The efficiencies of damage recognition and excision correlate with duplex destabilization induced by acetylaminofluorene adducts in human nucleotide excision repair.

abstract：:Caffeine on alkaline hydrolysis produces caffeidine [1-methyl-4-(methylamino)-5-(N-methylcarbamoyl)imidazole] and caffeidine acid [N-[4-(5-carboxy-1-methylimidazolyl)]-N,N'-dimethylurea]. We now report the synthesis and chemical characterization of mononitrosocaffeidine [1-methyl-4-(N-methyl-N-nitrosoamino)-5-(N-methy...

journal_title：Chemical research in toxicology

authors： Kumar R,Wacker CD,Mende P,Spiegelhalder B,Preussmann R,Siddiqi M

更新日期：1993-01-01 00:00:00

abstract：:Mitomycin C (MMC) is a genotoxic cancer chemotherapeutic agent that reacts principally at the N2 position of guanine to form one of two predominant monoadducts, or a G-G interstrand cross-link at CpG sites, or a G-G intrastrand cross-link at GpG sites. Previous studies of MMC adduction have principally used very short...

journal_title：Chemical research in toxicology

authors： Warren AJ,Hamilton JW

更新日期：1996-10-01 00:00:00

abstract：:Acyl glucuronides (AGs) are reactive metabolites of carboxylic acid-containing drugs, which are associated with idiosyncratic toxicity (IDT) such as anaphylaxis, drug-induced liver injury, and so on. In this study, we developed a new in vitro approach for the quantitative assessment of the reactivity of AGs and their ...

journal_title：Chemical research in toxicology

authors： Harada H,Toyoda Y,Abe Y,Endo T,Takeda H

更新日期：2019-10-21 00:00:00

abstract：:The synthesis of a series of 1,2,4-triazole-containing oligopeptide lexitropsins related to the natural antitumor antibiotic distamycin is described. The binding properties of these new agents to both native DNAs and synthetic polydeoxyribonucleotides were determined by UV absorption and circular dichroism studies. Th...

journal_title：Chemical research in toxicology

authors： Rao KE,Krowicki K,Burckhardt G,Zimmer C,Lown JW

更新日期：1991-03-01 00:00:00

abstract：:Because the manganese-based contrast agents used in magnetic, resonance imaging are unstable in vivo, some concern exists about the potential toxicity coming from the Mn2+ released by the complexes. This potential problem arises because the manganese is known to accumulate in the brain of people intoxicated by this me...

journal_title：Chemical research in toxicology

authors： Gallez B,Baudelet C,Adline J,Geurts M,Delzenne N

更新日期：1997-04-01 00:00:00

abstract：:Formyl chloride has been indirectly implicated as an intermediate in the oxidation of CH(2)Cl(2) and proposed to be a product of the oxidation of some other compounds. Formyl chloride was synthesized and added to aqueous solutions, with CO formed as a product. The presence of glutathione (GSH) did not reduce the yield...

journal_title：Chemical research in toxicology

authors： Watanabe K,Guengerich FP

更新日期：2006-08-01 00:00:00

abstract：:While xenobiotic carboxylic acids (XCAs) have been studied extensively with respect to their enzymatic conversion to potentially reactive acyl glucuronides with implications to drug induced hepatotoxicity, the formation of xenobiotic-S-acyl-CoA thioesters (xenobiotic-CoAs) have been much less studied in spite of data ...

journal_title：Chemical research in toxicology

authors： Darnell M,Weidolf L

更新日期：2013-08-19 00:00:00

abstract：:Exposures to sulfur mustard (HD; bis(2-chloroethyll) sulfide) are well-known to result in the formation of adducts with free aspartate and glutamate residues of plasma proteins (Lawrence, R. J., Smith, J. R., and Capacio, B. R. 2008 32, (1), 31-36). A modified version of the analytical method reported previously for t...

journal_title：Chemical research in toxicology

authors： Young SA,Capacio BR

更新日期：2020-07-20 00:00:00

abstract：:Dysregulation in the expression of microRNAs (miRNAs), single-stranded RNAs which regulate gene expression, has been associated with diseases such as Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN), although their cellular origin has not been explored. Thus, the focus of this work was to study expressi...

journal_title：Chemical research in toxicology

authors： Monroy-Arreola A,Durán-Figueroa NV,Méndez-Flores S,Domínguez-Cherit J,Watkinson J,Badillo-Corona JA,Whitaker P,Naisbitt DJ,Castrejón-Flores JL

更新日期：2018-06-18 00:00:00

abstract：:Catalase is an important antioxidant enzyme, which has been shown to provide cardiac protection from acute toxicity induced by doxorubicin, a most effective anticancer agent. Because cumulative dose-dependent chronic cardiomyopathy due to a long-term administration of doxorubicin is a significant clinical problem, the...

journal_title：Chemical research in toxicology

authors： Kang YJ,Sun X,Chen Y,Zhou Z

更新日期：2002-01-01 00:00:00

abstract：:Estrogen exposure through early menarche, late menopause, and hormone replacement therapy increases the risk factor for hormone-dependent cancers. Although the molecular mechanisms are not completely established, DNA damage by quinone electrophilic reactive intermediates, derived from estrogen oxidative metabolism, is...

journal_title：Chemical research in toxicology

authors： Chandrasena RE,Edirisinghe PD,Bolton JL,Thatcher GR

更新日期：2008-07-01 00:00:00

abstract：:There is limited and sometimes contradictory information about the genotoxicity of the polycyclic aromatic hydrocarbon benzo[ghi]perylene (B[ghi]P). Using recently developed metabolic toxicity screening arrays and a biocolloid reactor-LC-MS/MS approach, both featuring films of DNA and human metabolic enzymes, we demon...

journal_title：Chemical research in toxicology

authors： Pan S,Li D,Zhao L,Schenkman JB,Rusling JF

更新日期：2013-08-19 00:00:00

abstract：:Cyadox is a novel derivative of quinoxaline-1,4-dioxides (QdNOs) with the potential to be developed as a feed additive. However, the pharmacological and toxicological bioactive molecules of cyadox and the molecular mechanism of its pharmacological and toxic actions remain unclear. In the present study, cyadox and its ...

journal_title：Chemical research in toxicology

authors： Liu Q,Lei Z,Zhou K,Yu H,Liu S,Sun Q,Wang X,Dai M,Yuan Z

更新日期：2018-11-19 00:00:00

abstract：:Metabolic pathways of the mutagen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) remain incompletely characterized in humans. In this study, the metabolism of MeIQx was investigated in primary human hepatocytes. Six metabolites were characterized by UV and mass spectroscopy. Novel metabolites were additionally ...

journal_title：Chemical research in toxicology

authors： Langouët S,Welti DH,Kerriguy N,Fay LB,Huynh-Ba T,Markovic J,Guengerich FP,Guillouzo A,Turesky RJ

更新日期：2001-02-01 00:00:00

abstract：:NADPH in microsomes reduces the hydroxocob(III)alamin form of vitamin B12 to cob(II)alamin and the supernucleophilic cob(I)alamin, which are both highly reactive toward xenobiotic epoxides formed by mammalian metabolism of dienes such as the industrially important chemicals chloroprene and 1,3-butadiene. With styrene,...

journal_title：Chemical research in toxicology

authors： Watson WP,Munter T,Golding BT

更新日期：2004-12-01 00:00:00

abstract：:Methyleugenol (ME), an alkenylbenzene compound, is a natural ingredient of several herbs and is used as flavoring agent in foodstuffs and fragrance in cosmetics. The hepatotoxicity, cytotoxicity, and carcinogenesis of ME have been well documented, and metabolic activation has been suggested to involve in ME-induced to...

journal_title：Chemical research in toxicology

authors： Feng Y,Wang H,Wang Q,Huang W,Peng Y,Zheng J

更新日期：2017-02-20 00:00:00

abstract：:Jay Amin hydroxamic acid (JAHA; N8-ferrocenylN1-hydroxy-octanediamide) is a ferrocene-containing analogue of the histone deacetylase inhibitor (HDACi) suberoylanilide hydroxamic acid (SAHA). JAHA's cytotoxic activity on MDA-MB231 triple negative breast cancer (TNBC) cells at 72 h has been previously demonstrated with ...

journal_title：Chemical research in toxicology

authors： Librizzi M,Caradonna F,Cruciata I,Dębski J,Sansook S,Dadlez M,Spencer J,Luparello C

更新日期：2017-12-18 00:00:00

abstract：:Graphene oxide derivatives (GODs) have superb physical/chemical properties with promise for applications in biomedicine. Shape, size, and chemistry of the GODs are identified as the key parameters that impact any biological system. In this work, the GODs with a wide range of shapes (sheets, helical/longitudinal ribbon...

journal_title：Chemical research in toxicology

authors： Lu P,Zehtab Yazdi A,Han XX,Al Husaini K,Haime J,Waye N,Chen P

更新日期：2020-09-21 00:00:00

abstract：:Two 2-aminofluorene-derived hydroxamic acids that differ only in the nature of the N-acyl group were examined for their relative abilities to undergo covalent binding to nucleic acids. Studies of the bioactivation of N-hydroxy-N-acetyl-2-aminofluorene (N-OH-AAF) and N-hydroxy-N-glycolyl-2-aminofluorene (N-OH-GAF) were...

journal_title：Chemical research in toxicology

authors： Corbett MD,Lim LO,Corbett BR,Johnston JJ,Wiebkin P

更新日期：1988-01-01 00:00:00

abstract：:Mouse cytochrome P450 2A5 (CYP2A5) is upregulated in various pathophysiological liver diseases and induced by structurally variable hepatotoxic chemicals. A putative common feature for all of these conditions is altered cellular redox status. Nuclear factor erythroid 2-like 2 (Nrf2) is a transcription factor that is p...

journal_title：Chemical research in toxicology

authors： Lämsä V,Levonen AL,Leinonen H,Ylä-Herttuala S,Yamamoto M,Hakkola J

更新日期：2010-05-17 00:00:00

abstract：:The carcinogen 7r,8t-dihydroxy-9t,10t-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (anti-BPDE) alkylates DNA at dGuo, dAdo, and dCyd. dCyd adducts, formed in small amounts, elute near the more abundant dGuo adducts. We isolated the dCyd adducts formed with dCMP. Each BPDE enantiomer forms three major adducts with dCMP, two...

journal_title：Chemical research in toxicology

authors： Wolfe AR,Smith TJ,Meehan T

更新日期：2004-04-01 00:00:00

abstract：:Human exposure to engineered nanomaterials (ENMs) is inevitable due to the plethora of applications for which they are being manufactured and integrated within. ENMs demonstrate plentiful advantages in terms of industrial approaches as well as from a consumer perspective. However, despite such positives, doubts remain...

journal_title：Chemical research in toxicology

authors： Cronin JG,Jones N,Thornton CA,Jenkins GJS,Doak SH,Clift MJD

更新日期：2020-05-18 00:00:00

abstract：:Lesion-induced thermodynamic destabilization is believed to facilitate β-hairpin intrusion by the human XPC/hHR23B nucleotide excision repair (NER) recognition factor, accompanied by partner-base flipping, as suggested by the crystal structure of the yeast orthologue (Min, J. H., and Pavletich, N. P. (2007) Nature 449...

journal_title：Chemical research in toxicology

authors： Zheng H,Cai Y,Ding S,Tang Y,Kropachev K,Zhou Y,Wang L,Wang S,Geacintov NE,Zhang Y,Broyde S

更新日期：2010-12-20 00:00:00

abstract：:Nickel(II) compounds are established human carcinogens, but the molecular mechanisms underlying their activity are only partially known. One mechanism may include mediation by nickel of promutagenic oxidative DNA damage that depends on Ni(II) binding to chromatin. To characterize such binding at the histone moiety of ...

journal_title：Chemical research in toxicology

authors： Bal W,Lukszo J,Jezowska-Bojczuk M,Kasprzak KS

更新日期：1995-07-01 00:00:00

abstract：:The efficacy of DNA-damaging anticancer drugs is highly influenced by cellular DNA repair capacity, and by inhibiting the relevant DNA repair pathway, efficacy of alkylating agents may be increased. Therefore, combining DNA repair inhibitors with anticancer agents that selectively target tumor tissue should improve ca...

journal_title：Chemical research in toxicology

authors： van Midwoud PM,Sturla SJ

更新日期：2013-11-18 00:00:00

abstract：:Quantitation of DNA adducts could provide critical information on the relationship between exposure to tobacco smoke and cancer risk in smokers. In this study, we developed a robust and sensitive liquid chromatography-tandem mass spectrometry method for the analysis of 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB)-releasin...

journal_title：Chemical research in toxicology

authors： Stepanov I,Muzic J,Le CT,Sebero E,Villalta P,Ma B,Jensen J,Hatsukami D,Hecht SS

更新日期：2013-01-18 00:00:00

abstract：:Methylmercury (MeHg) reacts readily with GSH, leading to the formation of a MeHg-SG adduct that is excreted into extracellular space through multidrug-resistance-associated protein (MRP), which is regulated by the transcription factor Nrf2. We previously reported that MeHg covalently modifies Keap1 and activates Nrf2 ...

journal_title：Chemical research in toxicology

authors： Yoshida E,Abiko Y,Kumagai Y

更新日期：2014-10-20 00:00:00

abstract：:The Salmonella typhimurium (TA100) mutagenic compound, mucochloric acid [3,4-dichloro-5-hydroxy-2(5H)-furanone (MCA)], was inactivated by in vitro N-acetylcysteine (NAC). The reaction of MCA with NAC at pH7 was second order and gave products 4, 5, and 6a that resulted from the displacement of chlorine from C-3 or C-4 ...

journal_title：Chemical research in toxicology

authors： LaLonde RT,Xie S

更新日期：1992-09-01 00:00:00

abstract：:( E)-4-Hydroxynon-2-enal (HNE), an electrophilic bifunctional cytotoxic lipid peroxidation product, forms covalent adducts with nucleophilic side chains of amino acid residues. HNE-derived adducts have been implicated in many pathophysiological processes including atherosclerosis, diabetes, and Alzheimer's disease. Tr...

journal_title：Chemical research in toxicology

authors： Annangudi SP,Deng Y,Gu X,Zhang W,Crabb JW,Salomon RG

更新日期：2008-07-01 00:00:00

abstract：:The procarcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is the most abundant heterocyclic amine formed during the cooking of foods. Metabolism of PhIP by CYP1A2 differs substantially between humans and rodents, with more N2-hydroxylation (activation) and less 4'-hydroxylation (detoxication) in humans....

journal_title：Chemical research in toxicology

authors： Cheung C,Ma X,Krausz KW,Kimura S,Feigenbaum L,Dalton TP,Nebert DW,Idle JR,Gonzalez FJ

更新日期：2005-09-01 00:00:00