Ascorbate recycling in human neutrophils: induction by bacteria.

abstract：:Ras is a guanine nucleotide-binding protein that cycles between inactive GDP-bound and active GTP-bound states to regulate a diverse array of cellular processes, including cell growth, apoptosis, and differentiation. The guanine nucleotide-bound state of Ras is tightly maintained by regulatory factors to promote regul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Williams JG,Pappu K,Campbell SL

更新日期：2003-05-27 00:00:00

abstract：:Saccharomyces cerevisiae Hop2 and Mnd1 are abundant meiosisspecific chromosomal proteins, and mutations in the corresponding genes lead to defects in meiotic recombination and in homologous chromosome interactions during mid-prophase. Analysis of various double mutants suggests that HOP2, MND1, and DMC1 act in the sam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen YK,Leng CH,Olivares H,Lee MH,Chang YC,Kung WM,Ti SC,Lo YH,Wang AH,Chang CS,Bishop DK,Hsueh YP,Wang TF

更新日期：2004-07-20 00:00:00

abstract：:Genome packaging is an essential step in virus replication and a potential drug target. Single-stranded RNA viruses have been thought to encapsidate their genomes by gradual co-assembly with capsid subunits. In contrast, using a single molecule fluorescence assay to monitor RNA conformation and virus assembly in real ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Borodavka A,Tuma R,Stockley PG

更新日期：2012-09-25 00:00:00

abstract：:Group 3 innate lymphoid cells (ILC3s) have emerged as important cellular players in tissue repair and innate immunity. Whether these cells meaningfully regulate adaptive immune responses upon activation has yet to be explored. Here we show that upon IL-1β stimulation, peripheral ILC3s become activated, secrete cytokin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： von Burg N,Chappaz S,Baerenwaldt A,Horvath E,Bose Dasgupta S,Ashok D,Pieters J,Tacchini-Cottier F,Rolink A,Acha-Orbea H,Finke D

更新日期：2014-09-02 00:00:00

abstract：:Little is known about the molecular mechanisms by which the embryo proper and suspensor of plant embryos activate specific gene sets shortly after fertilization. We analyzed the upstream region of the scarlet runner bean (Phaseolus coccineus) G564 gene to understand how genes are activated specifically within the susp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kawashima T,Wang X,Henry KF,Bi Y,Weterings K,Goldberg RB

更新日期：2009-03-03 00:00:00

abstract：:The pH gradient (delta pH) across the membrane of bovine neurohypophysial granules was estimated by using the [14C]methylamine partition technique. The granule membrane showed high permeability to sugars such as sucrose or sorbitol and to cations. Granules suspended in sucrose medium showed an acidic internal delta pH...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scherman D,Nordmann JJ

更新日期：1982-01-01 00:00:00

abstract：:We measured the superconducting transition temperature of (6)Li between 16 and 26 GPa, and report the lightest system to exhibit superconductivity to date. The superconducting phase diagram of (6)Li is compared with that of (7)Li through simultaneous measurement in a diamond anvil cell (DAC). Below 21 GPa, Li exhibits...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schaeffer AM,Temple SR,Bishop JK,Deemyad S

更新日期：2015-01-06 00:00:00

abstract：:Eradication of an invasive species can provide significant environmental, economic, and social benefits, but eradication programs often fail. Constant and careful monitoring improves the chance of success, but an invasion may seem to be in decline even when it is expanding in abundance or spatial extent. Determining w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Keith JM,Spring D

更新日期：2013-08-13 00:00:00

abstract：:Agrobacterium tumefaciens is the causal agent of crown gall disease. The bacterium is capable of transferring a segment of single-stranded DNA (ssDNA) into recipient cells during the transformation process, and it has been widely used as a genetic modification tool for plants and nonplant organisms. Transferred DNA (T...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li X,Yang Q,Peng L,Tu H,Lee LY,Gelvin SB,Pan SQ

更新日期：2020-10-20 00:00:00

abstract：:The compact steep-spectrum sources (CSSs) are an interesting class of objects which are of subgalactic dimensions; they occur more frequently in high-frequency surveys because their spectra often turn over at lower frequencies. We have estimated the symmetry parameters of a well-defined sample of CSSs and compared the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saikia DJ

更新日期：1995-12-05 00:00:00

abstract：:The bacterial actin homolog, MreB, forms helical cables within the cell that are required for maintenance of a rod shape. These helical structures are thought to be involved in the spatial organization of cell wall (peptidoglycan) synthesizing complexes of penicillin-binding proteins (PBPs). Here, we examined the role...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Divakaruni AV,Loo RR,Xie Y,Loo JA,Gober JW

更新日期：2005-12-20 00:00:00

abstract：:Circadian pacemaking requires the orderly synthesis, posttranslational modification, and degradation of clock proteins. In mammals, mutations in casein kinase 1 (CK1) epsilon or delta can alter the circadian period, but the particular functions of the WT isoforms within the pacemaker remain unclear. We selectively tar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meng QJ,Maywood ES,Bechtold DA,Lu WQ,Li J,Gibbs JE,Dupré SM,Chesham JE,Rajamohan F,Knafels J,Sneed B,Zawadzke LE,Ohren JF,Walton KM,Wager TT,Hastings MH,Loudon AS

更新日期：2010-08-24 00:00:00

abstract：:31P nuclear magnetic relaxation rates for phosphocreatine in intact frog gastrocnemius were compared with those observed in model solutions at 4 degrees, a temperature at which muscle maintains its physiological state for at least 5 hr. Both nuclear Overhauser effect and spin-lattice relaxation rate (1/T1) experiments...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cohen SM,Burt CT

更新日期：1977-10-01 00:00:00

abstract：:Very little is known about how animals discriminate pathogens from innocuous microbes. To address this question, we examined infection-response gene induction in the nematode Caenorhabditis elegans. We focused on genes that are induced in C. elegans by infection with the bacterial pathogen Pseudomonas aeruginosa, but ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Estes KA,Dunbar TL,Powell JR,Ausubel FM,Troemel ER

更新日期：2010-02-02 00:00:00

abstract：:Using the technique of DNA fingerprinting, we investigated the genetic structure within and among four wild-caught colonies (n = 50 individuals) of a eusocial mammal, the naked mole-rat (Heterocephalus glaber; Rodentia: Bathyergidae). We found that DNA fingerprints of colony-mates were strikingly similar and that betw...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reeve HK,Westneat DF,Noon WA,Sherman PW,Aquadro CF

更新日期：1990-04-01 00:00:00

abstract：:Five patients with advanced breast cancer were treated with pooled dialyzable transfer factor from healthy adult donors. The period of treatment ranged from 21 to 310 days, the total dose from 20 to 257 ml. Transfer factor did not elicit inflammatory or hypersensitivity reactions or detectable formation of antibody to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oettgen HF,Old LJ,Farrow JH,Valentine FT,Lawrence HS,Thomas L

更新日期：1974-06-01 00:00:00

abstract：:In addition to tRNA and 5S RNA, Escherichia coli contains several other small, stable RNA species; these are M1, 10Sa, 6S, and 4.5S RNA. Although these RNAs are initially synthesized as precursor molecules, relatively little is known about their maturation. The data presented here show that 3' exoribonucleolytic trimm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li Z,Pandit S,Deutscher MP

更新日期：1998-03-17 00:00:00

abstract：:Phosphatidylinositol 4,5-bisphosphate (PIP2) is an important cellular effector whose functions include the regulation of ion channels and membrane trafficking. Aberrant PIP2 metabolism has also been implicated in a variety of human disease states, e.g., cancer and diabetes. Here we report that familial Alzheimer's dis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Landman N,Jeong SY,Shin SY,Voronov SV,Serban G,Kang MS,Park MK,Di Paolo G,Chung S,Kim TW

更新日期：2006-12-19 00:00:00

abstract：:Numerous international bodies have advocated the development of strategies to achieve the sustainability of marine environments. Typically, such strategies are based on information from expert groups about causes of degradation and policy options to address them, but these strategies rarely take into account assessed ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gelcich S,Buckley P,Pinnegar JK,Chilvers J,Lorenzoni I,Terry G,Guerrero M,Castilla JC,Valdebenito A,Duarte CM

更新日期：2014-10-21 00:00:00

abstract：:Accurate and timely surface precipitation measurements are crucial for water resources management, agriculture, weather prediction, climate research, as well as ground validation of satellite-based precipitation estimates. However, the majority of the land surface of the earth lacks such data, and in many parts of the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Overeem A,Leijnse H,Uijlenhoet R

更新日期：2013-02-19 00:00:00

abstract：:A mutant (ML 308-22) was isolated from Escherichia coli ML 308, which had lost the normal capacity to accumulate lactose analogs despite an increase in the membrane carrier activity. The exit of thiomethylgalactoside was much faster than normal, accounting for the inability of the cell to maintain high intracellular c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wong PT,Kashket ER,Wilson TH

更新日期：1970-01-01 00:00:00

abstract：:Massively parallel signature sequencing (MPSS) generates millions of short sequence tags corresponding to transcripts from a single RNA preparation. Most MPSS tags can be unambiguously assigned to genes, thereby generating a comprehensive expression profile of the tissue of origin. From the comparison of MPSS data fro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen YT,Scanlan MJ,Venditti CA,Chua R,Theiler G,Stevenson BJ,Iseli C,Gure AO,Vasicek T,Strausberg RL,Jongeneel CV,Old LJ,Simpson AJ

更新日期：2005-05-31 00:00:00

abstract：:Inhibitory postsynaptic currents occurring spontaneously in the teleost Mauthner cell were analyzed with the single-electrode voltage-clamp technique. They were collected during depolarizing steps and were outward-going; this procedure allowed them to be isolated from possible excitatory currents flowing in the opposi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Korn H,Burnod Y,Faber DS

更新日期：1987-08-01 00:00:00

abstract：:In light of the rapid recent retreat of Arctic sea ice, a number of studies have discussed the possibility of a critical threshold (or "tipping point") beyond which the ice-albedo feedback causes the ice cover to melt away in an irreversible process. The focus has typically been centered on the annual minimum (Septemb...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eisenman I,Wettlaufer JS

更新日期：2009-01-06 00:00:00

abstract：:The degradation of the plant cell wall by glycoside hydrolases is central to environmentally sustainable industries. The major polysaccharides of the plant cell wall are cellulose and xylan, a highly decorated β-1,4-xylopyranose polymer. Glycoside hydrolases displaying multiple catalytic functions may simplify the enz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McKee LS,Peña MJ,Rogowski A,Jackson A,Lewis RJ,York WS,Krogh KB,Viksø-Nielsen A,Skjøt M,Gilbert HJ,Marles-Wright J

更新日期：2012-04-24 00:00:00

abstract：:Understanding the genetic networks that operate inside cells will require the dissection of interactions among network members. Here we describe a peptide aptamer isolated from a combinatorial library that distinguishes among such interactions. This aptamer binds to cyclin-dependent kinase 2 (Cdk2) and inhibits its ki...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cohen BA,Colas P,Brent R

更新日期：1998-11-24 00:00:00

abstract：:Translocations involving c-myc and an Ig locus have been reported rarely in human multiple myeloma (MM). Using specific fluorescence in situ hybridization probes, we show complex karyotypic abnormalities of the c-myc or L-myc locus in 19 of 20 MM cell lines and approximately 50% of advanced primary MM tumors. These ab...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shou Y,Martelli ML,Gabrea A,Qi Y,Brents LA,Roschke A,Dewald G,Kirsch IR,Bergsagel PL,Kuehl WM

更新日期：2000-01-04 00:00:00

abstract：:Expression of glucokinase in hepatocytes and pancreatic 6-cells is of major physiologic importance to mammalian glucose homeostasis. Liver glucokinase catalyzes the first committed step in the disposal of glucose, and beta-cell glucokinase catalyzes a rate-limiting step required for glucose-regulated insulin release. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heimberg H,De Vos A,Moens K,Quartier E,Bouwens L,Pipeleers D,Van Schaftingen E,Madsen O,Schuit F

更新日期：1996-07-09 00:00:00

abstract：:Alcohol exposure during development can cause brain malformations and neurobehavioral abnormalities. In view of the teratogenicity of ethanol, identification of molecules that could counteract the neurotoxic effects of alcohol deserves high priority. Here, we report that pituitary adenylate cyclase-activating polypept...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vaudry D,Rousselle C,Basille M,Falluel-Morel A,Pamantung TF,Fontaine M,Fournier A,Vaudry H,Gonzalez BJ

更新日期：2002-04-30 00:00:00

abstract：:A general repressor extensively studied in vitro is the human Dr1/DRAP1 heterodimeric complex. To elucidate the function of Dr1 and DRAP1 in vivo, the yeast Saccharomyces cerevisiae Dr1/DRAP1 repressor complex was identified. The repressor complex is encoded by two essential genes, designated YDR1 and BUR6. The inviab...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim S,Na JG,Hampsey M,Reinberg D

更新日期：1997-02-04 00:00:00