Abstract:
BACKGROUND:Cryptococcal meningitis is one of the most important opportunistic infection and a major contributor to early mortality. In sub-Saharan Africa, particularly in Senegal, prevalence of cryptococcal meningitis remains high. This study aimed to describe the epidemiology, laboratory profile, therapeutic and outcome of cases diagnosed in Dakar. METHODS:We analyzed the cryptococcosis cases diagnosed at the department of parasitology-mycology in Fann Teaching Hospital in Dakar from 2004 to 2011. The diagnosis was confirmed by culture on Sabouraud's dextrose agar and/or by India ink preparation and/or by cryptococcal antigen detection. The diagnosis methods were assessed by using culture as reference. RESULTS:A total of 106 cases of cryptococcal meningitis were diagnosed. The prevalence of cryptococcal meningitis was 7.8 %. The mean age of the patients was 40.17 ± 9.89 years. There were slightly more male (53.8 %) than female (46.2 %) patients; 89.6 % were found to be infected with HIV, and the median CD4+ count was 27/mm(3). Approximately 79.5 % of the patients had <100 CD4+ lymphocytes/mm(3). India ink staining presented sensitivity at 94.11 % and specificity at 100 %. Sensitivity and specificity of cryptococcal antigen detection in cerebrospinal fluid were, respectively, 96.96 and 15.78 %. The most frequently used antifungal drug was fluconazole (86.7 %), and the mortality rate was 62.2 % (66 deaths). CONCLUSION:Early diagnosis is essential to control cryptococcosis, and countries should prioritize widespread and reliable access to rapid diagnostic cryptococcus antigen assays. But it is important to make available conventional methods (India ink and culture) in the maximum of laboratory in regional health facilities.
journal_name
Mycopathologiajournal_title
Mycopathologiaauthors
Sow D,Tine RC,Sylla K,Djiba M,Ndour CT,Dieng T,Ndiaye JL,Faye B,Ndiaye D,Gaye O,Dieng Ydoi
10.1007/s11046-013-9710-8subject
Has Abstractpub_date
2013-12-01 00:00:00pages
443-9issue
5-6eissn
0301-486Xissn
1573-0832journal_volume
176pub_type
杂志文章相关文献
MYCOPATHOLOGIA文献大全abstract::We report a familial infection caused by Microsporum canis. The first two patients were a 30-year-old female and her son, a 5-year-old boy, who came in contact with a pet dog at a farm house. The boy then suffered from hair loss for 3 months. There were circular and patchy alopecia with diffuse scaling on his scalp. M...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/s11046-013-9685-5
更新日期:2013-10-01 00:00:00
abstract::Sixty-four species and 2 varieties which belong to nineteen genera of fungi were identified from 40 peanut seed samples collected from different places in Egypt by using a dilution-plate method on glucose-Czapek's medium. The most frequent genera were Aspergillus (21 species & 2 varieties), Penicillium (16 species) an...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/BF00437651
更新日期:1987-06-01 00:00:00
abstract::The in vitro effect of each of the Penicillium mycotoxins citrinin (CIT), cyclopiazonic acid (CPA), ochratoxin A (OTA), patulin (PAT), penicillic acid (PIA) and roquefortine C (RQC) on mitogen induced lymphocyte proliferation was determined using purified lymphocytes from 6 piglets. Dose response curves for each mycot...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/s11046-005-5523-8
更新日期:2004-10-01 00:00:00
abstract::Onychomycosis is a common fungal infection of nails which is mainly caused by dermatophyte species and less often by yeasts and non-dermatophyte molds. We present a case of onychomycosis due to Aspergillus clavatus for the first time worldwide. The patient was an immunocompetent 32-year-old woman who identified with P...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/s11046-015-9954-6
更新日期:2016-04-01 00:00:00
abstract::To clarify the terbinafine (TRF) resistance mechanism in a TRF-resistant strain of Microsporum canis, the expression of the pleiotropic drug resistance (PDR1), multidrug resistance (MDR1), MDR2 and MDR4 genes were investigated by real-time quantitative PCR (RT-qPCR) analysis, given the known interaction of the corresp...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/s11046-018-0242-0
更新日期:2018-06-01 00:00:00
abstract::Of 30 bats belonging to four species, only one species, Brachyplylla cavernarum, yielded positive for Histoplasma capsulatum. Bats were collected at the Aguas Buenas Caves in Puerto Rico. The other species are: Artibeus jamaicensis, Monophyllus redmani portoricensis, and Erophylla bibombifrons; these resulted negative...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/BF00448410
更新日期:1977-04-29 00:00:00
abstract::Complement receptor type 1 (CR1) is a membrane glycoprotein that acts as a receptor for the C3b, iC3b and C4b fragments of complement. In primates, one function of erythrocytes is to promote safe clearance of immunocomplexes (IC) from the circulation through CR1. Theoretically, in diseases characterized by high levels...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1023/a:1013123721376
更新日期:2001-01-01 00:00:00
abstract::A low molecular weight fraction from chitinase digested cell walls of T. mentagrophytes containing both polysaccharide and peptide moieties was found to have immunological reactivity at both the cellular and humoral level. This fraction (UM2(a)) was further degraded by treatment with either a combination of pronase an...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/BF00683962
更新日期:1979-02-28 00:00:00
abstract::Sixteen fungal species were isolated from 182 specimens collected from four ruminants (buffalo, camel, cattle and sheep) in Southern Iraq. Fungi represented by five species of dermatophytes and eleven species of other fungi were screened for the activity of four enzymes: keratinase. proteinase, lipase and amylase. Ker...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1023/a:1010854322655
更新日期:2001-01-01 00:00:00
abstract::Trichosporon species cause wide varieties of fungal infections. White piedra, a superficial fungal infection on the hair shaft, is caused by Trichosporon species. We report here a case of white piedra over the scalp due to T. inkin, a rarely isolated pathogen from such a lesion. The identification of the fungus was co...
journal_title:Mycopathologia
pub_type: 杂志文章,评审
doi:10.1007/s11046-011-9454-2
更新日期:2011-12-01 00:00:00
abstract::The fungal flora of wheat flour and baladi bread in upper Egypt were investigated. Most of the isolated fungal species belong to the genus Aspergillus. The presence of non heat resistant fungi of the both flat surfaces of baladi bread, came from contamination after baking and from improper handling at homes. Among the...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/BF00437130
更新日期:1985-01-01 00:00:00
abstract::A dematiaceous fungus, Phialophora richardsiae (Nannf.) Conant, was isolated from human bone. In culture the fungus produced no yeast forms and was less pigmented than two other P. richardsiae isolates. While growth rates were similar, colonial forms differed. Phialides were of two kinds. While both had broad bases an...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/BF00436495
更新日期:1984-05-30 00:00:00
abstract::The identity and activity of an entomopathogenic fungus belonging to the Entomophthora muscae species complex and infecting Musca domestica in poultry houses from La Plata, Argentina, is reported. Entomophthora caused natural infections between September 2001 and September 2003. Primary conidia of this fungus were on ...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/s11046-005-0248-2
更新日期:2006-04-01 00:00:00
abstract::The aim of the present study was to ascertain whether cell-mediated immunity (CMI) is induced in animals by vaccination with Candida albicans ribosomes. Delayed type hypersensitivity (DTH) was detected in vivo in ribosome-vaccinated mice and guinea pigs by the footpad swelling and skin tests, respectively. The observe...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/BF00437023
更新日期:1983-11-25 00:00:00
abstract::This is a comparative study to isolate the dermatophytes of tinea capitis using the cytobrush and comparing it versus the standard method. A prospective, observational, comparative trial of 178 probable cases of tinea capitis was conducted in two dermatological centers. Each patient underwent mycological tests that in...
journal_title:Mycopathologia
pub_type: 临床试验,杂志文章
doi:10.1007/s11046-007-9019-6
更新日期:2007-06-01 00:00:00
abstract::Invasive aspergillosis (IA) is increasingly diagnosed in high-risk patients. The lesions are usually located in the lungs and/or sinuses, and the fungus may spread haematogenously to different organs; however, involvement of the heart during IA is very rare. We describe a unique case of invasive aspergillosis of the h...
journal_title:Mycopathologia
pub_type: 杂志文章,评审
doi:10.1007/s11046-016-0012-9
更新日期:2016-08-01 00:00:00
abstract::A total of 57 samples of feedstuffs commonly used for animal nutrition in Colombia (corn, soybean, sorghum, cottonseed meal, sunflower seed meal, wheat middlings and rice) were analyzed for Fusarium contamination. Fusarium fungi were identified at species level by means of conventional methods and the ability to produ...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/s11046-005-1590-0
更新日期:2005-08-01 00:00:00
abstract::Trichosporon species are opportunistic pathogens associated with a high mortality rate in immunocompromised patients. Disseminated trichosporonosis is uncommon but reports are increasing. In this study, using 16 stock clinical isolates of suspected Trichosporon species and 4 known Trichosporon strains, we investigated...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/s11046-005-0112-4
更新日期:2005-10-01 00:00:00
abstract::In a survey of the mycoflora and mycotoxins in foods and feeds, 66 samples of mixed poultry feeds and some component raw materials were investigated. Fungal counts ranged from < 10(2) to 1.3 x 10(6) CFU/g. Fusarium spp. counts ranged from 10(2) to 1.0 x 10(6) CFU/g. The fusarium spp. strains isolated were screened for...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/BF02373025
更新日期:1996-01-01 00:00:00
abstract::Rhodotorula species are increasingly being identified as a cause of fungal infection in the central nervous system, especially in patients with compromised immunity. The diagnosis could easily be missed due to low index of suspicion, as cryptococcus meningitis and cerebral toxoplasmosis are more common amongst immunoc...
journal_title:Mycopathologia
pub_type: 杂志文章,评审
doi:10.1007/s11046-015-9879-0
更新日期:2015-08-01 00:00:00
abstract::Every truck load of corn (n = 52) entering and every batch of poultry feed (n = 290) leaving a Bogor feedmill over one year was analysed for aflatoxins, zearalenone, ochratoxin A and sterigmatocystin. Fifty loads of corn and 274 of the batches of chicken feed contained aflatoxins. Zearalenone was detected in 11 corn s...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/BF00436251
更新日期:1988-04-01 00:00:00
abstract::Small ruminant production is a common agricultural activity worldwide. However, studies on the fungal microbiota of these animals are scarce. Therefore, this study aimed at isolating yeasts from goats and sheep and evaluating the antifungal susceptibility of the recovered Candida albicans. A total of 120 animals from ...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/s11046-015-9888-z
更新日期:2015-10-01 00:00:00
abstract::We investigated the antifungal susceptibility profiles of 207 independent Candida albicans strains isolated from patients with vulvovaginal candidiasis (VVC) in Xinjiang Province of China. Using CLSI M27-A3 and M27-S4 guidelines, anidulafungin and micafungin were the most active drugs against C. albicans showing an MI...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/s11046-018-0305-2
更新日期:2019-06-01 00:00:00
abstract::Testing for Candida albicans germ-tube antibody IFA IgG assay (CAGTA) is used to detect invasive candidiasis infection. However, most suitable assays lack automation and rapid single-sample testing. The CAGTA assay was adapted in an automatic monotest system (invasive candidiasis [CAGTA] VirClia® IgG monotest (VirClia...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/s11046-017-0125-9
更新日期:2017-08-01 00:00:00
abstract::A total of 110 commercially available samples of manufactured food products including bread, oat, barley, maize, corn, wheat, grape, soluble coffee, soya bean, red wine, and baby food were randomly collected in the northeast of China during the first six months of 2010. Samples were analyzed for the presence of ochrat...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/s11046-011-9393-y
更新日期:2012-03-01 00:00:00
abstract::The aims of this study were to evaluate the epidemiology of nosocomial candidemia in a tertiary hospital in South Brazil and the in vitro antifungal susceptibility of isolates. Blood strains from 108 patients were identified by PCR-based method. Some 30.5 % of candidemia were caused by Candida tropicalis, 28.7 % were ...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/s11046-014-9791-z
更新日期:2014-10-01 00:00:00
abstract::There are very few medical reports on the nomadic peoples of the world. In Nigeria such reports are non-existent. The present work has looked at the distribution of ringworm infections among the Nigerian nomadic Fulani herdsmen. An examination of their infected herds of cattle revealed similarities in the species of d...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/BF00467685
更新日期:1986-10-01 00:00:00
abstract::The toxicity of the fungal phytotoxin dothistromin (l) to microorganisms, its lysis of human red blood corpuscles and beetroot tissue, and its unexpectedly selective inhibition of radicle elongation for Trigonella foenum-graecum were strongly light-dependent. Dothistromin was also toxic to Artemia salina but without r...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/BF00436652
更新日期:1990-12-01 00:00:00
abstract::A 59-year-old man visited our hospital. The patient had suffered from generalized tinea superficialis for thirty years, had been treated with several topical antifungal preparations and was administered griseofulvin at another hospital. Clinical manifestations were as follows: There were large pigmentations on the che...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/BF00437334
更新日期:1983-05-22 00:00:00
abstract::Chromoblastomycosis and phaeohyphomycosis represent two poles of a disease spectrum caused by melanized fungi. Veronaea botryosa belongs to a small genus of saprobic fungi that occasionally cause human infections. To date, 11 cases of V. botryosa-induced cutaneous phaeohyphomycosis have been actually reported since 19...
journal_title:Mycopathologia
pub_type: 杂志文章,评审
doi:10.1007/s11046-015-9887-0
更新日期:2015-08-01 00:00:00