Metabolism of genistein by rat and human cytochrome P450s.

abstract：:Drug hypersensitivity reactions adversely affect treatment outcome, increase the length of patients' hospitalization, and limit the prescription options available to physicians. In addition, late stage drug attrition and the withdrawal of licensed drugs cost the pharmaceutical industry billions of dollars. This signif...

journal_title：Chemical research in toxicology

authors： Hammond S,Thomson PJ,Ogese MO,Naisbitt DJ

更新日期：2020-01-21 00:00:00

abstract：:Interstrand cross-links are minor components of the collection of products formed in DNA by ionizing radiation. Through their formation by other damaging agents, it is known that interstrand cross-links exert significant effects on replication and transcription. The structures of DNA interstrand cross-links produced a...

journal_title：Chemical research in toxicology

authors： Ding H,Greenberg MM

更新日期：2007-11-01 00:00:00

abstract：:Acetaminophen (APAP), a commonly used analgesic, is catalyzed by cytochrome P450 (P450) enzymes to a toxic intermediate which can be trapped by glutathione. Using this approach, involvement of enzymes in the activation of APAP and their kinetics were studied. With human liver microsomes, there were three apparent Km v...

journal_title：Chemical research in toxicology

authors： Patten CJ,Thomas PE,Guy RL,Lee M,Gonzalez FJ,Guengerich FP,Yang CS

更新日期：1993-07-01 00:00:00

abstract：:The binding of arsenite, As(III), and arsenate, As(V), by molecules in the intracellular compartment of rabbit erythrocytes has been studied by 1H- and 31P-NMR spectroscopy, uptake of 73As, and ultrafiltration experiments. For intact erythrocytes to which 0.1-0.4 mM arsenite was added, direct evidence was obtained for...

journal_title：Chemical research in toxicology

authors： Delnomdedieu M,Basti MM,Styblo M,Otvos JD,Thomas DJ

更新日期：1994-09-01 00:00:00

abstract：:The conjugation of reactive drug metabolites to GSH is considered an important detoxification mechanism that can be spontaneous and/or mediated by glutathione S-transferases (GSTs). In case GSTs play an important role in GSH conjugation, genetically determined deficiencies in GSTs may be a risk factor for adverse drug...

journal_title：Chemical research in toxicology

authors： Dragovic S,Boerma JS,van Bergen L,Vermeulen NP,Commandeur JN

更新日期：2010-09-20 00:00:00

abstract：:A diverse series of aliphatic alpha,beta-unsaturated esters, ketones, and aldehydes were evaluated for reactivity with the model nucleophile sulfhydryl group in the form of the cysteine residue of the tripeptide glutathione; the reactive end point (RC50) was then related to aquatic toxicity (IGC50) assessed in the Tet...

journal_title：Chemical research in toxicology

authors： Yarbrough JW,Schultz TW

更新日期：2007-03-01 00:00:00

abstract：:Nucleotide excision repair (NER) removes lesions caused by environmental mutagens or UV light from DNA. A hallmark of NER is the extraordinarily wide substrate specificity, raising the question of how one set of proteins is able to recognize structurally diverse lesions. Two key features of good NER substrates are tha...

journal_title：Chemical research in toxicology

authors： Yeo JE,Khoo A,Fagbemi AF,Schärer OD

更新日期：2012-11-19 00:00:00

abstract：:A series of tether-linked bis netropsins have been synthesized in order to assess the phasing problem, which arises because of the lack of dimensional correspondence between oligopeptides and oligonucleotides in DNA binding characteristics. The consequences of incorporating variable-length flexible and rigid tethers [...

journal_title：Chemical research in toxicology

authors： Kissinger KL,Dabrowiak JC,Lown JW

更新日期：1990-03-01 00:00:00

abstract：:The carcinogen 7r,8t-dihydroxy-9t,10t-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (anti-BPDE) alkylates DNA at dGuo, dAdo, and dCyd. dCyd adducts, formed in small amounts, elute near the more abundant dGuo adducts. We isolated the dCyd adducts formed with dCMP. Each BPDE enantiomer forms three major adducts with dCMP, two...

journal_title：Chemical research in toxicology

authors： Wolfe AR,Smith TJ,Meehan T

更新日期：2004-04-01 00:00:00

abstract：:Liver microsomes from uninduced hogs catalyzed the NADPH-dependent N-oxidation of the hydroxylamine (Z)-3-(4-bromophenyl)-N-hydroxy-N-methyl-3-(3-pyridyl)allylamine. The conjugated nitrone N-[(2Z)-3-(4-bromophenyl)-3-(3-pyridyl)-2-propenylidene]methylamin e N-oxide was the principal product and accounted for 90-95% of...

journal_title：Chemical research in toxicology

authors： Cashman JR,Yang ZC,Högberg T

更新日期：1990-09-01 00:00:00

abstract：:To obtain definitive information about the mechanisms of urinary calculus formation and the structural characteristics of the calculi induced by biphenyl administration in rats, with a focus on the sex dependency, the constituents of the urinary calculi were analyzed by HPLC, inductively coupled plasma spectroscopy (I...

journal_title：Chemical research in toxicology

authors： Ohnishi M,Yajima H,Yamamoto S,Matsushima T,Ishii T

更新日期：2000-08-01 00:00:00

abstract：:Capillary liquid chromatography-continuous-flow fast atom bombardment mass spectrometry is applied to the detection of deoxynucleoside adducts of N-acetoxy-N-acetyl-2-aminofluorene. In such a configuration, normal scan and tandem mass spectrometric techniques are shown to provide useful structural information for an N...

journal_title：Chemical research in toxicology

authors： Wolf SM,Vouros P

更新日期：1994-01-01 00:00:00

abstract：:The site specifically modified oligonucleotides 5'-d(TCCTCCTG1G2CCTCTC) (I) and 5'-d(CTATG1G2G3TATC) (II) were synthesized with single modified guanine residues at positions G1, G2, or G3, derived from the covalent binding reaction of 7R,8S-dihydroxy-9S,10R-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene ((+)-anti-BPDE) with ...

journal_title：Chemical research in toxicology

authors： Liu T,Xu J,Tsao H,Li B,Xu R,Yang C,Amin S,Moriya M,Geacintov NE

更新日期：1996-01-01 00:00:00

abstract：:Skin sensitizers chemically modify skin proteins rendering them immunogenic. Sensitizing chemicals have been divided into applicability domains according to their suspected reaction mechanism. The widely accepted Schiff base applicability domain covers aldehydes and ketones, and detailed structure-activity-modeling fo...

journal_title：Chemical research in toxicology

authors： Natsch A,Gfeller H,Haupt T,Brunner G

更新日期：2012-10-15 00:00:00

abstract：:Induction of Phase II enzymes of the [Ah] gene battery by L-buthionine (S,R)-sulfoximine (BSO) and other agents was examined in mouse hepatoma Hepa-1c1c7 cells. BSO, a nonelectrophilic inhibitor of gamma-glutamylcysteine synthetase (GCS), is routinely used to examine the toxicological implications of GSH depletion. Ex...

journal_title：Chemical research in toxicology

authors： Shertzer HG,Vasiliou V,Liu RM,Tabor MW,Nebert DW

更新日期：1995-04-01 00:00:00

abstract：:There is strong epidemiologic evidence linking chronic exposure to inorganic arsenic (iAs) to myriad adverse health effects, including cancer of the bladder. We set out to identify DNA methylation patterns associated with arsenic and its metabolites in exfoliated urothelial cells (EUCs) that originate primarily from t...

journal_title：Chemical research in toxicology

authors： Rager JE,Tilley SK,Tulenko SE,Smeester L,Ray PD,Yosim A,Currier JM,Ishida MC,González-Horta Mdel C,Sánchez-Ramírez B,Ballinas-Casarrubias L,Gutiérrez-Torres DS,Drobná Z,Del Razo LM,García-Vargas GG,Kim WY,Zhou YH,Wright

更新日期：2015-06-15 00:00:00

abstract：:The relation between organophosphorus-induced delayed neuropathy (OPIDN) and brain neuropathy target esterase (NTE) inhibition is further examined in hens by structure-activity studies leading to the most potent in vitro NTE inhibitors known, which are then examined for their neuropathic effects in vivo in hens. The p...

journal_title：Chemical research in toxicology

authors： Wu SY,Casida JE

更新日期：1995-12-01 00:00:00

abstract：:Acetaminophen (AP) is a popularly recommended over-the-counter analgesic-antipyretic in clinical use. However, the drug is handicapped by the occurrence of hepatotoxic insult following acute ingestion. Consequently, AP-induced hepatotoxicity is often implicated in accidental or suicidal overdose. In the current study,...

journal_title：Chemical research in toxicology

authors： Sahu A,Das D,Sahu P,Mishra S,Sakthivel A,Gajbhiye A,Agrawal R

更新日期：2020-02-17 00:00:00

abstract：:Cytochrome P450 2F1 (P450 2F1) is expressed exclusively in the human respiratory tract and is implicated in 3-methylindole (3MI)-induced pneumotoxicity via dehydrogenation of 3MI to a reactive electrophilic intermediate, 3-methyleneindolenine (3-MEI). Studies of P450 2F1 to date have been limited by the failure to exp...

journal_title：Chemical research in toxicology

authors： Behrendorff JB,Moore CD,Kim KH,Kim DH,Smith CA,Johnston WA,Yun CH,Yost GS,Gillam EM

更新日期：2012-09-17 00:00:00

abstract：:Aflatoxin Q1 8,9-oxide was synthesized and found to yield lower levels of N7-guanyl adducts than obtained from aflatoxin B1 8,9-oxide when mixed with calf thymus DNA or Salmonella typhimurium TA 98 cells. However, when S. typhimurium TA 98 was treated with the (analogous) epoxides of aflatoxin B1, aflatoxin G1, aflato...

journal_title：Chemical research in toxicology

authors： Raney KD,Shimada T,Kim DH,Groopman JD,Harris TM,Guengerich FP

更新日期：1992-03-01 00:00:00

abstract：:Drug-induced myocardial infarction (DIMI) is one of the most serious adverse drug effects that often lead to death. Therefore, the identification of DIMI at the early stages of drug development is essential. For this purpose, the in vitro testing and in silico prediction of interactions between drug-like substances an...

journal_title：Chemical research in toxicology

authors： Ivanov SM,Lagunin AA,Pogodin PV,Filimonov DA,Poroikov VV

更新日期：2014-07-21 00:00:00

abstract：:Many organic sulfides (mono-, di-, and polysulfides) are present in our environment. Simple derivatives are produced by some plants and animals, while complex sulfides are secondary metabolites of several genera of bacteria and fungi. Sulfides play an important role in the smell and taste of food, and many such compou...

journal_title：Chemical research in toxicology

authors： Munday R

更新日期：2012-01-13 00:00:00

abstract：:The measurement of metabolites constitutes a useful tool for detection of exposure and in pharmacokinetic studies. Epoxidation with subsequent glutathione conjugation and mercapturic acid formation is an important deactivation pathway for naphthalene, a toxin which presumably causes lung disease. The mercapturic acid ...

journal_title：Chemical research in toxicology

authors： Marco MP,Nasiri M,Kurth MJ,Hammock BD

更新日期：1993-05-01 00:00:00

abstract：:A model protein, ribonuclease A (bovine pancreas), was examined for its ability to coordinate Ni2+ and promote selective oxidation. In the presence of a peracid such as monopersulfate, HSO5-, nickel induced the monomeric RNase A to form dimers, trimers, tetramers, and higher oligomers without producing fragmentation o...

journal_title：Chemical research in toxicology

authors： Gill G,Richter-Rusli AA,Ghosh M,Burrows CJ,Rokita SE

更新日期：1997-03-01 00:00:00

abstract：:Lindane and paraquat induce biochemical changes in the liver. In order to specify their molecular impact at the cellular level, a 300 MHz 1H NMR investigation of hepatoma cell lines Hep 3B and Hep G2 responses was performed. Cells were exposed over 24 h to 50 mg/L lindane (0.178 mM) or to 100 mg/L (0.389 mM) paraquat ...

journal_title：Chemical research in toxicology

authors： Descampiaux B,Imbenotte M,Desenclos V,Vermeersch G,Lhermitte M,Erb F

更新日期：1997-01-01 00:00:00

abstract：:Many herbal medicines such as epimedium have been reported to cause adverse effects, and icaritin is the common aglycone of many glucosides in epimedium. Our present work aimed at the clarification of the metabolic activation of icaritin possibly responsible for the adverse effects of epimedium. A quinone methide meta...

journal_title：Chemical research in toxicology

authors： Chen Y,Guo X,Ma Y,Hu X,Peng Y,Zheng J

更新日期：2019-06-17 00:00:00

abstract：:As metals are ubiquitous in the environment, humans are continuously exposed to them. Although some metallic ions play key roles in human physiology, most metals are redundant and are actually hazardous to humans. A frequent event in the toxicological cascade triggered by nonessential metals concerns the abrogation of...

journal_title：Chemical research in toxicology

authors： Vinken M,Ceelen L,Vanhaecke T,Rogiers V

更新日期：2010-12-20 00:00:00

abstract：:The current study examined the bioactivation potential of a nonpeptidyl thrombopoietin receptor agonist, 1-(3-chloro-5-((4-(4-fluoro-3-(trifluoromethyl)phenyl)thiazol-2-yl)carbamoyl)pyridine-2-yl)piperidine-4-carboxylic acid (1), containing a 2-carboxamido-4-arylthiazole moiety in the core structure. Toxicological ris...

journal_title：Chemical research in toxicology

authors： Kalgutkar AS,Driscoll J,Zhao SX,Walker GS,Shepard RM,Soglia JR,Atherton J,Yu L,Mutlib AE,Munchhof MJ,Reiter LA,Jones CS,Doty JL,Trevena KA,Shaffer CL,Ripp SL

更新日期：2007-12-01 00:00:00

abstract：:Pyridoxamine (PM) is an effective inhibitor of the formation of the carcinogen acrylamide (AA) from its precursors in low-moisture model systems. Although AA is widely assumed to act by scavenging carbonyl compounds, no alternative pathways have to date been explored. In this work, we found AA to directly react with P...

journal_title：Chemical research in toxicology

authors： Arribas-Lorenzo G,Pintado-Sierra M,Morales FJ

更新日期：2011-03-21 00:00:00

abstract：:Hydroxyl radical can be induced from Fenton reaction or gamma radiolysis of water. It can add preferentially to the C5 position of thymidine to give the 5-hydroxy-5,6-dihydrothymidin-6-yl radical. In this report, we examined the independent generation and reactivity of this radical in oligodeoxyribonucleotides (ODNs)....

journal_title：Chemical research in toxicology

authors： Zhang Q,Wang Y

更新日期：2005-12-01 00:00:00