Abstract:
:Split and total renal function are commonly assessed from time-activity curves obtained from gamma camera renography with 99Tcm-diethylenetriamine pentaacetate (99Tcm-DTPA) and 99Tcm-mercaptoacetyl-triglycine (99Tcm-MAG3). The impact of the statistical noise associated with these curves on the total precision in split and total renal function impairment was studied at different levels of administered activity by simulation. The simulation consisted of generated time-activity curves, with statistical noise corresponding to the administration of 10-400 MBq 99Tcm-DTPA or 7.5-150 MBq 99Tcm-MAG3. Our results indicate that the error induced by statistical noise in split renal function calculations is generally very low (< 3% at 100 MBq 99Tcm-DTPA or 75 MBq 99Tcm-MAG3) and only affects precision slightly in calculations at 45-50 MBq 99Tcm or more. Similar results were obtained for precision in GFR calculations, where the total error increased from 12.3% at 100 MBq 99Tcm-DTPA to 12.8% at 50 MBq, but decreased to 12.0% at 400 MBq. Consequently, statistical noise has a minor effect on the precision in split and total renal function calculations at commonly used activity levels when it is reduced to approximately 50 MBq.
journal_name
Nucl Med Communjournal_title
Nuclear medicine communicationsauthors
Moonen M,Jacobsson Ldoi
10.1097/00006231-199704000-00174subject
Has Abstractpub_date
1997-04-01 00:00:00pages
346-51issue
4eissn
0143-3636issn
1473-5628journal_volume
18pub_type
杂志文章abstract:PURPOSE:This study aimed to evaluate the efficacy of automatic exposure control (AEC) in order to optimize low-dose computed tomography (CT) protocols for patients of different ages undergoing cardiac PET/CT and single-photon emission computed tomography/computed tomography (SPECT/CT). METHODS:One PET/CT and one SPECT...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000679
更新日期:2017-06-01 00:00:00
abstract::A method is described for studying protein kinetics in pleural effusions in humans. In 15 patients with pleural effusions from a variety of causes, protein inflow was monitored by measuring the rate of appearance in the effusion of the plasma protein transferrin, radiolabelled in vivo by intravenous injection of 113In...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199206000-00043
更新日期:1992-06-01 00:00:00
abstract:PURPOSES:This study aims to explore the prognostic value of left ventricular mechanical dyssynchrony (LVMD) in hypertrophic cardiomyopathy (HCM) patients with low risk of sudden cardiac death (SCD). METHODS:This retrospective study was performed in 50 patients with HCM who underwent Tc-99m sestamibi GSPECT-MPI. All pa...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000001322
更新日期:2021-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:It is known that fluorine-18 fluorodeoxyglucose PET/computed tomography (CT) segmentation algorithms have an impact on the metabolic tumor volume (MTV). This leads to some uncertainties in PET/CT guidance of tumor radiotherapy. The aim of this study was to investigate the effect of segmentation a...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000641
更新日期:2017-03-01 00:00:00
abstract::The ICRP has now recommended that the dose limit to the surface of the mother's abdomen during the declared term of pregnancy is reduced to 2 mSv. Direct measurements of the radiation dose to technologists carrying out a variety of imaging studies were made. The average dose ranged from 0.3 micro Sv for a liver scan t...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199211000-00004
更新日期:1992-11-01 00:00:00
abstract::A comparative study of bone marrow scintigraphy using 99Tcm-nanocolloid, conventional bone scintigraphy and bone marrow biopsy were performed in 35 patients with histologically proven small cell carcinoma of the lung to determine whether bone marrow scintigraphy has a role in the early detection of bone marrow metasta...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199401000-00006
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND AND AIM:To evaluate the diagnostic value of integrated 18F-fluorodeoxyglucose (FDG) positron emission tomography and computed tomography (PET/CT) to discriminate malignant from benign ovarian tumors. METHODS:One hundred and eight women suspected of having ovarian cancer underwent preoperative FDG-PET/CT sca...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e328345b339
更新日期:2011-07-01 00:00:00
abstract::We performed in vitro aggregation and indium-111 labeled platelet kinetic and biodistribution studies in seven patients with diabetes mellitus and in five control subjects. All subjects were male. All diabetic patients were poorly controlled at the time of study with blood glucose greater than 140 mg % and hemoglobin ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198803000-00006
更新日期:1988-03-01 00:00:00
abstract::Renal artery stenosis is an important and potentially curable cause of hypertension. Captopril renography is now recognized to have a high sensitivity and specificity in its diagnosis. Ultimately, however, the result is of little benefit if it does not lead to a change in patient management. To assess how patient mana...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199707000-00006
更新日期:1997-07-01 00:00:00
abstract::At present, it is difficult to distinguish between bacterial infections and sterile inflammatory processes using radiopharmaceuticals. This is so for a variety of reasons, including binding to bacteria with low affinity (e.g. infection) and binding to a specific micro-organism (e.g. radiolabelled monoclonal antibodies...
journal_title:Nuclear medicine communications
pub_type: 杂志文章,评审
doi:10.1097/00006231-199812000-00002
更新日期:1998-12-01 00:00:00
abstract::The blood flow in renal transplants can be represented by (1) a K/A ratio, the ratio of the slopes of the ascending part of the renal perfusion curve and the arterial curve, (2) a perfusion index, the ratio of a part of the area under the first-pass arterial curve and renal curve, and (3) a height ratio, the ratio of ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199011000-00006
更新日期:1990-11-01 00:00:00
abstract::Thirty patients with aortic valve incompetence and 21 control subjects were examined by M-mode echocardiography at rest and radionuclide ventriculography during submaximal handgrip exercise. The patients had greater left ventricular dimensions and end-systolic wall stress values but peak systolic wall stress values di...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199004000-00004
更新日期:1990-04-01 00:00:00
abstract:OBJECTIVE:To verify the negative predictive value of pulmonary ventilation/perfusion scintigraphy with single photon emission computed tomography (V/Q SPECT) in ruling out pulmonary thromboembolism. METHODS:V/Q SPECT using 99mTc-Technegas was performed on 584 patients to rule out pulmonary thromboembolism between Octo...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/MNM.0b013e32827a8e99
更新日期:2007-08-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to evaluate the uptake of (99m)Tc-NC100668 into blood clots and elucidate the potential for medications commonly used to treat thromboembolism to interfere with the uptake and retention of (99m)Tc-NC100668. METHODS:(99m)Tc-NC100668 in vivo uptake and retention in a range of blo...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/01.mnm.0000243378.34131.01
更新日期:2007-01-01 00:00:00
abstract:PURPOSE:Stunning of thyroid remnants after diagnostic scanning (Dx-WBS) using radioactive iodine- (¹³¹I) may limit the efficacy of I therapy. We aimed to evaluate this assumption in a prospectively designed study. METHODS:Forty patients who underwent thyroidectomy for differentiated thyroid carcinoma were studied and ...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/MNM.0b013e328362ad63
更新日期:2013-08-01 00:00:00
abstract:AIM:The objective of this study was to assess the relevance of physiological (68)Ga-DOTATATE PET/CT findings in the pancreas guided by morphological imaging (MI) in comparison with pathological tumour uptake in patients with neuroendocrine tumours (NETs). METHODS:A total of 138 patients with pancreatic NET (pNET; n=38...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000106
更新日期:2014-06-01 00:00:00
abstract:PURPOSE:The purpose of this study was to compare the use of fluorine-18-fluorodeoxyglucose (F-FDG) PET with computed tomography (CT) and dynamic contrast-enhanced (DCE) MRI to predict prognosis and monitor treatment in malignant pleural mesothelioma. PATIENTS AND METHODS:F-FDG PET/CT and DCE-MRI studies carried out as...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/MNM.0000000000000789
更新日期:2018-02-01 00:00:00
abstract::The ability of 99Tcm-methoxyisobutylisonitrile (MIBI) single photon emission tomography (SPET) to detect myocardial ischaemia and necrosis was assessed in 56 patients (45 male, 11 female, aged 55 +/- 5 years), with clinically recognized ischaemic heart disease (IHD). All underwent coronary angiography (CA) and left ve...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199212000-00004
更新日期:1992-12-01 00:00:00
abstract::The investigation of left ventricular contractile reserve usually requires the determination of left ventricular volume, but its measurement with radionuclide angiography is difficult. The aim of this study was to determine left ventricular volume directly during exercise by the simultaneous measurement of peak exerci...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199612000-00007
更新日期:1996-12-01 00:00:00
abstract:OBJECTIVE:To prepare the rhenium-188 (188Re)-arginine-glycine-aspartic acid (RGD) peptide in a convenient manner and to evaluate its potential as an agent for alphavbeta3 integrin receptor-positive tumors. METHODS:Radiolabeled RGD was obtained by conjugating the His group at the end of peptide with fac-[188Re(H2O)3(CO...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e3283334e48
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVES AND METHODS:The recommended method for the measurement of radiochemical purity (RCP) of ¹¹¹In-labelled pentetreotide is thin-layer chromatography with a silica gel as the stationary phase and a 0.1 N sodium citrate solution (pH 5) as the mobile phase. According to the supplier's instructions, the mobile phas...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e32834a7003
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to evaluate the incremental value of technetium-99m-methylene diphosphonate (99mTc-MDP) single-photon emission tomography/computed tomography (SPECT/CT) over planar bone scintigraphy (BS) and SPECT in the diagnosis of avascular necrosis (AVN) of the femoral head. MATERIALS AND METHOD...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000357
更新日期:2015-10-01 00:00:00
abstract::The effect of the dual window scatter subtraction method was tested for first-pass radiocardiography using 99Tcm. The photopeak window of 126-154 keV (20%) and Compton window of 93-125 keV (30%) were used. The set of scattered images was multiplied by a factor of 0.4 and subtracted from the primary images. The size of...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199611000-00009
更新日期:1996-11-01 00:00:00
abstract:PURPOSE:Patient-specific dosimetry of lutetium-177 ((177)Lu)-DOTATATE treatment in neuroendocrine tumours is important, because uptake differs across patients. Single photon emission computer tomography (SPECT)-based dosimetry requires a conversion factor between the obtained counts and the activity, which depends on t...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000079
更新日期:2014-05-01 00:00:00
abstract::In order to evaluate the utility of positron emission tomography (PET) with 18F-labelled deoxyglucose (FDG) for detection of pancreatic cancer 15 patients with pancreatic masses shown by computed tomography were investigated. Static PET scans covering an axial field of view of 15 cm were obtained 45 min after intraven...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199307000-00013
更新日期:1993-07-01 00:00:00
abstract::In ten patients with malignant gliomas the regional cerebral metabolic rate for glucose (rCMRGlc) was studied with positron emission tomography (PET) using 2-18F-deoxyglucose (18FDG) before and within 1 to 7 days after intra-arterial chemotherapy with the nitrosourea derivative ACNU (iaACNU). Three patients were studi...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198911000-00002
更新日期:1989-11-01 00:00:00
abstract:PURPOSE:Sickle cell disease (SCD) is a common hematologic hereditary disorder characterized by vaso-occlusive episodes affecting multiple organs, and substantially alters renal structure and function. We aimed to evaluate the utility of renal scintigraphy and single photon emission computed tomography/computed tomograp...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/MNM.0000000000001086
更新日期:2019-11-01 00:00:00
abstract::In an effort to develop new, clinically useful 99Tcm-diaminodithiol (99Tcm-DADT) complexes for the evaluation of regional cerebral perfusion, basic diaminodithiols (DADT-TM, DADT-HM and DADT-MHM) and three diaminodithiol ligands functionalized with p-iodophenethyl (DADT-IPE), N-ethyl-p-fluorophenethyl amine (DADT-EFPE...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199112000-00007
更新日期:1991-12-01 00:00:00
abstract::Scintigraphically, Warthin's tumour usually demonstrates increased tracer uptake compared to normal adjacent salivary tissue. A case is presented in which tumour uptake is no greater than the normal adjacent gland. Gustatory stimulation results in failure of tumour tracer washout, and this finding rather than 'hot' sa...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198806000-00007
更新日期:1988-06-01 00:00:00
abstract::Increasingly, dual-detector gamma cameras are being purchased as replacements for single-headed cameras. The improvement in sensitivity offered by a dual-detector device can be used in several ways: to shorten acquisition times, to improve signal-to-noise ratios, or to reduce administered doses. This paper focuses on ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章,评审
doi:10.1097/00006231-199507000-00003
更新日期:1995-07-01 00:00:00