解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Genetic architecture and phenotypic plasticity are important considerations when studying trait variation within and among populations. Since environmental change can induce shifts in the genetic architecture and plasticity of traits, it is important to consider both genetic and environmental sources of phenotypic var...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/s41437-020-0346-4
更新日期:2021-01-01 00:00:00
abstract::Habitat fragmentation is a major cause of biodiversity loss, responsible for an alteration of intraspecific patterns of neutral genetic diversity and structure. Although neutral genetic variation can be informative for demographic inferences, it may be a poor predictor of adaptive genetic diversity and thus of the con...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/s41437-020-00366-w
更新日期:2021-01-01 00:00:00
abstract::The widespread and locally massive introgression of Y chromosomes of the eastern house mouse (Mus musculus musculus) into the range of the western subspecies (M. m. domesticus) in Central Europe calls for an explanation of its underlying mechanisms. Given the paternal inheritance pattern, obvious candidates for traits...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/s41437-020-0330-z
更新日期:2020-10-01 00:00:00
abstract::Chicken growth traits are economically important, but the relevant genetic mechanisms have not yet been elucidated. Herein, we performed a genome-wide association study to identify the variants associated with growth traits. In total, 860 chickens from a Gushi-Anka F2 resource population were phenotyped for 68 growth ...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/s41437-020-00365-x
更新日期:2020-09-28 00:00:00
abstract::Advances in sequencing technologies have revolutionized wildlife conservation genetics. Analysis of genomic data sets can provide high-resolution estimates of genetic structure, genetic diversity, gene flow, and evolutionary history. These data can be used to characterize conservation units and to effectively manage t...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/s41437-020-0315-y
更新日期:2020-09-01 00:00:00
abstract::Genomic selection has become a reality in plant breeding programs with the reduction in genotyping costs. Especially in maize breeding programs, it emerges as a promising tool for predicting hybrid performance. The dynamics of a commercial breeding program involve the evaluation of several traits simultaneously in a l...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/s41437-020-0321-0
更新日期:2020-08-01 00:00:00
abstract::The central aim of evolutionary biology is to understand patterns of genetic variation between species and within populations. To quantify the genetic variation underlying intraspecific differences, estimating quantitative genetic parameters of traits is essential. In Pterygota, wing morphology is an important trait a...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/s41437-020-0318-8
更新日期:2020-08-01 00:00:00
abstract::Populations of the common chimpanzee (Pan troglodytes) are in an impending risk of going extinct in the wild as a consequence of damaging anthropogenic impact on their natural habitat and illegal pet and bushmeat trade. Conservation management programmes for the chimpanzee have been established outside their natural r...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/s41437-020-0313-0
更新日期:2020-08-01 00:00:00
abstract::Eukaryotic genomes frequently acquire new protein-coding genes which may significantly impact an organism's fitness. Novel genes can be created, for example, by duplication of large genomic regions or de novo, from previously non-coding DNA. Either way, creation of a novel transcript is an essential early step during ...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/s41437-020-0319-7
更新日期:2020-08-01 00:00:00
abstract::Sex chromosomes are predicted to harbour elevated levels of sexually antagonistic variation due to asymmetries in the heritability of recessive traits in the homogametic versus heterogametic sex. This evolutionary dynamic may manifest as high recessive load specifically affecting the homogametic sex, and the retention...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/s41437-020-0316-x
更新日期:2020-08-01 00:00:00
abstract::Mate choice behaviors are among the most important reproductive isolating barriers in many animals. Little is known about the genetic basis of reproductively isolating behaviors, but examples to date provide evidence that they can have a simple genetic basis. However, it is unclear if these results indicate that indiv...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/s41437-020-0309-9
更新日期:2020-06-01 00:00:00
abstract::Estimating kinship is fundamental for studies of evolution, conservation, and breeding. Genotyping-by-sequencing (GBS) and other restriction based genotyping methods have become widely applied in these applications in non-model organisms. However, sequencing errors, depth, and reproducibility between library preps cou...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/s41437-020-0302-3
更新日期:2020-05-01 00:00:00
abstract::The availability of whole genome sequencing (WGS) data enables the discovery of causative single nucleotide polymorphisms (SNPs) or SNPs in high linkage disequilibrium with causative SNPs. This study investigated effects of integrating SNPs selected from imputed WGS data into the data of 54K chip on genomic prediction...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/s41437-019-0246-7
更新日期:2020-01-01 00:00:00
abstract::Spatial patterns of genetic variation can reveal otherwise cryptic evolutionary and landscape processes. In northwestern Costa Rica, an approximately concordant genetic discontinuity occurs among populations of several plant species. We conducted phylogeographic analyses of an epiphytic orchid, Brassavola nodosa, to t...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/s41437-019-0218-y
更新日期:2019-11-01 00:00:00
abstract::Gene flow via pollen movement affects genetic variation in plant populations and is an important consideration in plant domestication. Fontainea picrosperma is a subcanopy rainforest tree that is of commercial interest because it is the source of tigilanol tiglate, a natural product used for the treatment of solid tum...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/s41437-019-0231-1
更新日期:2019-10-01 00:00:00
abstract::Deleterious mutations accumulating on non-recombining Y chromosomes can drive XY to XY turnovers, as they allow to replace the old mutation-loaded Y by a new mutation-free one. The same process is thought to prevent XY to ZW turnovers, because the latter requires fixation of the ancestral Y, assuming dominance of the ...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/s41437-019-0225-z
更新日期:2019-09-01 00:00:00
abstract::Colour polymorphisms have evolutionary significance for the generation and maintenance of species diversity. Demonstrating heritability of polymorphic traits can be challenging for wild populations of long-lived species because accurate information is required on trait expression and familial relationships. The Austra...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/s41437-019-0212-4
更新日期:2019-09-01 00:00:00
abstract::The evolutionary history of species is a dynamic process as they modify, expand, and contract their spatial distributions over time. Range expansions (REs) occur through a series of founder events that are followed by migration among neighboring demes. The process usually results in structured metapopulations and leav...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/s41437-018-0164-0
更新日期:2019-06-01 00:00:00
abstract::Infectious diseases have a huge impact on animal health, production and welfare, and human health. Understanding the role of host genetics in disease spread is important for developing disease control strategies that efficiently reduce infection incidence and risk of epidemics. While heritable variation in disease sus...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/s41437-018-0176-9
更新日期:2019-06-01 00:00:00
abstract::Plant breeders are supported by a range of tools that assist them to make decisions about the conduct or design of plant breeding programs. Simulations are a strategic tool that enables the breeder to integrate the multiple components of a breeding program into a number of proposed scenarios that are compared by a ran...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/s41437-018-0156-0
更新日期:2019-05-01 00:00:00
abstract::In wide-ranging taxa with historically dynamic ranges, past allopatric isolation and range expansion can both influence the current structure of genetic diversity. Considering alternate historical scenarios involving expansion from either a single refugium or from multiple refugia can be useful in differentiating the ...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/s41437-018-0135-5
更新日期:2019-04-01 00:00:00
abstract::The equal probability of transmission of alleles from either parent during sexual reproduction is a central tenet of genetics and evolutionary biology. Yet, there are many cases where this rule is violated. The preferential transmission of alleles or genotypes is termed transmission ratio distortion (TRD). Examples of...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/s41437-018-0107-9
更新日期:2019-03-01 00:00:00
abstract::Climatic changes have played major roles in plants' evolutionary history. Glacial oscillations have been particularly important, but some of their effects on plants' populations are poorly understood, including the numbers and locations of refugia in Asian warm temperate zones. In the present study, we investigated th...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/s41437-018-0123-9
更新日期:2019-03-01 00:00:00
abstract::The genetic structure of 13 populations of the amphiatlantic sea urchin Arbacia lixula, as well as temporal genetic changes in three of these localities, were assessed using ten hypervariable microsatellite loci. This thermophilous sea urchin is an important engineer species triggering the formation of barren grounds ...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/s41437-018-0098-6
更新日期:2019-02-01 00:00:00
abstract::North Africa is now recognized as a major area for the emergence and dispersal of anatomically modern humans from at least 315 kya. The Mediterranean Basin is thus particularly suited to study the role of climate versus human-mediated changes on the evolutionary history of species. The Algerian mouse (Mus spretus Lata...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/s41437-018-0089-7
更新日期:2019-02-01 00:00:00
abstract::Prolific breeds of domestic sheep (Ovis aries) are important genetic resources due to their reproductive performance, which is characterized by multiple lambs per birth and out-of-season breeding. However, the lack of a comprehensive understanding of the genetic mechanisms underlying the important reproductive traits,...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/s41437-018-0090-1
更新日期:2019-02-01 00:00:00
abstract::Many Odonata species exhibit female-limited polymorphisms, where one morph is similar to the conspecific male in body color and other traits (andromorph), whereas one or more other morphs differ from the male (gynomorphs). Here we investigated the differentially expressed transcripts (DETs) among males and two female ...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/s41437-018-0076-z
更新日期:2019-01-01 00:00:00
abstract::Lung cancer is the leading cause of cancer deaths in both men and women in the US. While most sporadic lung cancer cases are related to environmental factors such as smoking, genetic susceptibility may also play an important role and a number of lung cancer associated single-nucleotide polymorphisms (SNPs) have been i...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/s41437-018-0063-4
更新日期:2018-12-01 00:00:00
abstract::When individuals interact, their phenotypes may be affected not only by their own genes but also by genes in their social partners. This phenomenon is known as Indirect Genetic Effects (IGEs). In aquaculture species and some plants, however, competition not only affects trait levels of individuals, but also inflates v...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/s41437-018-0068-z
更新日期:2018-12-01 00:00:00
abstract::Whether or not evolution by natural selection is predictable depends on the existence of general patterns shaping the way mutations interact with the genetic background. This interaction, also known as epistasis, has been observed during adaptation (macroscopic epistasis) and in individual mutations (microscopic epist...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/s41437-018-0143-5
更新日期:2018-11-01 00:00:00
abstract::Reaction norms or tolerance curves have often been used to predict how organisms deal with fluctuating environments. A potential drawback is that reaction norms measured in different constant environments may not capture all aspects of organismal responses to fluctuating environments. We examined growth of the filamen...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/s41437-018-0138-2
更新日期:2018-10-01 00:00:00
abstract::How life-history strategies influence the evolution of populations is not well understood. Most existing models stem from the Wright-Fisher model which considers discrete generations and a fixed population size, thus not taking into account any potential consequences of overlapping generations and demographic stochast...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/s41437-018-0118-6
更新日期:2018-10-01 00:00:00
abstract::Identifying genetic cues of functional relevance is key to understanding the drivers of evolution and increasingly important for the conservation of biodiversity. This study introduces nuclear ribosomal DNA (nrDNA) to mitochondrial DNA (mtDNA) copy number ratios as a metric with which to screen for this functional gen...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/s41437-018-0088-8
更新日期:2018-08-01 00:00:00
abstract::Despite the crucial role of cyanobacteria in various ecosystems, little is known about their evolutionary histories, especially microevolutionary dynamics, because of the lack of knowledge regarding their mutation rates. Here we directly estimated cyanobacterial mutation rates based on ancient DNA analyses of ice core...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/s41437-017-0040-3
更新日期:2018-06-01 00:00:00
abstract::Metabolism is a key determinant of plant growth and modulates plant adaptive responses. Increased metabolic variation due to heterozygosity may be beneficial for highly homozygous plants if their progeny is to respond to sudden changes in the habitat. Here, we investigate the extent to which heterozygosity contributes...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/s41437-017-0030-5
更新日期:2018-05-01 00:00:00
abstract::There are only few studies of dominance effects in non-inbred aquaculture species, since commonly used mating designs often have low power to separate dominance, maternal and common environmental effects. Here, a factorial design with reciprocal cross, common rearing of eggs and subsequent lifecycle stages and pedigre...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/s41437-017-0046-x
更新日期:2018-05-01 00:00:00
abstract::Disease-associated variants in the human genome are continually being identified using DNA sequencing technologies that are especially effective for Mendelian disorders. Here we sequenced whole genome to high coverage (>30×) of 6 members of a 7-generation family with dwarfism from a consanguineous tribe in Pakistan to...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/s41437-017-0021-6
更新日期:2018-01-01 00:00:00
abstract::The impact of environmental conditions on the expression of genetic variance and on maternal effects variance remains an important question in evolutionary quantitative genetics. We investigate here the effects of early environment on variation in seven adult life history, morphological, and secondary sexual traits (i...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/s41437-017-0029-y
更新日期:2018-01-01 00:00:00
abstract::Trichogramma wasps can be rendered asexual by infection with the maternally inherited symbiont Wolbachia. Previous studies indicate the Wolbachia strains infecting Trichogramma wasps are host-specific, inferred by failed horizontal transfer of Wolbachia to novel Trichogramma hosts. Additionally, Trichogramma can becom...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/hdy.2017.53
更新日期:2017-12-01 00:00:00
abstract::In prediction of genomic values, the single-step method has been demonstrated to outperform multi-step methods. In statistical analyses of longitudinal traits, the random regression test-day model (RR-TDM) has clear advantages over other models. Our goal in this study was to evaluate the performance of a model that in...
journal_title:Heredity
pub_type: 杂志文章
doi:10.1038/hdy.2016.91
更新日期:2017-12-01 00:00:00