Physical effects of cholesterol on arterial smooth muscle membranes: evidence of immiscible cholesterol domains and alterations in bilayer width during atherogenesis.

abstract：:The beta-oxidation of stearic acid and of alpha- and gamma-methyl isoprenoid-derived fatty acids (pristanic and tetramethylheptadecanoic acids, respectively) was investigated in normal skin fibroblasts and in fibroblasts from patients with inherited defects in peroxisomal biogenesis. Stearic acid beta-oxidation by nor...

journal_title：Journal of lipid research

authors： Singh H,Usher S,Johnson D,Poulos A

更新日期：1990-02-01 00:00:00

abstract：:Serum triglyceride (TG) levels are increased in extremely obese individuals, indicating abnormalities in lipid metabolism and insulin resistance. We carried out a genome scan for serum TG in 320 nuclear families segregating extreme obesity and normal weight. Three hundred eighty-two Marshfield microsatellite markers (...

journal_title：Journal of lipid research

authors： Li WD,Dong C,Li D,Garrigan C,Price RA

更新日期：2005-03-01 00:00:00

abstract：:Accumulation of foam cells in the neointima represents a key event in atherosclerosis. We previously demonstrated that Tanshinone IIA (Tan), a lipophilic bioactive compound extracted from Salvia miltiorrhiza Bunge, inhibits experimental atherogenesis, yet the detailed mechanisms are not fully understood. In this study...

journal_title：Journal of lipid research

authors： Liu Z,Wang J,Huang E,Gao S,Li H,Lu J,Tian K,Little PJ,Shen X,Xu S,Liu P

更新日期：2014-02-01 00:00:00

abstract：:Bis(monoacylglycero)phosphate (BMP), also known as lysobisphosphatidic acid, is a phospholipid that promotes lipid sorting in late endosomes/lysosomes by activating lipid hydrolases and lipid transfer proteins. Changes in the cellular BMP content therefore reflect an altered metabolic activity of the endolysosomal sys...

journal_title：Journal of lipid research

authors： Grabner GF,Fawzy N,Schreiber R,Pusch LM,Bulfon D,Koefeler H,Eichmann TO,Lass A,Schweiger M,Marsche G,Schoiswohl G,Taschler U,Zimmermann R

更新日期：2020-07-01 00:00:00

abstract：:Apolipoprotein A-I (apoA-I) induces the translocation of newly synthesized cholesterol as well as caveolin-1 to the cytosolic lipid-protein particle (CLPP) fraction in astrocytes before its appearance in high density lipoprotein generated in the medium (Ito, J., Y. Nagayasu, K. Kato, R. Sato, and S. Yokoyama. 2002. Ap...

journal_title：Journal of lipid research

authors： Ito J,Li H,Nagayasu Y,Kheirollah A,Yokoyama S

更新日期：2004-12-01 00:00:00

abstract：:The ternary phase diagram of cholesteryl myristate--dimyristoyl lecithin--water has been determined by polarizing light microscopy, scanning calorimetry, and x-ray diffraction. Hydrated dimyristoyl lecithin forms a lamellar liquid--crystalline phase (L alpha) at temperatures greater than 23 degrees C into which limite...

journal_title：Journal of lipid research

authors： Janiak MJ,Small DM,Shipley GG

更新日期：1979-02-01 00:00:00

abstract：:It is becoming increasingly accepted that removal of cellular cholesterol occurs by at least two pathways, one involving the well-described aqueous diffusion mechanism and another promoted by lipid-free apolipoproteins. We compared the contribution of apolipoprotein-dependent and -independent pathways, taking into con...

journal_title：Journal of lipid research

authors： Mendez AJ

更新日期：1997-09-01 00:00:00

abstract：:Characterization of the chemical form and stereo-specificity of the fatty acid derivatives of arachidonic and linoleic acid in psoriatic epidermis is needed to define the enzymatic origin of these compounds and their possible role in pathogenesis. In an analysis of psoriatic skin scales, both free and esterified 13-hy...

journal_title：Journal of lipid research

authors： Baer AN,Costello PB,Green FA

更新日期：1990-01-01 00:00:00

abstract：:The Smith-Lemli-Opitz syndrome (SLOS) is a congenital birth defect syndrome caused by a deficiency of 3beta-hydroxysterol Delta(7)-reductase, the final enzyme in the cholesterol biosynthetic pathway. The patients have reduced plasma and tissue cholesterol concentrations with the accumulation of 7-dehydrocholesterol an...

journal_title：Journal of lipid research

authors： Honda A,Salen G,Shefer S,Batta AK,Honda M,Xu G,Tint GS,Matsuzaki Y,Shoda J,Tanaka N

更新日期：1999-08-01 00:00:00

abstract：:This paper describes the purification and some of the properties of an enzyme from human spleen that catalyzes the hydrolysis of sphingomyelin with the formation of ceramide and phosphoryl choline. The enzyme, which is located in the subcellular particulate fraction that sediments between 700 and 8500 g, is readily ma...

journal_title：Journal of lipid research

authors： Schneider PB,Kennedy EP

更新日期：1967-05-01 00:00:00

abstract：:The extent of hypercholesterolemia varies considerably in patients with familial hypercholesterolemia (FH). We hypothesized that the variability of the FH phenotype might be partly explained by variation in proprotein convertase subtilisin kexin type 9 (PCSK9) activity. Individuals between 18 and 53 years of age who h...

journal_title：Journal of lipid research

authors： Huijgen R,Fouchier SW,Denoun M,Hutten BA,Vissers MN,Lambert G,Kastelein JJ

更新日期：2012-05-01 00:00:00

abstract：:Since the discovery of proprotein convertase subtilisin/kexin type 9 (PCSK9) as an attractive target in the treatment of hypercholesterolemia, multiple anti-PCSK9 therapeutic modalities have been pursued in drug development. The objective of this research is to set the stage for the quantitative benchmarking of two an...

journal_title：Journal of lipid research

authors： Sokolov V,Helmlinger G,Nilsson C,Zhudenkov K,Skrtic S,Hamrén B,Peskov K,Hurt-Camejo E,Jansson-Löfmark R

更新日期：2019-09-01 00:00:00

abstract：:The pathogenesis of aortic valve stenosis (AS) is characterized by the accumulation of LDL-derived cholesterol in the diseased valves. Since LDL particles also contain plant sterols, we investigated whether plant sterols accumulate in aortic valve lesions. Serum samples were collected from 82 patients with severe AS a...

journal_title：Journal of lipid research

authors： Helske S,Miettinen T,Gylling H,Mäyränpää M,Lommi J,Turto H,Werkkala K,Kupari M,Kovanen PT

更新日期：2008-07-01 00:00:00

abstract：:The vitamin D signal transduction system involves a series of cytochrome P450-containing sterol hydroxylases to generate and degrade the active hormone, 1α,25-dihydroxyvitamin D3, which serves as a ligand for the vitamin D receptor-mediated transcriptional gene expression described in companion articles in this review...

journal_title：Journal of lipid research

authors： Jones G,Prosser DE,Kaufmann M

更新日期：2014-01-01 00:00:00

abstract：:H-Rev107 is a protein that was previously cloned as a negative regulator of proto-oncogene Ras and classified as a class II tumor suppressor. Its structural similarity to lecithin retinol acyltransferase and Ca2+-independent phosphatidylethanolamine (PE) N-acyltransferase led us to analyze H-Rev107 as an enzyme involv...

journal_title：Journal of lipid research

authors： Uyama T,Morishita J,Jin XH,Okamoto Y,Tsuboi K,Ueda N

更新日期：2009-04-01 00:00:00

abstract：:Optically active 1- or 3-acyl-sn-glycerols were synthesized from 2,3- or 1,2-isopropylidene-sn-glycerols, respectively. The 2,3- or 1,2-isopropylidene-sn-glycerols were condensed with appropriate long saturated or unsaturated fatty acids and the resulting acyl isopropylidene compounds were treated with dimethylboronbr...

journal_title：Journal of lipid research

authors： Kodali DR

更新日期：1987-04-01 00:00:00

abstract：:The use of lipoproteins has been suggested as a treatment for Gram-negative sepsis because they inhibit lipopolysaccharide (LPS)-mediated cytokine production. However, little is known about the neutralizing effects of lipoproteins on cytokine production by meningococcal LPS or whole Gram-negative bacteria. We assessed...

journal_title：Journal of lipid research

authors： Sprong T,Netea MG,van der Ley P,Verver-Jansen TJ,Jacobs LE,Stalenhoef A,van der Meer JW,van Deuren M

更新日期：2004-04-01 00:00:00

abstract：:More than 100 proteins necessary for eukaryotic cell growth, differentiation, and morphology require posttranslational modification by the covalent attachment of an isoprenoid lipid (prenylation). Prenylated proteins include members of the Ras, Rab, and Rho families, lamins, CENPE and CENPF, and the gamma subunit of m...

journal_title：Journal of lipid research

authors： Lane KT,Beese LS

更新日期：2006-04-01 00:00:00

abstract：:Five samples from three different types of 1500-year-old Mediterranean amphorae, as well as from a contemporary oil lamp found in the same deposit, were analyzed for the presence of lipid residues. Each sample of finely ground amphorae powder weighed 1-2 g. The abundance of interfering secondary products makes thin-la...

journal_title：Journal of lipid research

authors： Passi S,Rothschild-Boros MC,Fasella P,Nazzaro-Porro M,Whitehouse D

更新日期：1981-07-01 00:00:00

abstract：:To obtain a panel of monoclonal antibodies (MAbs) to study the folding and conformation of the low density lipoprotein receptor (LDLr), we have generated hybridomas from LDLr-deficient mice that had been immunized with the extracellular domain of the human LDLr. The 12 MAbs were specific for the ligand binding domain ...

journal_title：Journal of lipid research

authors： Nguyen AT,Hirama T,Chauhan V,Mackenzie R,Milne R

更新日期：2006-07-01 00:00:00

abstract：:Dysbetalipoproteinemia, an uncommon but highly atherogenic mixed hyperlipidemia due to the accumulation of remnants of triglyceride-rich lipoproteins, is characterized by cholesterol-enriched VLDL that migrates in the beta-position on agarose gels. The demonstration of a broad beta-band on agarose gel electrophoresis ...

journal_title：Journal of lipid research

authors： Blom DJ,Byrnes P,Jones S,Marais AD

更新日期：2003-01-01 00:00:00

abstract：:ABCA1 exports cholesterol and phospholipids from cells by a multistep pathway that involves forming cell surface lipid domains, solubilizing these lipids by apolipoproteins, binding of apolipoproteins to ABCA1, and activating signaling processes. Here we used a mutational analysis approach to evaluate the relationship...

journal_title：Journal of lipid research

authors： Vaughan AM,Tang C,Oram JF

更新日期：2009-02-01 00:00:00

abstract：:Adipose tissue was shown to contain 0.6-1.6 mg of cholesterol per gram wet weight. When expressed per unit of protein or organ mass, fat tissue contains more cholesterol than most other organs or membranes. The cholesterol content of fat tissue increased with the age and weight of the rat. Over 95% of adipose tissue s...

journal_title：Journal of lipid research

authors： Farkas J,Angel A,Avigan MI

更新日期：1973-05-01 00:00:00

abstract：:The sequences of the plasma apolipoproteins have a high degree of internal homology as they contain several 22-mer internal repeats. These amphipathic helical repeats are considered as the structural and functional units of this class of proteins. We proposed that the 22-mer repeats of the plasma apolipoproteins consi...

journal_title：Journal of lipid research

authors： Vanloo B,Demoor L,Boutillon C,Lins L,Brasseur R,Baert J,Fruchart JC,Tartar A,Rosseneu M

更新日期：1995-08-01 00:00:00

abstract：:Rab GTPases require special machinery for protein prenylation, which include Rab escort protein (REP) and Rab geranylgeranyl transferase (RGGT). The current model of Rab geranylgeranylation proposes that REP binds Rab and presents it to RGGT. After geranylgeranylation of Rab C-terminal cysteines, REP delivers the pren...

journal_title：Journal of lipid research

authors： Leung KF,Baron R,Seabra MC

更新日期：2006-03-01 00:00:00

abstract：:The demand to study the cellular localization of specific lipids has led to recent advances in lipid probes and microscopy. Alkyne lipids bear a small, noninterfering tag and can be detected upon click reaction with an azide-coupled reporter. Fluorescent alkyne lipid imaging crucially depends on appropriate azide repo...

journal_title：Journal of lipid research

authors： Gaebler A,Penno A,Kuerschner L,Thiele C

更新日期：2016-10-01 00:00:00

abstract：:Hepatic steatosis is one of the most common liver disorders in the general population. The main cause of hepatic steatosis is nonalcoholic fatty liver disease (NAFLD), representing the hepatic component of the metabolic syndrome, which is characterized by type 2 diabetes, obesity, and dyslipidemia. Insulin resistance ...

journal_title：Journal of lipid research

authors： Hooper AJ,Adams LA,Burnett JR

更新日期：2011-04-01 00:00:00

abstract：:In mammals, because they share a single synthetic pathway, n-6/n-3 ratios of dietary PUFAs impact tissue arachidonic acid (ARA) and DHA content. Likewise, SNPs in the human fatty acid desaturase (FADS) gene cluster impact tissue ARA and DHA. Here we tested the feasibility of using heterozygous Fads2-null-mice (HET) as...

journal_title：Journal of lipid research

authors： Su H,Zhou D,Pan YX,Wang X,Nakamura MT

更新日期：2016-11-01 00:00:00

abstract：:A deficiency of lysosomal phospholipase A2 (LPLA2) causes macrophage-associated phospholipidosis, suggesting that the enzyme is important in the lipid catabolism. Because LPLA2 is secreted by macrophages, extracellular LPLA2 activity may potentially reflect a change in macrophage activation. In this report, the detect...

journal_title：Journal of lipid research

authors： Abe A,Kelly R,Shayman JA

更新日期：2010-08-01 00:00:00

abstract：:HDL and its major component, apolipoprotein A-I (apoA-I), play a central role in reverse cholesterol transport. We recently reported the involvement of a glycosylphosphatidylinositol anchor (GPI anchor) in the binding of HDL and apoA-I on human macrophages, and purified an 80 kDa HDL/apoA-I binding protein. In the pre...

journal_title：Journal of lipid research

authors： Matsuyama A,Sakai N,Hiraoka H,Hirano K,Yamashita S

更新日期：2006-01-01 00:00:00