How does the major histocompatibility complex influence behavior?

Abstract:

:The major histocompatibility complex (MHC) encodes highly polymorphic cell surface glycoproteins that form the basis of immunological individuality. It has been postulated that MHC besides its role in immune defence also determines behavior through formation of specific odor cues. In addition several studies have implicated MHC disassortative odor and mating preferences in mice, rats, and humans. Further leading studies have suggested that mice and humans prefer to mate with MHC dissimilar individuals. Although the latter remains controversial, MHC dependent mating preferences provide a potentially important selective factor driving the polymorphisms of the MHC genes. Here we review some of the available data and hypotheses on the influence of the MHC on behavior and discuss its molecular and chemical basis.

authors

Janssen E,Zavazava N

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

139-42

issue

3

eissn

0004-069X

issn

1661-4917

journal_volume

47

pub_type

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