Abstract：
BACKGROUND:Uric acid stabilizes platelet aggregation and enhances thrombotic tendency. OBJECTIVE:To examine the relationship between raised serum uric acid and subsequent cardiovascular events (mortality, myocardial infarction, stroke). METHODS:This is a longitudinal study in a small random number (418) of patients in Kinshasa, Congo. In this hospital-based study, uricemia was determined with respect to gender, obesity and hypertension as well correlated with traditional cardiovascular risk factors. A univariate regression model was used to investigate the association of serum uric acid with the incidence of mortality, stroke and myocardial infarction. RESULTS:Serum uric acid was higher (P<0.05) in obese women and men as well in hypertensives, than in their controls. The significant (P<0.05 and 0.001) highest frequency of hyperuricemia was observed in both diabetic and hypertensive patients. Blood pressure (BP) was higher (P<0.001) in patients with hyperuricemia than in those with normal serum uric acid. Serum uric acid was significantly correlated with body weight, BP, glucose, fibrinogen, urea, creatinin and total cholesterol. In men, hyperuricemia was significantly (P<0.01) associated with a twofold increased risk of both myocardial infarction and stroke incidence. However, hyperuricemia was significantly related to a double risk of all mortality and stroke onset. CONCLUSION:Our results indicate that hyperuricemia among african patients is a strong predictor of myocardial infarction in men, stroke in both sexes and all causes of mortality in women.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Longo-Mbenza B,Luila EL,Mbete P,Vita EKdoi
10.1016/s0167-5273(99)00097-2subject
Has Abstractpub_date
1999-09-30 00:00:00pages
17-22issue
1eissn
0167-5273issn
1874-1754pii
S0167527399000972journal_volume
71pub_type
临床试验,杂志文章,随机对照试验abstract：BACKGROUND:There is increasing evidence for beneficial effects of the type 5 phosphodiesterase inhibitor, sildenafil, in idiopathic pulmonary arterial hypertension (PAH). The effects of sildenafil in severe PAH associated with an atrial septal defect (ASD) have not been clearly delineated. METHODS:This extended case s...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2006.06.045
更新日期：2007-05-31 00:00:00
abstract：:Aberrant origin of the main stem of the left coronary artery from the right sinus of Valsalva caused angina of effort in a 40 year-old patient. Diagnosis was revealed by transoesophageal echocardiography and confirmed by selective coronary angiography. Aorto-coronary bypass was performed in order to prevent the recurr...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(91)90050-y
更新日期：1991-07-01 00:00:00
abstract：:Atrioventricular valve development is described as following the general principle of junctional invagination and myocardial undermining. We have added considerations of the topographic relations of the developing mitral valve to these principles. Two groups of malformations are then distinguished: the first comprises...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(86)90202-0
更新日期：1986-04-01 00:00:00
abstract：BACKGROUND:Guideline-recommended beta-blocker (BB) target doses for patients with chronic heart failure can often not be reached. This secondary analysis of the CIBIS-ELD trial was carried out to better understand reasons for not achieving target doses. METHODS:Changes in heart rate (HR) and other parameters during a ...
journal_title：International journal of cardiology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ijcard.2011.11.018
更新日期：2012-02-23 00:00:00
abstract：OBJECTIVE:To compare the prevalence of type 2 diabetes mellitus (DM) and coronary artery disease (CAD) and hypertension in DM in the rural and urban populations of north India. DESIGN AND METHODS:Two populations of the same ethnic background were randomly selected for this cross sectional survey. There were 1769 rural...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/s0167-5273(98)00141-7
更新日期：1998-09-01 00:00:00
abstract：BACKGROUND:Advanced congestive heart failure (CHF) therapies include intravenous inotropic agents, change in class of diuretics, and venous ultrafiltration or hemodialysis. These modalities have not been associated with improved prognosis and are limited by availability and cost. Compared to high-dose furosemide alone,...
journal_title：International journal of cardiology
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.ijcard.2014.03.020
更新日期：2014-05-01 00:00:00
abstract：BACKGROUND:Diabetes mellitus is an independent risk factor for stroke and atrial fibrillation. Therefore, the risk/benefit profile of the oral factor Xa inhibitor edoxaban stratified by diabetes is of clinical interest. METHODS:21,105 patients enrolled in ENGAGE AF-TIMI 48 were stratified into 2 pre-specified groups: ...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2020.01.009
更新日期：2020-04-01 00:00:00
abstract：:To establish a noninvasive diagnostic method for early assessment of cardiac involvement in Kawasaki disease (KD), 28 children with KD were included in this study. Two-dimensional echocardiography (2D-Echo) to detect the aneurysms of coronary arteries (CA), as well as rest and dipyridamole-stress technetium-99m tetrof...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/s0167-5273(02)00525-9
更新日期：2003-07-01 00:00:00
abstract：BACKGROUND:Cancer cachexia is thought to be the cause of >20% of cancer related deaths. Symptoms of cancer cachexia patients include depression and anorexia significantly worsening their quality of life. Moreover, in rodent models of cancer cachexia atrophy of the heart has been shown to impair cardiac function. Here, ...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2013.10.022
更新日期：2013-12-10 00:00:00
abstract：INTRODUCTION:Increased central sympathetic activity has a central role in the pathophysiology of cardiac arrhythmias. Despite the recently published negative results regarding the impact of renal sympathetic denervation (RDN) on resistant hypertension treatment, the beneficial effects of this intervention on cardiac ar...
journal_title：International journal of cardiology
pub_type： 杂志文章,评审
doi：10.1016/j.ijcard.2016.06.043
更新日期：2016-10-01 00:00:00
abstract：BACKGROUND:Heart failure with preserved ejection fraction (HFpEF) is among the most common forms of heart failure (HF). We aimed to investigate the prognostic significance of serum potassium levels and its interaction with type-2 diabetes mellitus in patients with HFpEF. METHODS:Consecutive HFpEF patients were prospec...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2020.04.029
更新日期：2020-10-15 00:00:00
abstract：BACKGROUND:Despite frequent life-long hemodynamic and electrophysiologic abnormalities, adults with congenital heart defects (CHDs) are often lost to medical follow-up. Using a cohort of adults with CHD receiving hospital care in Arkansas, we sought to determine how often a CHD is recognized and coded during hospital a...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2017.02.100
更新日期：2017-05-15 00:00:00
abstract：:The effects of disopyramide on the atrial fibrillation threshold (AFT) in the human atrium were investigated. To evaluate atrial vulnerability, the following electrophysiologic parameters were measured before and after the administration of disopyramide (2 mg/kg) in 12 patients with paroxysmal atrial fibrillation: The...
journal_title：International journal of cardiology
pub_type： 临床试验,杂志文章
doi：10.1016/0167-5273(95)02467-b
更新日期：1995-11-24 00:00:00
abstract：BACKGROUND:Heart failure (HF) is increasingly common and characterised by frequent admissions to hospital. To reduce the risk of HF hospitalisation (HFH), approaches as telemonitoring (TM) have been introduced. This study aimed to develop an algorithm for detecting patients at high risk of HFH, using daily collected ph...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2016.04.149
更新日期：2016-08-01 00:00:00
abstract：:The relationship between transoesophageal Doppler pulmonary venous flow pattern and spontaneous left atrial contrast was studied in 23 patients with isolated severe mitral stenosis (mitral valve area = 0.8 +/- 0.2 cm2). The patients with none or minimal (1+) spontaneous contrast (n = 15, group I) were compared with th...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(92)90307-o
更新日期：1992-09-01 00:00:00
abstract：BACKGROUND:Data with animal cells and models suggest that thrombin activates cardiac fibroblasts (Fib) to myofibroblasts (myoFib) via protease-activated receptor 1 (PAR1) cleavage, and in this way promotes adverse atrial remodeling and, thereby, atrial fibrillation (AF). OBJECTIVE:Here, we explored the effects of thro...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2018.05.033
更新日期：2018-11-15 00:00:00
abstract：:Chronic sickle cell (SC) disease is known to cause pulmonary hypertension (PH) which eventually affects right as well as left ventricular function. However, the acute effects of SC crisis on right ventricular (RV) function in adults have not been well described. Our echocardiography database was queried for patients f...
journal_title：International journal of cardiology
pub_type： 信件
doi：10.1016/j.ijcard.2007.08.099
更新日期：2009-03-06 00:00:00
abstract：BACKGROUND:ACC/AHA guidelines support the use of the P2Y12 inhibitors clopidogrel, prasugrel, or ticagrelor in acute myocardial infarction (AMI). Little is known about trends in P2Y12 inhibitor selection over time. METHODS:Multicenter, longitudinal analysis of patients and hospitals in the National Cardiovascular Data...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2020.01.029
更新日期：2020-04-01 00:00:00
abstract：:A common data base of six coronary care units containing personal and clinical data of 17462 patients was used to investigate the relation between clinical symptoms of patients with acute myocardial infarction and size of infarction. In 1974 of the 5110 patients, in whom a final diagnosis of infarction was made, size ...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(88)90080-0
更新日期：1988-05-01 00:00:00
abstract：:We sought to investigate the relative clinical significance of target and nontarget lesions repeated percutaneous coronary intervention (re-PCI) in patients implanted with drug-eluting stents (DES). Out of 2626 consecutive DES patients, we retrospectively selected 166 (6.3%; 123 males, aged 65±10 years) who had a clin...
journal_title：International journal of cardiology
pub_type： 信件
doi：10.1016/j.ijcard.2009.11.049
更新日期：2010-11-19 00:00:00
abstract：BACKGROUND:The safety and efficacy of the Promus Element stent have been recently demonstrated in a selected population from one randomized trial. The aim of this study was to describe the initial clinical experience with the everolimus eluting platinum chromium stent (Promus Element) in unselected patients from a real...
journal_title：International journal of cardiology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ijcard.2011.12.057
更新日期：2013-07-15 00:00:00
abstract：BACKGROUND:Unwitnessed OHCA patients with non-shockable initial rhythms account for nearly half of all OHCA patients, and their prognosis is extremely poor. To date, no studies have focused on these patients. This study aimed to investigating the predictors of favorable and poor prognosis in these patients. METHODS:We...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2014.08.057
更新日期：2014-10-20 00:00:00
abstract：BACKGROUND:AKI is a known complication of PCI and is associated with higher rates of adverse events. We assessed temporal trends in rates of AKI, factors associated with risk of AKI and prognosis. METHODS:From a prospective registry of patients undergoing PCI at two hospitals of the Rabin Medical Center, 15,153 consec...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2020.10.039
更新日期：2020-10-22 00:00:00
abstract：:We report a 14 year old boy who presented as a neonate with functional pulmonary atresia due to Uhl's disease with emphasis on the later detection of restrictive right ventricular physiology. ...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/s0167-5273(98)00304-0
更新日期：1998-12-01 00:00:00
abstract：BACKGROUND:Heart failure (HF) imposes both direct costs to healthcare systems and indirect costs to society through morbidity, unpaid care costs, premature mortality and lost productivity. The global economic burden of HF is not known. METHODS:We estimated the overall cost of heart failure in 2012, in both direct and ...
journal_title：International journal of cardiology
pub_type： 杂志文章,评审
doi：10.1016/j.ijcard.2013.12.028
更新日期：2014-02-15 00:00:00
abstract：BACKGROUND:To provide confirmatory evidence that the accuracy of MSCT coronary angiography is comparable to that of conventional coronary angiography. METHOD:19 patients who had both MSCT and conventional coronary angiography were included in our study. The mean age of our patients was 62.3 (SD 7.7) and 42% of our pat...
journal_title：International journal of cardiology
pub_type： 信件
doi：10.1016/j.ijcard.2006.08.057
更新日期：2007-09-14 00:00:00
abstract：:We report documenting the "Fatigue" phenomenon in the accessory pathway of a patient with Wolff-Parkinson-White syndrome. ...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/0167-5273(85)90290-6
更新日期：1985-06-01 00:00:00
abstract：BACKGROUND:Doxorubicin (DOXO) is an effective anti-neoplastic drug but its clinical benefits are hampered by cardiotoxicity. Oxidative stress, apoptosis and myocardial fibrosis mediate the anthracycline cardiomyopathy. ROS trigger TGF-β pathway that activates cardiac fibroblasts promoting fibrosis. Myocardial stiffness...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2015.12.008
更新日期：2016-02-15 00:00:00
abstract：:Apical transient left ventricular diskynesia is a recently described entity able to imitate acute coronary syndrome. The presence of previous coronary artery disease (CAD) is an exclusion criterion for this diagnosis in several studies. We report the case of a sixty-three year-old-caucasian man with previously known C...
journal_title：International journal of cardiology
pub_type： 信件
doi：10.1016/j.ijcard.2007.11.056
更新日期：2008-11-12 00:00:00
abstract：BACKGROUND:Contrast-induced acute kidney injury (CI-AKI) is a recognised complication during primary PCI that affects short and long term prognosis. The aim of this study was to assess the impact of point-of-care (POC) pre-PPCI creatinine and eGFR testing in STEMI patients. METHODS:160 STEMI patients (STATCREAT group)...
journal_title：International journal of cardiology
pub_type： 杂志文章
doi：10.1016/j.ijcard.2017.03.147
更新日期：2017-08-01 00:00:00
