with elevated serum uric acid levels. Clinical manifestations include acute and chronic arthritis, tophi, interstitial renal disease and uric a...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：1999-04-01 00:00:00
abstract：:Acute bronchitis is one of the top 10 conditions for which patients seek medical care. Physicians show considerable variability in describing the signs and symptoms necessary to its diagnosis. Because acute bronchitis most often has a viral cause, symptomatic treatment with protussives, antitussives, or bronchodilator...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：2002-05-15 00:00:00
abstract：:Nephrolithiasis is a rare but important condition in pregnant women. The most common presenting complaint is flank pain. Recurrent or persistent urinary tract infections may also be due to nephrolithiasis. Ultrasound is the first-line diagnostic study, but a limited intravenous pyelogram can be obtained when indicated...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：1989-09-01 00:00:00
