Abstract:
:This report describes a case of d-lactic acidosis observed by the authors and then reviews all case reports of d-lactic acidosis in the literature in order to define its clinical and biochemical features and pathogenetic mechanisms. The report also reviews the literature on metabolism of d-lactic acid in humans. The clinical presentation of d-lactic acidosis is characterized by episodes of encephalopathy and metabolic acidosis. The diagnosis should be considered in a patient who presents with metabolic acidosis and high serum anion gap, normal lactate level, negative Acetest, short bowel syndrome or other forms of malabsorption, and characteristic neurologic findings. Development of the syndrome requires the following conditions 1) carbohydrate malabsorption with increased delivery of nutrients to the colon, 2) colonic bacterial flora of a type that produces d-lactic acid, 3) ingestion of large amounts of carbohydrate, 4) diminished colonic motility, allowing time for nutrients in the colon to undergo bacterial fermentation, and 5) impaired d-lactate metabolism. In contrast to the initial assumption that d-lactic acid is not metabolized by humans, analysis of published data shows a substantial rate of metabolism of d-lactate by normal humans. Estimates based on these data suggest that impaired metabolism of d-lactate is almost a prerequisite for the development of the syndrome.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Uribarri J,Oh MS,Carroll HJdoi
10.1097/00005792-199803000-00001subject
Has Abstractpub_date
1998-03-01 00:00:00pages
73-82issue
2eissn
0025-7974issn
1536-5964journal_volume
77pub_type
杂志文章,评审相关文献
MEDICINE文献大全abstract::Since its application in medical institutions in China, quality control circle (QCC) has gained achievements in medical care and thus earned more attention from the administrative department of health.In order to improve the quality of laboratory specimens, we launched a QCC activity to solve the problems and evaluate...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020333
更新日期:2020-05-22 00:00:00
abstract::Stereotactic radiotherapy (SRT) is a new approach to treat neovascular age-related macular degeneration (nAMD). The INTREPID trial suggested that SRT could reduce the frequency of regular intravitreal injections (IVIs) with antivascular endothelial growth factor drugs, which are necessary to control disease activity. ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000005729
更新日期:2016-12-01 00:00:00
abstract::The aim of this study was to explore the impact of 3% hypertonic saline (HS) intragastric administration for patients who underwent upper gastrointestinal surgery.During the postoperative period, 3% HS has been suggested as a means to improve the intestinal edema and reduce gastrointestinal complications.The medical r...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000006121
更新日期:2017-03-01 00:00:00
abstract::Acute motor axonal neuropathy (AMAN) is a variant of Guillain-Barre syndrome. It has been reported to have no sensory symptoms and is diagnosed by typical electrophysiological findings of low-amplitude or unobtainable compound muscle action potentials with normal sensory nerve action potentials. However, the authors e...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0000000000000392
更新日期:2015-01-01 00:00:00
abstract::To investigate the efficacy, key technical points, and complication management of the transabdominal preperitoneal (TAPP) approach for incarcerated inguinal hernia repair. Seventy-three patients with incarcerated inguinal hernias underwent TAPP surgery in our department between Jan 2010 and Dec 2015. A retrospective r...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000005686
更新日期:2016-12-01 00:00:00
abstract::This study investigated whether migraine influences the risk of primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG) in Taiwan.We retrieved the data analyzed in this study from the National Health Insurance Research Database in Taiwan. We included 17,606 newly diagnosed migraine patients withou...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000003670
更新日期:2016-05-01 00:00:00
abstract::The importance of bedside assistants has been well established in various robotic procedures. However, the effect of assistants on the surgical outcomes of thyroid surgery remains unclear. We investigated the effects of a dedicated robot assistant (DRA) in robotic thyroidectomy. We also evaluated the learning curve of...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000022133
更新日期:2020-09-04 00:00:00
abstract::Although cardiac troponin I (cTnI) elevation in patients presenting to the hospital with supraventricular tachycardia (SVT) is well recognized, the prevalence, predictors, and prognostic significance of cTnI elevation associated with SVT presentation are not known. We screened records of all patients presenting to 2 h...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0b013e3181dddb3b
更新日期:2010-05-01 00:00:00
abstract::To explore the correlation between platelet endothelial aggregation receptor-1 (PEAR1) genetic polymorphism and pulmonary thromboembolism (PTE).Variant loci of the PEAR1 gene were screened in a PTE pedigree, followed by verification using Sanger sequencing. These polymorphic loci were validated in 101 PTE patients and...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000005687
更新日期:2016-12-01 00:00:00
abstract::The purpose of study was to analyze the participants' opinions concerning the effectiveness of 6 denture adhesives (DA). The study group included 60 participants. Criteria for selecting the patients were as follows: reduced retention and stabilization of maxillary complete dentures and xerostomia. These features were ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000000545
更新日期:2015-02-01 00:00:00
abstract:INTRODUCTION:Pulmonary sequestration (PS) is a rare pulmonary congenital malformation characterized by disconnection with the tracheobronchial tree or the pulmonary arterial blood supply thus impeding the connection to the arterial blood supply from systemic circulation, ultimately resulting in a non-functional lung. ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020052
更新日期:2020-05-01 00:00:00
abstract:INTRODUCTION:Crohn disease (CD) is a chronic relapsing systemic inflammatory disease afflicting the gastrointestinal system with a high morbidity. There has been increasing clinical interest in traditional Chinese medicine (TCM) treatment for CD. This report aims to present patient outcome of therapeutic management usi...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000015148
更新日期:2019-04-01 00:00:00
abstract::Lung ultrasound (LU) is increasingly used to assess pleural and lung disease in intensive care unit (ICU) and emergency unit at the bedside. We assessed the performance of bedside chest radiograph (CR) and LU during severe acute chest syndrome (ACS), using computed tomography (CT) as the reference standard. We prospec...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000002553
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Allergic rhinitis is a major chronic inflammatory disease of the respiratory tract. A large number of epidemiological investigations have shown that the prevalence of allergic rhinitis (AR) is increasing, resulting in a large burden of disease. Desensitizing drugs such as nasal glucocorticoids and antihistam...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000013772
更新日期:2018-12-01 00:00:00
abstract::This study aimed to report our institution's experience in the diagnosis and treatment of chronic lateral ankle instability (CLAI) with ligamentum bifurcatum (LB) injury.This retrospective study included 218 consecutive patients with CLAI who underwent surgery from January 2012 to December 2015. The 218 patients recei...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000010028
更新日期:2018-03-01 00:00:00
abstract:RATIONALE:Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease that involves limb, axial, bulbar, and respiratory muscles. Fatigue and weakness of the respiratory muscles eventually induce respiratory insufficiency, which is one of the main causes of death in patients with ALS. In ALS ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000007899
更新日期:2017-08-01 00:00:00
abstract::This study investigated the effect of sex hormones on F-fluorodeoxyglucose (FDG) uptake in normal breast tissue.The retrospective study included 249 premenopausal women (median age, 45 years) who were diagnosed with unilateral breast cancer and underwent FDG positron emission tomography/computed tomography and hormone...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000016306
更新日期:2019-07-01 00:00:00
abstract::As the number of cardiac implantable electronic devices (CIEDs) is increasing annually, CIED-related complications are becoming increasingly important. The aim of the study was to assess the risks associated with CIEDs by a nationwide database. Patients were selected from the Taiwan National Health Insurance Database....
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000000213
更新日期:2014-12-01 00:00:00
abstract:RATIONALE:Coexistence of lung adenocarcinoma and polyserous effusions is quite rare. This complexity of etiology adds difficulty to the diagnosis and is likely to cause misdiagnosis and maldiagnosis. PATIENT CONCERNS:A 43-year-old woman was admitted with symptoms of dry cough, chest suffocation, polyserous effusions, ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000007867
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:Our study aimed to screen and explore the expression of inflammatory factors in keloid patients and to investigate how hyperbaric oxygen (HBO) therapy affects the expression levels of interleukin-12p40 (IL-12p40), macrophage inflammatory protein-1β (MIP-1β), platelet-derived growth factor-BB (PDGF-BB), and i...
journal_title:Medicine
pub_type: 临床试验,杂志文章
doi:10.1097/MD.0000000000019857
更新日期:2020-04-01 00:00:00
abstract::To evaluate the value of lymph node status of primary tumors in predicting the prognosis of synchronous resectable metastatic colorectal cancer (mCRC).The characteristics of resectable mCRC are substantially different from other cancers, and the prognostic factors of resectable mCRC are still controversial.The data of...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000001215
更新日期:2015-07-01 00:00:00
abstract:OBJECTIVE:Systematically review and Grading of Recommendations Assessment, Development, and Evaluation (GRADE) studies on prophylactic negative pressure wound therapy (pNPWT) to prevent surgical site infections (SSIs). INTRODUCTION:pNPWT has been suggested as a new method to prevent wound complications, specifically S...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000004673
更新日期:2016-09-01 00:00:00
abstract::The direction-changing bilateral gaze-evoked nystagmus (GEN) (BGEN) is a more specific sign for a gaze-holding deficit than unilateral GEN (UGEN) in a central lesion. We sought to clarify which cerebellar structure is responsible for the generation of BGEN compared with UGEN.We studied 47 cases of UGEN or BGEN associa...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000019866
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:Recently, many kinds of cages for cervical fusion have been developed to avoid the related complications caused by tricortical iliac crest graft. The existing literature has reported the excellent clinical efficacy and superior fusion rate. However, various types of cages have their own disadvantages. Which ...
journal_title:Medicine
pub_type: 临床试验,杂志文章
doi:10.1097/MD.0000000000017935
更新日期:2019-11-01 00:00:00
abstract::Kinesin family member 2A (KIF2A) is a member of Kinesin-13 family and involved in cell migration and cell signaling. Human epidermal growth factor receptor 2 (HER2-neu) is implicated in the development of many cancers. Both of these 2 proteins are upstream inducer of PI3K/AKT signaling pathway that plays an important ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000002803
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Coronavirus disease 2019 (COVID-19) is a potentially fatal disease. clinical practice shows that Chinese Patent Medicine (CPM) has played an important role in the outbreak, Among them, Jinhua Qinggan granules, Lianhua Qingwen capsule, and Xuebiqing injection have an effect in treating COVID-19 patients, but ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000022277
更新日期:2020-09-18 00:00:00
abstract::The study was conducted to investigate the diagnostic performance of serum LIM homeobox transcription factor 1 alpha (LMX1A) in patients with gastric cancer (GC).The serum level of LMX1A in GC, benign, and healthy groups was measured using quantitative real time PCR (qRT-PCR) and compared with the student t test. The ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000015783
更新日期:2019-05-01 00:00:00
abstract::We aimed to elucidate the relationship between serum liver fibrosis markers (Mac-2 binding protein glycosylation isomer (M2BPGi), FIB-4 index, aspartate aminotransferase to platelet ratio index and hyaluronic acid), and skeletal muscle mass and to investigate factors linked to skeletal muscle mass loss (SMML) in patie...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000008761
更新日期:2017-12-01 00:00:00
abstract:RATIONALE:Neurenteric cysts, are rare benign tumors of the central nervous system that are mostly located in the spinal cord and predominantly seen in male children although adult form of the disorder also occurs. The etiology and treatment of this disorder is still a matter of debate. Our case further throws more ligh...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000010489
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:The prognostic significance of circulating soluble programmed death ligand-1 (sPD-L1) in patients with solid tumors remains unclear. We performed a meta-analysis to address this issue. METHODS:Several electronic databases were searched from January 1970 to May 2017. The hazard ratios (HRs) and 95% confidenc...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000009617
更新日期:2018-01-01 00:00:00