Placental transfer of radiopharmaceuticals and dosimetry in pregnancy.

Abstract:

:The calculation of radiation dose estimates to the fetus is often important in nuclear medicine. To obtain the best estimates of radiation dose to the fetus, the best biological and physical models should be employed. In this paper the most recent data available on the placental crossover of many radiopharmaceuticals are presented. This information was used with standard kinetic models describing the maternal distribution and retention and with the best available physical models to obtain fetal dose estimates for these radiopharmaceuticals at all stages of pregnancy (presented in a separate paper). The literature yielded information on placental crossover of 15 radiopharmaceuticals, from animal or human data. From these data, radiation dose estimates were developed in early pregnancy and at 3, 6, and 9 mo gestation for these radiopharmaceuticals, as well as for many others used in nuclear medicine (the latter considering only maternal organ contributions to fetal dose).

journal_name

Health Phys

journal_title

Health physics

authors

Russell JR,Stabin MG,Sparks RB

doi

10.1097/00004032-199711000-00002

subject

Has Abstract

pub_date

1997-11-01 00:00:00

pages

747-55

issue

5

eissn

0017-9078

issn

1538-5159

journal_volume

73

pub_type

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