The genetic basis of murine and human sex determination: a review.

Abstract:

:Determination of mammalian sex depends on the presence or absence of a functional testis. Testes are determined by the activity of the testis determining factor encoded by the sex determining gene, Y (SRY) located on the Y chromosome. Considerable evidence suggests that the SRY gene is the only gene on the Y chromosome that is both necessary and sufficient to initiate testis determination. Other steps in the mammalian sex determining pathway are unknown, although recent advances have shown that mutations in X chromosome and autosomal loci are also associated with sex reversal, suggesting the presence of at least one other sex determining gene. Duplications of sequences on the short arm of the human X chromosome, including the DAX-1 (DSS-AHC critical region on the X chromosome, gene 1) gene, are occasionally associated with XY male-to-female sex reversal. In addition, mutations in the SRY-related gene SOX9 (SRY-related box) are associated with a failure of human testicular determination. Furthermore, the occurrence of inherited sex reversed conditions in both mice and men indicate the presence of at least one other sex determining gene. Breeding the Y chromosome from certain Mus musculus domesticus strains into the laboratory mouse strain C57BL/6J results in XY male-to-female sex reversal. This suggests both allelic variation of the Sry gene and the presence of autosomal sex determining genes. In humans, familial cases of SRY-negative XX males occur. Analysis of the transmission of the trait indicates the segregation of an autosomal or X-linked recessive mutation. The mutation may be in a gene whose wild-type function is to inhibit male sex determination. SRY may trigger male sex determination by repressing or functionally antagonizing the product of this gene.

journal_name

Heredity (Edinb)

journal_title

Heredity

authors

McElreavey K,Barbaux S,Ion A,Fellous M

doi

10.1038/hdy.1995.179

subject

Has Abstract

pub_date

1995-12-01 00:00:00

pages

599-611

eissn

0018-067X

issn

1365-2540

journal_volume

75 ( Pt 6)

pub_type

杂志文章,评审

相关文献

HEREDITY文献大全
  • Quantitative trait loci for upper thermal tolerance in outbred strains of rainbow trout (Oncorhynchus mykiss).

    abstract::The expression of three putative QTL for upper thermal tolerance (UTT) was examined in two strains of outbred rainbow trout unselected for this trait using simple-sequence repeat (SSR; microsatellite) markers associated with UTT in backcrosses of lines selected on this trait. Two-way diallel lots in the third generati...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1046/j.1365-2540.2001.00838.x

    authors: Perry GM,Danzmann RG,Ferguson MM,Gibson JP

    更新日期:2001-03-01 00:00:00

  • The role of ecophysiological models in QTL analysis: the example of specific leaf area in barley

    abstract::Crop modelling has so far contributed little to the genetic analysis of a quantitative trait. This study illustrates how a simple model for crop phenological development, which assumes that crop development rate is affected by daily effective temperature, can assist the identification of Quantitative Trait Loci (QTLs)...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/sj.hdy.6885030

    authors: Yin X,Kropff MJ,Stam P

    更新日期:1999-04-01 00:00:00

  • Molecular population divergence and sexual selection on morphology in the banded demoiselle (Calopteryx splendens).

    abstract::The importance of sexual selection in population divergence is of much interest, mainly because it is thought to cause reproductive isolation and hence could lead to speciation. Sexually selected traits have been hypothesized to diverge faster between populations than other traits, presumably because of differences in...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/sj.hdy.6800519

    authors: Svensson EI,Kristoffersen L,Oskarsson K,Bensch S

    更新日期:2004-11-01 00:00:00

  • Environmental influence on the genetic correlations between life-history traits in Caenorhabditis elegans.

    abstract::Empirical evidence is mounting to suggesting that genetic correlations between life-history traits are environment specific. However, detailed knowledge about the loci underlying genetic correlations in different environments is scant. Here, we studied the influence of temperature (12 degrees C and 24 degrees C) on th...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/sj.hdy.6800929

    authors: Gutteling EW,Doroszuk A,Riksen JA,Prokop Z,Reszka J,Kammenga JE

    更新日期:2007-04-01 00:00:00

  • Candidate genes associated with color morphs of female-limited polymorphisms of the damselfly Ischnura senegalensis.

    abstract::Many Odonata species exhibit female-limited polymorphisms, where one morph is similar to the conspecific male in body color and other traits (andromorph), whereas one or more other morphs differ from the male (gynomorphs). Here we investigated the differentially expressed transcripts (DETs) among males and two female ...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/s41437-018-0076-z

    authors: Takahashi M,Takahashi Y,Kawata M

    更新日期:2019-01-01 00:00:00

  • Loss of Wolbachia infection during colonisation in the invasive Argentine ant Linepithema humile.

    abstract::WOLBACHIA are maternally inherited bacteria, which are very common in arthropods and nematodes. Wolbachia infection may affect host reproduction through feminisation, parthenogenesis, male-killing, cytoplasmic incompatibility and increased fecundity. Previous studies showing discrepancies between the phylogenies of Wo...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/sj.hdy.6800601

    authors: Reuter M,Pedersen JS,Keller L

    更新日期:2005-03-01 00:00:00

  • Correlational selection and the evolution of genomic architecture.

    abstract::We review and discuss the importance of correlational selection (selection for optimal character combinations) in natural populations. If two or more traits subject to multivariate selection are heritable, correlational selection builds favourable genetic correlations through the formation of linkage disequilibrium at...

    journal_title:Heredity

    pub_type: 杂志文章,评审

    doi:10.1038/sj.hdy.6800148

    authors: Sinervo B,Svensson E

    更新日期:2002-11-01 00:00:00

  • Mapping and recombination analysis of two moth colour mutations, Black moth and Wild wing spot, in the silkworm Bombyx mori.

    abstract::Many lepidopteran insects exhibit body colour variations, where the high phenotypic diversity observed in the wings and bodies of adults provides opportunities for studying adaptive morphological evolution. In the silkworm Bombyx mori, two genes responsible for moth colour mutation, Bm and Ws, have been mapped to 0.0 ...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/hdy.2015.69

    authors: Ito K,Katsuma S,Kuwazaki S,Jouraku A,Fujimoto T,Sahara K,Yasukochi Y,Yamamoto K,Tabunoki H,Yokoyama T,Kadono-Okuda K,Shimada T

    更新日期:2016-01-01 00:00:00

  • Genome-wide prediction models that incorporate de novo GWAS are a powerful new tool for tropical rice improvement.

    abstract::To address the multiple challenges to food security posed by global climate change, population growth and rising incomes, plant breeders are developing new crop varieties that can enhance both agricultural productivity and environmental sustainability. Current breeding practices, however, are unable to keep pace with ...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/hdy.2015.113

    authors: Spindel JE,Begum H,Akdemir D,Collard B,Redoña E,Jannink JL,McCouch S

    更新日期:2016-04-01 00:00:00

  • Evolution of herbicide resistance in weeds: initial frequency of target site-based resistance to acetolactate synthase-inhibiting herbicides in Lolium rigidum.

    abstract::The frequency of individuals resistant to two acetolactate synthase (ALS)-inhibiting herbicides in three previously untreated populations of Lolium rigidum was determined. The frequency of individuals resistant to the sulfonylurea herbicide sulfometuron-methyl varied from 2.2 x 10(-5) to 1.2 x 10(-4) and the frequency...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/sj.hdy.6800004

    authors: Preston C,Powles SB

    更新日期:2002-01-01 00:00:00

  • Impacts of forest fragmentation on the mating system and genetic diversity of white spruce (Picea glauca) at the landscape level.

    abstract::We studied the mating system of white spruce (Picea glauca) in a landscape fragmented by agriculture in northern Ontario, Canada. We sampled 23 stands that ranged in size from 1 to >500 trees isolated by 250-3000 m from the nearest other stand. Six polymorphic allozyme loci from four enzyme systems were used to genoty...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/sj.hdy.6800886

    authors: O'Connell LM,Mosseler A,Rajora OP

    更新日期:2006-12-01 00:00:00

  • Detection of rare paternal chloroplast inheritance in controlled crosses of the endangered sunflower Helianthus verticillatus.

    abstract::A variety of questions in population and evolutionary biology are studied using chloroplast DNA (cpDNA). The presumed maternal inheritance in angiosperms allows for certain assumptions and calculations to be made when studying plant hybridization, phylogeography, molecular systematics and seed dispersal. Further, the ...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/hdy.2008.11

    authors: Ellis JR,Bentley KE,McCauley DE

    更新日期:2008-06-01 00:00:00

  • Genetic differentiation of the malaria vector Anopheles gambiae across Nigeria suggests that selection limits gene flow.

    abstract::Gene flow was investigated in Anopheles gambiae from eight localities that span the ecological zones of Nigeria (arid savanna zones in the north gradually turn into humid forest zones in the south). Genetic differentiation was measured over 10 microsatellite loci and, to determine any effects of selection, five loci w...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1046/j.1365-2540.2001.00957.x

    authors: Onyabe DY,Conn JE

    更新日期:2001-12-01 00:00:00

  • pLARmEB: integration of least angle regression with empirical Bayes for multilocus genome-wide association studies.

    abstract::Multilocus genome-wide association studies (GWAS) have become the state-of-the-art procedure to identify quantitative trait nucleotides (QTNs) associated with complex traits. However, implementation of multilocus model in GWAS is still difficult. In this study, we integrated least angle regression with empirical Bayes...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/hdy.2017.8

    authors: Zhang J,Feng JY,Ni YL,Wen YJ,Niu Y,Tamba CL,Yue C,Song Q,Zhang YM

    更新日期:2017-06-01 00:00:00

  • Sex ratio theory in geographically structured populations.

    abstract::Equilibrium sex ratios have been determined analytically under Wright's island model in order to determine the effect of population structure with limited dispersal. When mating occurs before dispersal, the dispersal rate has little or no effect, and the equilibrium sex ratio remains the same as under complete dispers...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/hdy.1986.10

    authors: Bulmer MG

    更新日期:1986-02-01 00:00:00

  • Patterns of pollen and seed dispersal in a small, fragmented population of the wind-pollinated tree Araucaria angustifolia in southern Brazil.

    abstract::Paternity analysis based on eight microsatellite loci was used to investigate pollen and seed dispersal patterns of the dioecious wind-pollinated tree, Araucaria angustifolia. The study sites were a 5.4 ha isolated forest fragment and a small tree group situated 1.7 km away, located in Paranalpha State, Brazil. In the...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/sj.hdy.6801019

    authors: Bittencourt JV,Sebbenn AM

    更新日期:2007-12-01 00:00:00

  • The effects of outbreeding on a parasitoid wasp fixed for infection with a parthenogenesis-inducing Wolbachia symbiont.

    abstract::Trichogramma wasps can be rendered asexual by infection with the maternally inherited symbiont Wolbachia. Previous studies indicate the Wolbachia strains infecting Trichogramma wasps are host-specific, inferred by failed horizontal transfer of Wolbachia to novel Trichogramma hosts. Additionally, Trichogramma can becom...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/hdy.2017.53

    authors: Lindsey ARI,Stouthamer R

    更新日期:2017-12-01 00:00:00

  • Effect of inbreeding and heritability of sperm competition success in the bulb mite Rhizoglyphus robini.

    abstract::Sperm competition is a potent evolutionary force shaping the reproductive biology of most animal species. Here, we estimated the heritability of sperm competition success in the promiscuous bulb mite Rhizoglyphus robini. Sperm competition success was measured with the sterile male technique as the proportion of eggs f...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/sj.hdy.6800649

    authors: Konior M,Keller L,Radwan J

    更新日期:2005-06-01 00:00:00

  • Allele frequency estimation at loci with incomplete co-dominant expression.

    abstract::Although allelic variants at a locus usually are expressed either dominantly or co-dominantly, there are many cases when a gene is dominantly expressed in some individuals and co-dominantly in others. We present a maximum-likelihood procedure for allele frequency estimation in such situations of "incomplete" co-domina...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/hdy.1990.114

    authors: Jorde PE,Ryman N

    更新日期:1990-12-01 00:00:00

  • Patterns of pollen dispersal in a small population of Pinus sylvestris L. revealed by total-exclusion paternity analysis.

    abstract::Patterns of pollen dispersal were investigated in a small, isolated, relict population of Pinus sylvestris L., consisting of 36 trees. A total-exclusion battery comprising four chloroplast and two nuclear microsatellites (theoretical paternity exclusion probability EP=0.996) was used to assign paternity to 813 seeds, ...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/sj.hdy.6800542

    authors: Robledo-Arnuncio JJ,Gil L

    更新日期:2005-01-01 00:00:00

  • Single-locus sex determination in the parasitoid wasp Cotesia glomerata (Hymenoptera: Braconidae).

    abstract::The parasitoid Cotesia glomerata usually produces female-biased sex ratios in the field, which are presumably caused by inbreeding and local mate competition (LMC); yet, sibling mating increases the production of males, leading to the male-biased sex ratio of broods in the laboratory. Previous studies have suggested t...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/sj.hdy.6800829

    authors: Zhou Y,Gu H,Dorn S

    更新日期:2006-06-01 00:00:00

  • Rickettsia associated with male-killing in a buprestid beetle.

    abstract::Many populations of the buprestid leaf-mining beetle, Brachys tessellatus, from central South Carolina, USA, show highly skewed sex ratios, ranging from 1.3 to 6.0 females per male. We have identified a Rickettsia bacterium that is associated with sex ratio distortion (SRD) and selective killing of male embryos in B. ...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1046/j.1365-2540.2001.00848.x

    authors: Lawson ET,Mousseau TA,Klaper R,Hunter MD,Werren JH

    更新日期:2001-04-01 00:00:00

  • A missense mutation in AGTPBP1 was identified in sheep with a lower motor neuron disease.

    abstract::A type of lower motor neuron (LMN) disease inherited as autosomal recessive in Romney sheep was characterized with normal appearance at birth, but with progressive weakness and tetraparesis after the first week of life. Here, we carried out genome-wide homozygosity mapping using Illumina Ovine SNP50 BeadChips on lambs...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/hdy.2012.23

    authors: Zhao X,Onteru SK,Dittmer KE,Parton K,Blair HT,Rothschild MF,Garrick DJ

    更新日期:2012-09-01 00:00:00

  • Amount and structure of intra- and interspecific genetic variation in the moss genus Polytrichum.

    abstract::Allozyme electrophoresis was used to determine amount and structure of genetic variation within and between five congeneric haploid moss species: Polytrichum formosum, P. commune, P. uliginosum, P. piliferum and P. juniperinum. For the different species, gene diversity within populations (HS) ranged from very low (0.0...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1046/j.1365-2540.2000.00762.x

    authors: Van Der Velde M,Bijlsma R

    更新日期:2000-10-01 00:00:00

  • Inheritance of litter size at birth in farmed arctic foxes (Alopex lagopus, Canidae, Carnivora).

    abstract::Natural populations of the arctic fox (Alopex lagopus, Canidae, Carnivora) differ drastically in their reproductive strategy. Coastal foxes, which depend on stable food resources, produce litters of moderate size. Inland foxes feed on small rodents, whose populations are characterized by cycling fluctuation. In the ye...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/sj.hdy.6800908

    authors: Axenovich TI,Zorkoltseva IV,Akberdin IR,Beketov SV,Kashtanov SN,Zakharov IA,Borodin PM

    更新日期:2007-02-01 00:00:00

  • Lack of genetic differentiation among widely spaced subpopulations of a butterfly with home range behaviour.

    abstract::We examine seven geographically separate subpopulations of Heliconius charithonia, a butterfly with well-documented home range behaviour, in Miami-Dade County, Florida, for genetic differentiation using cellulose acetate electrophoresis. These subpopulations exhibit little genetic variation (percent polymorphic loci =...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1046/j.1365-2540.2001.00830.x

    authors: Kronforst MR,Fleming TH

    更新日期:2001-02-01 00:00:00

  • Population genetic structure in a Mediterranean pine (Pinus pinaster Ait.): a comparison of allozyme markers and quantitative traits.

    abstract::F-statistics were employed to analyse quantitative and allozyme variation among 19 native populations of maritime pine (Pinus pinaster Ait.). Fourteen polymorphic allozyme loci were used to provide an empirical basis for constructing a null hypothesis to test natural selection as a determinant of quantitative evolutio...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/sj.hdy.6800114

    authors: González-Martínez SC,Alía R,Gil L

    更新日期:2002-09-01 00:00:00

  • Incorporating the single-step strategy into a random regression model to enhance genomic prediction of longitudinal traits.

    abstract::In prediction of genomic values, the single-step method has been demonstrated to outperform multi-step methods. In statistical analyses of longitudinal traits, the random regression test-day model (RR-TDM) has clear advantages over other models. Our goal in this study was to evaluate the performance of a model that in...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/hdy.2016.91

    authors: Kang H,Zhou L,Mrode R,Zhang Q,Liu JF

    更新日期:2017-12-01 00:00:00

  • Power law fitness landscapes and their ability to predict fitness.

    abstract::Whether or not evolution by natural selection is predictable depends on the existence of general patterns shaping the way mutations interact with the genetic background. This interaction, also known as epistasis, has been observed during adaptation (macroscopic epistasis) and in individual mutations (microscopic epist...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/s41437-018-0143-5

    authors: Passagem-Santos D,Zacarias S,Perfeito L

    更新日期:2018-11-01 00:00:00

  • Mitochondrial DNA and chromosomal studies of wild mice (Mus) from Turkey and Iran.

    abstract::Complete D-loop sequences of 20 Mus from three localities in Turkey and seven in Iran were characterized. These countries are thought to be close to the place of origin of the subspecies Mus musculus domesticus. Five new M. m. domesticus haplotypes were added to the nine already known for the region. Four of these 14 ...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1046/j.1365-2540.2000.00694.x

    authors: Gündüz I,Tez C,Malikov V,Vaziri A,Polyakov AV,Searle JB

    更新日期:2000-04-01 00:00:00