Postmenopausal estrogen use and invasive versus in situ breast cancer risk.

Abstract:

:To examine the effect of cancer histopathology on the relationship between estrogen-replacement therapy (ERT) use and breast cancer risk, we performed a case-control study of 109 postmenopausal women 45 years or older with in situ or invasive breast cancer matched to 545 controls. When in situ and invasive tumors were combined, the overall odds ratio (OR) describing the association between ERT use and breast cancer risk was not statistically significantly elevated (adjusted OR = 1.48, 95% confidence interval [CI] = 0.89-2.47). When the analyses were confined to women with invasive disease, risk estimates were uniformly higher (adjusted OR = 1.85, 95% CI = 1.00-3.45). In contrast, the overall estimate for the relationship between ERT use and in situ breast cancer was close to 1 (adjusted OR = 1.08, 95% CI = 0.42-2.77). The positive association between ERT use and invasive breast cancer we observed, and the lack of association in women with in situ disease, may represent a distinct biological difference or may be related to the small sample size of our study.

journal_name

J Clin Epidemiol

authors

Henrich JB,Kornguth PJ,Viscoli CM,Horwitz RI

doi

10.1016/s0895-4356(98)00116-4

subject

Has Abstract

pub_date

1998-12-01 00:00:00

pages

1277-83

issue

12

eissn

0895-4356

issn

1878-5921

pii

S0895435698001164

journal_volume

51

pub_type

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