Increased plasma valproate concentrations when coadministered with guanfacine.

Abstract:

:A preliminary clinical observation suggests the possibility of changes in valproate level when coadministered with guanfacine. Two pediatric inpatients (8 and 9 years of age) were treated with valproic acid and guanfacine concurrently. In one child, when guanfacine was tapered and discontinued, the plasma valproate concentration decreased by 41% from 128 microg/mL to 76 microg/mL. In the other case, studied in an ABA design, the child exhibited a rapid increase in plasma valproate levels while guanfacine was administered. It is proposed that guanfacine may affect the pharmacokinetics of valproic acid and lead to a significant increase in valproate plasma levels when used concurrently with this agent. The mechanism of this proposed interaction may involve drug-drug competition at the level of hepatic glucuronidation (conjugation), although shifts in protein binding cannot be ruled out.

authors

Ambrosini PJ,Sheikh RM

doi

10.1089/cap.1998.8.143

subject

Has Abstract

pub_date

1998-01-01 00:00:00

pages

143-7

issue

2

eissn

1044-5463

issn

1557-8992

journal_volume

8

pub_type

临床试验,杂志文章
  • Striatal creatine and glutamate/glutamine in attention-deficit/hyperactivity disorder.

    abstract:OBJECTIVE:The glutamatergic prefrontal-striatal pathway has been implicated previously in the neurobiology of attention-deficit/hyperactivity disorder (ADHD). We used short echo proton magnetic resonance spectroscopy (1H-MRS) to examine glutamate in the prefrontal cortex, left striatum, and, as a control area, the occi...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2006.0008

    authors: Carrey NJ,MacMaster FP,Gaudet L,Schmidt MH

    更新日期:2007-02-01 00:00:00

  • Chronic versus episodic irritability in youth: a community-based, longitudinal study of clinical and diagnostic associations.

    abstract:OBJECTIVE:Irritability is both a normal developmental phenomenon and a common psychiatric symptom in children. In psychiatric nosology, a distinction is made between chronic and episodic irritability. This study examines the validity of this distinction. METHODS:A sample of 776 youths received Diagnostic and Statistic...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2006.16.456

    authors: Leibenluft E,Cohen P,Gorrindo T,Brook JS,Pine DS

    更新日期:2006-08-01 00:00:00

  • Need for and Steps Toward a Clinical Guideline for the Telemental Healthcare of Children and Adolescents.

    abstract:OBJECTIVE:This article identifies and describes key considerations toward the development of a clinical guideline intended to optimize telemental healthcare (TMH) of children and adolescents. METHODS:The literature was searched with key terms and title words. Of 2824 articles that met primary or secondary key word sea...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章,评审

    doi:10.1089/cap.2015.0129

    authors: Hilty DM,Shoemaker EZ,Myers K,Snowdy CE,Yellowlees PM,Yager J

    更新日期:2016-04-01 00:00:00

  • A randomized, double-blind, placebo-controlled clinical trial on once-daily atomoxetine in Taiwanese children and adolescents with attention-deficit/hyperactivity disorder.

    abstract:OBJECTIVE:The aim of this study was to assess the efficacy and safety of the once-daily atomoxetine compared with placebo in pediatric patients with attention-deficit/hyperactivity disorder (ADHD) in Taiwan. METHOD:The study sample included 106 patients aged 6-16 years who met the Diagnostic and Statistical Manual of ...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/cap.2006.0091

    authors: Gau SS,Huang YS,Soong WT,Chou MC,Chou WJ,Shang CY,Tseng WL,Allen AJ,Lee P

    更新日期:2007-08-01 00:00:00

  • Open-label treatment of comorbid depression and attentional disorders with co-administration of serotonin reuptake inhibitors and psychostimulants in children, adolescents, and adults: a case series.

    abstract::Attention-deficit hyperactivity disorder (ADHD) and major depression are common ailments that can cause significant dysfunction throughout the life cycle. These two disorders may occur comorbidly. This case series describes 7 pediatric patients (aged 10-16 years) and 4 adults (aged 38-44 years) whose ADHD and comorbid...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.1996.6.165

    authors: Findling RL

    更新日期:1996-10-01 00:00:00

  • Risperidone treatment of children with autistic disorder: effectiveness, tolerability, and pharmacokinetic implications.

    abstract:BACKGROUND:Recent evidence indicates that atypical antipsychotics represent a promising option for the treatment of autistic disorder. In particular, risperidone appears to be effective in treating aggressiveness, hyperactivity, irritability, stereotypies, social withdrawal, and lack of interests. OBJECTIVE:The aim of...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1089/104454604773840472

    authors: Gagliano A,Germanò E,Pustorino G,Impallomeni C,D'Arrigo C,Calamoneri F,Spina E

    更新日期:2004-04-01 00:00:00

  • Omega-3 Fatty Acid Plasma Levels Before and After Supplementation: Correlations with Mood and Clinical Outcomes in the Omega-3 and Therapy Studies.

    abstract:OBJECTIVE:To examine fatty acid profiles, their response to omega-3 fatty acid (Ω3) supplementation, and associations with clinical status and treatment response in youth with mood disorders. METHODS:In a placebo-controlled 2X2 design, 7-14 year-olds (N = 95) in parallel pilot trials (depression N = 72; bipolar N = 23...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/cap.2016.0123

    authors: Arnold LE,Young AS,Belury MA,Cole RM,Gracious B,Seidenfeld AM,Wolfson H,Fristad MA

    更新日期:2017-04-01 00:00:00

  • Pharmacokinetics of methylphenidate in preschoolers with attention-deficit/hyperactivity disorder.

    abstract:OBJECTIVE:The aim of this study was to compare the pharmacokinetics of immediate-release methylphenidate (MPH) in preschool and school-aged children with attention-deficit/hyperactivity disorder (ADHD). METHODS:Preschool children 4-5 years (n = 14) and school-aged children 6-8 years (n = 9) with diagnoses of ADHD were...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1089/cap.2007.0043

    authors: Wigal SB,Gupta S,Greenhill L,Posner K,Lerner M,Steinhoff K,Wigal T,Kapelinski A,Martinez J,Modi NB,Stehli A,Swanson J

    更新日期:2007-04-01 00:00:00

  • Participant-perceived quality of life in a long-term, open-label trial of lisdexamfetamine dimesylate in adolescents with attention-deficit/hyperactivity disorder.

    abstract:OBJECTIVES:The purpose of this study was to assess long-term improvement in quality of life (QOL) in adolescents with attention-deficit/hyperactivity disorder (ADHD) treated with lisdexamfetamine dimesylate (LDX). METHODS:Adolescents with ADHD treated for ≥3 weeks in a 4 week, placebo-controlled study entered a 1 year...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1089/cap.2013.0077

    authors: Childress AC,Cutler AJ,Saylor K,Gasior M,Hamdani M,Ferreira-Cornwell MC,Findling RL

    更新日期:2014-05-01 00:00:00

  • Subjective effects, misuse, and adverse effects of osmotic-release methylphenidate treatment in adolescent substance abusers with attention-deficit/hyperactivity disorder.

    abstract:OBJECTIVE:Psychostimulants are effective treatments for attention-deficit/hyperactivity disorder (ADHD) but may be associated with euphoric effects, misuse/diversion, and adverse effects. These risks are perceived by some clinicians to be greater in substance-abusing adolescents relative to non-substance-abusing adults...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/cap.2011.0014

    authors: Winhusen TM,Lewis DF,Riggs PD,Davies RD,Adler LA,Sonne S,Somoza EC

    更新日期:2011-10-01 00:00:00

  • Pemoline treatment of adolescents with attention deficit hyperactivity disorder: a short-term controlled trial.

    abstract:BACKGROUND:Despite the increased recognition of attention deficit hyperactivity disorder (ADHD) in adolescents, few controlled studies have assessed treatments for this age group. Adolescent issues, such as embarrassment at receiving medication at school and experimentation with abusable substances, have accelerated ef...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1089/10445460050167313

    authors: Bostic JQ,Biederman J,Spencer TJ,Wilens TE,Prince JB,Monuteaux MC,Sienna M,Polisner DA,Hatch M

    更新日期:2000-10-01 00:00:00

  • Antipsychotic drug administration does not correlate with prolonged rate-corrected QT interval in children and adolescents: results from a nested case-control study.

    abstract:BACKGROUND:The rate-corrected QT interval (QTc) prolongation is a risk factor for sudden cardiac death and may be induced by antipsychotic drugs. OBJECTIVE:To determine the clinical characteristics associated with QTc prolongation (440 msec or greater) in children and adolescents hospitalized for treatment of psychiat...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1089/cap.2011.0024

    authors: Correll CU,Harris J,Figen V,Kane JM,Manu P

    更新日期:2011-08-01 00:00:00

  • The effect of methylphenidate on prefrontal cognitive functioning, inattention, and hyperactivity in velocardiofacial syndrome.

    abstract:OBJECTIVE:Methylphenidate (MPH) is commonly used to treat attention-deficit/hyperactivity disorder (ADHD) in all children, including those with velocardiofacial syndrome (VCFS). Yet concerns have been raised regarding its safety and efficacy in VCFS. The goal of this study was to examine the safety and efficacy of MPH ...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/cap.2011.0042

    authors: Green T,Weinberger R,Diamond A,Berant M,Hirschfeld L,Frisch A,Zarchi O,Weizman A,Gothelf D

    更新日期:2011-12-01 00:00:00

  • Evaluation of suicidal thoughts and behaviors in children and adolescents taking paroxetine.

    abstract:OBJECTIVE:The aim of this study was to summarize results of a blinded review of potential suicidal events and analyses comparing incidence rates between paroxetine- and placebo-treated pediatric patients. METHOD:One thousand one hundred ninety-one (1191) children and adolescents received paroxetine (n = 642) or placeb...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章,评审

    doi:10.1089/cap.2006.16.77

    authors: Apter A,Lipschitz A,Fong R,Carpenter DJ,Krulewicz S,Davies JT,Wilkinson C,Perera P,Metz A

    更新日期:2006-02-01 00:00:00

  • Treatment receipt and outcomes from a clinic employing the attention-deficit/hyperactivity disorder treatment guideline of the children's medication algorithm project.

    abstract:OBJECTIVE:Little is known about the pattern of service receipt and outcomes from clinics implementing best practice guidelines in child mental health. This study aimed to determine these variables for a clinic that implemented an attention-deficit/hyperactivity disorder (ADHD) treatment guideline proposed by the Childr...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2014.0014

    authors: Wagner DJ,Vallerand IA,McLennan JD

    更新日期:2014-11-01 00:00:00

  • Antidepressant prescribing practices for the treatment of children and adolescents.

    abstract:OBJECTIVE:This study evaluates pediatric antidepressant prescribing practices of Nebraska clinicians. METHODS:Surveys were sent in July, 2005, to 1,521 prescribing clinicians throughout Nebraska to assess pediatric antidepressant use along with any practice changes following the U.S. Food and Drug Administration (FDA)...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2007.0049

    authors: Bhatia SK,Rezac AJ,Vitiello B,Sitorius MA,Buehler BA,Kratochvil CJ

    更新日期:2008-02-01 00:00:00

  • Guanfacine treatment of hyperactivity and inattention in pervasive developmental disorders: a retrospective analysis of 80 cases.

    abstract:OBJECTIVE:The aim of this study was to retrospectively review a large sample of children and adolescents with pervasive developmental disorders (PDDs) treated with open-label guanfacine in order to gather preliminary data as to its effectiveness and safety. METHOD:Eighty (80) subjects with PDDs (10 females, 70 males) ...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/1044546041649084

    authors: Posey DJ,Puntney JI,Sasher TM,Kem DL,McDougle CJ

    更新日期:2004-07-01 00:00:00

  • Acute and Long-Term Cardiovascular Effects of Stimulant, Guanfacine, and Combination Therapy for Attention-Deficit/Hyperactivity Disorder.

    abstract:OBJECTIVES:This study examines cardiovascular (CV) effects of guanfacine immediate-release (GUAN-IR), dexmethylphenidate extended-release (DMPH), and their combination (COMB) during acute and long-term treatment of youth with attention-deficit/hyperactivity disorder. METHODS:Two hundred seven participants aged 7-14 ye...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/cap.2015.0264

    authors: Sayer GR,McGough JJ,Levitt J,Cowen J,Sturm A,Castelo E,McCracken JT

    更新日期:2016-12-01 00:00:00

  • Psychometric properties of the Children's Depression Rating Scale-Revised in adolescents.

    abstract:OBJECTIVE:The aim of this study was to present the reliability and validity of the Children's Depression Rating Scale-Revised (CDRS-R) in the adolescent age group. METHOD:Adolescents with symptoms of depression were assessed using the CDRS-R and global severity and functioning scales at screening, baseline, and after ...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2010.0063

    authors: Mayes TL,Bernstein IH,Haley CL,Kennard BD,Emslie GJ

    更新日期:2010-12-01 00:00:00

  • A review of developmental aspects of cytochrome P450.

    abstract::This article surveys the development of human hepatic P450 cytochromes (CYPs) involved in xenobiotic metabolism from the fetus through the life span and explores possible clinical consequences of developmental issues. These hepatic P450 CYPs come "on line" at different times during fetal and infant development, and ea...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章,评审

    doi:10.1089/cap.1998.8.161

    authors: Oesterheld JR

    更新日期:1998-01-01 00:00:00

  • Attention-Deficit/Hyperactivity Disorder-Related Deficits and Psychostimulant Medication Effects on Comprehension of Audiovisually Presented Educational Material in Children.

    abstract:: Objective: We aimed to (1) examine differences in observed visual attention and motor activity, as well as comprehension of a science video between children with and without attention-deficit/hyperactivity disorder (ADHD) and (2) explore if psychostimulant medication impro...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/cap.2018.0006

    authors: Orban SA,Karamchandani TA,Tamm L,Sidol CA,Peugh J,Froehlich TE,Brinkman WB,Estell N,Mii AE,Epstein JN

    更新日期:2018-12-01 00:00:00

  • Does comorbid depression predict subsequent adverse life events in youth with attention-deficit/hyperactivity disorders?

    abstract:OBJECTIVES:Studies have primarily focused on adverse life events (ALEs) as potential causes rather than as outcomes of pediatric depression. The current study prospectively examines ALEs in a sample of youth with attention-deficit/hyperactivity disorders (ADHD) to determine whether having a major depressive disorder (M...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2011.0046

    authors: Daviss WB,Diler R

    更新日期:2012-02-01 00:00:00

  • A pharmacological functional magnetic resonance imaging study probing the interface of cognitive and emotional brain systems in pediatric bipolar disorder.

    abstract:OBJECTIVE:This functional magnetic resonance imaging (fMRI) study investigated the effects of pharmacotherapy on brain function underlying affect dysregulation and cognitive function in pediatric bipolar disorder (PBD). METHOD:Healthy controls (HC) (n=14; mean age =14.1 ± 2.4 years) and unmedicated PBD patients with m...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2009.0105

    authors: Pavuluri MN,Passarotti AM,Parnes SA,Fitzgerald JM,Sweeney JA

    更新日期:2010-10-01 00:00:00

  • Screening for adolescent depression: comparison of the Kutcher Adolescent Depression Scale with the Beck depression inventory.

    abstract::Self-report instruments commonly used to assess depression in adolescents have limited or unknown reliability and validity in this age group. We describe a new self-report scale, the Kutcher Adolescent Depression Scale (KADS), designed specifically to diagnose and assess the severity of adolescent depression. This rep...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/104454602760219153

    authors: LeBlanc JC,Almudevar A,Brooks SJ,Kutcher S

    更新日期:2002-07-01 00:00:00

  • Psychotropic medication use and clinical outcomes among children and adolescents receiving system of care services.

    abstract:OBJECTIVE:Few studies of psychotropic medication use among children and adolescents address the effectiveness of this medication, as it is typically used in naturalistic treatment settings. The objective of this study was to investigate psychotropic medication use among children and adolescents treated in system of car...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2012.0026

    authors: Drilea SK,Jowers K,Lichtenstein C,Hale M,Blau G,Stromberg S

    更新日期:2013-02-01 00:00:00

  • Clinical-Serological Characterization and Treatment Outcome of a Large Cohort of Italian Children with Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infection and Pediatric Acute Neuropsychiatric Syndrome.

    abstract:: Objective: Pediatric autoimmune neuropsychiatric disorder associated with Streptococcus pyogenes infection (PANDAS) and pediatric acute-onset neuropsychiatric syndrome (PANS) are emerging immune-mediated encephalopathies characterized by sudden onset of seemingly inexplica...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2018.0151

    authors: Lepri G,Rigante D,Bellando Randone S,Meini A,Ferrari A,Tarantino G,Cunningham MW,Falcini F

    更新日期:2019-10-01 00:00:00

  • Palpebral twitching in a depressed adolescent on citalopram.

    abstract::Current estimates suggest that between 0.4% and 8.3% of children and adolescents are affected by major depression. We report a favorable response to treatment with citalopram by a 15-year-old boy with major depression who exhibited palpebral twitching during his first 2 weeks of treatment. This may have been a side ef...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/10445460152595621

    authors: Rojas VM,Silva R

    更新日期:2001-10-01 00:00:00

  • Methylphenidate improves Stroop naming speed, but not response interference, in children with attention deficit hyperactivity disorder.

    abstract:OBJECTIVE:The goal of this study was to investigate the effect of methylphenidate (MPH) on response interference, as measured by the Stoop Color and Word Test, in children with attention deficit hyperactivity disorder (ADHD). Response interference is a core component of response inhibition that has been shown to be imp...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1089/104454602762599844

    authors: Bedard AC,Ickowicz A,Tannock R

    更新日期:2002-01-01 00:00:00

  • No Differences in Weight Gain Between Risperidone and Aripiprazole in Children and Adolescents After 12 Months.

    abstract:BACKGROUND:Weight gain due to the use of second-generation antipsychotics is a major health care issue for adult and paediatric psychiatric patients. Little is known about long-term weight gain effects of aripiprazole compared to risperidone in children and adolescents. OBJECTIVE:The primary aim of this study is to as...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2018.0111

    authors: Schoemakers RJ,van Kesteren C,van Rosmalen J,Eussen MLJM,Dieleman HG,Beex-Oosterhuis MM

    更新日期:2019-04-01 00:00:00

  • Aripiprazole in children and adolescents with Tourette's disorder: an open-label safety and tolerability study.

    abstract:OBJECTIVE:The aim of this study was to conduct a prospective safety and tolerability study of aripiprazole for the treatment of tics in children and adolescents with Tourette's disorder (TD). METHOD:Eleven subjects (10 males) with TD (age 9-19 years, mean 13.36, standard deviation [SD] 3.33) who did not respond or wer...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1089/cap.2009.0035

    authors: Lyon GJ,Samar S,Jummani R,Hirsch S,Spirgel A,Goldman R,Coffey BJ

    更新日期:2009-12-01 00:00:00