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Prediction of response to fluoxetine and placebo in children and adolescents with major depression: a hypothesis generating study.

Abstract：

BACKGROUND:The results of multivariate analyses to identify potential predictors of response to fluoxetine or placebo separately in 96 child and adolescent outpatients with major depressive disorder from a recent controlled trial are presented. METHODS:A variety of clinical, demographic and laboratory factors were examined as possible predictors of response to fluoxetine or placebo using logistic regression models. RESULTS:No single variable or combination of variables strongly predicted response to fluoxetine. For the placebo group, a younger age, a shorter duration of depressive episode, and a lower socioeconomic status predicted response with an overall predictive power of 81%. CONCLUSIONS:This study is limited by the small sample size and should be considered hypothesis generating rather than confirming.

journal_name

J Affect Disord

journal_title

Journal of affective disorders

authors

Kowatch RA,Carmody TJ,Emslie GJ,Rintelmann JW,Hughes CW,Rush AJ

doi

10.1016/s0165-0327(98)00205-5

subject

Has Abstract

pub_date

1999-08-01 00:00:00

pages

269-76

issue

3

eissn

0165-0327

issn

1573-2517

pii

S0165-0327(98)00205-5

journal_volume

54

pub_type

临床试验,杂志文章,随机对照试验

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