Prognostic significance of circulating soluble programmed death ligand-1 in patients with solid tumors: A meta-analysis.

Abstract:

BACKGROUND:The prognostic significance of circulating soluble programmed death ligand-1 (sPD-L1) in patients with solid tumors remains unclear. We performed a meta-analysis to address this issue. METHODS:Several electronic databases were searched from January 1970 to May 2017. The hazard ratios (HRs) and 95% confidence interval (95% CI) were calculated to determine the relationship between the level of soluble PD-L1 in peripheral blood and patient overall survival. RESULTS:A total of 1040 patients with solid tumors from 8 eligible studies were included in the present meta-analysis. The pooled HR suggested that a high level of soluble PD-L1 (sPD-L1) in peripheral blood was significantly correlated with a worse overall survival (HR = 2.26, 95% 1.83-2.80, Z = 7.51, P < .001). CONCLUSION:The present meta-analysis demonstrated that a high level of soluble PD-L1 in peripheral blood significantly predicts poor prognosis in patients with solid tumors, suggesting that high level of sPD-L1 may serve as a predictive biomarker for poor prognosis.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Wei W,Xu B,Wang Y,Wu C,Jiang J,Wu C

doi

10.1097/MD.0000000000009617

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

e9617

issue

3

eissn

0025-7974

issn

1536-5964

pii

00005792-201801190-00024

journal_volume

97

pub_type

杂志文章,meta分析

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