Abstract：
:Intraperitoneal administration of the mycotoxin penitrem A 30 min before a training session in passive avoidance task, impaired performance of rats subjected to a test-session 24 h after. This effect was not antagonised by pretraining administration of physostigmine or bicuculline. Administration of penitrem A 20 min before a training session or 30 min before a test-session did not impair performance. In the Morris water maze, doses of penitrem A that induces slight to moderate tremors, but not a lower dose, disrupted place learning. These results suggest that penitrem A disrupts the processes that take place at the time of acquisition, but not those just after acquisition, and does not alter the restitution of information. This effect would not be related to a decrease of cholinergic neurotransmission nor to a stimulation of GABA A receptors. Nevertheless, it could not be totally excluded that the performance impairments induced by penitrem A would be secondary to a motor disruption.
journal_name
Mycopathologiajournal_title
Mycopathologiaauthors
Deschaux O,Bizot JCdoi
10.1023/a:1006853600205subject
Has Abstractpub_date
1997-01-01 00:00:00pages
99-104issue
2eissn
0301-486Xissn
1573-0832journal_volume
138pub_type
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