Moderate hyperhomocysteinaemia and vascular disease: evidence, relevance and the effect of treatment.

Abstract:

UNLABELLED:Convincing evidence of moderate hyperhomocysteinaemia as a risk factor for vascular disease has accumulated within the last decade being independent of conventional risk factors and equally strong as hypercholesterolaemia and smoking. A synergistic interaction with hypertension and smoking in their joint arteriosclerotic effect in patients is demonstrated which makes the result of homocysteine-lowering intervention very promising, especially in those vascular patients with an association of these risk factors. CONCLUSION:Despite the proven homocysteine-lowering effect of intervention with sample, safe, and cheap vitamin regimen, no data are so far available on the clinical outcome of such treatment. Clinical trials to demonstrate a hopefully beneficial result of homocysteine reduction are urgently needed.

journal_name

Eur J Pediatr

authors

Boers G

doi

10.1007/pl00014292

subject

Has Abstract

pub_date

1998-04-01 00:00:00

pages

S127-30

eissn

0340-6199

issn

1432-1076

journal_volume

157 Suppl 2

pub_type

杂志文章,评审
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    更新日期:2003-10-01 00:00:00

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    journal_title:European journal of pediatrics

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    更新日期:2016-05-01 00:00:00

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    pub_type: 杂志文章,meta分析,评审

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    更新日期:2013-06-01 00:00:00

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