Evaluation of suicidal thoughts and behaviors in children and adolescents taking paroxetine.

Abstract:

OBJECTIVE:The aim of this study was to summarize results of a blinded review of potential suicidal events and analyses comparing incidence rates between paroxetine- and placebo-treated pediatric patients. METHOD:One thousand one hundred ninety-one (1191) children and adolescents received paroxetine (n = 642) or placebo (n = 549) during placebo-controlled portions of all acute double-blind trials of paroxetine (n = 5). An expert panel blindly reviewed and categorized all identified cases detected by electronic and manual search of adverse events (AEs), serious AEs, and selected cases as suicidal or non-suicidal behavior. Incidence rates were calculated for suicide-related events and for rating scale items assessing suicidality. RESULTS:Suicide-related events occurred more often in paroxetine (22 of 642, 3.4%) than placebo groups (5 of 549, 0.9%); odds ratio (OR) 3.86 (95% CI 1.45, 10.26; p = 0.003). All suicide-related events occurred in adolescents of at least 12 years, except for 1 of 156 paroxetine-treated children. All suicide attempts occurred in major depressive disorder (MDD); few suicide-related events occurred in patients with a primary anxiety disorder. Suicide item analyses did not reveal significant differences between paroxetine and placebo. CONCLUSIONS:Adolescents treated with paroxetine showed an increased risk of suicide-related events. Suicidality rating scales did not show this risk difference. The presence of uncontrolled suicide risk factors, the relatively low incidence of these events, and their predominance in adolescents with MDD make it difficult to identify a single cause for suicidality in these pediatric patients.

authors

Apter A,Lipschitz A,Fong R,Carpenter DJ,Krulewicz S,Davies JT,Wilkinson C,Perera P,Metz A

doi

10.1089/cap.2006.16.77

keywords:

subject

Has Abstract

pub_date

2006-02-01 00:00:00

pages

77-90

issue

1-2

eissn

1044-5463

issn

1557-8992

journal_volume

16

pub_type

杂志文章,评审
  • Decreasing Trend in the Use and Long-Term Use of Benzodiazepines Among Young Adults.

    abstract:OBJECTIVE:Patterns of benzodiazepine (BZD) use and long-term use among young adults are not well known. Our aim was to study trends in BZD use and long-term use among 18-25-year-old young adults by gender and active substance in a nationwide retrospective longitudinal register-based setting. METHODS:All Finns aged 18-...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2017.0140

    authors: Tähkäpää SM,Saastamoinen L,Airaksinen M,Tuulio-Henriksson A,Aalto-Setälä T,Kurko T

    更新日期:2018-05-01 00:00:00

  • Clinical gains from including both dextroamphetamine and methylphenidate in stimulant trials.

    abstract:OBJECTIVE:The purpose of this study was to investigate clinical gains from including both dextroamphetamine and methylphenidate in stimulant trials. METHOD:Thirty-six medication-naïve children ages 9-14 years diagnosed with attention-deficit/hyperactivity disorder (ADHD) were enrolled for 6 weeks in a crossover trial,...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/cap.2012.0085

    authors: Ramtvedt BE,Røinås E,Aabech HS,Sundet KS

    更新日期:2013-11-01 00:00:00

  • A Quantitative Comparison Approach for Methylphenidate Drug Regimens in Attention-Deficit/Hyperactivity Disorder Treatment.

    abstract:OBJECTIVE:Different methylphenidate (MPH) formulations, immediate release (IR) or extended release (ER), have been developed to treat Attention-Deficit/Hyperactivity Disorder (ADHD). A better use of these formulations, with a proper choice of their timing, dosage, and combination, can help to attain optimal therapeutic...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2018.0093

    authors: Soufsaf S,Robaey P,Bonnefois G,Nekka F,Li J

    更新日期:2019-04-01 00:00:00

  • Efficacy, long-term safety, and tolerability of ziprasidone in children and adolescents with bipolar disorder.

    abstract:OBJECTIVE:The purpose of this study was to evaluate the short- and long-term efficacy and safety of ziprasidone in children and adolescents with bipolar I disorder. METHODS:Subjects 10-17 years of age with a manic or mixed episode associated with bipolar I disorder participated in a 4 week, randomized, double-blind, p...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1089/cap.2012.0029

    authors: Findling RL,Cavuş I,Pappadopulos E,Vanderburg DG,Schwartz JH,Gundapaneni BK,DelBello MP

    更新日期:2013-10-01 00:00:00

  • Clozapine versus "high-dose" olanzapine in refractory early-onset schizophrenia: an open-label extension study.

    abstract:OBJECTIVE:A recent 12-week controlled comparison demonstrated the superiority of clozapine to "high-dose" olanzapine in adolescents with treatment-refractory schizophrenia. In the present study, the authors conducted a 12-week, open-label, follow-up study to examine changes in lipid and glucose metabolism in youths mai...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/cap.2007.0089

    authors: Kumra S,Kranzler H,Gerbino-Rosen G,Kester HM,DeThomas C,Cullen K,Regan J,Kane JM

    更新日期:2008-08-01 00:00:00

  • The effect of fluvoxamine and behavior therapy on children and adolescents with obsessive-compulsive disorder.

    abstract:OBJECTIVE:The efficacy of medications, consisting of serotonin partial and specific reuptake blockers, and behavior therapy, consisting of exposure and response prevention in addition to social skills training, cognitive therapy, and habit reversal, in the treatment of obsessive-compulsive disorder are well documented....

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1089/cap.2000.10.295

    authors: Neziroglu F,Yaryura-Tobias JA,Walz J,McKay D

    更新日期:2000-01-01 00:00:00

  • Antipsychotic drug administration does not correlate with prolonged rate-corrected QT interval in children and adolescents: results from a nested case-control study.

    abstract:BACKGROUND:The rate-corrected QT interval (QTc) prolongation is a risk factor for sudden cardiac death and may be induced by antipsychotic drugs. OBJECTIVE:To determine the clinical characteristics associated with QTc prolongation (440 msec or greater) in children and adolescents hospitalized for treatment of psychiat...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1089/cap.2011.0024

    authors: Correll CU,Harris J,Figen V,Kane JM,Manu P

    更新日期:2011-08-01 00:00:00

  • A prospective, open-label trial of galantamine in autistic disorder.

    abstract:OBJECTIVE:Post-mortem studies have reported abnormalities of the cholinergic system in autism. The purpose of this study was to assess the use of galantamine, an acetylcholinesterase inhibitor and nicotinic receptor modulator, in the treatment of interfering behaviors in children with autism. METHODS:Thirteen medicati...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2006.16.621

    authors: Nicolson R,Craven-Thuss B,Smith J

    更新日期:2006-10-01 00:00:00

  • Sertraline treatment of 5 children diagnosed with selective mutism: a single-case research trial.

    abstract::In this single-case research study, we examined the efficacy and acceptability of sertraline treatment in children diagnosed with selective mutism. We utilized a double-blind, placebo-controlled trial of sertraline within a replicated multiple baseline/across participants research design (n = 2; n = 3). Multiple metho...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1089/cap.1999.9.293

    authors: Carlson JS,Kratochwill TR,Johnston HF

    更新日期:1999-01-01 00:00:00

  • Chronic versus episodic irritability in youth: a community-based, longitudinal study of clinical and diagnostic associations.

    abstract:OBJECTIVE:Irritability is both a normal developmental phenomenon and a common psychiatric symptom in children. In psychiatric nosology, a distinction is made between chronic and episodic irritability. This study examines the validity of this distinction. METHODS:A sample of 776 youths received Diagnostic and Statistic...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2006.16.456

    authors: Leibenluft E,Cohen P,Gorrindo T,Brook JS,Pine DS

    更新日期:2006-08-01 00:00:00

  • Stimulants and Pediatric Cardiovascular Risk.

    abstract:OBJECTIVE:Concerns about serious cardiovascular (CV) events among stimulant-treated youth have led to clinical and policy debates. Accordingly, several population-based empirical studies have assessed the risk of CV events in children and adolescents treated with stimulants. The main objective of this review was to sum...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章,评审

    doi:10.1089/cap.2015.0239

    authors: Zito JM,Burcu M

    更新日期:2017-08-01 00:00:00

  • Methylphenidate combined with aripiprazole in children and adolescents with bipolar disorder and attention-deficit/hyperactivity disorder: a randomized crossover trial.

    abstract::In clinical samples, juvenile bipolar disorder (JBPD) is frequently accompanied by co-morbid attention-deficit/hyperactivity disorder (ADHD). Clinical trials assessing combined psychopharmacological interventions in this population are scarce, and methylphenidate (MPH) may worsen manic symptoms. We conducted a randomi...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/cap.2009.0037

    authors: Zeni CP,Tramontina S,Ketzer CR,Pheula GF,Rohde LA

    更新日期:2009-10-01 00:00:00

  • Standardized Observation Analogue Procedure in the Treatment of Severe Childhood Aggression Study.

    abstract:: Objective: To explore blinded observational outcomes in the Treatment of Severe Childhood Aggression (TOSCA) study. Methods: During a 9-week acute trial, children with severe physical aggression and attention-deficit/hyperactiv...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2019.0109

    authors: Grondhuis SN,Farmer CA,Arnold LE,Gadow KD,Findling RL,Molina BSG,Kolko DJ,Buchan-Page KA,Rice RR , Jr,Butter EM,Aman MG

    更新日期:2020-02-01 00:00:00

  • The efficacy and tolerability of quetiapine versus divalproex for the treatment of impulsivity and reactive aggression in adolescents with co-occurring bipolar disorder and disruptive behavior disorder(s).

    abstract:OBJECTIVE:The aim of this study was to compare the efficacy and tolerability of quetiapine and divalproex for the treatment of impulsivity and reactive aggression in adolescents with co-occurring bipolar disorder and disruptive behavior disorders. METHOD:Patients were included in this post hoc analysis if they scored ...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/cap.2006.16.665

    authors: Barzman DH,DelBello MP,Adler CM,Stanford KE,Strakowski SM

    更新日期:2006-12-01 00:00:00

  • Atomoxetine and stimulants in combination for treatment of attention deficit hyperactivity disorder: four case reports.

    abstract::Atomoxetine and stimulants have both been demonstrated effective as single agents for treatment of attention deficit hyperactivity disorder in children, adolescents, and adults. However, attention deficit hyperactivity disorder symptoms in some patients do not respond adequately to single-agent treatment with these me...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/104454604773840571

    authors: Brown TE

    更新日期:2004-04-01 00:00:00

  • A systematic review of combination therapy with stimulants and atomoxetine for attention-deficit/hyperactivity disorder, including patient characteristics, treatment strategies, effectiveness, and tolerability.

    abstract:OBJECTIVE:The purpose of this article was to systematically review the literature on stimulant and atomoxetine combination therapy, in particular: 1) Characteristics of patients with attention-deficit/hyperactivity disorder (ADHD) given combination therapy, 2) treatment strategies used, 3) efficacy and effectiveness, a...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章,评审

    doi:10.1089/cap.2012.0093

    authors: Treuer T,Gau SS,Méndez L,Montgomery W,Monk JA,Altin M,Wu S,Lin CC,Dueñas HJ

    更新日期:2013-04-01 00:00:00

  • Open-label treatment of comorbid depression and attentional disorders with co-administration of serotonin reuptake inhibitors and psychostimulants in children, adolescents, and adults: a case series.

    abstract::Attention-deficit hyperactivity disorder (ADHD) and major depression are common ailments that can cause significant dysfunction throughout the life cycle. These two disorders may occur comorbidly. This case series describes 7 pediatric patients (aged 10-16 years) and 4 adults (aged 38-44 years) whose ADHD and comorbid...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.1996.6.165

    authors: Findling RL

    更新日期:1996-10-01 00:00:00

  • Preschool onset attention-deficit/hyperactivity disorder: course and predictors of stability over 24 months.

    abstract:OBJECTIVE:The present study examined the course of ADHD over 24 months in a preschool population. METHOD:n=48 preschoolers with ADHD, aged 3.0-5.11 years, subjects included in a larger sample of preschoolers with depression and other disorders (n=306) were comprehensively assessed at 3 annual time points over 24 month...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2010.0045

    authors: Tandon M,Si X,Luby J

    更新日期:2011-08-01 00:00:00

  • Does pharmacotherapy for attention-deficit/hyperactivity disorder predict risk of later major depression?

    abstract:OBJECTIVE:This study's goal was to determine among youths with attention-deficit/hyperactivity disorder (ADHD) how the history of ADHD pharmacotherapy influenced the risk of developing major depressive disorder (MDD), compared to other commonly reported predictors. METHOD:Diagnostic and treatment history data were ana...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2007.0100

    authors: Daviss WB,Birmaher B,Diler RS,Mintz J

    更新日期:2008-06-01 00:00:00

  • Evaluation of patients' and parents' quality of life in a randomized placebo-controlled atomoxetine study in attention-deficit/hyperactivity disorder.

    abstract:OBJECTIVE:The aim of this study was to demonstrate the superior efficacy of atomoxetine with respect to placebo and to compare parent and child perceptions of health-related quality of life (HRQoL). METHOD:This randomized, placebo-controlled, 12-week parallel clinical trial included 151 untreated children/adolescents ...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/cap.2008.0109

    authors: Escobar R,Montoya A,Polavieja P,Cardo E,Artigas J,Hervas A,Fuentes J

    更新日期:2009-06-01 00:00:00

  • Childhood hyperactivity and psychostimulants: a review of extended treatment studies.

    abstract::ABSTRACT Clinical trials with a treatment duration of at least 3 months were reviewed to determine the effect of psychostimulants on the core symptoms of attention-deficit hyperactivity disorder (ADHD) and on its commonly associated features. Eighteen studies were identified: 17 were studies of methylphenidate, 1 was ...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.1993.3.81

    authors: Schachar R,Tannock R

    更新日期:1993-07-01 00:00:00

  • Adjunctive Amantadine Treatment for Aggressive Behavior in Children: A Series of Eight Cases.

    abstract:PURPOSE:Amantadine has a growing body of evidence for the treatment of aggressive behavior in patients with traumatic brain injury, autism spectrum disorder, and developmental disability. We describe our experience with adjunctive amantadine treatment for aggressive behavior in eight hospitalized children. METHODS:We ...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2016.0042

    authors: McGrane IR,Loveland JG,Zaluski HJ

    更新日期:2016-12-01 00:00:00

  • Atomoxetine treatment in adolescents with attention-deficit/hyperactivity disorder.

    abstract:INTRODUCTION:This study compared two atomoxetine titration dosing schedules and two atomoxetine maintenance doses for treating adolescent attention-deficit/hyperactivity disorder (ADHD) inattention and hyperactivity/impulsivity. METHODS:Adolescents (N = 267) were randomized to a slow or fast titration schedule. Patien...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/cap.2008.074

    authors: Wietecha LA,Williams DW,Herbert M,Melmed RD,Greenbaum M,Schuh K

    更新日期:2009-12-01 00:00:00

  • Pemoline treatment of adolescents with attention deficit hyperactivity disorder: a short-term controlled trial.

    abstract:BACKGROUND:Despite the increased recognition of attention deficit hyperactivity disorder (ADHD) in adolescents, few controlled studies have assessed treatments for this age group. Adolescent issues, such as embarrassment at receiving medication at school and experimentation with abusable substances, have accelerated ef...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1089/10445460050167313

    authors: Bostic JQ,Biederman J,Spencer TJ,Wilens TE,Prince JB,Monuteaux MC,Sienna M,Polisner DA,Hatch M

    更新日期:2000-10-01 00:00:00

  • Comparison of Depression and Burnout Levels of Mothers of Children with Attention-Deficit Hyperactivity Disorder Before and After Treatment.

    abstract:OBJECTIVE:This study aimed to compare the depression and burnout levels of mothers of children having attention-deficit/hyperactivity disorder (ADHD) between the child's pre- and posttreatment periods. METHOD:The study sample consisted of 40 children aged between 4 and 10 years and their mothers. Initially, 40 cases p...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2017.0050

    authors: Gokcen C,Coskun S,Kutuk MO

    更新日期:2018-06-01 00:00:00

  • Neuroleptic malignant syndrome in children and adolescents: two case reports and a warning.

    abstract::ABSTRACT Neuroleptic malignant syndrome (NMS) is a potentially fatal disorder associated with the use of neuroleptics. Clinical research on NMS to date has focused exclusively on adults, but increasing numbers of juvenile cases have been reported. Two cases of juvenile NMS treated by the authors are discussed to demon...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.1992.2.123

    authors: Latz SR,McCracken JT

    更新日期:1992-07-01 00:00:00

  • Neuroleptic malignant syndrome: review of experience with children and adolescents.

    abstract::ABSTRACT A report of neuroleptic malignant syndrome (NMS) in an adolescent patient with bipolar disorder is presented, and findings from a literature review of 35 child and adolescent cases (presenting before age 19) are compared with the reported experience in adults. Fever, rigidity, altered mental status, and tachy...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.1992.2.183

    authors: Steingard R,Khan A,Gonzalez A,Herzog DB

    更新日期:1992-10-01 00:00:00

  • Pharmacokinetics and pharmacodynamics of edivoxetine (LY2216684), a norepinephrine reuptake inhibitor, in pediatric patients with attention-deficit/hyperactivity disorder.

    abstract:OBJECTIVE:Edivoxetine (LY2216684) is a selective and potent norepinephrine reuptake inhibitor (NERI). The pharmacokinetics (PK) and pharmacodynamics (PD) of edivoxetine were assessed in children and adolescent patients with attention-deficit/hyperactivity disorder (ADHD) following single and once-daily oral doses of ed...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2011.0151

    authors: Kielbasa W,Quinlan T,Jin L,Xu W,Lachno DR,Dean RA,Allen AJ

    更新日期:2012-08-01 00:00:00

  • Anxiety and Gender Influence Reward-Related Processes in Children and Adolescents.

    abstract:OBJECTIVE:This study examined the effects of pediatric anxiety and its interaction with gender on reward processes. Based on the purported greater sensitivity to risk in females than males and the propensity for risk aversion in anxiety, clinical anxiety and female gender were hypothesized to act synergistically in red...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2015.0008

    authors: Dorfman J,Rosen D,Pine D,Ernst M

    更新日期:2016-05-01 00:00:00

  • Treatment receipt and outcomes from a clinic employing the attention-deficit/hyperactivity disorder treatment guideline of the children's medication algorithm project.

    abstract:OBJECTIVE:Little is known about the pattern of service receipt and outcomes from clinics implementing best practice guidelines in child mental health. This study aimed to determine these variables for a clinic that implemented an attention-deficit/hyperactivity disorder (ADHD) treatment guideline proposed by the Childr...

    journal_title:Journal of child and adolescent psychopharmacology

    pub_type: 杂志文章

    doi:10.1089/cap.2014.0014

    authors: Wagner DJ,Vallerand IA,McLennan JD

    更新日期:2014-11-01 00:00:00