Abstract：
:p21 protein has been reported to be a critical downstream effector of p53 and a potent inhibitor of cyclin-dependent kinases. Thus, the p21 gene is thought to play a central role in tumor suppression. In this study we investigated p21 protein expression and mutation in gastric adenocarcinoma. A total of 76 primary gastric carcinoma specimens were immunohistochemically stained for p21 protein expression and evaluated the correlations between p21 expression and clinicopathologic features. In a proportion of them (20 cases), we also analyzed the possible presence of p21 gene mutations using PCR-SSCP method. Fourty seven out of 76 cases (61.8%) were p21-negative, and the remaining twenty nine cases (38.2%) were p21 -positive on immunostains. There was a correlation between the expression of p21, and the depth of tumor invasion and lymph node metastasis (p<0.05). No mutation of the p21 gene was detected in all of 20 tumor tissues. These results suggest that the status of p21 expression may have prognostic value in gastric adenocarcinoma.
journal_name
J Korean Med Scijournal_title
Journal of Korean medical scienceauthors
Park YE,Choi KC,Choi YHdoi
10.3346/jkms.1998.13.5.507subject
Has Abstractpub_date
1998-10-01 00:00:00pages
507-12issue
5eissn
1011-8934issn
1598-6357journal_volume
13pub_type
杂志文章abstract：:Fenofibrate is a drug that has been suggested to inhibit weight gain by increasing the catabolism of fatty acid in the hepatic mitochondria. We hypothesized that fenofibrate induces an increase in energy expenditure in the hepatic mitochondria, which results in the reduction of adipose tissue. In this study we measure...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2007.22.2.235
更新日期：2007-04-01 00:00:00
abstract：:Central obesity has been reported as a risk for atherosclerosis and metabolic syndrome. The influence of central obesity on diurnal blood pressure (BP) has not been established. In this study, we investigated the influence of central obesity on the circadian parameters of BP by 24 hr ambulatory BP monitoring. Total 1,...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2013.28.10.1461
更新日期：2013-10-01 00:00:00
abstract：:Intraspinal bronchogenic cysts are rare congenital cystic lesions. In all the reported cases, the cysts have been located in the cervical, upper thoracic or thoracolumbar segments. We report the case of an intraspinal bronchogenic cyst in the sacral location. We present the case of a 5-month-old female with a skin dim...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2008.23.5.895
更新日期：2008-10-01 00:00:00
abstract：:With the rapid aging of the population, Korea introduced public long-term care insurance for older people in 2008. The long-term care insurance was designed as a separate scheme from the national health insurance, with eligibility qualifications and the certification process based on functional disability, benefits an...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2012.27.S.S41
更新日期：2012-05-01 00:00:00
abstract：:A santorinicele is defined as a focal cystic dilatation of the terminal portion of the dorsal pancreatic duct at the minor papilla. Most cases reported previously were associated with pancreas divisum and a santorinicele without pancreas divisum is known to be rare. We recently experienced a typical case of a santorin...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2006.21.2.358
更新日期：2006-04-01 00:00:00
abstract：:Creutzfeldt-Jakob disease (CJD), a relatively uncommon human dementia, is caused by an unconventional slow infectious agent. Several cases of CJD, clinically or histopathologically diagnosed, have been reported in Korea. In order to confirm the diagnosis of CJD and also differential diagnosis of sporadic and familial ...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.1998.13.3.234
更新日期：1998-06-01 00:00:00
abstract：BACKGROUND:The purpose was to compare the efficacy between tenofovir disoproxil fumarate (TDF) and lamivudine (LMV) in children with nucleos(t)ide-naive chronic hepatitis B (CHB) infection. Patients with CHB were treated with TDF in the immune-reactive phase and compared with a historical control group of patients trea...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2018.33.e11
更新日期：2018-01-08 00:00:00
abstract：:To investigate what heterogeneity exists in breast cancer, 228 consecutive patients with operable invasive duetal carcinoma (IDC), not otherwise specified, were categorized on the basis of the horizontal progression model of carcinogenesis. Using the reversed Black's nuclear grade (RBNG) in the IDC component and the a...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2006.21.3.460
更新日期：2006-06-01 00:00:00
abstract：:In this study, the effects of high-intensity-focused ultrasound (HIFU) treatment on benign uterine tumor patients were examined. A total of 333 patients diagnosed with fibroids or adenomyosis using diagnostic sonography, treated with HIFU between February 4, 2010 and December 29, 2014 at a hospital in Korea, and follo...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2016.31.8.1279
更新日期：2016-08-01 00:00:00
abstract：:Type 1 myotonic dystrophy (DM1) is an autosomal-dominant inherited disorder with a multisystem involvement, caused by an abnormal expansion of the CTG sequence of the dystrophic myotonia protein kinase (DMPK) gene. DM1 is a variable multisystem disorder with muscular and nonmuscular abnormalities. Increasingly, endocr...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2013.28.7.1111
更新日期：2013-07-01 00:00:00
abstract：BACKGROUND:Transportation costs can be a barrier to healthcare services, especially for low-income, disabled, elderly, and geographically isolated populations. This study aimed to estimate the transportation costs of healthcare service utilization and related influencing factors in Korea in 2016. METHODS:Transportatio...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2020.35.e290
更新日期：2020-09-07 00:00:00
abstract：:We describe a case of solitary myeloma showing cystic change filled with massive crystalline structures in a 54-year-old woman. A bone X-ray showed a solitary cystic osteolytic lesion in the right iliac bone. Serum and urine protein electrophoresis showed no demonstrable M-protein, and bone-marrow aspirates did not sh...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.1991.6.2.165
更新日期：1991-06-01 00:00:00
abstract：:The prognostic significance of multidrug resistance (MDR) gene expression is controversial. We investigated whether multidrug resistance gene 1 (MDR1), multidrug resistance-related protein (MRP) and lung resistance protein (LRP) mRNA expression are associated with outcomes in acute leukemia patients. At diagnosis we e...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2006.21.2.253
更新日期：2006-04-01 00:00:00
abstract：:This study is designed to evaluate the immune status of schoolchildren with respect to Streptococcus pyogenes, and to ascertain the usefulness of antideoxyribonuclease B (ADNase B). Antistreptolysin O (ASO) and ADNase B concentrations were measured quantitatively in 266 serum samples from healthy elementary school chi...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2005.20.6.938
更新日期：2005-12-01 00:00:00
abstract：:Phospholipase C (PLC) and related enzymes in signal transduction system are closely linked to cellular damage in ischemic encephalopathy. This study was undertaken to elucidate the time sequential changes of PLC isoenzymes (beta and gamma) in vulnerable areas of hippocampus in global ischemia and infarcted area in foc...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.1996.11.1.44
更新日期：1996-02-01 00:00:00
abstract：:One important mechanism of drug resistance in acute leukemia is the overexpression of the multi-drug resistance (MDR1) gene that encodes a 170-kDa membrane protein called P-glycoprotein. To estimate the incidence and role of MDR1 gene expression in patients with acute leukemia, we investigated the expression of MDR1 b...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.1998.13.6.617
更新日期：1998-12-01 00:00:00
abstract：Background:We aimed to estimate whether elevated levels of complement C3a and C5a in amniotic fluid (AF) are independently associated with increased risks of intra-amniotic infection and/or inflammation (IAI) and spontaneous preterm delivery (SPTD) in women with cervical insufficiency or a short cervix (≤ 25 mm). Meth...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2018.33.e220
更新日期：2018-07-05 00:00:00
abstract：:Tumor-to-tumor metastasis is rare. We report a case of metastatic renal cell carcinoma in meningioma. A 67-year-old woman presented a two-week history of motor dysphagia and decreased short-term memory. She had undergone a left radical nephrectomy for a renal cell carcinoma 7 years ago, and had not received any adjuva...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2000.15.5.593
更新日期：2000-10-01 00:00:00
abstract：:This paper presents an unusual solid mesenchymal hamartoma of the liver (MHL) in adult. A well defined solid mass in the left lobe of the liver was found in a 57-year-old female. Preoperative radiologic examinations demonstrated solid mass with multifocal calcifications abutting the gallbladder. By light microscopy, t...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.1999.14.3.335
更新日期：1999-06-01 00:00:00
abstract：:Complement C7 deficiency is an autosomal recessive disorder well known to be associated with increased susceptibility to meningococcal infection and has mostly been reported in Caucasians. In the Korean population, no case of C7 deficiency has been reported to date. Recently we experienced an 11-yr-old girl with menin...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2005.20.2.220
更新日期：2005-04-01 00:00:00
abstract：:Vascular endothelial growth factor (VEGF) is a multi-functional cytokine involved in inflammation, repair and angiogenesis in asthmatic airway. This study aimed to evaluate the role of VEGF in immediate bronchoconstriction induced by TDI inhalation, and in chronic TDI-asthma patients. 11 newly diagnosed TDI-asthma pat...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2004.19.3.359
更新日期：2004-06-01 00:00:00
abstract：:Glioblastoma (GBM) can be classified into molecular subgroups, on the basis of biomarker expression. Here, we classified our cohort of 163 adult GBMs into molecular subgroups according to the expression of proteins encoded by genes of alpha thalassemia/mental retardation syndrome X-linked (ATRX), isocitrate dehydrogen...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2016.31.8.1208
更新日期：2016-08-01 00:00:00
abstract：:Information on precise effects of deflazacort on bone cell function, especially osteoclasts, is quite limited. Therefore, the present study was undertaken to test effects of deflazacort on osteoclast-like cell formation in mouse bone marrow cultures and on the regulation of osteoprotegerin (OPG) and its ligand (RANKL)...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2001.16.6.769
更新日期：2001-12-01 00:00:00
abstract：:Cardiac resynchronization therapy (CRT) has been proven its value in adult patients with congestive heart failure of low ejection fraction and wide QRS duration. Contrast to adult patients, CRT has been rarely applied for young patients. We report on a 9-yr-old boy with progressive left ventricular (LV) dilatation and...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2010.25.12.1809
更新日期：2010-12-01 00:00:00
abstract：:The purpose of this study was to investigate the therapeutic effects of small hairpin RNA (shRNA) targeting endothelin-converting enzyme (ECE)-1 in monocrotaline (MCT)-induced pulmonary hypertensive rats. Ninty-four Sprague-Dawley rats were divided into three groups: control (n = 24), MCT (n = 35) and shRNA (n = 35). ...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2012.27.12.1507
更新日期：2012-12-01 00:00:00
abstract：:The evaluation of prognostic factors in infants with critical stenosis of the aortic valve and intact ventricular septum is often misleading due to a complex interaction among lesions in the mitral and aortic valves, and the left ventricular myocardium. The clinical parameters on the left ventricular function, such as...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.1997.12.1.49
更新日期：1997-02-01 00:00:00
abstract：:Activated protein C (APC) is known to be beneficial on ischemia reperfusion injury in myocardium. However, the protection mechanism of APC is not fully understood. The purpose of this study was to investigate the effects and possible mechanisms of APC on myocardial ischemic damage. Artificially ventilated anaesthetize...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2010.25.11.1609
更新日期：2010-11-01 00:00:00
abstract：:Some types of workers such as farmers and soldiers are at a higher risk of work-related injury and illness than workers from other occupations. Despite this fact, they are not covered under the Industrial Safety Health (ISH) Act or the Industrial Accident Compensation Insurance (IACI) Act. The Safety Aid System for Fa...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2014.29.S.S24
更新日期：2014-06-01 00:00:00
abstract：:The objective of this study was to develop a Korean version of the Assessment of Spondyloarthritis International Society-Health Index/Environmental Factor (ASAS HI/EF) and to evaluate its reliability and validity in Korean patients with axial spondyloarthritis (SpA). A total of 43 patients participated. Translation an...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2014.29.3.334
更新日期：2014-03-01 00:00:00
abstract：:It has been suggested that there is an association between environmental, low-level arsenic exposure and the risk of diabetes mellitus (DM), but little research has been conducted. Here, the glucose tolerance status and urinary creatinine adjusted total arsenic concentrations were analyzed in 3,602 subjects ≥ 20 yr of...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2013.28.6.861
更新日期：2013-06-01 00:00:00
