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Intraarterial biocompatibility of polyethylene terephthalate self-expandable stents implanted in porcine peripheral arteries.

Abstract：

RATIONALE AND OBJECTIVES:We tested deployment feasibility and intraarterial biocompatibility of polyethylene terephthalate (PET) self-expandable vascular stents in a porcine peripheral artery model. METHODS:To assess the thrombogenicity and neointimal response to oversized PET self-expandable stents, we implanted 10 stents in porcine common iliac arteries, followed by a 6-mm balloon inflation to 6 atm. RESULTS:All pigs survived until the study termination 6 weeks after stent implantation. Control angiography revealed stent closure in three pigs. Minimal stent luminal diameter (MSLD) was measured using a semiautomated edge detection algorithm. The difference in MSLD after stent implantation and at control after 6 weeks was not significant (4.9 +/- 0.5 mm-->4.7 +/- 1.0 mm). Histopathologic examination showed signs of thrombotic occlusion and revascularization in occluded stents. In patient stents only a mild fibromuscular neointimal response was seen. CONCLUSION:PET self-expandable stents implanted in porcine iliac arteries are possibly thrombogenic but do not lead to a significant neointimal response.

journal_name

Acad Radiol

journal_title

Academic radiology

authors

De Scheerder IK,Wilczek KV,Verbeken EV,Barios L,Piessens J,De Geest H

doi

10.1016/S1076-6332(05)80151-5

subject

Has Abstract

pub_date

1995-02-01 00:00:00

pages

154-8

issue

2

eissn

1076-6332

issn

1878-4046

pii

S1076-6332(05)80151-5

journal_volume

2

pub_type

杂志文章

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