Intestinal absorption of strontium chloride in healthy volunteers: pharmacokinetics and reproducibility.

abstract：:WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT Reflux oesophagitis is a common clinical disorder associated with significant morbidity. Proton pump inhibitors are the current pharmacotherapy of choice, but not all treated patients achieve symptom relief. Little is known about the efficacy of mosapride, a prokinetic agent wh...

journal_title：British journal of clinical pharmacology

authors： Hsu YC,Yang TH,Hsu WL,Wu HT,Cheng YC,Chiang MF,Wang CS,Lin HJ

更新日期：2010-08-01 00:00:00

abstract：AIM:The aim of the study was to simplify the dosing regimen of peginterferon alfa-2a in paediatric patients with chronic hepatitis C. METHODS:A population pharmacokinetic (PK) model was developed using PK data from 14 children aged 2-8 years and 402 adults. Simulations were produced to identify a simplified dosing reg...

journal_title：British journal of clinical pharmacology

authors： Brennan BJ,Lemenuel-Diot A,Snoeck E,McKenna M,Solsky J,Wat C,Mallalieu NL

更新日期：2016-04-01 00:00:00

abstract：AIMS:To measure the prevalence of beta-blocker eye drop prescribing and respiratory effect of ocular beta-blocker administration in people with asthma. METHODS:We measured the prevalence of ocular beta-blocker prescribing in people with asthma and ocular hypertension, and performed a nested case-control study (NCCS) m...

journal_title：British journal of clinical pharmacology

authors： Morales DR,Dreischulte T,Lipworth BJ,Donnan PT,Jackson C,Guthrie B

更新日期：2016-09-01 00:00:00

abstract：:1 The new converting enzyme inhibitor RHC 3659 was tested in 15 male volunteers. The study consisted of two parts: first, the ability of a single oral dose (5, 10, 20, 40 or 80 mg) to inhibit the pressor response to exogenous angiotensin I was tested with blood pressure and heart rate monitored continuously through an...

journal_title：British journal of clinical pharmacology

authors： Burnier M,Turini GA,Brunner HR,Porchet M,Kruithof D,Vukovich RA,Gavras H

更新日期：1981-12-01 00:00:00

abstract：AIMS:Drug disposition in children may vary from adults due to age-related variation in drug metabolism. Microdose studies present an innovation to study pharmacokinetics (PK) in paediatrics; however, they should be used only when the PK is dose linear. We aimed to assess dose linearity of a [14 C]midazolam microdose, b...

journal_title：British journal of clinical pharmacology

authors： van Groen BD,Vaes WH,Park BK,Krekels EHJ,van Duijn E,Kõrgvee LT,Maruszak W,Grynkiewicz G,Garner RC,Knibbe CAJ,Tibboel D,de Wildt SN,Turner MA

更新日期：2019-10-01 00:00:00

abstract：AIM:The combination of ephedrine and caffeine has been used in herbal products for weight loss and athletic performance-enhancement, but the pharmacokinetic profiles of these compounds have not been well characterized. This study aimed to develop a mechanistic model describing ephedrine, norephedrine, and caffeine phar...

journal_title：British journal of clinical pharmacology

authors： Csajka C,Haller CA,Benowitz NL,Verotta D

更新日期：2005-03-01 00:00:00

abstract：:1. We investigated the effect of the haemostatic agent ethamsylate on aspirin-induced gastric mucosal bleeding. 2. Eighteen healthy subjects were studied three times: at the end of 48 h periods of treatment with (a) placebo, (b) aspirin 600 mg four times daily, (9 doses) and (c) aspirin 600 mg four times daily with ea...

journal_title：British journal of clinical pharmacology

authors： Daneshmend TK,Stein AG,Bhaskar NK,Hawkey CJ

更新日期：1989-07-01 00:00:00

abstract：:1. This study further examines the quinoline-derivative abanoquil with particular respect to the duration of its alpha 1-adrenoceptor antagonist activity and its concentration-effect relationship following a single intravenous bolus dose of 0.5 micrograms kg-1 in young, normotensive males. 2. alpha 1-adrenoceptor anta...

journal_title：British journal of clinical pharmacology

authors： Schafers RF,Elliott HL,Meredith PA,Miller SH,Reid JL

更新日期：1991-11-01 00:00:00

abstract：AIMS:The aim of this analysis was to develop a population pharmacokinetic model for Emfilermin (recombinant human leukaemia inhibitory factor, r-hLIF) following subcutaneous administration to healthy postmenopausal women and to infertile patients undergoing in vitro fertilization and embryo transfer (IVF-ET). METHODS:...

journal_title：British journal of clinical pharmacology

authors： Goggin T,Nguyen QT,Munafo A

更新日期：2004-05-01 00:00:00

abstract：:1. We compare the sensitivity and specificity of chosen outcome criteria in a placebo-controlled, randomised cross-over study of the efficacy of maintenance therapy with the levodopa/carbidopa combination (Sinemet Plus) alone. Patients were characterised by having idiopathic Parkinsonism with no overt fluctuations in ...

journal_title：British journal of clinical pharmacology

authors： Bowes SG,Clark PK,Charlett A,O'Neill CJ,Leeman AL,Weller C,Nicholson PW,Deshmukh AA,Dobbs SM,Dobbs RJ

更新日期：1991-03-01 00:00:00

abstract：:Responses of human bronchial strip preparations to contractile and relaxant agonists were measured in preparations from non-diseased and from asthmatic lung obtained 3-15 h post-mortem. The potencies of carbachol and histamine were approximately two times less in asthmatic than in non-diseased bronchi. This was statis...

journal_title：British journal of clinical pharmacology

authors： Goldie RG,Spina D,Henry PJ,Lulich KM,Paterson JW

更新日期：1986-12-01 00:00:00

abstract：:1. Blood and urine concentrations of the macrolide immunosuppressant FK506 and its metabolites were measured in seven orthotopic liver transplant patients after the first oral dose of FK506 (0.04 +/- 0.02 mg kg-1) used as primary immunosuppressant. A specific h.p.l.c.-MS assay was used, allowing the measurement of par...

journal_title：British journal of clinical pharmacology

authors： Gonschior AK,Christians U,Braun F,Winkler M,Linck A,Baumann J,Sewing KF

更新日期：1994-12-01 00:00:00

abstract：AIMS:Pravastatin is a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, which is widely used both in primary and secondary prevention of coronary heart disease (CHD). Pravastatin is not subject to metabolism by cytochrome P450s, but it is actively transported from blood into target tissues (e.g. hepa...

journal_title：British journal of clinical pharmacology

authors： Zhang W,Chen BL,Ozdemir V,He YJ,Zhou G,Peng DD,Deng S,Xie QY,Xie W,Xu LY,Wang LC,Fan L,Wang A,Zhou HH

更新日期：2007-09-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:Structured medication interviews improve the medication history upon hospitalization. Pharmacy records are valid lists of the prescribed medications available to individual patients. In Denmark, treating doctors now have access to their patients' pharmacy records through a real-...

journal_title：British journal of clinical pharmacology

authors： Glintborg B,Poulsen HE,Dalhoff KP

更新日期：2008-02-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:* Exposure to bosentan was lower in paediatric pulmonary arterial hypertension (PAH) patients treated with the marketed adult formulation at a dose of about 2 mg kg(-1) when compared with adult PAH patients. * In healthy adult subjects, bosentan pharmacokinetics are less than do...

journal_title：British journal of clinical pharmacology

authors： Beghetti M,Haworth SG,Bonnet D,Barst RJ,Acar P,Fraisse A,Ivy DD,Jais X,Schulze-Neick I,Galiè N,Morganti A,Dingemanse J,Kusic-Pajic A,Berger RM

更新日期：2009-12-01 00:00:00

abstract：:1 Mianserin does not affect the uptake of biogenic amines into rat brain, in contrast to tricyclic antidepressants which block amine uptake. 2 Mianserin increases the turnover of noradrenaline (NA) in rat brain after acute or chronic administration, whereas tricyclic antidepressants reduce turnover of NA and 5-hydroxy...

journal_title：British journal of clinical pharmacology

authors： Leonard BE

更新日期：1978-01-01 00:00:00

abstract：:1. The effects of sodium octanoate and sodium salicylate on the rectal absorption of cefoxitin were investigated in healthy volunteers. Drug solutions were given either as a bolus or as a zero-order infusion. 2. On rectal infusion sodium octanoate and sodium salicylate both enhanced mean cefoxitin bioavailability (+/-...

journal_title：British journal of clinical pharmacology

authors： Van Hoogdalem EJ,Wackwitz AT,De Boer AG,Cohen AF,Breimer DD

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:Benzodiazepines and "Z drugs" are often prescribed in residents of nursing homes (NH) despite their well-known deleterious effects. We aimed to investigate if a general intervention on quality of care led to discontinuation of benzodiazepine, and to examine which NH-related factors were associated in change ...

journal_title：British journal of clinical pharmacology

authors： de Souto Barreto P,Lapeyre-Mestre M,Cestac P,Vellas B,Rolland Y

更新日期：2016-04-01 00:00:00

abstract：:A possible route of metabolism of beta-adrenoceptor stimulating drugs used in obstetrics consists of conjugation by the enzyme phenol sulphotransferase. The substrate specificities of the platelet and the placental enzymes towards these drugs were tested. The specific activities of the beta-adrenoceptor agonists were ...

journal_title：British journal of clinical pharmacology

authors： Sodha RJ,Schneider H

更新日期：1984-01-01 00:00:00

abstract：:1. A rapid intravenous bolus injection of 4.0 g Magnapen (which contains 2.0 g of ampicillin and 2.0 g of flucloxacillin) was to seven patients undergoing total hip replacement immediatly before induction of general anesthesia. Postoperatively the patients patients received 2.0 g Magnapen by intramuscular injection ev...

journal_title：British journal of clinical pharmacology

authors： Parsons RL,Beavis JP,Laurence M,David JA,Paddock GM,Trounce JR

更新日期：1978-08-01 00:00:00

abstract：AIMS:To compare the disposition of fluoxetine and norfluoxetine enantiomers in the mother, foetus and infant. METHODS:Blood from pregnant women taking fluoxetine (n = 9), during pregnancy was sampled in the third trimester and at delivery (maternal and cord venous blood), and from the infants 48 h after delivery. The ...

journal_title：British journal of clinical pharmacology

authors： Kim J,Riggs KW,Misri S,Kent N,Oberlander TF,Grunau RE,Fitzgerald C,Rurak DW

更新日期：2006-02-01 00:00:00

abstract：:The metabolism of morphine was studied in seven fullterm neonates and five infants receiving a continuous infusion of morphine. All the patients had detectable plasma concentrations of morphine 3-glucuronide (M3G) and 10 had detectable concentrations of morphine 6-glucuronide (M6G). The mean plasma clearance of morphi...

journal_title：British journal of clinical pharmacology

authors： Choonara I,Lawrence A,Michalkiewicz A,Bowhay A,Ratcliffe J

更新日期：1992-11-01 00:00:00

abstract：:Nine young and 12 elderly healthy volunteers received nisoldipine 10 mg once a day for 7 days. Plasma nisoldipine concentrations were measured on Day 1 and on Day 7. Higher plasma drug concentrations were observed in the elderly group than in the young group with the values for AUC being approximately doubled in the e...

journal_title：British journal of clinical pharmacology

authors： Baksi AK,Edwards JS,Ahr G

更新日期：1991-03-01 00:00:00

abstract：AIMS:There are insufficient direct comparative studies addressing the impact of the type of statin on their respective efficacy in heart failure (HF). The aim of the current study was to compare the effects of lipophilic (atorvastatin) vs hydrophilic (rosuvastatin) on left ventricular function, inflammatory and fibrosi...

journal_title：British journal of clinical pharmacology

authors： El Said NO,El Wakeel LM,Khorshid H,Darweesh EAG,Ahmed MA

更新日期：2020-12-08 00:00:00

abstract：:Osteoporosis is a skeletal disease characterized by a decrease in bone mass and bone quality that predispose an individual to an increased risk of fragility fractures. Evidence demonstrating a positive link between certain dietary patterns (e.g. Mediterranean diet or high consumption of fruits and vegetables) and bone...

journal_title：British journal of clinical pharmacology

authors： Sacco SM,Horcajada MN,Offord E

更新日期：2013-03-01 00:00:00

abstract：AIMS:To determine the paediatric licensing status in the USA, UK, Australia and New Zealand of the 79 medicines granted paediatric exclusivity in the USA, and to assess the importance of those medicines to paediatric practice. METHODS:The medicines granted a patent extension in the USA as of 10 November 2003 were iden...

journal_title：British journal of clinical pharmacology

authors： Grieve J,Tordoff J,Reith D,Norris P

更新日期：2005-06-01 00:00:00

abstract：AIM:To review the literature on adverse drug reactions (ADRs) in children with respect to occurrence, seriousness, type, therapeutic group, age and gender of the child and category of reporter. METHODS:Medline and Embase databases were searched from origin and updated until February 2010. We included empirically based...

journal_title：British journal of clinical pharmacology

authors： Aagaard L,Christensen A,Hansen EH

更新日期：2010-10-01 00:00:00

abstract：AIM:Drug-induced liver injury (DILI) is often responsible for acute liver failure, drug withdrawal, boxed warnings or drug non-approval. Therefore, we conducted a case-control study to determine the hepatotoxic risk of a wide range of drugs. METHODS:The Berlin Case-Control Surveillance Study FAKOS included all 51 Berl...

journal_title：British journal of clinical pharmacology

authors： Douros A,Bronder E,Andersohn F,Klimpel A,Thomae M,Sarganas G,Kreutz R,Garbe E

更新日期：2015-06-01 00:00:00

abstract：AIMS:Mexiletine has been reported to be hydroxylated by cytochrome P450 2D6 (CYP2D6) in humans. However, the involvement of CYP1A2 in the metabolism of mexiletine has been proposed based on the interaction with theophylline which is mainly metabolized by CYP1A2. The aim of this study was to clarify the role of human CY...

journal_title：British journal of clinical pharmacology

authors： Nakajima M,Kobayashi K,Shimada N,Tokudome S,Yamamoto T,Kuroiwa Y

更新日期：1998-07-01 00:00:00

abstract：AIMS:Paraquat poisoning is a medical problem in many parts of Asia and the Pacific. The mortality rate is extremely high as there is no effective treatment. We analyzed data collected during an ongoing cohort study on self-poisoning and from a randomized controlled trial assessing the efficacy of immunosuppressive ther...

journal_title：British journal of clinical pharmacology

authors： Wunnapuk K,Mohammed F,Gawarammana I,Liu X,Verbeeck RK,Buckley NA,Roberts MS,Musuamba FT

更新日期：2014-10-01 00:00:00